ライフサイエンスコーパス: pioneer

1 arge Amish families descending from the same pioneer.

2 MET, and suggest unexpected complexity to TF pioneering.

3 The Indian state of Tamil Nadu has pioneered a "One Health" committee to address the challe

4 ve been widely developed since Morgan et al. pioneered a work about partitioning a data matrix into s

5 Pioneering a novel RNA beacon to illuminate RNA traffick

6 Our work thereby pioneers a perspective to protect crystalline porous mat

7 The Pioneer Accountable Care Organization (ACO) Model aims t

8 012, a total of 32 organizations entered the Pioneer accountable care organization (ACO) program, in

9 through 2011) and after (2012) the start of Pioneer ACO contracts, with adjustment for geographic ar

10 Beneficiary alignment with a Pioneer ACO in 2012 or 2013.

11 In the first 2 years of the Pioneer ACO Model, beneficiaries aligned with Pioneer AC

12 Year 1 of the Pioneer ACO program was associated with modest reduction

13 are spending for beneficiaries attributed to Pioneer ACOs (ACO group) with other beneficiaries (contr

14 ses among random samples of beneficiaries in Pioneer ACOs (n = 13,097), FFS (n = 116,255), or Medicar

15 fferences associated with characteristics of Pioneer ACOs have not been well described.

16 otal spending for beneficiaries aligned with Pioneer ACOs in 2012 or 2013 increased from baseline to

17 ioneer ACO Model, beneficiaries aligned with Pioneer ACOs, as compared with general Medicare FFS bene

18 The conditional pioneer activity observed with Sox2 at a subset of bindi

19 Pioneer activity relates simply to the ability of a give

20 ding in which directional and nondirectional pioneer activity shapes the chromatin landscape for popu

21 c and extrinsic features that determine Sox2 pioneer activity.

22 While several pioneers already investigated Next Generation Sequencing

23 us on work conducted by R.R. Hardy, an early pioneer and codiscoverer of B-1 cells, whose seminal con

24 lia are key for assembly initiation, guiding pioneer and follower axons using distinct signals.

25 ard will be presented to Mary-Claire King, a pioneer and visionary who revolutionized the use of gene

26 This meeting brought together pioneers and leading experts in the fields of stem cells

27 ine roles for glial Netrin and Semaphorin in pioneer- and follower-axon guidance, respectively, and f

28 ory--the history of ideas and the stories of pioneers--and draw lessons about the remarkable ecosyste

29 e establish that without these two endocytic pioneers, AP-2 assemblies are fleeting and endocytosis s

30 We then discuss pioneering applications executed by the genomics communi

31 Pioneering archaeological expeditions lead by Richard Ma

32 Pioneers are also more likely to find and mate with gene

33 Many pioneering articles on rheumatoid arthritis (RA) also ha

34 reveal previously undescribed glial roles in pioneer-axon guidance, suggesting conserved principles o

35 Brain assembly is hypothesized to begin when pioneer axons extend over non-neuronal cells, forming tr

36 ng ensuing morphological growth to establish pioneer axons.

37 showed a significant reduction in the early pioneering bacteria Gammaproteobacteria (P = 0.03) and e

38 ineralization of the tooth by recruiting the pioneer bacterium Streptococcus mutans to the surface.

39 inatus over competing M. steenstrupii, among pioneer biocrust-formers.

40 Silver birch (Betula pendula) is a pioneer boreal tree that can be induced to flower within

41 MeHg concentrations in pioneer but not in recolonized beaver systems were up to

42 Vessel repair techniques, pioneered by Alexis Carrel and others in the 20th centur

43 ing trustworthy clinical practice guidelines pioneered by investigators in the 1980s.

44 erric salts have been known since the 1970s, pioneered by Kochi for cross-coupling using alkylmagnesi

45 Pioneered by Lehn, Cram, Peterson and Breslow, supramole

46 t for cell-based immunotherapies, which were pioneered by the development of allogeneic hematopoietic

47 ction with the molecular recognition toolkit pioneered by the field of supramolecular chemistry, ther

48 r, at a subset of genomic sites, the role of pioneer can be reversed, with the steroid receptors serv

49 Interestingly, pioneer cells delaminate shortly after ingression.

50 We identify pioneer cells expressing neurog1 outside the otic epithe

51 egrating cell dynamics whereby ingression of pioneer cells instructs neuronal specification.

