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1 spectrum disorders, valid disease models are pivotal.
2 on of human antibodies from these donors was pivotal.
5 ably, we find that domain III of IF2 plays a pivotal, allosteric, role in IF2 activation, suggesting
6 se reactions proceeded rapidly to afford the pivotal alpha-chloroglycine intermediate in excellent yi
7 0 inhibition compromises the activity of the pivotal B-cell antigen receptor (BCR)-proximal effector
9 mics was established, thus demonstrating the pivotal balance between intermolecular interaction and m
10 tructure of the viral community and also the pivotal biological functions affiliated with microbes in
12 ressed within the nucleus accumbens (NAc), a pivotal brain region underlying reward and motivation.
14 for miR-519d in determining expression of a pivotal cell adhesion molecule that may impact risks of
16 Our findings suggest that glycolysis is a pivotal, cell-intrinsic determinant of NPC fate, with a
17 asingly recognized for its role in mediating pivotal cellular mechanisms contributing to disease.
18 a(2+)-dependent gene expression patterns are pivotal characteristics of failing cardiomyocytes, with
19 d convergent to the shoulder mobility at the pivotal clavicle-sternal joint in marsupial and placenta
22 t relapse risk (the primary endpoint of many pivotal clinical trials testing the efficacy of multiple
24 tion data from regulatory submissions of the pivotal Comparison of Alemtuzumab and Rebif Efficacy in
25 The hypothalamic-pituitary-adrenal axis is a pivotal component of an organism's response to stressful
26 tionally upregulates expression of RICTOR, a pivotal component of mTOR complex 2 (mTORC2), to further
28 ay, in particular, has been proposed to be a pivotal cytokine promoting ovarian cancer progression.
29 olid Organ Transplant Patients) has provided pivotal data on extended-spectrum beta-lactamase (ESBL)-
31 tritium-labeled pharmaceutical compounds are pivotal diagnostic tools in drug discovery research, pro
32 sease (GVHD), these cytokines are considered pivotal during the initiation as well as propagation pha
33 uppel-like transcription factor, KLF10, is a pivotal effector of TGFbeta/SMAD signaling that mediates
34 Multi-electron heterogeneous catalysis is a pivotal element in the (photo)electrochemical generation
37 ites in southeast Europe to reconstruct this pivotal event in the early history of animal husbandry.
38 dvent of complex multicellularity (CM) was a pivotal event in the evolution of animals, plants and fu
42 Our study highlights redox potential as a pivotal factor that could serve as a sculpturing force o
43 d proteins and mitochondrial dysfunction are pivotal factors that promote age-associated functional n
45 ith MKP-1, and demonstrated that MKP-1 was a pivotal feedback control for both MAP kinases and NF-kap
50 eak protein-protein interactions that may be pivotal for function but neglected in the absence of spe
51 e cell cycle or exits and differentiates are pivotal for generating cells in the correct numbers and
52 once escaped detection are now thought to be pivotal for governing RNA lifetimes in both prokaryotes
53 polypeptide (NTCP/SLC10A1) is believed to be pivotal for hepatic uptake of conjugated bile acids.
54 ides a new branch of GATA3 signaling that is pivotal for inhibition of breast cancer progression and
55 n reactions in water-alkali electrolyzers is pivotal for large-scale and sustainable hydrogen product
58 unction in general, the changes proved to be pivotal for proarrhythmic myofibroblast-cardiomyocyte cr
61 in the T cell zone of lymph nodes (LNs) are pivotal for T cell survival, mobility, and peripheral to
62 re of the added metal cation was found to be pivotal for the achievement of the imidazo[1,5-a]pyridin
63 ediated disassembly of adherens junctions is pivotal for the acute epidermal damage in radiation derm
64 ure-function-toxicity relationship may prove pivotal for the detection and mitigation of amyloid dise
65 a suggest that circadian rhythm stability is pivotal for the maintenance of mucosal barrier function.
69 ing for size-specific temperature effects is pivotal for understanding how warming affects animal pop
70 logy of this sex bias is far from known, but pivotal for understanding the etiology of ASDs in genera
72 ive activity, here monitored on genes with a pivotal function in epithelial and hepatic morphogenesis
73 aptability to metabolic stress and uncover a pivotal function of BAP1 in the regulation of the ER str
75 ross-talk, BECs are also suspected to play a pivotal immunosuppressive role in T cell alloreactivity.
