ライフサイエンスコーパス: pig

1 e samples to 50 x 10(6) autologous cells per pig.

2 gainst capsaicin-induced cough in the guinea pig.

3 radar, of the bed topography across parts of PIG.

4 ared six representative genotypes of H3N2 in pigs.

5 ion, inflammation and cell death in mice and pigs.

6 okines and cell-mediated immune responses in pigs.

7 are released from coronary artery PVAT from pigs.

8 ion in cynomolgus and rhesus macaques and in pigs.

9 no-generation of human tissues and organs in pigs.

10 agricultural animals co-occurring with wild pigs.

11 d in humans, mice, ruminants and recently in pigs.

12 respiratory pathogenic/commensal bacteria of pigs.

13 d these reactions are highly reproducible in pigs.

14 ting the diaphragm in sedated and ventilated pigs.

15 n of the atrioventricular junction in intact pigs.

16 the ability to colonize and cause disease in pigs.

17 ation of different genomic constellations in pigs.

18 in obese-stimulated compared with lean mini-pigs.

19 in 10 anesthetized, spontaneously breathing pigs.

20 A viruses was the same as that of miniature pigs.

21 ls were studied, including 182 mice and five pigs.

22 sudden sensorineural hearing loss in guinea pigs.

23 ypacing, as well as in sham-operated control pigs.

24 lin administration were similar to wild-type pigs.

25 biotics enhanced growth and health of weaned pigs.

26 microRNAs were also detected in GRG and OURT pigs.

27 pain sensitivity induced by tail injuries in pigs.

28 Twelve mechanically ventilated pigs.

29 ses was the same as that of larger miniature pigs.

30 rgest contributors, followed by chickens and pigs.

31 elopment of robust early warning systems for pigs.

32 biochemical analyses comparable to wild-type pigs.

33 Newborn and 3 days to 1 week old pigs.

34 SV-1-infected mice and HSV-2-infected guinea pigs.

35 xpression and response to PRRSV infection in pigs.

36 vestigated in tumor-bearing mice and healthy pigs.

37 ion and glucose metabolism regulation in DKO pigs.

38 ction of NAbs and T cell responses in guinea pigs.

39 neurons of the inferior colliculus in guinea pigs.

40 ial passages favour H9N2 virus adaptation to pigs.

41 oss of both HAM-1 and its target, the kinase PIG-1 [PAR-1(I)-like Gene], leads to abnormal dopaminerg

42 iscrete genetic relationships between ham-1, pig-1 and apoptosis pathway genes in dopaminergic head n

43 ets and pathways that mediate the effects of PIG-1 kinase loss in C. elegans embryos.

44 hosphorylation levels, between wild-type and pig-1 mutant embryos are predominantly connected with pr

45 Female crossbred Landrace/Yorkshire/Duroc pigs (27-32 kg).

46 ely to originate from chickens (56%) or from pigs (32%).

47 Ten pigs, 35 +/- 5.2 kg.

48 METHODS AND In 8 pigs (+/-70 kg), the suprasternal esophagus was surgical

49 g epidemic events of infection in which most pigs (98.4%) tested PCR positive for IAVs.

50 lacetoacetate hydrolase deficient (FAH(-/-)) pigs, a novel large-animal model of HT1, develop fibrosi

51 portant candidates for deletion in producing pigs against which there is a reduced primate immune res

52 nd that naive hPSCs robustly engraft in both pig and cattle pre-implantation blastocysts but show lim

53 We exposed pig and human airway explants, pig and human ASL, and th

54 We exposed pig and human airway explants, pig and human ASL, and the human cationic AMPs beta-defe

55 air pollution leads to activation of guinea pig and human sensory nerves, which are responsible for

56 ed for the establishment of pregnancy in the pig and may serve to regulate the proinflammatory respon

57 nd growing contribution to sea level rise of PIG and nearby glaciers.

58 HOMA-insulin resistance in fasted adult DKO pigs and blood glucose and C-peptide changes after intra

59 hip among LA-MRSA CC398 isolates from Danish pigs and cases of BSI and SSTI.

60 The co-occurrence of wild pigs and farms increased annually at a rate of 1.2% with

61 s to reduce the risk of transmission between pigs and from pigs to people.

