ライフサイエンスコーパス: pinpoint

1 reason for this phenomenon has been hard to pinpoint.

2 ble additional research can be completed are pinpointed.

3 date, few critical target proteins have been pinpointed.

4 that underpins the adult outcome of ADHD was pinpointed.

5 CNV and single-nucleotide variant (SNV) data pinpointed 10 genes enriched for putative loss of functi

6 We pinpoint 18 associations to a single causal variant with

7 These findings pinpoint a complex, presumably concentration-dependent r

8 Our findings pinpoint a conserved mechanism of eukaryotic mitophagy a

9 E) transcriptomic signature that leads us to pinpoint a critical time window when DE differentiation

10 genetic interaction profile of cdc1-314(ts) pinpoint a distinct cell wall defect.

11 and health outcomes, making it difficult to pinpoint a goal for surgical scale-up.

12 ly induced seizure model can be leveraged to pinpoint a new target for seizure control: VIP interneur

13 Furthermore, our results pinpoint a role of this complex in protein trafficking a

14 These results pinpoint a specific molecular mechanism underlying our p

15 ing for cancer-relevant noncoding DNA, which pinpointed a Cdkn2a cis-regulatory region.

16 analysis of rubusoside:protein interactions pinpointed a major difference in substrate cavity betwee

17 Previous theoretical studies pinpointed a marker called lambdaalt that directly quant

18 These observations pinpointed a new mechanism by which this oncometabolite

19 mapping followed by replication studies, and pinpointed a possible causal variant.

20 We have pinpointed a role for Gos28 in the intra-Golgi transport

21 A structure-based program pinpointed a role of the ZA loop, paving the way for the

22 Thus, by pinpointing a cellular protein that is important in the

23 olgi dispersal in several cancer cell lines, pinpointing a possible link between drug-induced toxicit

24 models of encoding and retrieval dynamics by pinpointing a specific contextual factor that differenti

25 of respiratory abnormality in Rett syndrome, pinpoints a brain site responsible and provides a clear

26 Probing the responsible cellular mechanisms pinpoints a disturbance in the expression and function o

27 In summary, our work pinpoints a multifaceted activity of Tob1 in both homeos

28 the Warburg effect in the studied cells and pinpoints a subset of human tumours with greater vulnera

29 years of inhalational insults to the lungs, pinpointing abnormalities or disruption of the pathways

30 iple 100pico-liter (pL) volume droplets with pinpoint accuracy into a single diatom frustule with dim

31 ith known synergistic molecules allows us to pinpoint additional molecule combinations that also act

32 has been made, it has proved challenging to pinpoint additional relevant genes with confidence.

33 utionary-ancient resonance to outgroup pain, pinpointing adolescents' interpersonal and sociocognitiv

34 The metabolic patterns pinpoint alterations in hexosamine biosynthetic pathway,

35 rotypes, and the protein sequence around the pinpointed amino acids from the NS3 and NS5 regions are

36 These results pinpoint an age and cellular compartment to focus furthe

37 These findings functionally pinpoint an atomic-scale interaction essential for effec

38 ed, and further study on one peptide (PepB2) pinpointed an asparagine residue necessary for CPP activ

39 In this study, we pinpointed an ER-resident factor that executes a crucial

40 By combining heterozygous mutations, we pinpointed an optimal balance of flowering signals, resu

41 Therefore, this study pinpoints an effective therapeutic approach to preventin

42 To pinpoint and quantify the impacts of modifying one targe

43 reomers to be prepared-enabled us rapidly to pinpoint and synthesize the correct structures.

44 omplexity of the JA gene regulatory network, pinpoints and validates previously unknown regulators, a

45 he high sensitivity of (18)F-fluoride PET to pinpoint areas with the dominant disease activity and th

46 residues threonine-154 and tyrosine-310 were pinpointed as being involved in binding CoA-conjugated p

47 This finding pinpoints at a potential role for adenine-6 in the catal

48 randomly selected loci, our algorithm always pinpoints at least one patient from the WTCCC dataset.