52 Ablation experiments reveal that pioneer cells promote neurog1 expression in other otic c

53 ricultural importance in cotton, but through pioneering chimeric and morphometric studies, it has con

54 Pioneering clinical trials suggest that bone marrow-deri

55 This strategy should lead to pioneering clinical trials with xenotransplantation for

56 The pioneer colonization of ephemeral freshwater pools by br

57 cus gordonii and Streptococcus sanguinis are pioneer colonizers of dental plaque and important agents

58 Although the field of genetics has pioneered data sharing for these reasons, neuroimaging h

59 Since the pioneering days of total synthesis and retrosynthetic an

60 As pioneer decomposers of leaf litter, variations in divers

61 This method could be a pioneer developer in TU sensitive chemical sensor develo

62 With our recent pioneering developments in single bacterial cell transcr

63 postulate that the documented settlement of pioneers directly on the wave front in North America has

64 Just as past studies of blood cancers led to pioneering discoveries relevant to other cancers, determ

65 genda, we report the advances and use of the pioneering "Drug hypersensitivity" subsection of ICD-11

66 odeling complex opposes this transcriptional pioneering during B cell programming of multipotent lymp

67 is to affirm existing dogmas rather than to pioneer efforts involving unconventional thought.

68 t for such thinking in nonhuman animals (for pioneering efforts, see [2, 3]).

69 ) motifs within the early-arriving endocytic pioneers Eps15/R are differentially decoded by other end

70 In this study, we build on these pioneering experimental studies to provide fundamental m

71 These pioneering experiments demonstrated that the behavior of

72 easurements proposed here chart a course for pioneering exploration of the veiled inner workings of t

73 hromatin, suggesting that TP53 has intrinsic pioneer factor activity and binds within structurally in

74 in opening, is an important feature of PHA-4 pioneer factor activity.

75 Overexpression of the proneural pioneer factor Ascl1 results in a well-defined initializ

76 Scl does not act as a pioneer factor but rather exploits a pre-established epi

77 Tcf7l1 represses FoxA2, a pioneer factor for endoderm specification.

78 The pioneer factor FoxA displaces linker histone H1, thereby

79 We implicate the pioneer factor FOXA1 as a driver of enhancer activation

80 These properties mark EBF1 as a pioneer factor in B cell development and demonstrate a r

81 remodeller in promoting the activity of the pioneer factor OCT4 and regulating the pluripotency netw

82 we discover that the pluripotency-associated pioneer factor OCT4 binds chromatin to shape accessibili

83 Forkhead box protein A1 (FOXA1) is a pioneer factor of estrogen receptor alpha (ER)-chromatin

84 n complete downregulation of the melanotroph pioneer factor PAX7, and subsequently a switch of identi

85 norhabditis elegans foregut development, the pioneer factor PHA-4/FoxA binds promoters and recruits R

86 4, we demonstrate that NF-kappaB might be a pioneer factor required for the regulation of TNFalpha-i

87 chromatin analyses revealed that HNF4G is a pioneer factor that generates and maintains enhancer lan

88 At this latter class, it acts as a pioneer factor, recruiting H3K27 acetyltransferase activ

89 We provide evidence that the maternal pioneer factor, Zelda, is responsible for establishing p

90 erns though its unique ability to serve as a pioneer factor.

91 alter the genomic distribution of the FoxA1 pioneer factor.

92 elda possesses some key characteristics of a pioneer factor.

93 This finding, which established FoxO1 as a "pioneer" factor, suggested a model whereby FoxO1 chromat

94 was strikingly enriched in binding sites for pioneer factors (NFYA/B, DMRT1, and hormone receptors).

95 Pioneer factors (PFs) such as FOXA1 are able to directly

96 inding, yet it remains unclear how different pioneer factors achieve this.

