ライフサイエンスコーパス: place cell

1 an impair the precision and stability of CA1 place cells.

2 that responded to tastes, some of which were place cells.

3 ond temporal organization of discharge among place cells.

4 ot impact the firing rates or proportions of place cells.

5 affected by the nature of the input from the place cells.

6 ciations due to learned associations between place cells.

7 sensory inputs via boundary vector cells and place cells.

8 tial learning, supported by the discovery of place cells.

9 g-induced spatial maps represented by rodent place cells.

10 sentation and the mean firing rates (FRs) of place cells.

11 d formation of the spatial firing pattern of place cells.

12 local attractors within a spatial map of CA3 place cells.

13 erience onto a spatial framework embodied by place cells.

14 ation of the firing locations of hippocampal place cells.

15 the phase precession observed in ~37% of CA1 place cells.

16 sical distance traveled, as were ~40% of CA1 place cells.

17 elds, an observation that we extended to CA3 place cells.

18 also point to some form of goal encoding by place cells.

19 identified such responses within hippocampal place cells [1], the activity of which is thought to aid

20 This developmental switch in place cell accuracy coincides with the emergence of the

21 sible head-directional tuning of hippocampal place cells across species.

22 , providing causal evidence that hippocampal place cells actively support spatial navigation and memo

23 es exert a powerful control over hippocampal place cell activities that encode external spaces.

24 udies sought to verify the spatial nature of place cell activity and determine its sensory origin.

25 fore weaning (post-natal day [P]21), offline place cell activity associated with sharp-wave ripples (

26 location-specific activity leads hippocampal place cell activity both spatially and temporally.

27 onal environments, the population vectors of place cell activity changed more abruptly with distance

28 ppocampal replays are episodes of sequential place cell activity during sharp-wave ripple oscillation

29 segregated by these boundaries, by recording place cell activity from CA1 and CA3 while rats foraged

30 We recorded place cell activity in rats exploring morphing linear tr

31 Based on observation of place cell activity it is possible to accurately decode

32 entive behaviors that punctuate exploration, place cell activity mediates the one-trial encoding of o

33 However, the direct influence of place cell activity on spatial navigation behavior has n

34 We addressed this question by monitoring CA1 place cell activity, with tetrodes, in control and KO mi

35 ithin synaptic weights to produce predictive place cell activity.

36 a computational framework for understanding place cell activity.

37 s testing to identify additional features of place cell activity.

38 Notably, manipulating single place-cell activity also affected activity in small grou

39 ndings suggest that the relationship between place-cell activity and theta oscillations in primate hi

40 Hippocampal place-cell activity associated with theta oscillations e

41 Hippocampal place-cell activity associated with theta oscillations u

42 erating small sequences of spatially related place-cell activity that we call "snippets".

43 ed by locomotion nor consistently coupled to place-cell activity.

44 path-integration gain, as estimated from the place cells after the landmarks were turned off.

45 Together with place cells and boundary vector cells they can support a

46 Models of hippocampal place cells and entorhinal grid cells based on path inte

47 healthy brains, spatially tuned hippocampal place cells and entorhinal grid cells exhibit distinct s

48 Animal studies have identified place cells and grid cells as important for path integra

49 n spatial cell types in the circuit, such as place cells and grid cells.

50 onments, consistent with global remapping in place cells and grid cells.

51 alled replays, which are well-established in place cells and have been recently reported in grid cell

52 consistent with prior studies of hippocampal place cells and providing a rich representational repert

53 ng decreased theta frequency oscillations of place cells and reduced distance-time compression but pr

54 on both precise location-specific firing of place cells and the coarse-coded, goal-trajectory planni

55 The hippocampus comprises two neural signals-place cells and theta oscillations-that contribute to fa

56 Hippocampal place cells and time cells seem well suited to represent

57 ina whereby DSCAM eliminates inappropriately placed cells and connections.

58 ratory behavior, disrupted spatial coding by place cells, and caused selective alterations in spatial

59 ow that dorsal CA1 pyramidal neurons are all place cells, and do not respond to the tone when the ani

60 ern separation, global and rate remapping of place cells, and realignment of grid cells.