49 Results obtained pinpoint BDNF as an important regulator of NDO appearanc

50 g to their developmental progression, and it pinpoints bifurcation points by labeling each cell as pr

51 o identify additional Ypk1 substrates, which pinpointed both catalytic subunits of the ceramide synth

52 eizure spread, we developed a novel tool for pinpointing brain regions that facilitate synchronizatio

53 receptor-like kinase gene 1 (SIK1), which is pinpointed by a trait-associated SNP and encodes a leuci

54 patch at the 30s region of its sequence, as pinpointed by computational results and site-directed mu

55 ation between symmetry and functionality was pinpointed by Pierre Curie who stated that it is the sym

56 initiator of cognitive pathology in AD, and pinpoint calcium dysregulation mediated by NgRs and T-ty

57 It pinpoints cancer drivers that are difficult to find with

58 ith complex traits, but it is challenging to pinpoint causal genes in these loci and to exploit subtl

59 the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illu

60 and gene annotations, researchers trying to pinpoint causal genetic variants are faced with a challe

61 res subsequent fine-mapping or sequencing to pinpoint causal mutations.

62 ty loci to immune-mediated diseases but also pinpointed causal amino-acid variants of HLA genes that

63 i associated with human traits and diseases, pinpointing causal alleles remains difficult, particular

64 We demonstrate MPRA's capabilities for pinpointing causal alleles, using it to identify 842 var

65 ers of common, noncoding variants from which pinpointing causal genes remains challenging.

66 years have seen a surge of studies aimed at pinpointing causal variants using both statistical evide

67 n the human tumor genome, it is difficult to pinpoint causative driver genes.

68 These data pinpoint CD86 upregulation as an additional mechanism by

69 The novel mechanism pinpoints CDK8 in the development of walleye dermal sarc

70 ave begun to unravel this diversity and have pinpointed cell wall-degrading enzyme (CWDE) families th

71 Pinpointing cellular components necessary for supporting

72 Specifically, visual comparison can pinpoint changes in spatial organization between Hi-C da

73 By inference, our model pinpoints co-enriched genes as new causes of development

74 systems, highlight the recent breakthroughs, pinpoint common grounds and discuss the bottlenecks and

75 3'RR quasi-palindromic region (3'PAL KO), we pinpointed common features and differences that specify

76 oughly investigated HB system, liquid water, pinpoints common behaviours of their THz microscopic dyn

77 Our analytical calculations pinpoint connection properties critical to response reve

78 Together, our data pinpoint convergent neurobiological features in PTHS mou

79 pectra could ultimately prove invaluable for pinpointing critical regions of the vast non-protein-cod

80 le point mutants of the lipid-binding pocket pinpoints critical residues involved in substrate bindin

81 g these findings with molecular modeling, we pinpoint crucial enzyme-ligand interactions required for

82 Moreover, our findings also pinpoint crucial physiological challenges for spacefarin

83 instrument is rugged and versatile, enabling pinpoint deployment of sophisticated diagnostics to dist

84 us heuristic methods exist that successfully pinpoint disease associated modules, the basic underlyin

85 Through neoepitope assays, tools to pinpoint disease progression, evaluation methods for the

86 Despite this, GWASs alone are unable to pinpoint disease-causing single nucleotide polymorphisms

87 rs with data from functional RNAi screens to pinpoint driver genes within large recurrently amplified

88 cedented ability to map neural circuitry and pinpoint drug-induced synaptic modifications.

89 for combined chemo-photothermal therapy with pinpointed drug delivery and release capabilities and mi

90 bal epigenomic changes in H3K27ac deposition pinpoint dynamic changes in enhancers that mediate the e

91 uld be an important factor in MM disease and pinpoint Emicro-bcl-b mice as a pertinent model to valid

92 These data pinpoint ETS1 and H3K4Me3 as key transcriptional regulat

93 ays, X-ray crystallography, and modeling, to pinpoint factors that influence the magnitude of the ind

94 Our approach pinpoints favourable compositions and demonstrates that

95 ral measurements, and computer scientists to pinpoint fruitful directions for algorithm improvement,

96 Our method pinpoints functional NAMs, scales with the complexity of

97 ithelial-to-mesenchymal transition (EMT), we pinpoint genes encoding multiple promesenchymal glycosyl

98 Using the L. pyrrhocoris genome, we pinpointed genes gained in Leishmania.

99 t available, such as genomics techniques for pinpointing genes, gene expression, lipid and protein pr

100 Furthermore, we apply MiSL to pinpoint genetic biomarkers for drug sensitivity.

101 wide, but it remains far more challenging to pinpoint genetic variants affecting TF binding.

