ライフサイエンスコーパス: pigment epithelial cell

1 eavage before internalization by the retinal pigment epithelial cell.

2 e the proliferative potential of the retinal pigment epithelial cell.

3 types, human trabecular meshwork and retinal pigment epithelial cells.

4 generation of rod photoreceptors and retinal pigment epithelial cells.

5 CD mRNA expression in cultured human retinal pigment epithelial cells.

6 horylation in TGF-beta-treated human retinal pigment epithelial cells.

7 ascular complex, surrounded by FasL+ retinal pigment epithelial cells.

8 support functions usually adopted by retinal pigment epithelial cells.

9 ll-to-cell spread in polarized human retinal pigment epithelial cells.

10 erior retinal blood vessels and some retinal pigment epithelial cells.

11 so stimulated proliferation of human retinal pigment epithelial cells.

12 y reveals sporadic degeneration of scattered pigment epithelial cells.

13 entration (IC(5)(0)) of 20 mug/mL in retinal pigment epithelial cells.

14 nesis and a cytoprotective agent for retinal pigment epithelial cells.

15 and reduced cathepsin D activity in retinal pigment epithelial cells.

16 egument protein were tested in human retinal pigment epithelial cells.

17 inal capillary endothelial cells and retinal pigment epithelial cells.

18 f increased iron on the functions of retinal pigment epithelial cells.

19 upregulates IL-8 and CCL2 levels in retinal pigment epithelial cells.

20 ytes, retinal endothelial cells, and retinal pigment epithelial cells.

21 e stress on the UPP in cultured human retina pigment epithelial cells.

22 itis and that IL-22 can affect human retinal pigment epithelial cells.

23 gamma, to increase CFH expression in retinal pigmented epithelial cells.

24 man leukemia cells, HL-60, and human retinal pigmented epithelial cells.

25 through the transdifferentiation of the iris-pigmented epithelial cells.

26 d vessels surrounded by proliferated retinal pigmented epithelial cells.

27 lated from mammalian endothelial and retinal pigmented epithelial cells.

28 rms fewer atypical fibers with human retinal pigmented epithelial cells.

29 Over time, the Mreg(-/-) mouse retinal pigment epithelial cells accumulate the lipofuscin compo

30 n had a moderate effect on enhancing retinal pigmented epithelial cell adhesion and migration on norm

31 ing spontaneously immortalized human retinal pigment epithelial cells (adult retinal pigment epitheli

32 O-2s protect human neuroblastoma and retinal pigmented epithelial cells against hydroxyl radicals in

33 Retinal pigment epithelial cells and cells in the inner retina,

34 a novel, high Mr protein from human retinal pigment epithelial cells and endothelial cells by affini

35 se-negative normal human cell types, retinal pigment epithelial cells and foreskin fibroblasts, were

36 4F2hc or b(0,+)AT and rBAT in human retinal pigment epithelial cells and in COS-1 cells.

37 debris by monocytes/macrophages and retinal pigment epithelial cells and is capable of producing an

38 be required for viral replication in retinal pigment epithelial cells and microvascular endothelial c

39 ls, whereas AdV5-GFP transduced only retinal pigment epithelial cells and occasional photoreceptors a

40 gment changes indicative of reactive retinal pigment epithelial cells and photoreceptor degeneration.

41 The RPE65 protein is located in the retinal pigment epithelial cells and plays an important role in

42 cular, retrolental tissue containing retinal pigment epithelial cells and remnants of the hyaloid vas

43 teinase (MMP) inhibitory activity in retinal pigment epithelial cells and resulted in increased secre

44 od outer segment-challenged, control retinal pigment epithelial cells and zif-268, AP-1, AP-2, or tis

45 AT), an enzyme present mainly in the retinal pigmented epithelial cells and liver, converts all-trans

46 In 2 wk, we generated both retinal pigmented epithelial cells and self-forming neural retin

47 n Muller cells (rMCs), primary mouse retinal pigment epithelial cells, and astrocytes.