97 Recent studies have shown that pioneer factors are also crucial for cellular reprogramm

98 teractions between transcription factors and pioneer factors are highly dynamic.

99 Our findings provide insight into how pioneer factors can target naive chromatin sites.

100 AG factors function as both decommission and pioneer factors during ES to TS-like cell fate conversio

101 During this process, pioneer factors establish an accessible chromatin state

102 er reprogramming factors appear dependent on pioneer factors for engaging nucleosomes and closed chro

103 s, embryonic C cells were found to coexpress pioneer factors forkhead box (Fox) a1 and Foxa2 before n

104 by many transcriptional cofactors, including pioneer factors FOXA1 and GATA2, which, however, exhibit

105 hormone-independent binding patterns of the pioneer factors FoxA1 and GATA2.

106 reduces binding of RNA polymerase II and the pioneer factors FoxA1/A2.

107 provide an overview of the contexts in which pioneer factors function, how they can target silent gen

108 Understanding how pioneer factors regulate gene expression greatly enhance

109 aken together, the distinguishing feature of pioneer factors remains nucleosomal access rather than a

110 Pioneer factors such as FoxA target nucleosomal DNA and

111 icate that TP53, along with TP63, may act as pioneer factors to specify epithelial enhancers.

112 ging transcription factors, a subset called 'pioneer factors' are dominant in their ability to engage

113 Multiple mechanisms, including pioneer factors, coregulators and epigenetic modificatio

114 However, recruitment of all TFs, including pioneer factors, is impeded by condensed H3K27me3-contai

115 etylated, closed chromatin, independently of pioneer factors, where it induces nucleosome displacemen

116 when they are retained with, and exposed by, pioneer factors.

117 Here, we identify an additional role for pioneer factors.

118 d more than 90% of hotspots were occupied by pioneering factors.

119 the transcription factors, and the upstream 'pioneering' factors that regulate their accessibility to

120 re differentially decoded by other endocytic pioneers Fcho1/2 and AP-2.

121 ccessibility and suggest that the concept of pioneer function extends to acute gene regulation.

122 scape, suggesting that these factors serve a pioneering function during Tr1 cell differentiation.

123 ing pregastrular stages by expression of the pioneer gene onecut.

124 c incompatibility factor genes cifA and cifB pioneers genetic studies of prophage WO-induced reproduc

125 nvestigators embraced these opportunities by pioneering genome-wide association studies at the popula

126 d on molecular dipole detection enabled by a pioneering graphene nanoelectronic heterodyne sensor.

127 imates of Model Accuracy (EMA), which uses a pioneering hybrid quasi-single model approach.

128 or the placebo groups: 41.8% versus 26.0% in PIONEER I (P=0.003) and 58.9% versus 27.6% in PIONEER II

129 We enrolled 307 patients in PIONEER I and 326 in PIONEER II.

130 PIONEER I and II were similarly designed, phase 3 multic

131 mumab and 1.3% of those receiving placebo in PIONEER I and in 1.8% and 3.7% of patients, respectively

132 IONEER I (P=0.003) and 58.9% versus 27.6% in PIONEER II (P<0.001).

133 us score for disease severity) at week 12 in PIONEER II only.

134 nrolled 307 patients in PIONEER I and 326 in PIONEER II.

135 1.8% and 3.7% of patients, respectively, in PIONEER II.

136 d total D-AAs in Vibrio cholera cultures are pioneer illustrated as relevant examples of each enantio

137 Nevertheless, Ton That Tung remains a pioneer in liver anatomy and liver surgery.

138 Such methods were pioneered in plant and animal-breeding literature and ha

139 This HSV pseudotyping system pioneered in this work opens doors for future systematic

140 g and appreciating the past contributions of pioneers in cataract surgery is vital to understanding t

141 Elledge, two pioneers in elucidating the DNA damage response, whose c

142 enschlager, Charles Rice, and Michael Sofia, pioneers in the development of curative and safe therapi

143 He was among the major pioneers in the development of original techniques for t

144 leaf segments from seedlings in a variety of Pioneer inbred lines, routinely recovering healthy, fert

145 For example, the Pioneer inbred PHH5G is recalcitrant to biolistic and Ag

146 esigned and statistically powered to deliver pioneering insights into the genetic architecture of tra

147 between October 2011 and March 2014 from the PIONEER intraoperative and perioperative OCT study were

148 Our results show that pioneer inundation by beavers can increase MeHg concentr

149 xalates is proposed that is based on earlier pioneering investigations of Okada and Barton.

