ライフサイエンスコーパス: pivot

1 ut any rotation around the second sigma(C-N) pivot.

2 nonracemizing rotation around the sigma(C-C) pivot.

3 tion during the transport cycle use G93 as a pivot.

4 l-ordered linker and C-terminus serving as a pivot.

5 in various directions, KT diffusion, and MT pivoting.

6 enhancing the effects of KT diffusion and MT pivoting.

7 tly impact ErbB2 activity by disrupting this pivoting.

8 Of the 587 patients in PIVOT, 557 had full NC results and were included.

9 possibility that N-TIMP-1 might dynamically pivot a few degrees or more in the arc toward the MT1-MM

10 avascular Venous Oxygen saturation, and T2* (PIVOT), a recently developed MRI technique, was used to

11 a pendant pentyloxy group and the ability to pivot about a strong hydrogen-bonding network.

12 interdomain/cAMP-binding and D/D domains to pivot about each other.

13 OHCs moved antiphasic to the outer row; OHCs pivoted about the RL; and Hensen's cells followed the mo

14 atively rigid hydrogen-bonded unit, possibly pivoting about a central position near residue Val87.

15 ly toward the nucleotidyltransferase domain, pivoting about a short linker region.

16 e "flipped" within the transporter cavity by pivoting about Lys-436 leading to net transport from the

17 s, filaments can be seen passing through and pivoting about single points on the motility surface.

18 ltage-sensing arginines in their S4 segments pivot across the lipid bilayer as voltage sensor paddles

19 e between the mode of oscillation of a rigid pivoted airfoil in a flow and a hinged-free elastic plat

20 To examine linkage between the core pivot and DNA binding domains, the L148F substitution wa

21 d rotation of the two lobes around a central pivot and opening of a "lid" region that facilitates sub

22 h the alpha-helical transmembrane domain can pivot and rotate relative to the rigid beta-sheet bindin

23 to signaling that exploits differential heme pivoting and heme bending.

24 possible activation pathways, which involve pivoting and rotational motions of the helices, respecti

25 nter of the platform, can undergo remarkable pivoting and tilting motions that appear buffered by N-g

26 to methyl-substituted triptycenes acting as pivots and encapsulating frames.

27 We make a distinction between such pivots and templates and discuss the biological implicat

28 y demanding tasks to a search for landmarks, pivots, and hubs.

29 -like nucleotide-binding domains of Galphai1 pivot apart to occupy multiple resolved states with disp

30 tional rearrangements: a winged-helix domain pivots approximately 90 degrees to close onto duplex DNA

31 and the amino acids involved in creating the pivot are not conserved.

32 iffer, with only minor exceptions equivalent pivots are seen in comparisons of Escherichia coli struc

33 Small rigid helices upstream of these 'pivots' are aligned, thereby decoupling their motion fro

34 agents (e.g. top connectors and stereocilia pivots) are responsible for approximately 9% of the over

35 We speculate that E proteins could pivot around the fusion loop-pocket junction, allowing v

36 mutating a critical residue proposed to be a pivot around which the two lobes of NCT rotate.

37 The oligomeric interface pivoted around residue T585 as a joint that links and st

38 ia deflect by bending along their length and pivoting around an effective hinge located below the bas

39 tition responds principally as a rigid plate pivoting around its insertion along the spiral lamina.

40 showed that MT gliding along cell edges and pivoting around the centrosome regulate MT rearrangement

41 rally been accepted that the head rotates by pivoting around the neck helix (h28) of 16S rRNA, its so

42 oximal rhynchokinesis in which the upper jaw pivots around the nasal-frontal (N-F) hinge.

43 d in the post-cleavage furrow; then one cell pivots around the other, resulting in stacking into a co

44 ected by a sensory stimulus, the stereocilia pivot as a unit, producing a shearing displacement betwe

45 ion process, we observed domain rotation and pivoting as well as a translation and simultaneous rolli

46 reatest in individuals closest to the center pivot, as a result of a higher pathogen dose.

