ライフサイエンスコーパス: place cell

1 lar locations along the animal's trajectory (place cells).

2 ond temporal organization of discharge among place cells.

3 sentation and the mean firing rates (FRs) of place cells.

4 d formation of the spatial firing pattern of place cells.

5 local attractors within a spatial map of CA3 place cells.

6 erience onto a spatial framework embodied by place cells.

7 ation of the firing locations of hippocampal place cells.

8 rsus visual information varied widely across place cells.

9 However, other sensory cues also influence place cells.

10 of sequential neural activity in hippocampal place cells.

11 lly localized firing by the remaining 75% of place cells.

12 the medial entorhinal cortex (MEC) input to place cells.

13 a firing rate modulation of spatially stable place cells.

14 oduce stress-like alterations on hippocampal place cells.

15 ot impact the firing rates or proportions of place cells.

16 affected by the nature of the input from the place cells.

17 sensory inputs via boundary vector cells and place cells.

18 tial learning, supported by the discovery of place cells.

19 g-induced spatial maps represented by rodent place cells.

20 This developmental switch in place cell accuracy coincides with the emergence of the

21 sible head-directional tuning of hippocampal place cells across species.

22 es exert a powerful control over hippocampal place cell activities that encode external spaces.

23 udies sought to verify the spatial nature of place cell activity and determine its sensory origin.

24 location-specific activity leads hippocampal place cell activity both spatially and temporally.

25 ppocampal replays are episodes of sequential place cell activity during sharp-wave ripple oscillation

26 rahippocampal inhibition of PKMzeta disrupts place cell activity in a familiar environment, where the

27 We recorded place cell activity in rats exploring morphing linear tr

28 entive behaviors that punctuate exploration, place cell activity mediates the one-trial encoding of o

29 nactivated the mPFC and recorded hippocampal place cell activity while animals were performing the na

30 ironment result in plasticity of hippocampal place cell activity, while in the absence of changes, pl

31 We addressed this question by monitoring CA1 place cell activity, with tetrodes, in control and KO mi

32 ithin synaptic weights to produce predictive place cell activity.

33 Notably, manipulating single place-cell activity also affected activity in small grou

34 Together with place cells and boundary vector cells they can support a

35 Animal studies have identified place cells and grid cells as important for path integra

36 n spatial cell types in the circuit, such as place cells and grid cells.

37 ontrary to expectations from basic models of place cells and neuronal integration, a small, spatially

38 ted changes in spatial representation by CA1 place cells and novelty-responsive behavior.

39 integration is supported by the discovery of place cells and other neurons that show path-invariant r

40 consistent with prior studies of hippocampal place cells and providing a rich representational repert

41 help to preserve the spatial specificity of place cells and spatial memories at vastly different run

42 on both precise location-specific firing of place cells and the coarse-coded, goal-trajectory planni

43 ion of GluA1-containing AMPARs to individual place cells and the hippocampal population code for spac

44 Hippocampal place cells and time cells seem well suited to represent

45 as sufficient for localized firing in 25% of place cells and to maintain a local field potential thet

46 ina whereby DSCAM eliminates inappropriately placed cells and connections.

47 ratory behavior, disrupted spatial coding by place cells, and caused selective alterations in spatial

48 ow that dorsal CA1 pyramidal neurons are all place cells, and do not respond to the tone when the ani

49 ern separation, global and rate remapping of place cells, and realignment of grid cells.

50 l plasticity for actively firing hippocampal place cells, and that the BLA mediates this plasticity w

51 The unitary firing fields of hippocampal place cells are commonly assumed to be generated by inpu

52 Hippocampal place cells are key to episodic memories.

53 Hippocampal place cells are neurons thought to be important for repr

54 This suggests that place cells are part of an autobiographical record of ev

55 s of environments, different combinations of place cells are recruited, consistent with the notion of

56 fear influences the stability of hippocampal place cells as a function of threat distance in rats for

57 d spatial activity of dorsal hippocampal CA1 place cells as male rats explored a familiar or a novel

58 lateral mammillary nuclei and then recorded place cells as rats explored multiple, connected compart

59 We recorded hippocampal CA1 place cells as the rats explored a familiar environment.

60 ntials recorded originally in vivo in a CA1 "place cell" as the animal traversed the associated place

61 mpal cognitive map in a network of transient place cell assemblies and demonstrate, using methods of

62 mma frequency transitions between sequential place cell-assemblies.