61 The unitary firing fields of hippocampal place cells are commonly assumed to be generated by inpu

62 Hippocampal place cells are key to episodic memories.

63 While LS place cells are less numerous than in hippocampus, they

64 Hippocampal place cells are neurons thought to be important for repr

65 s of environments, different combinations of place cells are recruited, consistent with the notion of

66 Place cells are spatially modulated neurons found in the

67 Hippocampal place cells are spatially tuned neurons that serve as el

68 To detect the animal's location, place cells are thought to rely upon two interacting mec

69 fear influences the stability of hippocampal place cells as a function of threat distance in rats for

70 Furthermore, modeling place cells as driven by boundaries explains the observa

71 d spatial activity of dorsal hippocampal CA1 place cells as male rats explored a familiar or a novel

72 lateral mammillary nuclei and then recorded place cells as rats explored multiple, connected compart

73 elationships between engrams and hippocampal place cells, as well as the molecular, cellular, physiol

74 mpal cognitive map in a network of transient place cell assemblies and demonstrate, using methods of

75 dual, goal novelty-related reorganization of place cell assemblies and with trajectory replay that re

76 ined demand on these memories influenced CA1 place cell assemblies while reference memories were part

77 iation of distal dendritic inhibition by CA1 place cells attenuated the excitatory entorhinal input a

78 By contrast, place cells become equally stable and accurate throughou

79 stability, decreased overall excitability of place cells, behavior variables, or the absence of indiv

80 irectional late-to-early phase precession of place cells, bidirectional phase modulation acted to ret

81 iscussions of the hippocampus often focus on place cells, but many neurons are not place cells in any

82 eatures result solely from varying inputs to place cells, but recent studies suggest instead that pla

83 hibitory conductance enhances rate coding in place cells by suppressing out-of-field excitation and b

84 er that neuronal firing rates of hippocampal place cells code for periodically repeating events and t

85 nd that (1) the interaction between grid and place cells converges quickly; (2) the spatial code of p

86 viously showed that ensembles of hundreds of place cells could accurately encode topological informat

87 del to assess the effect of running speed in place cell data recorded from rats running on linear tra

88 lty of performing functional recordings from place cell dendrites, no direct evidence of regenerative

89 Neurons in the hippocampus called place cells discharge as an animal enters specific place

90 CA1 place cells discharge in prospective and retrospective m

91 Our results suggest that place cells do not encode all of the navigationally rele

92 cells is not tuned to a single place, while place cells do not encode head direction.

93 s converges quickly; (2) the spatial code of place cells does not require, but is altered by, grid ce

94 lp localize the firing fields of hippocampal place cells during formation and use of the hippocampal

95 n of visual cortical neurons and hippocampal place cells during spatial navigation behavior has yet t

96 lated activity in individual hippocampal CA1 place cells during spatial navigation in a virtual reali

97 fast gamma rhythms differentially coordinate place cells during the two modes.

98 capacity involves the replay of hippocampal place-cells during awake states, generating small sequen

99 nsive research, the learning-related role of place cell dynamics in health and disease remains elusiv

100 more, we find that both splitter neurons and place cells emerged rapidly and maintained stable trajec

101 ippocampal function, embracing the idea that place cells encode a geometric representation of space.

102 Hippocampal place cells encode an animal's current position in space

103 Hippocampal place cells encode an animal's past, current, and future

104 This suggests that dorsal hippocampal place cells encode space independently of its associated

105 Hippocampal place cells encode the animal's spatial position.

106 Non-place cells encoded position and contributed to position

107 rate remapping, in which the spatial map of place cells encodes contextual information through firin

108 und grid cells to be spatially coherent with place cells, encoding locations 11 ms delayed relative t

109 heir spatial code following threat exposure, place cells enhance their spatial coding with the possib

110 This discoordination causes place cell ensemble representations of a familiar space

111 aracterize the long-term effects of shock on place cell ensemble stability, demonstrating that shock

112 d restrict the range of parameters for which place cell ensembles are capable of producing a map with

113 uring active navigation, rat hippocampal CA1 place cell ensembles are inherently organized to produce

114 populations, and encode activation of local place cell ensembles during in vivo replays.

115 Hippocampal place cell ensembles form a cognitive map of space durin

116 , 15], since the reactivation of hippocampal place cell ensembles occurs during ripples [16-19].

117 Place cell ensembles reorganize to support learning but

118 babilities on the ability of the hippocampal place cell ensembles to produce a cognitive map of the e

119 n conjunction with the ordered activation of place cell ensembles.

120 e, we review theoretical models of lingering place cell excitability and behaviorally induced synapti

121 Hippocampal place cells exhibit spatially selective activity within

122 The high temporal coordination between place cells exhibited in theta sequences is compatible w

123 ion in the CA1 area of the hippocampus, with place cells exhibiting larger place fields.