102 To pinpoint genomic regions that are regulated by O-GlcNAc

103 plant height with a sorghum diversity panel pinpointed genomic regions underlying the trait variatio

104 diversity, the model described in this paper pinpoints geographic areas and clades most urgently requ

105 gut microbiome were exceptionally stable and pinpointed >80% of individuals.

106 he central mannose-binding site on LMAN1 and pinpoint histidine 178 and glycines 251/252 as critical

107 and who subsequently developed thousands of pinpoint, histologically atypical melanocytic tumors and

108 s the killing of bacteria on the surface and pinpoints how the critical colony size depends on key pa

109 abolites, representing an efficient means to pinpoint important functional food ingredients from Alli

110 n this field during the past two decades and pinpoints important avenues for future research.

111 tomic-resolution imaging, we are now able to pinpoint individual dislocation cores at the atomic scal

112 coupled to electron transfer dissociation to pinpoint individual residues in the heavy chain of FVIIa

113 Nonetheless, pinpointing individual variants is a critical goal for g

114 al-organic molecular orbital methodology, to pinpoint interaction between the tectonic building block

115 ng and tandem mass spectrometry were used to pinpoint its binding site on ERK.

116 upon INO80 downregulation in CH12-F3 cells, pinpointing its role in cohesin activity.

117 dissecting its circuit specific actions and pinpointing its role in regulating morphine reward by co

118 nneled through the Ras1/2 GTPase is delayed, pinpointing its time scale and its contribution to the d

119 f transposition events in the population and pinpoint junctions of high frequency transposition event

120 oires of closely related microbes to rapidly pinpoint key proteins with beneficial functions.

121 of DNA lost in different human lineages and pinpoint large duplications that introgressed from the e

122 cell immediately hardware-triggers a lethal pinpoint laser irradiation to kill it on the spot in a t

123 t differences in the proportion of eyes with pinpoint leakage on FA (P < .001), punctate hypercyanesc

124 significant multilink motifs of interaction, pinpointing locations in the network where aminergic and

125 Hence, our method pinpoints locus-specific effects where possible and boos

126 We pinpoint macropinosomes as the sites for Rab8-mediated b

127 in (SBD) of heat shock protein 70 (Hsp70) to pinpoint mechanical units and flexible hinges.

128 Our results pinpoint mechanisms enabling continued proliferation aft

129 f exercise, identify the optimal "dose", and pinpoint mechanisms of action.

130 We have demonstrated that pinpoint membrane poration can be produced at the leadin

131 wer of large scale integrative approaches to pinpoint metabolic adjustment to changing environments.

132 This correlation analysis also pinpointed metabolic pathways which are significant for

133 al allowed assessing assembly properties and pinpointing misassemblies.

134 lines, and an RNA interference (RNAi) screen pinpointed mitochondrial oxidative phosphorylation (OXPH

135 on was not found during a three-minute rest, pinpointing neural synchrony to social interactions amon

136 art Study continues to evolve as it seeks to pinpoint new causes of disease with the hope of advancin

137 m multiple cancer types and could be used to pinpoint new driver genes that sustain somatic alteratio

138 rget in KRAS-mutant lung adenocarcinomas and pinpoint new potential targets.

139 ty-related genes influence weight would help pinpoint novel targets for intervention.

140 etween AA and white female hypertensives and pinpointed novel mRNA-microRNA pairs differentially-expr

141 entified canonical splicing events, but also pinpointed novel, but rare, exon-skipping events, which

142 The findings pinpoint Oct1 and OCA-B as central mediators of CD4(+) T

143 Accurate pinpointing of focal memory-related deficits will allow

144 and chromatin immunoprecipitation sequencing pinpointed oncogenic transcriptional amplification media

145 protein expression data, did not allow us to pinpoint one PGE2-G lipase, and rather support the invol

146 These findings pinpoint outside-xylem tissues as a central locus for th

147 cted functional implications of mutations to pinpoint pathogenic variants are prone to produce false

148 ul molecular prognostic system that can help pinpoint patients with the highest mortality risk.

149 ul molecular prognostic system that can help pinpoint patients with the highest mortality risk.