47 rds the east and opens anticlockwise about a pivot at its eastern end.

48 ional to height, indicating that stereocilia pivot at their basal insertion points.

49 h transients on fibers in rigor do not cause pivoting at Gly699 or reverse the power stroke.

50 Pivoting at Gly699 rotates probes at SH1 suggesting that

51 A different structure, generated by pivoting at Gly699, better resembles the native rigor co

52 Movement originates from pivoting at stacked non-canonical base pairs in a Family

53 aided by a model of energy transduction that pivots at Gly699 to change probe-binding cleft conformat

54 domain is ejected from the complex and VPS15 pivots at the base of the V.

55 tilts (around its phosphate group and N1 as pivots) away from the catalytic lysine 145 and the prote

56 prechordal plate appears as a mesendodermal pivot between the notochord and the ventral foregut midl

57 The loop pivots between different conformational states about a h

58 ractions between substituents vicinal to the pivot bond.

59 he138, appear to work in conjunction with FY-pivot canonical residues to facilitate alternative confo

60 and width of surrounding tidal flats have a pivoting control on marsh erosion.

61 B cell-NK/NKT cell cross-talk is a critical pivot controlling survival of infection with virulent F.

62 The classical QR factorization with pivoting, developed as a fast numerical solution to eige

63 distal residues flexible, through a beta-Man pivot, ensuring anchored projection from the protein she

64 ains around the wedge helix, which acts as a pivot, facilitates nucleolytic cleavage.

65 animals can successfully employ short range 'pivot' feeding effectively on evasive prey.

66 y (copepods) using a technique known as the 'pivot' feeding, which involves rapid movement to overcom

67 opposite end of the substrate, serving as a pivot for the actions of F53 and H110.

68 hat each foot can act as a temporarily fixed pivot for the other.

69 rients actin filaments using the contacts as pivots, forming bundles that then generate lateral tensi

70 Of the 21 pivots found, six are observed in the large subunit rRNA

71 litude distribution, could differentiate the pivot from surrounding peripheral regions and thereby as

72 We call these 'FY-pivot' GTPases after their most distinguishing feature,

73 ther, a number of LacI mutations in the core pivot have been identified recently by their altered beh

74 ing of the catalytic cleft since R463 on the pivot helix is pushed into contact distance with the bet

75 enzyme-binding site lies directly under the "pivot helix" of the NAD(+) binding domain.

76 er, ADP, NAD(+), and NADH all bind under the pivot helix, but a second GTP molecule does not.

77 DP interact with R459 (R463 in huGDH) on the pivot helix.

78 exception of the truncated side chain on the pivot helix.

79 s more disordered the further it is from the pivot helix.

80 served at the second coenzyme site under the pivot helix.

81 ity to directly explore the role of the core pivot in repressor function.

82 Here, we identify FOXO4 as a pivot in senescent cell viability.

83 bons 3 and 3' was isolated and its role as a pivot in the anthocyanins-type multistate of chemical re

84 This interaction acts as a pivot in the conformational search associated with foldi

85 nar cell polarity signaling enables cells to pivot in the direction of limb elongation via this N-cad

86 to migrate against the flow direction while pivoting in a zig-zag motion.

87 minal peptide of hCCS are consistent with a "pivot, insert, and release" mechanism that is similar to

88 hereas in the subunit that binds GS-Hna, R15 pivots into the active site, which breaks its interactio

89 osure of pathogens aerosolized during center pivot irrigation of diluted dairy wastewaters.

90 The pivot is critical to rotors postulated to maintain atria

91 Each pivot is typically in direct physical contact with at le

92 n the middle of transmembrane helix 6, which pivots its intracellular half outward to accommodate the

93 An ethynyl unit as spacer and pivot joint provides almost free azimuthal rotation of t

94 We identified inter-ring pivot joints that articulate during ring closure.

95 Z- and PIWI-containing lobes, as well as the pivot-like conformational changes associated with comple

96 We observe pivot-like domain movements within the Ago scaffold on p

97 ical tissue architecture is established by a pivot-like process between sister cells.