124 tly, reductions in the number of hippocampal place cells exhibiting significant theta rhythmicity and

125 ce, the cellular and network origin of these place cell features is unknown.

126 Hippocampal place cells fire at different rates when a rodent runs t

127 Hippocampal place cells fire at discrete locations as subjects trave

128 patterns produced when groups of hippocampal place cells fire in sequences that reflect a compressed

129 Although place cell firing activities accurately represented the

130 Compressed sequences of place cell firing also occur during exploration: during

131 First, reduced variability of place cell firing appears to indicate an impairment of a

132 CA1 place cell firing fields are preserved under PCP, but th

133 e, we tested the hypothesis that hippocampal place cell firing is impaired after PAE by performing in

134 mporally ordered and compressed sequences of place cell firing observed during wakefulness are reinst

135 These results indicate that place cell firing on overlapping routes reflects the ani

136 In this view, grid and place cell firing patterns are not successive stages of

137 Place cell firing patterns predominantly reflect visual

138 Place cell firing rate increases in early stages of expl

139 ("learn" the space) within certain values of place cell firing rate, place field size, and cell popul

140 Place cell firing relies on information about self-motio

141 We found that place cell firing sequences during self-running on the t

142 By contrast, sequential place cell firing, describing extended trajectories thro

143 ossible contributions of these cell types to place cell firing, taking advantage of a developmental t

144 elated input that contributes to maintaining place cell firing.

145 cally depend on the integrity of hippocampal place cell firing.

146 correlated fashion with those of hippocampal place cells firing at overlapping locations.

147 We report that sequences of place-cell firing in a novel environment are formed from

148 ts distinctly via changes in the pattern of "place cell" firing.

149 sponses and taste responses were confined to place cells' firing fields.

150 at are functionally coupled with hippocampal place cells for spatial processing during natural behavi

151 Hippocampal place cells form a spatial 'map' which is modifiable by

152 been implicated in localized plasticity and place cell formation.

153 Specifically, place cells from dorsal cornu ammonis field 1 (CA1) were

154 se conditions, no recovery was observed upon placing cells from the exposed cultures into fresh media

155 These include place cells, grid cells, head direction cells, and bound

156 Hippocampal place cells have been proposed to have a role in navigat

157 s self-organized; and (6) grid cell input to place cells helps stabilize their code under noisy and/o

158 l memory and elicited drastic changes in CA1 place cells in a familiar environment, similar to those

159 cus on place cells, but many neurons are not place cells in any given environment.

160 Place cells in CA1, indeed, do not rely only on vision;

161 As shown previously, we found that place cells in control animals exhibited repeated fields

162 We found that CA1 place cells in epileptic mice were unstable and complete

163 presented the less discriminable routes, and place cells in general over-represented the start locati

164 ions that co-fluctuate with those encoded by place cells in hippocampal area CA1 [2, 5].

165 ing of spikes from spatial neurons including place cells in hippocampus and grid cells in medial ento

166 We report place cells in marmoset hippocampus during free navigati

167 We recorded place cells in rats and found that increased neural acti

168 We wirelessly recorded place cells in rats as they explored a cubic lattice cli

169 Place cells in the CA1 region of the hippocampus express

170 ad direction (HD), boundary vector, grid and place cells in the entorhinal-hippocampal network form t

171 change in the spatial characteristics of CA1 place cells in the familiar environment following ReRh l

172 Place cells in the hippocampus and grid cells in the med

173 Spiking activity of place cells in the hippocampus encodes the animal's posi

174 Here, we investigated place cells in the hippocampus, implicated in processing

175 Place cells in the mammalian hippocampus signal self-loc

176 The discovery of place cells in the rodent hippocampus immediately sugges

177 n without working memory demands, similar to place cells in these areas.

178 Our findings are consistent with a model of place cells in which they provide a spontaneously constr

179 Place cells, initially thought to be location-specifiers

180 task, suggesting a functional role for local place cell interactions in shaping firing fields.

181 support the idea that synaptic plasticity in place cells is involved in forming new place fields.

