ライフサイエンスコーパス: pikromycin

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1 cluding the natural ketolides narbomycin and pikromycin.

2 for the biosynthesis of the erythromycin and pikromycin 14-membered ring aglycones, respectively.

3 including methymycin (2), neomethymycin (3), pikromycin (4), and narbomycin (5) produced by Streptomy

4 A natural ketolide pikromycin and a related compound methymycin are produce

5 PKS genes from the pikromycin and erythromycin pathways were hybridized in

6 omethymycin, and 14-membered ring macrolides pikromycin and narbomycin.

7 10-deoxymethynolide, whereas narbomycin and pikromycin are derived from the 14-membered ring macrola

8 e Streptomyces venezuelae pikD gene from the pikromycin biosynthetic cluster was analyzed, and its de

9 The pikromycin biosynthetic gene cluster contains the pikAV

10 de analogues for the study of enzymes in the pikromycin biosynthetic pathway.

11 sed to biotransform synthetic narbonolide to pikromycin by glycosylation and oxidation in vivo.

12 s methymycin, neomethymycin, narbomycin, and pikromycin in Streptomyces venezuelae, is described.

13 of narbonolide and its biotransformation to pikromycin is reported.

14 roduction of the final glycosylated products pikromycin, narbomycin, methymycin and neomethymycin) an

15 nomodular type I polyketide synthases of the pikromycin pathway in vitro followed by direct appendage

16 eactivity of a monooxygenase (PikC) from the pikromycin pathway is modified through computationally g

17 tecture of a full-length PKS module from the pikromycin pathway of Streptomyces venezuelae creates a

18 of PikAIV, the sixth and final module of the pikromycin (Pik) pathway.

19 synthesized and assayed a series of modified pikromycin (Pik) pentaketides that mimic early pathway e

20 e 6-deoxyerythronolide B synthase (DEBS) and pikromycin (Pik) polyketide synthase (PKS) are unique mu

21 The unique ability of the pikromycin (Pik) polyketide synthase to generate 12- and

22 The unique ability of the pikromycin (Pik) polyketide synthase to generate 12- and

23 eneck processing unnatural substrates in the pikromycin (Pik) system, preventing the formation of epi

24 The pikromycin (Pik)/methymycin biosynthetic pathway of Stre

25 Antibiotics methymycin (MTM) and pikromycin (PKM), co-produced by Streptomyces venezuelae

26 cryo-microscopy structures of a full-length pikromycin PKS module in three key biochemical states of

27 The unique ability of the pikromycin polyketide synthase (Pik PKS) to generate 12-

28 An unusual feature of the 6-module pikromycin polyketide synthase (PikPKS, PikAI-PikAIV) of

29 ample in which alternative expression of the pikromycin polyketide synthase results in the generation

30 isolated from a PKS-like gene cluster of the pikromycin producer Streptomyces venezuelae ATCC 15439,

31 evidence on the regulation of methymycin and pikromycin production in S. venezuelae ATCC 15439.

32 The methymycin and pikromycin series of antibiotics are structurally relate

33 s erythromycin and oleandomycin, each of the pikromycin series producers harbors a six module PKS clu

34 the C2-type KR from the third module of the pikromycin synthase, analogous to the KR from the third

35 The pikromycin TEII exhibited high K(m) values (>100 microm)

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