48 idual cells, such as photoreceptors, retinal pigment epithelial cells, and blood cells in the retinal

49 orphogenetic protein-4 expression in retinal pigment epithelial cells, and both bone morphogenetic pr

50 cell lines including hepatoma cells, retinal pigment epithelial cells, and keratinocytes as well as i

51 hree cell types: dermal fibroblasts, retinal pigment epithelial cells, and vascular endothelial cells

52 We disrupted CETN2 in human retinal pigmented epithelial cells, and despite having intact ce

53 including lung and skin fibroblasts, retinal pigmented epithelial cells, and endometrial stromal fibr

54 cally localized to renal medulla and retinal pigmented epithelial cells, and it was prominent in neur

55 as readily observed in the dedifferentiating pigmented epithelial cells, and the levels of expression

56 Retinal pigment epithelial cells appear to demonstrate a distinc

57 ofuscin granules isolated from human retinal pigment epithelial cells are examined by using steady-st

58 pofuscin pigments that accumulate in retinal pigment epithelial cells are implicated in the etiology

59 beam radiation, retinal ganglion and retinal pigment epithelial cells are preserved while choroidal e

60 Our results indicate that retinal pigment epithelial cells are the initial site of insult

61 ic factor IL-1beta strongly, whereas retinal pigment epithelial cells are the main source of VEGF-A.

62 ed epithelial cells, such as ARPE-19 retinal pigmented epithelial cells, are poorly infected by labor

63 Retinal pigment epithelial cells (ARPE-19 and B6-RPE07) were sti

64 Human retinal pigment epithelial cells (ARPE-19) and rat neurosensory

65 on the ability of immortalized human retinal pigment epithelial cells (ARPE-19) to regulate complemen

66 ion of lipid rafts in cultured human retinal pigment epithelial cells (ARPE-19) was studied by confoc

67 Human retinal pigment epithelial cells (ARPE-19) were cultured either

68 Retinal pigment epithelial cells (ARPE-19) were cultured for 18

69 lls (RGC-5), and serum-starved human retinal pigment epithelial cells (ARPE-19) were exposed to 2, 4,

70 , and peroxynitrite) for human adult retinal pigment epithelial cells (ARPE-19) were quantified by me

71 ized NORPEG, a novel gene from human retinal pigment epithelial cells (ARPE-19), in which its express

72 e experimental model, and from human retinal pigment epithelial cells (ARPE-19).

73 ) is exported out of the adult human retinal pigment epithelial cells (ARPE19) packaged in exosomes.

74 retinoid pigments that accumulate in retinal pigment epithelial cells as lipofuscin are associated wi

75 ence in normal human fibroblasts and retinal pigment epithelial cells, as ectopic expression of the t

76 ds human primary blood leukocytes or retinal pigment epithelial cells at effective concentrations; pr

77 as an oxidative stressor leading to retinal pigment epithelial cell atrophy.

78 e life span of human fibroblasts and retinal pigment epithelial cells beyond senescence without causi

79 bovine retinal pericytes (BRPs) and retinal pigment epithelial cells (BRPECs) were evaluated by dete

80 crophages, choroidal fibroblasts and retinal pigment epithelial cells, but also on the expression of

81 that tenascin-C is anti-adhesive for retinal pigmented epithelial cells, but after integrin activatio

82 nner nuclear layer, ganglion cell layer, and pigmented epithelial cells, but not in photoreceptors.

83 that IL-22 can affect primary human retinal pigment epithelial cells by decreasing total tissue resi

84 manipulation of integrin function in retinal pigment epithelial cells can restore their adhesion and

85 ed against the noncancerous ARPE-19 (retinal pigment epithelial cells) cell line, in order to evaluat

86 al College of Surgeons-p+ dystrophic retinal pigment epithelial cells challenged with rod outer segme

87 ta1 localizes to the basal aspect of retinal pigment epithelial cells colocalizing with the basal lam

88 structures stained with these dyes included pigment epithelial cells, cone outer segments, and Mulle

89 e hypothesis that blue light is toxic to non-pigmented epithelial cells, confluent cultures of human

90 We conclude that iris pigment epithelial cells constitutively express cell sur

91 pic expression of ngn2 in nonneural, retinal pigment epithelial cell culture triggered de novo genera

92 Retinal pigment epithelial cell cultures prepared from RCS and c

93 key role of oxidative stress-induced retinal pigment epithelial cell death and secondary photorecepto

94 s uses two different routes to enter retinal pigmented epithelial cells, depending on the cell type i

95 r (CNTF), a combination of BDNF and CNTF, or pigment epithelial cell-derived growth factor (PEDF) mig

96 Retinal pigment epithelial cells did not stain for iNOS.

97 presumptive neural retina, without affecting pigmented epithelial cell differentiation.