63 iation of distal dendritic inhibition by CA1 place cells attenuated the excitatory entorhinal input a

64 By contrast, place cells become equally stable and accurate throughou

65 stability, decreased overall excitability of place cells, behavior variables, or the absence of indiv

66 Also, the firing rates of place cells between preamygdalar and postamygdalar stimu

67 ractor, grid cells as a plane attractor, and place cells both as a plane attractor and as a point att

68 iscussions of the hippocampus often focus on place cells, but many neurons are not place cells in any

69 eatures result solely from varying inputs to place cells, but recent studies suggest instead that pla

70 hibitory conductance enhances rate coding in place cells by suppressing out-of-field excitation and b

71 Unlike the usual place cells commonly described in the literature, we fou

72 rogeneity, the behavior of fully half of the place cells conformed to a model of path integration in

73 erous discrepancies in the literature on the place cell contribution to the etiology of aged-related

74 nd that (1) the interaction between grid and place cells converges quickly; (2) the spatial code of p

75 Hippocampal place cells convey spatial information through a combina

76 viously showed that ensembles of hundreds of place cells could accurately encode topological informat

77 d evenly over all place cells, the number of place cells decreases with seizure number, although the

78 lty of performing functional recordings from place cell dendrites, no direct evidence of regenerative

79 llations in the local field potential (LFP): place cells discharge at progressively earlier theta pha

80 CA1 place cells discharge in prospective and retrospective m

81 e CS with a location in-field for a specific place cell disrupted the stability of that neuron's plac

82 cells is not tuned to a single place, while place cells do not encode head direction.

83 s converges quickly; (2) the spatial code of place cells does not require, but is altered by, grid ce

84 n of visual cortical neurons and hippocampal place cells during spatial navigation behavior has yet t

85 lated activity in individual hippocampal CA1 place cells during spatial navigation in a virtual reali

86 revealed that the sequential reactivation of place cells during SWR events was completely abolished i

87 fast gamma rhythms differentially coordinate place cells during the two modes.

88 nsive research, the learning-related role of place cell dynamics in health and disease remains elusiv

89 ippocampal function, embracing the idea that place cells encode a geometric representation of space.

90 Hippocampal place cells encode an animal's past, current, and future

91 Hippocampal place cells encode the animal's spatial position.

92 Hippocampal CA1 and CA3 pyramidal neuron place cells encode the spatial location of an animal thr

93 rate remapping, in which the spatial map of place cells encodes contextual information through firin

94 und grid cells to be spatially coherent with place cells, encoding locations 11 ms delayed relative t

95 This discoordination causes place cell ensemble representations of a familiar space

96 populations, and encode activation of local place cell ensembles during in vivo replays.

97 Hippocampal place cell ensembles form a cognitive map of space durin

98 , 15], since the reactivation of hippocampal place cell ensembles occurs during ripples [16-19].

99 Place cell ensembles reorganize to support learning but

100 n conjunction with the ordered activation of place cell ensembles.

101 e, we review theoretical models of lingering place cell excitability and behaviorally induced synapti

102 The high temporal coordination between place cells exhibited in theta sequences is compatible w

103 ion in the CA1 area of the hippocampus, with place cells exhibiting larger place fields.

104 report that temporal sequences of firing of place cells expressed during a novel spatial experience

105 ce, the cellular and network origin of these place cell features is unknown.

106 X disrupted the stability of rat hippocampal place cell fields in a familiar environment.

107 Hippocampal place cells fire at different rates when a rodent runs t

108 Hippocampal place cells fire at discrete locations as subjects trave

109 patterns produced when groups of hippocampal place cells fire in sequences that reflect a compressed

110 Although place cell firing activities accurately represented the

111 lds." To explore the mechanisms that control place cell firing and their relationship to spatial memo

112 absence of vestibular motion signals, normal place cell firing and theta rhythmicity were found.

113 First, reduced variability of place cell firing appears to indicate an impairment of a

114 stored spatial memory and the disruption of place cell firing are parallel effects of PKMzeta blocka

115 The stability and precision of place cell firing continue to develop throughout juvenil

116 CA1 place cell firing fields are preserved under PCP, but th

117 Simultaneously recorded place cell firing fields remapped and showed a smaller,

118 These results indicate that place cell firing on overlapping routes reflects the ani

119 model of hippocampal cell assembly activity, place cell firing order is established for the first tim

120 In this view, grid and place cell firing patterns are not successive stages of

121 Task-dependent alterations in place cell firing patterns may reflect the operation of

122 ("learn" the space) within certain values of place cell firing rate, place field size, and cell popul

123 ons that impair spatial learning by altering place cell firing rates or spatial specificity.