150 As a pioneering knowledge-based approach, SDM has been highli

151 Health Research and Prevention to honor its pioneering leader.

152 the cardiovascular community to build on its pioneering leadership in evidence-based medicine through

153 ing platforms which are acutely sensitive to pioneer master regulators whose levels define not only s

154 Scaffold modification based on Wang's pioneering MDM2-p53 inhibitors led to novel, chemically

155 Moreover, the results of pioneering measurements differed from theoretical predic

156 As such, we have pioneered methodology in which site-specific incorporati

157 The pioneering model of the housefly sodium channel visualiz

158 The Miller-Urey experiments pioneered modern research on the molecular origins of li

159 can be identified with fast-growing and long pioneering MTs in the region near the cell edge, which h

160 h and bimodal MT length distributions, i.e., pioneering MTs; the other stable state corresponds to an

161 , Eden Alternative, Wellspring, Green House, Pioneer Network, dementia, nursing home, assisted living

162 How do the pioneer networks in the axial core of the vertebrate ner

163 on guidance, respectively, and for glial and pioneer-neuron Flamingo (CELSR) in follower-axon navigat

164 Yet pioneer-neuron identities, their guidance substrates, an

165 reas no prominent anterior medial cluster of pioneer neurons is present in insects.

166 d KPC-1 function noncanonically, in glia and pioneer neurons, for guidance-cue trafficking.

167 Phylogenetic analysis indicated that pioneers occur more frequently in clades where phosphoru

168 st currents of these types to be explored by pioneering oceanographers.

169 of research began many decades ago, when the pioneers of cell culture began to ask questions we still

170 Forty years ago the pioneers of moonshine asked if there is anything similar

171 Pioneers of such diastereodivergent catalytic asymmetric

172 Prize in Chemistry 2016 goes to three of the pioneers of the field of synthetic molecular machines, J

173 Here, pioneers of this new drug class provide a bench-to-bedsi

174 on of several species without replacement of pioneer organisms, thereby creating a significant increa

175 , the paradigm Lewis acid originally used to pioneer our combined electrochemical/frustrated Lewis pa

176 Different protocols, pioneered over the last decade, and now widely applied i

177 ablishes a specialized subpopulation with a "pioneer" phenotypic program in Saccharomyces cerevisiae.

178 Pioneering photon counting experiments, such as the inte

179 started early as an incipient inclination of pioneer plants, and the arrangement propagated gradually

180 previously characterized primary commissure pioneer (PNP) neurons of the locust brain that pioneer t

181 wing from empirical research oriented toward pioneering policies in Costa Rica.

182 The genome of the proposed pioneer population, 'Candidatus Reconcilibacillus cellul

183 rminal kinase (JNK) signaling in guiding the pioneering population of cortical interneurons into the

184 on mating patterns and genetic diversity of pioneer populations.

185 When bird populations spread, long-distance pioneering populations are often backfilled by a more sl

186 ding, and the 13 ACOs that withdrew from the Pioneer program after 2012 and the 19 that did not.

187 data established a biophysical basis for the pioneering properties associated with PU.1, which robust

188 Since the pioneering proposal of the replicon model of DNA replica

189 ome-binding sequences in the transcriptional pioneer protein FOXA1.

190 we identify the RAA7 locus, which encodes a pioneer protein with no previously known protein domain

191 of these features, drawing inspiration from pioneering research in molecular recognition and structu

192 eck European Brain Research Prize for their 'pioneering research on higher brain mechanisms underpinn

193 Pioneering research studies, beginning with those using

194 Kuhn, like the other pioneering researchers of his day, was given access to n

195 esquiterpene compounds are reviewed from the pioneering results to the end of 2015.

