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1 in which each of the linking arms contains a piperazine ring.
2 nzyl moiety, respectively, on the piperidine/piperazine ring.
3 in this series included an aryl-substituted piperazine ring, a varying alkyl chain linker (C3-C5), a
5 omatic hydrophobic moieties connected to the piperazine ring and bioisosteric replacement of the arom
6 he scaffold, we have maintained the original piperazine ring and introduced four different functional
7 (SAR) of the aromatic ring linked to the N-4-piperazine ring confirmed the superiority of 2-pyridine
8 ing-containing buffers (e.g., Mops, Mes) and piperazine ring-containing zwitterionic buffers (e.g., P
10 roup adjacent to either nitrogen atom of the piperazine ring (e.g. 25 and 27) was not well tolerated.
11 f the benzene ring after the cleavage of the piperazine ring (e.g., CIP product with m/z 280) is desc
12 DNA binding drug Hoechst 33258, in which the piperazine ring has been replaced by an amidinium group
13 example, analogues prepared by replacing the piperazine ring in the GBR structure with an N, N'-dimet
15 alkyl chain between the phenyl group and the piperazine ring influenced binding affinity and selectiv
17 ridine ring and the terminal nitrogen of the piperazine ring, leading to compound (4S)-4-[({4-[4-(met
21 sulfonamide group at the 1N-position of the piperazine ring to fill the S1' pocket of the enzyme, an
22 e) is attached to the distal nitrogen of the piperazine ring via alkyl chains of varying lengths or d
24 on spacer between the hydroxyl group and the piperazine ring was essential for enantioselectivity, an
25 n of compounds involving changes in the core piperazine ring was synthesized to improve antimalarial
26 ), which differed by the substitution on the piperazine ring where the piperazine of LDK1203 and LDK1
27 to form a five-ring compound with a central piperazine ring, which was characterized by electrospray
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