62 nted into the mandibles of host Yucatan mini-pigs and grown for 3 or 6 mo.

63 evaluated for visualization of beta-cells in pigs and nonhuman primates by positron emission tomograp

64 ompeted away dose-dependently in nondiabetic pigs and nonhuman primates.

65 ht kidneys were removed from 30-kg Yorkshire pigs and preserved with 8-hour NEVKP or in 4 degrees C h

66 ulting in the presence of human genotypes in pigs and supporting further investigation of zoonotic As

67 other cathelicidins, including human, mouse, pig, and dog cathelicidins, which lack antimicrobial act

68 small-animal species, namely, ferret, guinea pig, and hamster.

69 the microminipig was similar to that of the pig, and the sensitivity of microminipigs to influenza A

70 sults obtained in rodents, primates, humans, pigs, and dogs.

71 amples of cats, chickens, cows, dogs, ducks, pigs, and pigeons.

72 With the pigs anesthetized and mechanically ventilated, 40 mL/kg

73 eN double bond, caused by an increase of its pig* antibonding character.

74 Pigs are an important biomedical model species and a key

75 in farrow-to-wean farms, which is where most pigs are born.

76 Pigs are considered a mixing vessel for the generation o

77 atures of immune responses in PRRSV-infected pigs are delayed onset and low levels of virus neutraliz

78 mited because experiments with regular-sized pigs are difficult to perform.

79 one intact NANOS2 allele and female knockout pigs are fertile.

80 Commercial pigs are frequently exposed to tail mutilations in the f

81 Wild pigs are increasingly a potential veterinary and public

82 CD163 knockout (KO) pigs are resistant to infection with genotype 2 (type 2)

83 the way for the development of macaques and pigs as immunocompetent animal models to study HBV infec

84 aker was epicardially tested in a euthanized pig at 60 beats per minute, 2 V amplitude, and 1 ms puls

85 ted in animal fats (butter fat, subcutaneous pig back-fat and subcutaneous ham fat).

86 Ps concentration of 802 ng/g ww, whereas the pig-based feed contained summation operatorPOPs of 24 ng

87 om cynomolgus macaques, rhesus macaques, and pigs became fully susceptible to HBV upon hNTCP expressi

88 -genome DNA methylation datasets from single pig blastocysts showing differences between in vivo and

89 emale mice and in the isolated female guinea pig brain preparation during perfusion with 4-AP.

90 gential brain slices and the isolated guinea pig brain with the potassium channel blocker 4-aminopyri

91 cortex of the in vitro isolated whole guinea pig brain.

92 ce to this study, is the antibiotic abuse in pig breeding.

93 y 33% (P < 0.01) in obese-nonstimulated mini-pigs but was no different in obese-stimulated compared w

94 ncreased replication and transmissibility in pig, but were still inefficient when compared to pH1N1.

95 proteins were not identical for patients and pigs, but in-silico pathway analysis of proteins with >/

96 All six genotypes efficiently infected pigs, but they resulted in different degrees of lung dam

97 iac arrest was induced in female large white pigs by intravenous injection of potassium chloride.

98 n characterized in vivo in five anesthetized pigs, by placing one antenna outside the body, and the o

99 sociated compared with lumenal microbiota in pig caecum.

100 e editing shown here demonstrates that these pigs can serve as a powerful tool for dissecting in vivo

101 This study demonstrates that pigs can support low-level amplification of CWD prions,

102 ad transitions in isolated murine and guinea pig cardiac myocytes and mitochondria.

103 uggest that CO induces arrhythmias in guinea pig cardiac myocytes via the ONOO(-)-mediated inhibition

104 ptic connections in the retina of the guinea pig (Cavia porcellus) by recording inhibitory currents f

105 tractile indices in detergent-skinned guinea pig (Cavia porcellus) cardiac muscle fibers in the absen

106 rcumstantial evidence suggesting that guinea pigs (Cavia porcellus) lack CD59, at least on erythrocyt

107 However, pig CD47 has previously been shown to be ineffective in

108 ransplant patients to 3 glycan knockout (KO) pig cells and class I swine leukocyte antigens (SLA).