98 and transiently increased in normal retinal pigment epithelial cells during rod outer segment phagoc

99 n the stimulation of fibroblasts and retinal pigment epithelial cells during the formation of choroid

100 drusen deposition is associated with retinal pigmented epithelial cell dysfunction and degeneration o

101 expression in cultures of non-neural retinal pigment epithelial cells elicited transdifferentiation i

102 oaded nanotube were non-cytotoxic to retinal pigment epithelial cells even at a concentration of 200

103 MREG-deficient human and mouse retinal pigment epithelial cells exhibit diminished activity of

104 Human retinal pigment epithelial cells exposed to superoxide or hydrog

105 Cloned retinal pigment epithelial cells expressed the IGF-1 transgene a

106 Evaluation of retinal pigment epithelial cell extracts derived from E-FABP nul

107 L localizes to the primary cilium of retinal pigment epithelial cells, fibroblasts and kidney tubular

108 LEDGF1-326 also increased retinal pigment epithelial cell FluoSphere uptake to 140 +/- 10%

109 ombospondin and incubated with human retinal pigment epithelial cells for 3 hours.

110 Retinal pigment epithelial cells from normal and RCS rats were g

111 It has been shown that allografts of retinal pigment epithelial cells from normal perinatal rats have

112 Retinal pigment epithelial cell heights were measured on light a

113 portance of alpha1beta1 integrin for retinal pigment epithelial cell homeostasis and retinal health w

114 Glucose consumption of HRECs, human retinal pigment epithelial cells (HRPEs), and human Muller cells

115 ls, Muller cells, photoreceptors and retinal pigment epithelial cells in a spatial arrangement simila

116 improved survival of retinal endothelial and pigment epithelial cells in conjunction with reduced str

117 senescence-associated phenotypes in retinal pigment epithelial cells in culture.

118 gocytosis and lysosomal functions of retinal pigment epithelial cells in the aged RPE/choroid.

119 is and unique suppressive mechanisms used by pigment epithelial cells in the eye.

120 raphic) atrophy frequently occurs in retinal pigment epithelial cells in the human disease, age-relat

121 Reoxygenation of human retinal pigment epithelial cells in vitro and ocular reperfusion

122 racrine biological activity in human retinal pigment epithelial cells in vitro.

123 ow that B(e)P is a toxicant to human retinal pigment epithelial cells in vitro.

124 roximately 40% of the animals and in retinal pigmented epithelial cells in 4 animals.

125 Retinal pigmented epithelial cells in the eye produce retinyl es

126 tracellular iron on the functions of retinal pigment epithelial cells, in vitro ARPE-19 cells were tr

127 ignificantly activated by hypoxia in retinal pigment epithelial cells, indicating that ERK5 regulatio

128 embly compartments in differentiated retinal pigment epithelial cells, infected AmEpCs made dispersed

129 The role of AMPK in retinal pigment epithelial cell inflammatory response is address

130 results suggest that manipulation of retinal pigment epithelial cell integrins through integrin activ

131 doses of light with NACA maintained retinal pigment epithelial cell integrity and prevented outer nu

132 etected in the conditioned medium of retinal pigment epithelial cells, interphotoreceptor matrix, and

133 neration, and transplantation of new retinal pigment epithelial cells is an attractive strategy to pr

134 Integrity of retinal pigment epithelial cells is necessary for photoreceptor

135 Thus, SCD expression in retinal pigment epithelial cells is regulated by retinoic acid,

136 ated that the developmental potential of the pigmented epithelial cells is not completely restricted;

137 Retinal pigment epithelial cells isolated from dystrophic RCS ra

138 Thus, in retinal pigment epithelial cell layers, rapamycin decreased nucl

139 to the ganglion, inner nuclear, and retinal pigment epithelial cell layers.

140 id phenylalanine (Phe) between human retinal pigment epithelial cell line (ARPE-19) and tachyzoites o

141 ndothelial growth factor (VEGF) in a retinal pigment epithelial cell line (ARPE-19) and to determine

142 tubular cell line (TEC) and a human retinal pigment epithelial cell line (ARPE-19).