182 l input; (3) plasticity in sensory inputs to place cells is key for pattern completion but not patter

183 y oscillations, and the ensemble activity of place cells is organized into temporal sequences bounded

184 rge of a subset of pyramidal neurons called "place cells" is spatially organized such that discharge

185 In contrast, place cells located in the deep sublayer were more activ

186 We found that CA1 place cells located in the superficial sublayer were mor

187 t during spatial navigation, hippocampal CA1 place cells maintain a continuous spatial representation

188 Here we show that, like hippocampal place cells, many neurons in the primary visual cortex (

189 heta phase procession arose in a minority of place cells, many of which displayed two preferred firin

190 al field potential affects the efficiency of place cell map formation.

191 We argue that hippocampal place-cell maps are metric in all three dimensions, and

192 t it is unclear how spatial information from place cells may reciprocally organize subcortical theta-

193 a computational model, that the hippocampal place cells may ultimately be interested in a space's to

194 nterneurons had spatially uniform effects on place cell membrane potential dynamics, substantially re

195 CA1) regulates the overrepresentation of CA1 place cells near rewarded locations.

196 t issue is understanding how the hippocampal place-cell network represents specific properties of the

197 This view is supported by the finding of place cells, neurons whose firing is tuned to specific l

198 Control place cells (nonsilenced or silenced outside SPW-Rs) lar

199 In contrast, the place cells of animals with lesions of the head directio

200 at regenerative dendritic events do exist in place cells of behaving mice, and, surprisingly, their p

201 r the spatial representations encoded by CA1 place cells of both familiar and novel environments.

202 essential for the angular disambiguation by place cells of visually identical compartments.

203 ch mixed populations, treating place and non-place cells on the same footing.

204 ve less spatially specific firing fields and place cells only responded to tastes delivered inside th

205 e responsiveness is intrinsic to a subset of place cells or emerges as a result of experience that re

206 Analysis of place cells' out-of-field firing in mice navigating in v

207 In addition, route-dependent place cells over-represented the less discriminable rout

208 e occasions in which the firing of different place cells overlaps.

209 The result reveals a specific place-cell pattern underlying inhibitory avoidance behav

210 tials that can coordinate theta sequences in place cell populations.

211 l sharp wave-ripples (SPW-Rs) and associated place-cell reactivations are crucial for spatial memory

212 d as multimodal attractors in populations of place cells, recent experiments morphed one familiar con

213 We then investigated field stability of place cells recorded across 5 d both in the familiar and

214 rning, in vitro synaptic plasticity, in vivo place cell recording, and western blot analysis to deter

215 5, 9], receiving support from the way rodent place cells "remap" nonlinearly between spatial represen

216 contrast, the place fields of SPW-R-silenced place cells remapped, and their spatial information rema

217 ual fear conditioning results in hippocampal place cell remapping and long-term stabilization of nove

218 rid realignment can be explained in terms of place cell remapping as opposed to the other way around;

219 report that extinction learning also induces place cell remapping in C57BL/6 mice.

220 ation mimicking this LC-CA1 activity induces place cell reorganization around a familiar reward, whil

221 p stability and the absence of goal-directed place cell reorganization.

222 Hippocampal place cells replay spatial paths during immobility in re

223 Hippocampal place-cell replay has been proposed as a fundamental mec

224 We saw out-of-field goal firing in place cells, replicating previous observations that the

225 Hippocampal place cells represent location, but their role in the le

226 Hippocampal place cells represent the cellular substrate of episodic

227 We find that before weaning, the place cell representation of space is denser, more stabl

228 heories of hippocampal function propose that place cell representations are formed during an animal's

229 Second, impaired stability of place cell representations could explain the long-term m

230 don et al. (2014) show that the formation of place cell representations in new environments is preser

231 Place cells represented the entire volume of the mazes:

232 We found that place cells representing the shock zone were reactivated

233 llocentric code of boundary vector cells and place cells requires consistent head-direction informati

234 This representation captures many aspects of place cell responses that fall outside the traditional v

235 the increased excitatory weights, such that place cells return to their baseline firing rate after e

236 iously shown to exhibit impaired hippocampal place cell selectivity.

237 nchronization of neuronal assemblies such as place cell sequence coding.

238 ve been reported to co-occur with long-range place cell sequence replays during the quiet awake state

239 biophysical modeling, and explore the LFP of place cell sequence spiking ("replays") during sharp wav

240 Reactivation of hippocampal place cell sequences during behavioral immobility and re

241 Place cell sequences during theta oscillations are thoug

242 ccurred in ripple-associated awake replay of place cell sequences encoding the paths from the animal'

243 Replay of hippocampal place cell sequences has been proposed as a fundamental

244 rrent positions to the shock zone but not in place cell sequences within individual cycles of theta o

245 est epochs and analysis of the recurrence of place cell sequences-reveal that the enhancement of repl

246 ippocampus-dependent activity reminiscent of place cell sequences.