124 Place cell firing relies on information about self-motio

125 We found that place cell firing sequences during self-running on the t

126 vironments, the preferred theta phase of CA1 place cell firing should shift closer to the CA1 pyramid

127 Conversely, profound modifications of place cell firing variability (overdispersion) were obse

128 nction of the hippocampus, as exemplified by place cell firing, may reflect the "where" component of

129 hanisms underlying theta phase precession of place cell firing, ranging from membrane potential oscil

130 ossible contributions of these cell types to place cell firing, taking advantage of a developmental t

131 elated input that contributes to maintaining place cell firing.

132 the environment also result in plasticity of place cell firing.

133 correlated fashion with those of hippocampal place cells firing at overlapping locations.

134 We report that sequences of place-cell firing in a novel environment are formed from

135 ts distinctly via changes in the pattern of "place cell" firing.

136 at are functionally coupled with hippocampal place cells for spatial processing during natural behavi

137 Hippocampal place cells form a spatial 'map' which is modifiable by

138 been implicated in localized plasticity and place cell formation.

139 Specifically, place cells from dorsal cornu ammonis field 1 (CA1) were

140 se conditions, no recovery was observed upon placing cells from the exposed cultures into fresh media

141 , we consider the likely interaction between place cells, grid cells and boundary vector cells in est

142 These include place cells, grid cells, head direction cells, and bound

143 the spatial receptive fields of hippocampal place cells has not been established.

144 Hippocampal place cells have been proposed to have a role in navigat

145 years, large-scale population recordings of place cells have revealed that spatial sequences are sto

146 t with this idea, the firing of hippocampal "place cells" have been shown to represent not only locat

147 s self-organized; and (6) grid cell input to place cells helps stabilize their code under noisy and/o

148 l memory and elicited drastic changes in CA1 place cells in a familiar environment, similar to those

149 hippocampus by altering the firing rates of place cells in a manner similar to behavioral stress.

150 cus on place cells, but many neurons are not place cells in any given environment.

151 As shown previously, we found that place cells in control animals exhibited repeated fields

152 the local regions of activity recorded from place cells in exploring rodents, can undergo large chan

153 alistic spike trains recorded in hippocampal place cells in exploring rodents.

154 presented the less discriminable routes, and place cells in general over-represented the start locati

155 We recorded from the same place cells in mouse hippocampal area CA1 over several d

156 Place-field locations and the set of active place cells in one environment can be independently rear

157 We recorded place cells in rats and found that increased neural acti

158 bited decreased stability of firing rates of place cells in the CA1 hippocampus, accompanied by impai

159 Place cells in the CA1 region of the hippocampus express

160 ad direction (HD), boundary vector, grid and place cells in the entorhinal-hippocampal network form t

161 change in the spatial characteristics of CA1 place cells in the familiar environment following ReRh l

162 result in part from the combined activity of place cells in the hippocampus and grid cells in posteri

163 Place cells in the hippocampus and grid cells in the med

164 Place cells in the hippocampus of higher mammals are cri

165 ulated cells in the same cortical region and place cells in the hippocampus retained their spatial fi

166 Here, we investigated place cells in the hippocampus, implicated in processing

167 The discovery of place cells in the rodent hippocampus immediately sugges

168 n without working memory demands, similar to place cells in these areas.

169 Place cells, initially thought to be location-specifiers

170 task, suggesting a functional role for local place cell interactions in shaping firing fields.

171 al cell types, including cancerous types, by placing cells into normally inaccessible spurious states

172 support the idea that synaptic plasticity in place cells is involved in forming new place fields.

173 l input; (3) plasticity in sensory inputs to place cells is key for pattern completion but not patter

174 suggesting that the decline in the number of place cells is not a simple matter of increased inhibito

175 y oscillations, and the ensemble activity of place cells is organized into temporal sequences bounded

176 rge of a subset of pyramidal neurons called "place cells" is spatially organized such that discharge

177 upon a previous rate-based model of grid and place cell learning, and thus illustrate a general metho

178 t during spatial navigation, hippocampal CA1 place cells maintain a continuous spatial representation

179 Here we show that, like hippocampal place cells, many neurons in the primary visual cortex (

180 al field potential affects the efficiency of place cell map formation.

181 We argue that hippocampal place-cell maps are metric in all three dimensions, and

182 dPlaceMap model simulates how grid cells and place cells may develop.