77 and cannabinoid CB1 receptor (CB1R), are of pivotal importance in the control of neuronal excitabili
78 the core unit exerted upon the rotors proved pivotal in controlling the speed of rotation, where a sm
79 sults suggest that SNARE availability may be pivotal in determining whether neurotransmitters or horm
80 dy provides candidate proteins that could be pivotal in engendering resistance and implicates chlorop
83 ficient clearance of apoptotic cells (AC) is pivotal in preventing autoimmunity and is a potent immun
86 virus-host interaction events that could be pivotal in regulating flavivirus virulence and attenuati
87 and latitudes north of the equator as being pivotal in the evolution of highly specialized systems i
89 gulation of pancreatic insulin production is pivotal in the pathophysiology and treatment of diabetes
91 neurons modulate amygdala circuits could be pivotal in understanding emotional regulation in health
93 llectively, our findings identified TNC as a pivotal initiator of elevated NOTCH signaling in BTIC an
94 Taken together, our findings highlight a pivotal link between an epigenetic regulator, WHSC1, and
95 ss and activate innate immunity to provide a pivotal mechanism by which an organism can respond to da
98 of proinflammatory cytokines, microglia are pivotal mediators of neuroinflammation and can induce or
99 interactions of Hippo core kinases with the pivotal MOB1 signal transducer.The Hippo tumor suppresso
100 ophages and microglial cells in gliomas as a pivotal modifier of tumor neovascularization and immunos
103 of catenanes by Sauvage and co-workers was a pivotal moment in the development of the field of interl
104 tif of Otx2 broadly delays the maturation of pivotal parvalbumin-positive (PV+) interneurons not only
105 the known phenotype of CTEPH, including the pivotal pathophysiological role of impaired vascular end
106 y more have been linked to the regulation of pivotal pathways related to cellular response and stabil
109 epidemiology of dengue viruses (DENV) in two pivotal phase III trials of the tetravalent dengue vacci
114 nt regulation of endothelial glycolysis is a pivotal process in developmental and adult vascular grow
115 he discovery of new chemical matter for this pivotal protease of the complement system: in silico act
120 itide-dependent protein kinase 1 (PDK1) is a pivotal regulator in the phosphoinositide 3-kinase (PI3K
121 n together, our findings establish CCN3 as a pivotal regulator of AR signaling and prostate cancer pr
125 events by a wide repertoire of proteases are pivotal regulators of most, if not all, physiological an
126 s of the MiT transcription factor family are pivotal regulators of several lineage-selective differen
132 These results identify for the first time a pivotal role for Arg-dependent polyamine production duri
135 revented and reduced resistance suggesting a pivotal role for immunity in deterring antibiotic resist
136 ecreased patient survival, consistent with a pivotal role for KLF10 in distinguishing the antiprolife
140 the topological winding number which plays a pivotal role for the determination of the emergent prope
141 ttention, despite overwhelming evidence of a pivotal role for the PAG in coordinating motor responses
144 receptors in the ephrin system that plays a pivotal role in a variety of cell-cell interactions, mos
145 iously shown that cofilin activation plays a pivotal role in Abeta-induced mitochondrial and synaptic
147 ensitive and accurate diagnostics can play a pivotal role in achieving disease elimination goals.
148 ption factor LATERAL SUPPRESSOR (Ls) plays a pivotal role in AM determination during the vegetative p
151 -coupled receptor family member that plays a pivotal role in brain angiogenesis and in ensuring a tig
152 e expression by alternative splicing plays a pivotal role in brain, where it affects neuronal develop
153 ral microm) current filaments, which plays a pivotal role in building up the cancer inhibition proper
155 these results, we propose that NTRC plays a pivotal role in chloroplast redox regulation, being nece
157 athway.IMPORTANCE The DNA sensor STING plays pivotal role in controlling HSV-1 infection both in cell
158 Because vasopressin (VP) neurons play a pivotal role in coordinating neuroendocrine and autonomi
160 studies demonstrate that the solvent plays a pivotal role in determining the reaction thermodynamics
162 PKCzeta, a cell polarity protein that has a pivotal role in directing asymmetric division of mammali
163 an malaria transmission studies and played a pivotal role in dissecting the mosquito immune response
165 s between lipid and protein molecules play a pivotal role in efficiently sequestering the amyloid fol
167 and their combined toxic effects can play a pivotal role in health and disease, yet are largely unex
169 eptor potential (TRP) ion channel C6 plays a pivotal role in hereditary and sporadic glomerular kidne
171 han catabolism (IDO1, KMO, KYNU) that play a pivotal role in immune evasion by certain other microbia
172 NLRP3) inflammasome has been shown to play a pivotal role in inflammation in a mouse kidney disease m
175 essing the transcription factor FOXP3 play a pivotal role in maintaining immunologic self-tolerance.