143 Knockdown of Tgifs in a human retinal pigment epithelial cell line also increased EVI5L expres

144 utamate transporter xc- in the human retinal pigment epithelial cell line ARPE-19 and in retina from

145 xpression was inhibited in the human retinal pigment epithelial cell line ARPE-19 by siRNA.

146 y of differentiation in vitro of the retinal pigment epithelial cell line ARPE-19 has been previously

147 e transporter (x(c)(-)) in the human retinal pigment epithelial cell line ARPE-19, clone the light ch

148 We next used the human retinal pigment epithelial cell line RPE-1 as a model system and

149 After introducing a retinal pigment epithelial cell line to the subretinal space ear

150 n the present study, using the human retinal pigment epithelial cell line, ARPE-19.

151 cysteine and expressed in the human retinal pigment epithelial cell line.

152 III myosin, MYO3A, from retina and a retinal pigment epithelial cell line.

153 Confluent cultures of a human retinal pigmented epithelial cell line (ARPE-19) were deprived o

154 gulate the expression of VEGF in the retinal-pigmented epithelial cell line ARPE-19.

155 s this question we established human retinal pigment epithelial cell lines expressing wild type or S1

156 mRNAs in mouse and human retinas and retinal pigment epithelial cell lines.

157 erstanding of the adverse effects of retinal pigment epithelial cell lipofuscin.

158 Retinal pigment epithelial cell malfunction is a causative featu

159 in the skate but not the rat retina, retinal pigment epithelial cells may be an alternative source of

160 Thus, FasL expressed on retinal pigment epithelial cells may control the growth and deve

161 gocytosis of extracellular matrix by retinal pigment epithelial cells may represent a novel mechanism

162 were blood-borne macrophages and not retinal pigment epithelial cells nor Muller glia.

163 f N5-methyltetrahydrofolate in human retinal pigment epithelial cells occurs exclusively through the

164 ent materials, called lipofuscin, in retinal pigment epithelial cells of the aging retina is most pro

165 After lens removal, the pigment epithelial cells of the dorsal, but not the vent

166 After lens removal, the pigmented epithelial cells of the dorsal iris proliferat

167 ing melanocytes, mast cells, osteoclasts and pigmented epithelial cells of the eye.

168 (BMs) serve as attachment sites for retinal pigment epithelial cells on Bruch's membrane and Muller

169 of such a process is transdifferentiation of pigmented epithelial cells (PECs) to lens cells during l

170 Human retinal pigment epithelial cells play a pivotal role in supplyin

171 Subconfluent retinal pigment epithelial cells preferentially phagocytose FN o

172 anes of CMV-infected polarized human retinal pigment epithelial cells propagated on permeable filter

173 mations in photoreceptor (RDH12) and retinal pigment epithelial cells (RDH11).

174 cell line as well as human and mouse retinal pigment epithelial cells resulted in killing of T. gondi

175 protein levels, and inducing MYCN in retinal pigmented epithelial cells resulted in CHK1 phosphorylat

176 Microarray measurements in retinal pigment epithelial cells revealed 36 genes regulated by

177 caused replication defects in rhesus retinal pigment epithelial cells: Rh01 (an HCMV TRL1 orthologue)

178 The results suggest that in retinal pigment epithelial cells, rod outer segment-specific pha

179 The retinal pigment epithelial cell (RPE cell) layer protects the ph

180 ry activity, it also participates in retinal pigment epithelial cell (RPE) mediated activation of mac

181 and differentiated these cells into retinal pigment epithelial cells (RPE) to study the mechanisms o

182 ogram light peak (LP), lipofuscin in retinal pigment epithelial cells (RPE), and fluid- and debris-fi

183 lium; and primary cultures of bovine retinal pigment epithelial cells (RPE), pericytes (RPC), and end

184 plasma membrane protein expressed in retinal pigment epithelial cells (RPE).

185 r of blue-light-induced apoptosis in retinal pigment epithelial cells (RPE).

186 nvolving photoreceptors and adjacent retinal pigment epithelial cells (RPE).

187 complex set of reactions in adjacent retinal pigment epithelial cells (RPE).