183 a computational model, that the hippocampal place cells may ultimately be interested in a space's to

184 nterneurons had spatially uniform effects on place cell membrane potential dynamics, substantially re

185 t issue is understanding how the hippocampal place-cell network represents specific properties of the

186 This view is supported by the finding of place cells, neurons whose firing is tuned to specific l

187 Control place cells (nonsilenced or silenced outside SPW-Rs) lar

188 In contrast, the place cells of animals with lesions of the head directio

189 at regenerative dendritic events do exist in place cells of behaving mice, and, surprisingly, their p

190 r the spatial representations encoded by CA1 place cells of both familiar and novel environments.

191 essential for the angular disambiguation by place cells of visually identical compartments.

192 ch mixed populations, treating place and non-place cells on the same footing.

193 In addition, route-dependent place cells over-represented the less discriminable rout

194 Place cell overdispersion might provide the functional b

195 between the degree of firing variability of place cells ("overdispersion") and performance during th

196 e occasions in which the firing of different place cells overlaps.

197 relationship between within-theta delays of place cell pairs and their distance representations ("co

198 The result reveals a specific place-cell pattern underlying inhibitory avoidance behav

199 n is represented by partial remapping of the place cell population or, instead, via firing rate modul

200 nt in RW are necessary to fully activate the place-cell population.

201 tials that can coordinate theta sequences in place cell populations.

202 Different grid and place cells prefer spatially offset regions, with their

203 In horizontal planar environments, place cells provide focal positional information, wherea

204 Medial entorhinal grid cells and hippocampal place cells provide neural correlates of spatial represe

205 l sharp wave-ripples (SPW-Rs) and associated place-cell reactivations are crucial for spatial memory

206 d as multimodal attractors in populations of place cells, recent experiments morphed one familiar con

207 We then investigated field stability of place cells recorded across 5 d both in the familiar and

208 rning, in vitro synaptic plasticity, in vivo place cell recording, and western blot analysis to deter

209 with seizure number, although the remaining place cells remain quite intact.

210 5, 9], receiving support from the way rodent place cells "remap" nonlinearly between spatial represen

211 Furthermore, just as most place cells "remap" when a salient spatial cue is altere

212 contrast, the place fields of SPW-R-silenced place cells remapped, and their spatial information rema

213 ual fear conditioning results in hippocampal place cell remapping and long-term stabilization of nove

214 rid realignment can be explained in terms of place cell remapping as opposed to the other way around;

215 report that extinction learning also induces place cell remapping in C57BL/6 mice.

216 ically, these studies identified rigidity in place cell remapping in similar environments in the CA3.

217 in a new environment, reducing the extent of place cell "remapping."

218 p stability and the absence of goal-directed place cell reorganization.

219 Hippocampal place-cell replay has been proposed as a fundamental mec

220 Hippocampal place cells represent location, but their role in the le

221 The place cells represent much larger spaces than the grid c

222 Hippocampal place cells represent the cellular substrate of episodic

223 We find that before weaning, the place cell representation of space is denser, more stabl

224 heories of hippocampal function propose that place cell representations are formed during an animal's

225 Second, impaired stability of place cell representations could explain the long-term m

226 don et al. (2014) show that the formation of place cell representations in new environments is preser

227 We found that place cells representing the shock zone were reactivated

228 The activity of ensembles of hippocampal place cells represents a hallmark of an animal's spatial

229 llocentric code of boundary vector cells and place cells requires consistent head-direction informati

230 ow-rate" cells as opposed to gradual loss of place cell resolution.

231 Our results demonstrate that place cells respond to the presence of an aversive stimu

232 This representation captures many aspects of place cell responses that fall outside the traditional v

233 To do this, we construct a model in which place-cell responses arise from network competition medi

234 iously shown to exhibit impaired hippocampal place cell selectivity.

235 R)-dependent synaptic plasticity play in CA1 place cell sequence encoding and learning during novel s

236 These findings suggest that the place cell sequence of a novel spatial experience is det

237 ve been reported to co-occur with long-range place cell sequence replays during the quiet awake state

238 biophysical modeling, and explore the LFP of place cell sequence spiking ("replays") during sharp wav

239 ms that enable the rapid expression of novel place cell sequences are not entirely understood.

240 Reactivation of hippocampal place cell sequences during behavioral immobility and re

241 ccurred in ripple-associated awake replay of place cell sequences encoding the paths from the animal'

242 Replay of hippocampal place cell sequences has been proposed as a fundamental

243 rrent positions to the shock zone but not in place cell sequences within individual cycles of theta o

244 ironment leads to off-line pre-activation of place cells sequences corresponding to that space.

