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1 reductive amination sequence that closes the piperidine ring.
2 olysis reaction stereoselectively formed the piperidine ring.
3 henyl group located on the 4-position of the piperidine ring.
4 nteractions to control the conformation of a piperidine ring.
5 oducts containing only fused pyrrolidine and piperidine rings.
6 hydroxyl group into the C-4 position on the piperidine ring (10e) resulted in a substantial decrease
7 uents, (3) introducing unsaturation into the piperidine ring, (4) ring-opening or eliminating the pip
8 try between the 3- and 4-substituents in the piperidine ring, a trans-crotyl or allyl substituent on
9 (phenylalkyl)amine series indicates that the piperidine ring and alkyl chain substitutions common to
10 udies indicated that the sulfonyl group, the piperidine ring and benzothiazole were the key component
11 g a hydroxy group onto the 4-position of the piperidine ring and the beta-carbon of the N-alkyl space
12 t one additional methylene group between the piperidine ring and the polar group in the 3alpha-substi
13 ne ring, (4) ring-opening or eliminating the piperidine ring, and (5) removing the piperidino N-methy
14 itrogen, the lack of a 2-methyl group in the piperidine ring, and either no substitution or hydroxyl
16 -hydroxy substituent axially oriented to the piperidine ring (C9beta-hydroxy) was a mu-agonist about
17 he stereomutation of such piperidines is the piperidine ring flip and not nitrogen inversion or rotat
18 membered bicyclic aryl rings attached to the piperidine ring had a marked impact on these effects.
20 ain between the arene and tosyl group on the piperidine ring is proposed to rationalize the greater s
21 c nitrogen, by adding a fluorine atom to the piperidine ring, leading to 3-(4-fluoropiperidin-3-yl)-2
22 ectrostatic interaction between the ORG27569 piperidine ring nitrogen and K3.28(192) that is importan
23 y the optimal spacing and orientation of the piperidine ring nitrogen relative to the benzimidazole.
24 umerous attempts toward the formation of the piperidine ring of 1 from vinyl iodide 56 were made and
26 hydroxy substituent was introduced into the piperidine ring of one of our disubstituted lead analogu
27 clash of the modified C386 residue with the piperidine ring of SR141716A and/or disruption of an aro
28 nverse interaction of amino acid 351 and the piperidine ring of the antiestrogen side chain of raloxi
29 y step was employed to construct the central piperidine ring of the iminosugar and the C-glycosidic s
30 cement of the carboxylate group at C2 in the piperidine ring of the inhibitors causes electrostatic d
31 bered ring to the conformationally mobile D'-piperidine ring provided an isolated atropisomer 81a, wh
32 l ether substituent on the 5-position of the piperidine ring provided ultrapotent inhibitor 38 (DH376
33 complex noviose sugar with readily available piperidine rings resulted in approximately 100 fold incr
35 clic tropane ring system with the monocyclic piperidine ring system or an acyclic aminoalkylene chain
39 ands, cyTPA and 1-isocyTPQA, which feature a piperidine ring that provides a structurally rigid backb
40 f enantioenriched pyrrolidine, indoline, and piperidine rings using an organocatalyzed, intramolecula
41 med then precipitates the contraction of the piperidine ring via C2-C3 bond cleavage, and the resulti
42 7 indicated that the benzylated six-membered piperidine ring was disordered and exposed to solvent.
44 rigid carbocyclic structure and an attached piperidine ring which is free to rotate were synthesized
46 precedented level of substitution to provide piperidine rings with adjacent tetrasubstituted carbon a
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