188 microvascular endothelial cells and retinal pigment epithelial cells (RPE).

189 uman skin fibroblasts (BJ-hTERT) and retinal pigment epithelial cells (RPE-hTERT) retain normal growt

190 ion in mouse retinal cells and human retinal pigmented epithelial cells (RPE) through STAT1-mediated

191 thy and that smooth muscle cells and retinal pigment epithelial cells secrete HGF in the eye.

192 ic protein-4 may interact to promote retinal pigment epithelial cell senescence and that bone morphog

193 ent mild oxidative stress can induce retinal pigment epithelial cell senescence through p53-p21(Cip1/

194 Retinal pigment epithelial cell signals also changed dramaticall

195 lymers were shown to be non-toxic to retinal pigment epithelial cells, studies of drug release using

196 lture supernatants of astrocytes and retinal pigment epithelial cells support the CD8 autoreactive T

197 via VEGF receptors expressed on the retinal pigment epithelial cells that drive this disease, VEGF's

198 he ciliary epithelium in the eye consists of pigmented epithelial cells that express the alpha1beta1

199 transfected into embryonic or mature chicken pigment epithelial cells, these cells adopt a neuronal m

200 were induced to undergo apoptosis by retinal pigment epithelial cells through a Fas-FasL interaction.

201 tion greatly enhanced the ability of retinal pigment epithelial cells to adhere to tenascin-rich wet

202 ing that ngn2 can instruct nonneural retinal pigment epithelial cells to differentiate toward retinal

203 fective in improving the efficacy of retinal pigment epithelial cell transplantation in wet age-relat

204 e secretion of angiogenic factors by retinal pigmented epithelial cells under normoxic, hypoxic, and

205 alphaB is secreted from human adult retinal pigment epithelial cells via microvesicles (exosomes), i

206 LEDGF1-326 increased human retinal pigment epithelial cell viability from 48.3 +/- 5.6 to 1

207 holinos, we found that proliferation of iris pigment epithelial cells was dramatically reduced both i

208 hic Royal College of Surgeons-p+ rat retinal pigment epithelial cells was studied in primary cell cul

209 Notably, using polarized adult retinal pigment epithelial cells, we show that the secretion of

210 Human retinal pigment epithelial cells were cultured on an impermeable

211 ARPE-19 retinal pigment epithelial cells were depleted of their mitochon

212 Human retinal pigment epithelial cells were transfected in vitro with

213 Human retinal pigment epithelial cells were treated with various combi

214 Retinal pigment epithelial cells were visible in patient 3 where

215 ut not in regions with scotomas, and retinal pigment epithelial cells were visible in regions without

216 Iris pigment epithelial cells, when cultured at high densitie

217 taset obtained on differentiation of retinal pigment epithelial cells where 399 proteins were quantif

218 ns in photoreceptors and in adjacent retinal pigment epithelial cells where all-trans-retinol is isom

219 egments and to the apical surface of retinal pigment epithelial cells where it might be involved in t

220 l cells, and Muller cells as well as retinal pigment epithelial cells, whereas AdV5-GFP transduced on

221 pically central retina) composed of modified pigment epithelial cells, which we hypothesize to be the

222 ipofuscin pigment A2E accumulates in retinal pigment epithelial cells with age and is particularly ab

223 scent lipofuscin that accumulates in retinal pigment epithelial cells with age may contribute to an a

224 orescent pigments that accumulate in retinal pigment epithelial cells with aging and in some retinal

225 E, a fluorophore that accumulates in retinal pigment epithelial cells with aging and in some retinal

226 In vitro treatments of human retinal pigment epithelial cells with CEP-dipeptide or CEP-HSA d

227 e observed in human liver, lens, and retinal pigment epithelial cells with increasing concentrations

228 ysis, increased after stimulation of retinal pigment epithelial cells with LPS or poly(I:C), indicati

229 Treatment of human retinal pigment epithelial cells with NACA protected against oxi

230 is, we altered the GSSG:GSH ratio in retinal pigment epithelial cells with the thiol-specific oxidant

231 tively, we find that transduction of retinal pigmented epithelial cells with alpha9 integrin, a tenas

232 e actin (SMA) expression in adjacent retinal pigment epithelial cells, with subsequent formation of a