245 The hypothesis was that CA1 place cells should show field remapping in the condition

246 In VR, place cells showed robust spatial selectivity; however,

247 ity recording methods to monitor hundreds of place cells simultaneously while rats explored multiple

248 ulti-plane two-photon calcium imaging of CA1 place cell somata, axons and dendrites in mice navigatin

249 Instead, we propose that place cell spatial firing patterns are determined by env

250 ta sequences," ordered series of hippocampal place cell spikes that reflect the order of behavioral e

251 This allowed us to determine whether place cells stably represent parts of the environment th

252 ally reduces the information conveyed by the place cell subset of pyramidal cells.

253 Simulating several theoretical models of place-cells suggested that combining sensory information

254 reward sensitivity and policy dependence in place cells suggests that the representation is not pure

255 nformation processing within the hippocampus place cell system.

256 Hippocampal place cells take part in sequenced patterns of reactivat

257 vation into the microbes' natural habitat by placing cells taken from varying environmental samples i

258 Additionally, hippocampal place cells tend to develop a secondary place field at t

259 modifying physical properties of spiking in place cells that contribute to changes in navigation and

260 tial navigation is supported by a network of place cells that exhibit increased firing whenever an an

261 ltiple scales combine adaptively to activate place cells that represent much larger spaces than grid

262 s the sequential reactivation of hippocampal place cells that represent previously experienced behavi

263 s require the location-specific discharge of place cells that together form a stable cognitive map us

264 o affected activity in small groups of other place cells that were active around the same time in the

265 -specific firing distributed evenly over all place cells, the number of place cells decreases with se

266 ation arising from recent data with grid and place cells: the integration of piecemeal representation

267 As HCN1 is only weakly expressed in CA3 place cells, their altered activity likely reflects loss

268 lls, but recent studies suggest instead that place cells themselves may play an active role through r

269 r results express a possible linkage between place cell to grid cell interactions and PCA.

270 The present study examined dorsal CA1 place cells to elucidate the computational changes assoc

271 The cumulative transformation of place cells to low-rate cells by repetitive seizures may

272 The ability of the place cells to remap parallels the acquisition of reward

273 here is a cell-specific conversion of robust place cells to sporadically firing (<0.1 spike/s) "low-r

274 mpared the changes in downstream hippocampal place cells to those of neurons in MEC.

275 oth layer 5 and CA1 pyramidal neurons, this "place cell train" generated small, long-lasting AHPs cap

276 Place-cell-train-induced AHPs were blocked by ouabain or

277 A place cell typically fires whenever an animal is present

278 s face different directions, suggesting that place cells use a directional input to differentiate oth

279 nt, computationally modeling the activity of place cells using methods derived from algebraic topolog

280 Since the first place cell was recorded and the cognitive-map theory was

281 The goal-related activity of place cells was not affected at either single unit or lo

282 While the remapping capacity of the place cells was not affected by the lesion, our results

283 or randomly dispersed food pellets while CA1 place cells were monitored across two recording sessions

284 ocks in a shock zone on a track, we analyzed place cells when the animals were placed on the track ag

285 rticular environment, earning them the name "place cells." When an animal explores a novel environmen

286 ar to canonical, sparsely firing hippocampal place cells, whereas neurons in the distal subiculum hav

287 n environment's geometry, unlike hippocampal place cells, which activate at particular random locatio

288 The brain's grid and place cells, which contribute to spatial representations

289 In addition to place cells, which encode the current virtual location,

290 pocampal pyramidal cells can be divided into place cells, which fire action potentials when an animal

291 rain represents space is through hippocampal place cells, which indicate when an animal is at a parti

292 asis of this theory, we examined hippocampal place cells, which represent spatial information, in rat

293 vironmental location provided by hippocampal place cells while mice navigated a virtual reality envir

294 the downstream projection from grid cells to place cells, while recent data have pointed out the impo

295 e demonstrate that bimodal excitation drives place cells, while unimodal excitation drives weaker or

296 well known phenomenon in which a hippocampal place cell will fire action potentials at successively e

297 neurophysiological correlates of hippocampal place cells with navigational planning and action.

298 firing fields of multiple spatial scales and place cells with one or more firing fields that match ne

299 in this first line of defense, strategically placed cells within the vasculature and tissue respond t

300 ion to entorhinal grid cells and hippocampal place cells, yaw plane optic flow signals likely influen