247 ironment leads to off-line pre-activation of place cells sequences corresponding to that space.

248 following fear acquisition, hippocampal CA1 place cells sharpen their spatial tuning and dynamically

249 of the theta oscillation, the set of active place cells shifts from those signaling positions behind

250 Hippocampal place cells show position-specific activity thought to r

251 CA1 neurons, including place cells, showed disrupted remapping, although their

252 s, time, and conditions; generates realistic place cell simulation data; and conceptualizes a framewo

253 ity recording methods to monitor hundreds of place cells simultaneously while rats explored multiple

254 n their vicinity with a higher proportion of place cells, smaller place fields, increased spatial sel

255 ulti-plane two-photon calcium imaging of CA1 place cell somata, axons and dendrites in mice navigatin

256 ntrast, the activity patterns of hippocampal place cells span distinct low-dimensional manifolds in d

257 Instead, we propose that place cell spatial firing patterns are determined by env

258 Hippocampal CA1 place cell spatial maps are known to alter their firing

259 ta sequences," ordered series of hippocampal place cell spikes that reflect the order of behavioral e

260 the firing-rate code and theta-phase code in place cell spiking.

261 Our model suggests that place cell stability can be attributed to strong excitat

262 Simulating several theoretical models of place-cells suggested that combining sensory information

263 reward sensitivity and policy dependence in place cells suggests that the representation is not pure

264 nformation processing within the hippocampus place cell system.

265 Hippocampal place cells take part in sequenced patterns of reactivat

266 vation into the microbes' natural habitat by placing cells taken from varying environmental samples i

267 modifying physical properties of spiking in place cells that contribute to changes in navigation and

268 NIFICANCE STATEMENT The hippocampus contains place cells that encode an animal's location.

269 ics, we identified and selectively activated place cells that encoded behaviorally relevant locations

270 o affected activity in small groups of other place cells that were active around the same time in the

271 n the reactivation ('replay') of hippocampal place cells that were active during recent behaviour.

272 epresents spatial information, such as with "place cells" that represent an animal's current location

273 physiological evidence from rat hippocampal place cells, that the path-integration gain is a highly

274 lls, but recent studies suggest instead that place cells themselves may play an active role through r

275 r results express a possible linkage between place cell to grid cell interactions and PCA.

276 The present study examined dorsal CA1 place cells to elucidate the computational changes assoc

277 The ability of the place cells to remap parallels the acquisition of reward

278 rea CA1 of the hippocampus, the selection of place cells to represent a new environment is biased tow

279 mpared the changes in downstream hippocampal place cells to those of neurons in MEC.

280 n the hippocampus tuned to spatial location (place cells) typically change their tuning when an anima

281 s firing fields, and artificial remapping of place cells under depolarization, but not under hyperpol

282 ly that CA3 is the predominant driver of CA1 place cells under normal conditions, while also revealin

283 s face different directions, suggesting that place cells use a directional input to differentiate oth

284 nt, computationally modeling the activity of place cells using methods derived from algebraic topolog

285 Since the first place cell was recorded and the cognitive-map theory was

286 While the remapping capacity of the place cells was not affected by the lesion, our results

287 Targeted stimulation of a small number of place cells was sufficient to bias the behavior of anima

288 Importantly, place cells were not modulated by goal value.

289 ocks in a shock zone on a track, we analyzed place cells when the animals were placed on the track ag

290 n environment's geometry, unlike hippocampal place cells, which activate at particular random locatio

291 TATEMENT We investigated whether hippocampal place cells, which compute a self-localization signal, a

292 rain represents space is through hippocampal place cells, which indicate when an animal is at a parti

293 asis of this theory, we examined hippocampal place cells, which represent spatial information, in rat

294 PV-iLTD and SST-iLTP cooperate to stabilise place cells while facilitating representation of multipl

295 the downstream projection from grid cells to place cells, while recent data have pointed out the impo

296 e demonstrate that bimodal excitation drives place cells, while unimodal excitation drives weaker or

297 ured network of taste-responsive hippocampal place cells with large fields, whose spatial representat

298 patterns observed during recent experience: place cells with overlapping spatial fields show a great

299 d activity in the out-of-field firing of CA1 place cells, with a ramping-up of firing rate during the

300 in this first line of defense, strategically placed cells within the vasculature and tissue respond t