150 ults indicated that transcriptomics may even pinpoint pertinent adverse outcomes (i.e., liver vacuoli

151 ion resistance against Enterobacteriaceae to pinpoint possible control points for curbing their sprea

152 Based on recent findings, we pinpoint potential targets for novel therapies to slow d

153 this excess variation occurs and can help to pinpoint practice styles that should be emulated or avoi

154 in the Ras processing and MAPK pathways and pinpoint PREX1 as an AML-specific activator of MAPK sign

155 that PTPRD is a bona fide tumor suppressor, pinpoint PTPRD loss as a cause of aberrant STAT3 activat

156 can inform future microbiome-based therapy, pinpointing putative intervention targets for manipulati

157 egion, whereas divergent structural elements pinpoint regions mediating virus-specific functions and

158 We pinpoint regions of the hGLUT proteins that can be targe

159 Using this approach, we pinpointed regions of TRPV1 that affect channel properti

160 The model pinpoints regions where coral reefs presently have the b

161 ap can be customized with expression data to pinpoint regulated subnetworks and druggable molecules.

162 ormation gained from these advances can help pinpoint relevant biomarkers for early diagnosis and imp

163 hIP protocols in resolution and specificity, pinpoints relevant binding sites within enhancers contai

164 from the cytoplasm of VACV-infected cells to pinpoint replication origins.

165 folded and unfolded states of a protein can pinpoint residues of critical importance that should be

166 identification of coevolving amino acids can pinpoint residues required for interaction specificity.

167 ymous variants in known epilepsy genes, thus pinpointing risk factors of disease from non-coding sequ

168 modulated by changes in RLC phosphorylation, pinpointing RLC phosphorylation as a modulator of the Fr

169 To pinpoint S Typhimurium virulence factors responsible for

170 mmediate benefit of identifying bottlenecks, pinpoint sections which could benefit from parallelizati

171 in THADA mutant flies rescues their obesity, pinpointing SERCA as a key effector of THADA function.

172 bination with evolutionary trace analysis to pinpoint several surface-exposed regions of potential fu

173 s, scans for signatures of natural selection pinpointed several regions under non-neutral evolution.

174 Many prior papers have pinpointed several serine residues in the low complexity

175 itter binding to pore opening, but they also pinpoint significant differences among subtypes.

176 was performed for similar tissue samples to pinpoint significant metabolic differences.

177 Our method successfully pinpointed significant enlargement of many areas of the

178 secondary structure in the two states and to pinpoint some subtle conformational changes that the pep

179 A damage and DNA mutations by stem cells and pinpointing sources of damage and mutations would furthe

180 We further pinpoint specific chemokine ligands/receptors whose epig

181 These findings pinpoint specific ways in which to improve the predictiv

182 ighted the differences among the samples and pinpointed specific classes of compounds for each plant

183 m mice and humans affected with GD1 not only pinpoint sphingosine as being an osteoblast toxin, but a

184 nses through direct and indirect mechanisms, pinpointing SQSTM1 as a key mediator of JunB suppression

185 Through this approach we were able to pinpoint stress-mediated transcriptional and metabolic s

186 Organotypic airway cultures pinpoint TAp73 as necessary and sufficient for basal bod

187 More importantly, we have pinpointed TGF-beta3 as the major upstream molecular tha

188 We were able to pinpoint that the extended solid-solution region with su

189 Finally, a vibrational analysis pinpointed that such charge fluctuations are strongly co

190 Phenotypic characterization pinpoints that ADCA-DN and HSAN IE represent two discret

191 transfer dissociation (ETD) was then used to pinpoint the 12 occupied O-glycosylation sites.

192 Our data pinpoint the anatomical process underlying the loss of d

193 alter the risk for severe anaphylaxis and to pinpoint the associated mechanism.

194 ssumptions on the data structure and fail to pinpoint the associated microbial communities.

195 yl radical-mediated footprinting strategy to pinpoint the binding sites of Pyrococcus furiosus (Pfu)

196 e reagent pair EDC/GEE, are used together to pinpoint the binding sites of rifamycin SV, doxycycline,

197 dult blood vessel maintenance, and they also pinpoint the Bmk1/Erk5 pathway as a critical mediator of

198 ant neural responses is critical not only to pinpoint the brain regions that are mediating our robust

199 e mechanism underlying these variants and to pinpoint the causal alleles.