109 nt of a latent viral reservoir in the guinea pig challenge model of HSV-2 infection.

110 d divergent changes between Chinese domestic pigs (CHD) and European domestic pigs (EUD).

111 the travelling wave in regions of the guinea pig cochlea that respond to low frequencies (<2 kHz) and

112 processing of sound performed by the guinea pig cochlea varies substantially between the cochlear ap

113 uted over the apical two turns of the guinea pig cochlea.

114 Fourteen TD and 12 PIGD cognitively-intact patients and 21 age- and sex-mat

115 from cases of H. parasuis-related disease in pigs collected between 2013 and 2014.

116 ISPR/Cas9 gene editing was used to knock out pig conceptus IL1B2 expression and the secretion of IL1B

117 Pig conceptuses undergo a unique rapid morphological tra

118 h-risk areas for PRRS were best-predicted by pig density and climate seasonality and included Minneso

119 month after mitral regurgitation induction, pigs developed HF as evidenced by increased left ventric

120 Guinea pigs developed high titers of broadly cross-reactive ant

121 As expected, control nonimmune pigs developed signs of acute African swine fever (ASF).

122 ied all Iberian ham samples according to the pigs' diet (classification rate of 100%).

123 ed in vivo imaging technique, that wild-type pigs display both a basal and a Toll-like receptor-media

124 including mouse, ferret, hamster, and guinea pig DPP4, do not.

125 permissivity for ferret, hamster, and guinea pig DPP4.

126 responses were reduced in immunocompromised pigs during the acute phase of infection, but TNF-alpha-

127 port efficient disabling pancreatogenesis in pig embryos via zygotic co-delivery of Cas9 mRNA and dua

128 ow limited contribution to post-implantation pig embryos.

129 se domestic pigs (CHD) and European domestic pigs (EUD).

130 Hyperglycemia in db pigs, even without ischemia, induced capillary rarefacti

131 ; 2 pigs had 2 fluorescent lymph nodes and 1 pig exhibited a single lymph node.

132 baboons receiving hematopoietic cells from a pig expressing high levels of human CD47.

133 This inexpensive pig eye model provides a safe and effective microsurgica

134 tome-mediated ab interno trabeculectomies in pig eyes (n = 63).

135 for adenocarcinomas, but not with poultry or pig farming.

136 siblings were fed a control diet containing pig fat as the main fat source.

137 mpound profile of dry-cured Iberian ham from pigs fattened on acorn and pasture or on feed.

138 terations of microbiota in the distal gut of pigs fed E. faecalis UC-100 substituting antibiotics, th

139 The intestinal microbiota of finishing pigs, fed with 16%, 13% and 10% crude protein (CP) in di

140 streamlining the production of genome-edited pigs for disease modeling.

141 rst evaluation of glucose homeostasis in DKO pigs for two major xenoantigens paves the way to their u

142 mplete genome data from 47 wild and domestic pigs from Asia and Europe.

143 ics, this study assessed fecal microbiota in pigs from different dietary treatments: the basal diet g

144 alues of virus-like particles (VLPs) against pig gastric mucin (PGM) using 4 VLPs that represent diff

145 METHODS AND Four 5-pig groups underwent different I/R protocols: 40-minute

146 f 5 fluorescent lymph nodes were detected; 2 pigs had 2 fluorescent lymph nodes and 1 pig exhibited a

147 Moreover, 78% of the pigs had recurrent infections with IAVs closely related

148 However, the use of pig has not proven popular due to technical difficulties

149 Miniature pigs have been used as an experimental animal model, but

150 prevent disease transmission into commercial pig herds, it is therefore vital to have knowledge about

151 nsuming and costly, generating genome-edited pigs holds great promise for agricultural, biomedical, a

152 llenge with the parental virulent virus, all pigs immunized by the intramuscular route (11/11) and al

153 METHODS AND Pigs implanted with single-chamber implantable cardiover

154 anges may be required to become virulent for pigs.IMPORTANCE Swine play an important role in the inte

155 f the acceptability of meat from entire male pigs in 8 different meat products (cutlets, bacon, blade

156 netic resources that enable effective use of pigs in both agricultural production and biomedical rese

157 r, experiments to understand reassortment in pigs in detail have been limited because experiments wit

158 d in two children with diarrhea and numerous pigs in Taiwan.