98 sted that potassium channels are gated via a pivoted mechanism of the pore-lining helix.

99 ter, and (ii) as a modulator to restrict the pivot motion at the S4-S5 linker and at a critical hinge

100 around their long axis, and undergo an acute pivoting movement to reorient perpendicular to the oocyt

101 mophore to its all-trans form, that involves pivoting movements of kinked helices, which, while maint

102 As a group, the behaviors of the core pivot mutants are consistent with the allosteric structu

103 rogenitor cells (MSCs) in bone marrow is the pivot of differentiation potency from osteoblast to adip

104 ggests a conformational change that involves pivoting of a transmembrane, four-helix bundle (M1, M2,

105 Pivoting of helix M is accompanied by counterclockwise r

106 olarity through PI3K-dependent branching and pivoting of protrusions.

107 e transporter family, show that the downward pivoting of the Core domains relative to the Gate domain

108 Pivoting of the prybar induced by force demolishes an in

109 esidue and its neighbour (Im9 Tyr55) are the pivots of a 19 degrees rigid-body rotation that relates

110 me signaling molecules, which thereby become pivots of angiogenic balance.

111 bout which the kinase and regulatory domains pivot on conserved hinges to modulate transphosphorylati

112 advances in childhood cancer treatment will pivot on developing biology-driven new drug development

113 all thickening and its clinical implications pivot on different wall thickening mechanisms in various

114 The route pivoted on the construction of a late-stage protecting-g

115 tended CYPOR structures demonstrate that, by pivoting on the C terminus of the hinge, the FMN domain

116 helix undergoes a lever-like swinging motion pivoting on the intrasubunit hinge, and the entire TM2 b

117 ghtly folded core containing the latch motif pivots on a more flexible hinge region to occlude the po

118 The antimicrobial use of silver compounds pivots on the 100-year-old application of silver nitrate

119 egion together with bound CaM forms a hinge, pivots on the conserved Arg(536), and regulates electron

120 Auxin-regulated transcription pivots on the interaction between the AUXIN/INDOLE-3-ACE

121 ode II there appears to be a definite "point pivot" on the major-groove side of the two base-pairs th

122 pulations that were 1 to 10 km from a center pivot operation.

123 exerted torque during manipulation of freely pivoting or unstable objects.

124 hat V3 can move independently of V2, with V3 pivoting out from its "tucked" position in the trimer wh

125 The F-G-helix cassette pivots over the I-helix in direct response to the size o

126 orter during reentrant propagation (ie, with pivoting) parallel to fibers (10.6 +/- 4.2 mm) compared

127 red with plane wave propagation (ie, without pivoting) parallel to fibers (32.8 +/- 6.5 mm, P < .02),

128 urrounding the reactive cysteine SH1 and the pivot point about which the light chain-containing regio

129 uster of Phe residues at the fulcrum of this pivot point allows for dramatic repositioning of the cas

130 helices swing as a single rigid body about a pivot point at the N-terminal end of the F helix, allowi

131 arrangement is the formation of a molecular pivot point between the two domains as a result of diffe

132 ons, indicating that the V3 base serves as a pivot point during the transition between these two stat

133 erms of the role of this residue (G699) as a pivot point for motion of the lever arm.

134 imately 30 degrees , and tilts sideways at a pivot point formed by a highly conserved hydrophobic reg

135 ated counterclockwise by 30 degrees around a pivot point in an alpha-helix of ARPC4 (Glu(1)-Asn(1)) t

136 etry-related histidine residues at a central pivot point in the dimer interface suggests a mechanism

137 The other pivot point is an intersubunit one at which all four TM2

138 We identified a hydrophobic pivot point located at the dimer-dimer assembly interfac

139 e motion of the TM2 segments that includes a pivot point near middle of the helix.