200 ications involved tedious genetic mapping to pinpoint the causative mutations.

201 ts, but in many cases it can be difficult to pinpoint the cause of death.

202 f each organ quantitatively will allow us to pinpoint the cause of the low tumor delivery efficiency.

203 We pinpoint the cell fate-determining factor to the length

204 ipheral and brain inflammation, our findings pinpoint the choroid plexus as an important target for f

205 Our results pinpoint the coinhibitory molecule CTLA4 as an immunolog

206 different species, it should be possible to pinpoint the conserved fundamental processes that result

207 e products using microbial factories and can pinpoint the contributions of microorganisms to planetar

208 We pinpoint the defect to a failure in the partial NE break

209 nate between them phenotypically, efforts to pinpoint the developmental origins of human B-1 and B-2

210 We pinpoint the differences between the PFM and traditional

211 To pinpoint the effect of cycloplegia, we recorded refracti

212 uantum treatment of the dopant-STM system to pinpoint the exact coordinates of the dopant in the Si c

213 ompletely dependent on the cerebellum and to pinpoint the exact location in the deep cerebellar nucle

214 we used magnetoencephalography in humans to pinpoint the factors underlying the beta-band modulation

215 nt stem cell platform was herein designed to pinpoint the initial transcriptome dysfunction and mecha

216 Recent findings pinpoint the key regulatory role of the UPR in hepatic l

217 es released after photoactivation as well as pinpoint the location at which uncaging of the molecules

218 o high-resolution melting analysis as we can pinpoint the location of m(6)A in the target.

219 uoroscopy-guidance in a rat model of RIPF to pinpoint the location of the endomicroscope during FE im

220 These results pinpoint the location of the transformation from a retin

221 Our data pinpoint the locations and determine the structures of o

222 ne central goal in molecular evolution is to pinpoint the mechanisms and evolutionary forces that cau

223 to acute exercise in the elderly may help to pinpoint the mechanisms by which exercise training can r

224 traits, we developed a computational tool to pinpoint the molecular mechanisms by which genetic marke

225 regions within multispecies microbiomes can pinpoint the molecular mechanisms that play key roles in

226 Here, we use a data-driven approach to pinpoint the movements that discriminate female dance qu

227 NSE can pinpoint the nanoscale dynamics changes in a highly spec

228 The results pinpoint the nature of developmental change priming bran

229 eld imaging of scattered excitation light we pinpoint the objective, intermediate lenses and, particu

230 It is challenging to pinpoint the origin of odd-even effects and address the

231 In addition, we pinpoint the origin of the lack of activity of the E24A

232 in T-cell neoplasms is critical not only to pinpoint the origin of these tumors but also to define i

233 overstory and multiple understory) and also pinpoint the required density for reasonable tree segmen

234 dentified, and structure-guided GusR mutants pinpoint the residues essential for DNA binding and gluc

235 ion of surface expression of MICA018, and we pinpoint the residues essential for this N-glycosylation

236 ciation (ETD) fragmentation has been used to pinpoint the residues responsible for the observed diffe

237 These results allowed us to pinpoint the role of dynamics in beta2m aggregation and

238 We show that both datasets pinpoint the same phylogenetic position of the eukaryoti

239 to HIV entry routes and novel approaches to pinpoint the sites of virus entry.

240 ts that confound current recordings can help pinpoint the source of those currents by providing a sig

241 ical systems is hampered by our inability to pinpoint the specific glycans and corresponding biosynth

242 Here, we use expression of FoxD3 to pinpoint the specification and emigration of trunk neura

243 To pinpoint the structural elements discriminating collagen

244 spatial proteomics experiments enable us to pinpoint the sub-cellular distribution of thousands of p

245 HMs and which HM marker is more effective to pinpoint the TFBRs have not been systematically investig

246 These experiments pinpoint the TMD as the "tetramerization domain" for AMP

247 Using this approach, we have pinpointed the DAT as a critical governor of diurnal var

248 ing and morphological and molecular analyses pinpointed the neuroblast stage as the main developmenta

249 Recent studies pinpointed the phase and/or frequency of the neural osci

250 mical modification, and mutagenesis, we have pinpointed the source of the quenching action to cystein

251 er schedules will likely depend on correctly pinpointing the causes of resurgence, with misdiagnosis

252 Our approach allows pinpointing the contribution of distinct cytoskeletal pr

253 his study, we provide these missing links by pinpointing the dysfunction to a point mutation in the b

254 tability, and cell internalization pathways, pinpointing the high sensitivity of stability-activity r

255 to a dramatic reduction of the growth rate, pinpointing the key role of this enzyme in fermentative

256 relativistic particle acceleration, thereby pinpointing the location of gamma-ray production.