159 e 2009 IAV pandemics highlighted the role of pigs in the emergence of IAVs with pandemic potential.

160 aracterize differentially expressed genes in pigs infected with a low pathogenic ASFV isolate, OUR T8

161 ecordings of neural activity from the guinea pig inferior colliculus have shown that individual audit

162 In anesthetized guinea pigs intratracheal administration of DEPs activated airw

163 ediating adverse cardiopulmonary distress in pigs irrespective of complement activation.

164 In conclusion, the FAH(-/-) pig is a large-animal model of HT1 with clinical charact

165 In particular, the domestic pig is a proven model of human physiology and an agricul

166 Pig is also a useful medical model for humans due to its

167 A TMA-like state also developed in guinea pigs IV administered PEO+.

168 analysis of Lobster hepatopancreas (TORT-2), pig kidney (ERM-BB186), and groundwater (ERM-CA615) cert

169 Finally, in the preclinical pig kidney transplant model, intravenous injection of GC

170 here is a reduced primate immune response in pig kidney xenograft.

171 After implantation into pig knees, hMSCs labeled with group 1 medium showed sign

172 We recently identified the low KM guinea pig L-asparaginase (gpASNase1).

173 We conclude that guinea pigs lack an intact gene encoding CD59; to our knowledge

174 g in pigs, we report here establishment of a pig line with Cre-inducible Cas9 expression that allows

175 herapy is available, may be candidates for a pig liver, even if only as a bridge until an allograft b

176 plied this to experimentally infected guinea pig lung sections and were able to distinguish both cell

177 ws respiratory oscillations in the uninjured pig lung, in the absence of cyclical atelectasis (as det

178 Therefore, the miniature pig may be an appropriate animal model for preclinical s

179 Our data confirmed the utility of a pig model for intranasal particulate flu vaccine deliver

180 In a well-established guinea pig model of aerosol infection with Mycobacterium tuberc

181 After promising results in the guinea pig model of EBOV infection, EBOTAb was tested in the cy

182 This pig model will aid in delineating the mechanisms of chro

183 volume loading in both normal animals and a pig model with diastolic dysfunction.

184 h open (n=3) and closed chest (n=5) and in a pig model with features of human heart failure and prese

185 rotective cell-mediated immune response in a pig model.

186 a triggers secretion in wild-type but not in pig models of cystic fibrosis, suggesting an impaired re

187 reperfusion reduces infarct size in rat and pig models of myocardial infarction.

188 system is developed; it automatically tracks pig movement with depth video cameras, and automatically

189 mp recordings were made from isolated guinea pig myocytes as well as from human embryonic kidney 293

190 induced early afterdepolarizations in guinea pig myocytes.

191 Using the DiamondTemp (DT) catheter, pigs (n = 6) underwent discrete atrial ablation in a tem

192 ne on the altricial rat and precocial guinea pig neonate demonstrated that the effect of vasopressin

193 ced by hemorrhage and resuscitation in large pigs, noninvasive cardiac output monitoring has acceptab

194 In both humans and pigs, nonwounded skin contained abundantly CD26-positive

195 n auditory neurons of chinchillas and guinea pigs of both sexes, and show how heterogeneous tuning pr

196 ompared the pathogenesis and transmission in pigs of six representative genotypes.

197 Rearing entire male pigs, one of the alternatives for surgical castration, e

198 extended survival of genetically engineered pig organs in nonhuman primates, varying from almost 10

199 mulus-oocyte complexes derived from immature pig ovaries and provides a twofold increase in the effic

200 ABSTRACT: A computational model of guinea-pig pancreatic duct epithelium was developed to determin

201 ence genome sequences of the DNA eliminating pig parasitic nematode Ascaris suum and the horse parasi

202 ircuit in healthy controls, TD patients, and PIGD patients before and after levodopa administration.

203 After levodopa intake, the PIGD patients had significantly increased activation in

204 it during tapping in TD patients, but not in PIGD patients.