177 1, and 40S regulatory ubiquitylation plays a pivotal role in mammalian ribosome-associated QC pathway
178 eristics of synthetic macromolecules plays a pivotal role in many areas, in particular the life scien
180 ion and contractile activity and thus play a pivotal role in matching energy supply and demand in car
181 at c-Jun amino-terminal kinase (JNK) plays a pivotal role in mediating vesicle-induced CPS in recipie
183 Rs) are highly variable elements that play a pivotal role in multiple genetic diseases, population ge
186 Results suggest that platelet CD40 plays a pivotal role in neointima formation after arterial injur
188 These data indicate that MakatG1 plays a pivotal role in penetration, reacting to and detoxifying
189 age-associated molecular patterns may play a pivotal role in preventing inflammation and that the ant
193 age compensation and demonstrated H4K20me1's pivotal role in regulating higher-order chromosome struc
194 se of ES6 binding factors and likely plays a pivotal role in remodeling this pre-rRNA region in both
197 ults show that liver-derived exosomes play a pivotal role in the accumulation of Tfr cells, likely le
201 rged that the inflammasome appears to play a pivotal role in the development of multiple inflammatory
202 mitochondrial biogenesis and function, has a pivotal role in the early dysfunction of the proximal tu
207 CE KSHV productive lytic replication plays a pivotal role in the initiation and progression of Kaposi
210 SKN-1, are transcription factors that have a pivotal role in the oxidative stress response, cellular
211 Immuno-inflammation has been shown to play a pivotal role in the pathogenesis of moyamoya disease (MM
212 l and peripheral chemoreflex pathway plays a pivotal role in the pathophysiology of HF with reduced e
213 suggest that the PERK arm of the UPR plays a pivotal role in the regulation of satellite cell homeost
216 Three-dimensional porous scaffolds play a pivotal role in tissue engineering and regenerative medi
218 esistance, ER signaling continues to exert a pivotal role in tumor progression in the majority of cas
220 es have shown that microRNAs (miRNAs) play a pivotal role in vascular development, homeostasis and a
227 relapse of status epilepticus, suggesting a pivotal role of deep brain stimulation in the treatment
230 tuberculosis model further corroborated the pivotal role of SET8-responsive NQO1 and TRXR1 in mycoba
232 we extend these concepts by highlighting the pivotal role of the hypothalamic peptide oxytocin in aug
234 in dynamics of {Cr(III)Dy(III)6} reveals the pivotal role played by ferrotoroidic states in slowing d
239 tease-activated receptor 2 (PAR2) that plays pivotal roles in angiogenesis and tumor development.
240 n interactions (PPIs) of these subunits play pivotal roles in assembling the functional polymerase co
241 h factor receptor (EGFR) family members play pivotal roles in cell proliferation, differentiation and
242 Sponges are benthic filter feeders that play pivotal roles in coupling benthic-pelagic processes in t
244 ciating core binding factor-beta (CBFB) play pivotal roles in leukemogenesis, and inhibition of RUNX1
245 es that target self-antigens, which can play pivotal roles in maintaining homeostasis, distinguishing
247 -23 (IL-23), an IL-12 family cytokine, plays pivotal roles in pro-inflammatory T helper 17 cell respo
249 re are also variant histones that often have pivotal roles in regulating chromatin dynamics and in th
250 ding RNAs, and mitotic gene bookmarking play pivotal roles in stringent gene regulation during lineag
251 N-Methyl-D-aspartate receptors (NMDARs) play pivotal roles in synaptic development, plasticity, neura
256 hat contain iron-sulfur (Fe-S) clusters play pivotal roles in various metabolic processes such as pho
258 al benefits have included elucidation of the pivotal roles of mTOR signaling in the regulation of cel
259 This review discusses the roles of PIFs as pivotal signal integrators in regulating plant growth an
267 entify the cell surface molecule Nrp2 as the pivotal switch of a novel, actionable pathway driving EG
268 Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical armamentarium against
270 predicts that type I IFN modulation will be pivotal to cure human chronic infections, cancer, or aut
271 t of ideal bandgap (1.3-1.4 eV) absorbers is pivotal to further improve PCE of single junction perovs
272 ecent advances in nanomaterials are becoming pivotal to generate the high-resolution, high-contrast i
275 and quaternary structure of Hsp27, which is pivotal to its function as a key component of the proteo
277 biology, homology, and physical linkage was pivotal to later studies that investigated the transcrip
278 mmunodeficiency virus (HIV) load testing are pivotal to limiting the threat of HIV drug resistance (H
281 of the cell wall and cellulose synthesis is pivotal to plant cell growth, and its regulation is poor
283 suggest that proper regulation of miR-27 is pivotal to safeguarding Treg-mediated immunological tole
285 ch wall, which envelopes the fungal cell, is pivotal to the maintenance of cellular integrity and for
286 n of tau exon 10 splicing are believed to be pivotal to the pathogenesis of tau pathology, but the mo
287 ve and rapid regulation of ionic channels is pivotal to the understanding of physiological processes
288 trawling fishing pressure on the seafloor is pivotal to understand its effects on deep-sea benthic ha
289 activity leads to genome instability, it is pivotal to understand the mechanism underlying Cse4 regu
290 lts demonstrated that root tip geometry is a pivotal trait governing root penetration stress and root
291 nt binding protein (CREB), which serves as a pivotal transcription factor for upregulating IL-10 prod
294 ylation of diketopiperazines has served as a pivotal transformation in the synthesis of complex epipo
298 enecyclopropane (IMDAMC) reaction provided a pivotal tricyclic enone intermediate with more than 99 %
299 strate that the direction of sex change is a pivotal variable in predicting demographic changes and r
300 identify the strains driving fermentation is pivotal when aiming at stable and palatable products.
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