257 iation across cell types, we were capable of pinpointing the most likely hypersensitive sites related

258 ur chemical-genetic screening strategies for pinpointing the physiologically relevant targets of chem

259 ly generates bidirectional paired-end reads, pinpointing the position of modified nucleotides in a se

260 With its extended Transatlantic dispersal, pinpointing the role of ocean dynamics is crucial to und

261 Our results suggest that, if pinpointing the start date of the spring bloom is the pr

262 that is, few-layer graphene/phthalocyanine, pinpointing the uncommon electron donating character of

263 ation to allele-specific copy-number changes pinpoints the common ancestor to a point prior to chemot

264 This pinpoints the dislodging and tethering of the VPS34 cata

265 m the two eyes must be combined: a new study pinpoints the location in the human brain where the requ

266 that UQ interacts with phenylalanine 211 and pinpoints the location of the binding site in the interf

267 Our work also pinpoints the regulation of B-cell receptor (BCR) signal

268 e site poised for catalysis of APOBEC3A, but pinpoints the residues that confer specificity towards C

269 is of the 2.56 A KDM4B-DTD crystal structure pinpoints the underlying residues required for exclusive

270 osition of the gases, making it difficult to pinpoint their origin.

271 s of tree bark POPs concentrations can often pinpoint their sources.

272 usands of proteins across various tissues to pinpoint their spatial location in the human body.

273 ft measurement, because of the difficulty in pinpointing their celestial coordinates.

274 high-throughput genomic sequencing data and pinpoints their breakpoints at single base-pair resoluti

275 and high-resolution mass spectrometry helped pinpoint this factor as thrombospondin-1 (TSP-1).

276 We pinpoint three molecular requirements within dualsteric

277 nally conserved Rab11 genes, we were able to pinpoint three specific amino acid residues that may be

278 We have pinpointed three circumstances where heterogeneous ice n

279 Together, our study pinpoints three novel genomic regions where longitudinal

280 ve sites of key biosynthetic enzymes are now pinpointed through a curated pattern-matching procedure

281 le, the coal tar S-containing compounds were pinpointed through multiple-reaction-monitoring analysis

282 sets from 24 mouse models for breast cancer pinpoint to a potential new function for insulin-like gr

283 These genes may pinpoint to driver pathway(s) that play an important rol

284 HaNLP3, as well as amino acid substitutions, pinpointed to a small central region of the protein that

285 The initial domestication region was pinpointed to central China (demarcated by the Great Wal

286 Our study thus pinpoints two ER lumenal factors that coordinately prime

287 complementary use of iPSCs and mouse models pinpoint unique cellular mechanisms by which EIF4A3 muta

288 ization of certain proteins, but not others, pinpointing unique roles for PCM1 and a group of satelli

289 y 30% of individuals could still be uniquely pinpointed using metagenomic codes from a typical body s

290 ns of the subsequently installed linkers are pinpointed via single-crystal X-ray diffraction analyses

291 he nuclear proteome during infection, we can pinpoint vital components required for immunity or susce

292 tabolism in fission yeast and beyond, and it pinpoints weaknesses of commonly used auxotroph mutants

293 his provides an unprecedented opportunity to pinpoint when each patient was infected and which viruse

294 urons interact with Kenyon cells but also to pinpoint where exactly in the mushroom body they do so.

295 loci are often large, making it difficult to pinpoint which genes are driving the cancer.

296 The focus of the field is now on pinpointing which molecular effects in specific neurons

297 A major challenge in human genetics is pinpointing which non-coding genetic variants affect gen

298 identify electron-density redistribution and pinpoint why the TS for guanosine 5'-triphosphate (GTP)

299 dual molecular ruthenium catalysts have been pinpointed within growing polynorbornene, thereby reveal

300 its interaction with polyubiquitinated PCNA, pinpointing ZRANB3 as a key effector of error-free DNA d