205 Human IgG, eluted from human and pig peripheral blood mononuclear cells, interacted acros

206 As animal sources we considered chicken, pig, pet dog or cat, cattle, and poultry other than chic

207 We found that NANOS2 knockout pigs phenocopy knockout mice with male specific germline

208 reversion in conscious long-term tachypaced pigs: Pigs were subjected to atrial tachypacing (7 Hz) u

209 spread to Russia, jeopardizing the European pig population and making it essential to deepen knowled

210 and other European countries with industrial pig production.

211 The benefits of MR antagonism in the pig provide a rational basis for future clinical trials

212 ent inducers; untreated male monkeys, guinea pigs, rabbits, and hamsters; and female dogs.

213 SLA class I KO cells after depletion with WT pig RBCs to remove cell surface reactive antibodies, but

214 lowed a bimodal pattern in all 40-minute I/R pigs, regardless of cardioprotective strategy and the de

215 Pigs represent ideal human disease models due to their s

216 wave of LA-MRSA CC398 SSTIs and an expanding pig reservoir.

217 Deletion of a third gene from pigs resulted in 30% of human samples having less IgG an

218 N1 pandemic virus (H1N1pdm09) from humans to pigs resulted in substantial evolution of influenza A vi

219 F delta retinal ganglion cells in the guinea pig retina and monitored synaptic currents that were evo

220 4, 7, 11 and 14 days post infection from 44 pigs revealed 6,430 differentially expressed genes at on

221 PIG's retreat rate has increased in recent decades with

222 Closed-chest 40 min I/R was performed in 20 pigs sacrificed at 120 min, 24 hours, 4days, and 7days a

223 ain was also impaired for survival in guinea pig sera and sheep blood.

224 for quantitative analysis of cloxacillin in pig serum.

225 While only 2/6 direct-contact pigs showed nasal virus excretion of H9N2:pH1N1 (P0) >/=

226 acute edematous wave was ameliorated only in pigs showing cardioprotection (ie, those undergoing shor

227 s of skin preparation and DF injection using pig skin and SimSkin (silicone) materials, respectively.

228 g dermal accumulation of the ATRA in explant pig skin.

229 In 15 adult mini-pigs, stimulating electrodes were placed around the dors

230 response to iNSC therapy in a translational pig stroke model with increased predictive potential str

231 tricular refractoriness or blood pressure in pigs subjected to 7 days atrial tachypacing, as well as

232 t experiments were performed in anesthetized pigs subjected to a transient or stable BP increase indu

233 jected to renal ischemia-reperfusion injury, pigs subjected to renal transplantation and liver transp

234 -to-wean farms over time, demonstrating that pig subpopulation dynamics are important to better under

235 distribution and diversity of IAVs among the pig subpopulations studied.

236 D) and postural instability/gait difficulty (PIGD) subtype patients during a motor task.

237 tive results obtained with orally inoculated pigs suggest that it may be possible for swine to serve

238 en-toed hoofed Goettingen miniature domestic pig (Sus scrofa domesticus) were evaluated by immunohist

239 s, we obtained a 2.24-A crystal structure of pig-tailed macaque APOBEC3H with bound RNA.

240 We compared and contrasted pathogenic (in pig-tailed macaques [PTMs]) and nonpathogenic (in Africa

241 Our findings further support female pig-tailed macaques as a model of M. genitalium infectio

242 Pine Island Glacier (PIG) terminates in a rapidly melting ice shelf, and ocea

243 Using this approach a line of pigs that carry pseudo attP sites within the COL1A locus

244 s and often lethal viral disease of domestic pigs that has significant economic consequences for the

245 ation consisted of female and castrated male pigs that were sired by boars represented by 4 breeds.

246 In neonatal gnotobiotic pigs, the icPC22A-S1Delta197 virus caused mild to modera

247 In mice and guinea pigs, the rLmIII/a30 and rLmI/h30 vaccines were generall

248 In five pigs, the same protocol was repeated during mechanical v

249 In pigs, the virus replicates predominantly in macrophages.

250 hough all six genotypes efficiently infected pigs, they resulted in different degrees of pathology an

251 with experiments in heart cells from guinea pigs to determine how cellular electrical activity is re

252 y for the use of large animal models such as pigs to either serve as an alternative, or complement in

253 e risk of transmission between pigs and from pigs to people.