196 GelMA has a critical pioneering role in this process and could be used to acc

197 (FOXA1) is an FKHD family protein that plays pioneering roles in lineage-specific enhancer activation

198 include polypeptides produced as part of the pioneer round of translation, premature translation term

199 mutant proteins originated primarily in the pioneer round of translation.

200 s in emissive charge-transfer molecules have pioneered routes to reduce the energy gap between triple

201 xample, we show that this is the case in the pioneering S/FI (where FI is a insulating ferromagnet) t

202 After a pioneering single treatment we now report the outcome of

203 n growth resulted in a single "r-strategist" pioneer species (the bryozoan Fenestrulina rugula) domin

204 periment to measure seedling responses of 15 pioneer species to phosphorus addition with an analysis

205 rus acquisition and use may be strongest for pioneer species with high phosphorus demand.

206 al niche trade-offs and loss of fast-growing pioneer species.

207 robur, and Quercus petraea; "losers"-mostly pioneer species: Betula pendula, Larix decidua, Picea ab

208 fect on fouling in SAnMBRs as they represent pioneering species attaching to membranes to form foulin

209 Cells in the pioneer state readily disperse in water, enabling them t

210 Here, we review the pioneering steps in the development of molecular MRI met

211 s with micromechanical sensors is one of the pioneer studies in the mass sensing applications.

212 nd shells around NPs, illustrating important pioneering studies and examples of current research.

213 Pioneering studies by Kuivila, published more than 50 ye

214 We compare our results with pioneering studies carried out in the 1970s and 1990s by

215 These pioneering studies have led to successful therapeutic tr

216 Pioneering studies in visual cortex initially indicated

217 een used as proxy for genetic relatedness in pioneering studies of neutral theory and human migration

218 Pioneering studies on a few overdoped samples indicated

219 We review recent pioneering studies that address the complex effects of o

220 ium fosters academic-industry partnership in pioneering studies to combat serious bacterial infection

221 These pioneering studies will now permit an analysis of the ph

222 Although postulated since Darwin's pioneering studies, these secretory events have not been

223 This simulation work serves as a pioneering study demonstrating how the molecular simulat

224 Twenty-five years ago, a pioneering study on healthy participants heralded the in

225 c Imaging with Optical Coherence Tomography (PIONEER) study with postoperative outcomes.

226 Pioneer sublateral neurons, with unique growth propertie

227 oked, it is undeniable that he was America's pioneer surgical historian and, as such, afforded surgeo

228 Five were pioneer systems, inundated for the first time since beav

229 innovative surgeon who developed some of the pioneering techniques in glaucoma filtering surgery.

230 However, many pioneering techniques were based on serendipitous discov

231 hanistic basis by which GATA3 functions as a pioneer TF in a cellular reprogramming event relevant to

232 cooperates with intrinsic properties of the pioneer TF Sox2 to facilitate its binding to intractable

233 FoxA, the paradigm pioneer TF, has a winged helix DBD that resembles linker

234 work for de novo enhancer establishment by a pioneer TF.

235 The mechanism by which pioneer TFs gain access to chromatin remains an importan

236 binding sites may be a key feature of other pioneer TFs operating at intractable genomic loci.

237 nspecific synergistic effects, largely among pioneer TFs, is sufficient to predict a large fraction o

238 d on natural photoreceptor systems have been pioneered that allow distinct cellular signaling pathway

239 oneer (PNP) neurons of the locust brain that pioneer the first commissure in the brain.

240 We pioneer the first description of AMPA receptor (AMPAR)-m

241 e internalized these cells extend axons that pioneer the primary axonal scaffold of the central nervo

242 ancer therapy, and one (Donald Pinkel) would pioneer the successful "total therapy" for pediatric ALL

243 Their existence as quasi-species has pioneered the concept of "lethal mutagenesis" that promp

244 It has also pioneered the concepts of stem cell therapy and immunoth

245 s due to the nurses and music therapists who pioneered the idea in nursing care, consideration of pat

246 We pioneered the observation that a common feature of addic

247 Mogens Schou pioneered the study of lithium for prophylaxis of the re

248 We have pioneered the use of the commensal gut bacterium Bactero

249 lleagues reported one of the earliest trials pioneering the use of high-dose chemotherapy and autolog

250 This work pioneers the scalable synthesis of transparent conductiv

251 Such a hydrogel system pioneers the study of active motile systems in porous me

252 esent a modeling environment for MATLAB that pioneers these challenges.