140 Lys42, Ile190, and Gly191 are located at the pivot point of intersubunit conformational changes that

141 port enzyme-PCNA alignments and a kinked DNA pivot point that appear suitable to coordinate rotary ha

142 results suggest that Ser-257 functions as a pivot point, allowing the nicotinamide of NADP(+) to sli

143 between the two domains of RSV CA creates a pivot point, which is central to controlling their relat

144 rmational diffusion time can be considered a pivot point.

145 arget for signaling inputs, resides near the pivot point.

146 terminus of the D1-D2 linker functions as a pivoting point that allows the dynamic movement of the D

147 ion of the CcpA subdomains and relocation of pivot-point residue Thr61, which leads to juxtaposition

148 mber of rigid-body movements (twists) around pivot points (hinges) introduced in the reference protei

149 nal DHQS domains further reveals a series of pivot points about which these movements occur and illus

150 d, based on the selection of two appropriate pivot points along the RNA backbone, P and C4'.

151 n atomic description of the locations of the pivot points and the motional features of key structural

152 Pivot points are short, functionally important, and high

153 orrelate with areas of slowed conduction and pivot points of reentrant wavelets.

154 k in the "normal" myocardial zone and at the pivot points to the entrance to the CCP.

155 Two pivot points were found in the motions of the inner TM2

156 glycines flanking the beta strand may act as pivot points, facilitating the conformational changes of

157 it is transmitted to the other via conserved pivot points, where the E and F' helices from two partne

158 ed of four segments, joined by very flexible pivots positioned at alanine 5, 8, and 11.

159 The pivoting positions are typically associated with structu

160 Abrupt changes in loading during wave-front pivoting, rather than membrane ionic properties or fiber

161 compared with muscle actin in the barbed end pivot region and areas in subdomains 1 and 2 and for F-a

162 were a peptide on top of subdomain 2 and the pivot region between subdomains 1 and 3 with muscle acti

163 dicate the structural importance of the core pivot region that connects the N- and C-subdomains flank

164 at an interface between two subdomains that pivot relative to one another, as revealed by comparison

165 d that NCT with the mutation of the proposed pivot rescues gamma-secretase activity inNCT-deficient c

166 We reasoned that wavefronts circling the pivot should broaden the amplitude distribution of bipol

167 ding stereocilia together is >1000 times the pivot stiffness of stereocilia and that these links can

168 We found that the presence of a sorting pivot, such as the nest wall or an attraction force towa

169 This anchoring site may act as a pivot that amplifies transverse movements of the ErbB2 T

170 , late in protraction, the intrinsic muscles pivot the vibrissae farther forward.

171 0) to factor Xa in different orientations by pivoting the C-terminal kringle-2/protease domain pair o

172 ithout the steps of stitching image columns, pivoting the light-sheet and sectioning the heart mechan

173 s accomplished by planting the head and then pivoting the trunk.

174 that helix-7 acts as a molecular wedge that pivots to enforce rapid making and breaking of miRNA:tar

175 the S4-S5 linkers dilate the central pore by pivoting together around a hinge at the base of the pore

176 declines, the focus of malaria management is pivoting toward low-density, subclinical infections and

177 oup) or ongoing triple ART (OT group) in the PIVOT trial.

178 Pivot, twisting, or valgus forces were reported mechanis

179 6.5 mm, P < .02), indicating that wave-front pivoting was primarily responsible for shortening of lam

180 om increased current load experienced by the pivoting wave front.

181 The micro-reentry pivot waves were anchored to the longitudinal block regi

182 tilise water in the formation of a molecular pivot which is essential in allowing relative movement o

183 op of Dll4/Notch utilizes Nrp1 levels as the pivot, which in turn establishes differential responsive

184 henylalanine or tyrosine that functions as a pivot within this network.

185 negatively associated with distance from the pivot zone in simulated spiral waves, rats, and sheep.

186 n bipole was consistently colocated with the pivot zone.