254 In addition to the concerns about pig-to-human immunological compatibility, the risk of cr

255 The majority of these events indicates the pig-to-human spillover, although a reverse route of tran

256 rough mixed hematopoietic chimerism across a pig-to-primate barrier.

257 Seventy-two ex vivo pig tracheal two-lung blocks.

258 psies from patients undergoing CABG and from pigs undergoing coronary occlusion/reperfusion without (

259 In the experimental study, 20 pigs underwent 40-minute ischemia/reperfusion followed b

260 Three female pigs underwent a submucosal injection of the bladder wit

261 eight classes and applied it to 43 anonymous pig urine and muscle paired samples and fulfilled the pa

262 of injection overcomes adverse reactions in pigs using two independent approaches.

263 This new route for genome engineering in pigs via zygote injection should greatly enhance applica

264 To further facilitate genome editing in pigs, we report here establishment of a pig line with Cr

265 ensity ranged between 0 and 71 cases per 100 pigs-week.

266 Brain samples from selected pigs were also bioassayed in mice expressing porcine pri

267 Thirty pigs were anesthetized and then randomized to cardiac ar

268 rmine the temporal profile of sensitisation, pigs were exposed to surgical tail resections and mechan

269 Pigs were fed a normocholesterolemic (NC) or hypercholes

270 fection with both type 1 and type 2 viruses, pigs were genetically modified (GM) to possess one of th

271 METHODS AND Ten pigs were randomized to either sham irradiation or irrad

272 month after mitral regurgitation induction, pigs were randomized to intracoronary delivery of either

273 Pigs were randomly assigned to "control" (FIO2 0.3, adju

274 Pigs were randomly assigned to cardiac arrest caused by

275 Pigs were randomly assigned to cardiac arrest induced by

276 After 60 minutes, pigs were resuscitated with shed blood and crystalloid.

277 etylgalactosaminyl transferase (B4GalNT2) KO pigs were screened for human antibody binding using flow

278 Eighteen Yorkshire pigs were studied.

279 sion in conscious long-term tachypaced pigs: Pigs were subjected to atrial tachypacing (7 Hz) until t

280 FAH(-/-) pigs were treated with the protective drug 2-(2-nitro-4-

281 Guinea pigs were used as an animal model to understand the hema

282 METHODS AND A total of 43 pigs were used for the studies.

283 Two DEGs (ACP5 and PIGS) were observed in all comparisons.

284 The retreating Pine Island Glacier (PIG), West Antarctica, presently contributes 5-10% of g

285 (Arg)9] were efficacious in vivo in mice and pigs, where specific CD8(+) T and CD4(+) T-cell response

286 -one phyla and 137 genera were shared by all pigs, whereas 12 genera were uniquely identified in the

287 rgen-specific blocking IgG in outbred guinea pigs which had been immunized with recombinant birch pol

288 emia in mice and abortion in pregnant guinea pigs, while complementation of capsule expression almost

289 agious and often lethal disease for domestic pigs with a significant economic impact for the swine in

290 tudy defines evolution of coagulopathy in 10 pigs with acetaminophen (APAP)-induced ALI compared to 3

291 on the healing of burn wounds in the skin of pigs with experimentally induced type 1 diabetes.

292 ured in all animals by surgical ischaemia in pigs with human sized livers (1.2-1.6 kg liver weights).

293 Moreover, male pigs with one intact NANOS2 allele and female knockout p

294 Nineteen hypercholesterolemic pigs with preexisting coronary artery disease.

295 Infection of CD163-modified pigs with representative type 1 and type 2 viruses confi

296 cine alveolar macrophages (PAMs) showed that pigs with the KO or SRCR domain 5 deletion did not expre

297 anism in pancreatic sections from humans and pigs without diabetes, but not those with diabetes.

298 ry of anaesthetized, mechanically ventilated pigs, without lung injury.

299 (PEDV) is a devastating cause of diarrhea in pigs worldwide.

300 natural and elicited antibodies specific for pig xenoantigens, alpha-(1,3)-galactose (GAL) and N-glyc