253 ry-based strategy, peptidogenomics, has been pioneered to effectively mine microbial strains for nove

254 atest minimally invasive transanal technique pioneered to facilitate difficult pelvic dissections.

255 Growth responses of pioneers to phosphorus addition revealed a clear tradeof

256 However, the relationship of these pioneers to the long-established Papuan people of the Ne

257 nses with superior spatiotemporal precision, pioneering tools have recently been crafted to modulate

258 he arcade cell epithelium is mediated by the pioneer transcription factor and master regulator PHA-4/

259 A2 has been well-characterized as a critical pioneer transcription factor for androgen receptor (AR)

260 l, Liu and Kraus (2017) demonstrate that the pioneer transcription factor Sox2 requires PARP1 to bind

261 Pioneer transcription factors (TFs) access silent chroma

262 Pioneer transcription factors (TFs) function as genomic

263 This process typically requires pioneer transcription factors (TFs) to induce de novo fo

264 ocalized chromatin modifications imparted by pioneer transcription factors are sufficient to initiate

265 Pioneer transcription factors can bind DNA sites on nucl

266 these enhancers are first recognized by the pioneer transcription factors FOXA1 and FOXA2 when compe

267 the emerging role of chromatin modifiers and pioneer transcription factors in adult stem cell fate de

268 I posit that this is due to the role of pioneer transcription factors in engaging silent, unmark

269 27me3 on nascent DNA is essential to recruit pioneer transcription factors in stem cell differentiati

270 Pioneer transcription factors initiate cell-fate changes

271 Pioneer transcription factors recognise and bind their t

272 nhancers and promoters, which is mediated by pioneer transcription factors that recruit activating ch

273 of a silent gene locus is thought to involve pioneering transcription factors that initiate changes i

274 Moreover, such pioneering transducing approach allowed amplification of

275 Although pioneering treatment trials based on small numbers of pa

276 Differences in pioneer tree density linked to disturbance regime can in

277 In forests with gap disturbance regimes, pioneer tree regeneration is typically abundant followin

278 s J. copaia (Bignoniaceae) is a fast growing pioneer tree that occurs at high densities.

279 y arrays for the long-lived, self-compatible pioneer tree, Vochysia ferruginea, at two Costa Rican si

280 of early twentieth century cytoarchitectonic pioneers Von Economo and Koskinas (1925) on the microsca

281 Herein, detailed attention is given to the pioneering work based on synthetic optimization of diffe

282 However, despite decades of pioneering work by some of the brightest scientists in b

283 s potential has only begun to be explored in pioneering work harnessing DNA scaffolds to dictate the

284 This pioneering work has made a new model of the human intest

285 In this review, we will examine some of the pioneering work in this field, and speak on the use of b

286 Since the pioneering work of Elie Metchnikoff and the discovery of

287 The pioneering work of Eugene Kennedy in the 1950s establish

288 model and subsequent proof was driven by the pioneering work of Hugh Huxley (1924-2013).

289 Since the pioneering work of Turing on the formation principles of

290 ematologist, John V. Dacie was known for his pioneering work on hemolytic disorders, especially parox

291 (F-279) in honor of Michael Faraday's (1857) pioneering work on nanoparticles.

292 Pioneering work on soybean's interactions with these org

293 Pioneering work on the dimensions of mind perception has

294 Pioneering work revealed that acyclic boronic acids can

295 s an extensive and useful documentation from pioneering work to recent advances in phosphorus stereoc

296 From pioneering work to recent developments, we review how th

297 The pioneering work was that of Franz Hofmeister who studied

298 f variation is the direct descendant of this pioneering work.

299 Despite pioneering works in yeast, it is unclear how mammalian c

300 ulsions in such mixtures was proposed in the pioneering works of Barden and coworkers in the 1970s an