ライフサイエンスコーパス: pimozide

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1 greater extrapyramidal symptoms relative to pimozide.

2 treatment with the 5-HT7 receptor antagonist pimozide (1 mg/kg, intraperitoneal) lowered cAMP in non-

3 - 4.28 ml h-1; P < 0.05, paired t test), and pimozide (1.5 x 10-4 M), another blocker of cyclic nucle

4 fects of both 5-HT and 5-MeOT are blocked by pimozide (10 microM) and SB-269970 [(R)-3-(2-(2-(4-methy

5 Pimozide (10 microM) caused inhibition of whole-cell cat

6 Related phenothiazines and pimozide also inhibited HCV infection and preferentially

7 Pimozide also selectively inhibits colony formation of C

8 administration of the dopamine antagonists, pimozide and alpha-flupenthixol, to rats reduced Pavlovi

9 inhibited by antagonists of T-type channels (pimozide and amiloride) as well as by antagonists whose

10 valuated the relative efficacy and safety of pimozide and haloperidol in the treatment of Gilles de l

11 The therapeutic doses of pimozide and haloperidol were equivalent (mean = 3.4 mg/

12 r inhibition with pharmacologic antagonists (pimozide and haloperidol) reduced proliferation of pancr

13 Simultaneously inhibiting STAT5 with pimozide and the kinase inhibitors imatinib or nilotinib

14 idazolam, St. John's Wort, carbamazepine and pimozide, are contraindicated with DAAs.

15 pproach, we identified the psychotropic drug pimozide as a STAT5 inhibitor.

16 rapy used included benzhexol, tetrabenazine, pimozide, baclofen, chlorpromazine, haloperidol, carbama

17 s research shows that a dopamine antagonist, pimozide, changes response rates through the direct acti

18 Pimozide decreases STAT5 tyrosine phosphorylation, altho

19 Furthermore, pimozide decreases the expression of STAT5 target genes

20 However, phenothiazines and pimozide exhibited improved genotype coverage including

21 ed after 6 weeks of each treatment (placebo, pimozide, haloperidol), with a 2-week placebo baseline p

22 Sequential addition of Zn(2+) and pimozide, in either order, revealed no overlapping inhib

23 geted pharmacologic inhibition of STAT5 with pimozide induced apoptosis in primary T-PLL cells.

24 Importantly, pimozide induces similar effects in the presence of the

25 At equivalent doses, pimozide is superior to haloperidol for controlling symp

26 CL5 neutralizing antibody or STAT5 inhibitor Pimozide led to reverse CD8+ T cell-enhanced BECs prolif

27 ug therapy with benzhexol, tetrabenazine and pimozide or haloperidol may be beneficial in some cases.

28 ying rise in [Ca(2+)](i) was also blocked by pimozide or penfluridol.

29 evation in [Ca(2+)](i) could be inhibited by pimozide or penfluridol.

30 of high [K(+)](o) or the Ca channel blockers pimozide, penfluridol, or Ni(2+), but not nifedipine or

31 Trifluoperizine, trifluperidol and pimozide produced time-dependent blockade of hKv2.1 with

32 Pimozide proved significantly different from placebo in

33 hibitor tofacitinib, and the STAT5 inhibitor pimozide reversed steroid resistance of BAL ILC2s.

34 functional epithelial Na(+) channels (ENaC), pimozide-sensitive cation channels, K(+) channels, and t

35 ic fibrosis transmembrane regulator, but few pimozide-sensitive cation channels.

36 nd supported the notion that the Zn(2+)- and pimozide-sensitive currents are identical.

37 Although pimozide, sertindole, droperidol, and haloperidol have b

38 The inhibitory effect of pimozide was concentration dependent with an IC(50) of a

39 ivalent dose formulations of haloperidol and pimozide was conducted with 22 subjects, aged 7-16 years

40 gs, such as chlorpromazine, fluphenazine and pimozide, were more toxic than the atypical drugs, inclu

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