ライフサイエンスコーパス: placenta

1 eks 12-25 for cord blood and weeks 15-27 for placenta).

2 ed TB cell lines and primary cells from term placenta.

3 hrough the endothelium of brain, retina, and placenta.

4 us CTBs normally upregulate as they exit the placenta.

5 itor cells for both the new organism and the placenta.

6 give rise to complex structures such as the placenta.

7 lobal metabolism in the late gestation human placenta.

8 orphological and functional phenotype of the placenta.

9 th the Igf2r cluster extending over 10 Mb in placenta.

10 ed by preserving PPARgamma expression in the placenta.

11 the transport capacity and metabolism of the placenta.

12 iral infections within the immune-privileged placenta.

13 ssion plasmids, which we tested in the mouse placenta.

14 e the risk of LBW by transmission across the placenta.

15 xposure by altering BCRP expression in human placenta.

16 xtravillous trophoblast lineage in the human placenta.

17 he first single-cell RNA-seq analysis of the placenta.

18 xtraembryonic lineage that gives rise to the placenta.

19 entiate into all trophoblast subtypes of the placenta.

20 l ends of mutant ovaries and thinning of the placenta.

21 to the plasma membrane of the trophoblast in placenta.

22 ed in regulating HOX genes expression in the placenta.

23 rophoblast giant cells (p-TGCs) of the mouse placenta.

24 he pregnant mother affects metabolism of the placenta.

25 ion to form the yolk sac, umbilical cord and placenta.

26 the organism being detected in the diseased placenta.

27 eeclamptic placenta as well as uncomplicated placenta.

28 ion enables confirmation that it crosses the placenta.

29 in primary human trophoblasts isolated from placenta.

30 ransferred from mother to neonate across the placenta.

31 y with calcifications in the fetal brain and placenta.

32 the normal immunoprotective responses of the placenta.

33 elatively very low levels in adult brain and placenta.

34 or listeriosis with a strong tropism for the placenta.

35 the chorion and labyrinth layer of the mouse placenta.

36 micals may sex-dependently accumulate in the placenta.

37 to Plasmodium falciparum accumulation in the placenta.

38 ve rise to specialized cell types within the placenta.

39 press C19MC miRNA members selectively in the placenta.

40 which is expressed nearly exclusively in the placenta.

41 during gestation, while some only infect the placenta.

42 anti-angiogenic factors originating from the placenta.

43 (CSE) is down-regulated in growth-restricted placentas.

44 DLX5 was upregulated in 69% of preeclamptic placentas.

45 n the high- compared with low-altitude human placentas.

46 OPA1 mRNA and protein expression in the eoPE placentas.

47 hway genes-HSD11B2, NR3C1, and FKBP5-in term placentas.

48 horionic villi of one of the first trimester placentas.

49 , Mmrn1, were temporally dysregulated in the placentas.

50 lls mimics the transcriptome of preeclamptic placentas.

51 iscrepancies in vessel length density in FGR placentas.

52 ut wall thickness remained unchanged in IUGR placentas.

53 QTLs at </=10% false discovery rate in human placentas.

54 us for IGF2 and H19 methylation levels of 48 placentas.

55 rebrain, suggesting that altered maternal or placenta 5-HT system function could impact the developin

56 Capsaicinoids of placenta (7.35+/-2.241%) was higher followed by seed (3.

57 ithin the uterine environment depends on the placenta, a highly complex vascularized organ comprised

58 t is the primary epithelial cell type in the placenta, a transient organ required for proper fetal gr

59 are epithelial stem cells of the early human placenta, able to differentiate either into syncytiotrop

60 ult bloodstream by lipoproteins and that the placenta acquires, assembles, and secretes lipoproteins,

61 This study showed that the placenta actively produces transthyretin and in preeclam

62 spite its defective development, the alpha/+ placenta adapted functionally to increase the supply of

63 The placenta adapts its transport capacity to nutritional cu

64 abolic rhythmicity of the liver, muscle, and placenta affect fetal size.

65 The placentas also showed abnormal fetal vessel patterning a

66 rofiles depending on the location within the placenta and (2) "semi-composite" 16S profiles using mul

67 me-wide assessment of DNA methylation in the placenta and arsenic exposure in the New Hampshire Birth

68 spiratory syndrome virus (PRRSV) crosses the placenta and begins to infect fetuses.

69 topathological analysis was performed on the placenta and brain tissue from infants who died.

70 Zika virus (ZIKV) crosses the placenta and causes congenital disease.

71 king during pregnancy have been described in placenta and cord blood at delivery, in fetal lung, and

72 nd lipid metabolism) were hypermethylated in placenta and cord blood from SGA newborns, whereas GPR12

73 d differences in regulation of imprinting in placenta and cord blood; a lack of correlation of the me

74 We introduce the structure of the human placenta and describe the innate mechanisms by which the

75 Ala56 genotypes to examine effects on blood, placenta and embryo serotonin levels and neurodevelopmen

76 derived hemato-vascular precursors, in mouse placenta and embryo.

77 Ala56 genotype was associated with decreased placenta and embryonic forebrain 5-HT levels at E14.5.

78 n and that maternal miRNA can traffic to the placenta and even into the fetal compartment.

79 Strains of S. simulans from the placenta and fetal brain were equally highly resistant t

80 essed genome-wide expression profiles in the placenta and fetal brain.

81 at was associated with ZIKV infection of the placenta and fetal brain.

82 Despite the parallel development of the placenta and fetal heart early in pregnancy, very few st

83 , Il6, Ccl2, Pghs2, and Mpges1 expression in placenta and fetal membranes, and it elevated amniotic f

84 monal, miRNA-based communication between the placenta and feto-maternal compartments.

85 rnal immunity required for protection of the placenta and fetus against congenital cytomegalovirus (C

86 IKV transmission in utero, we found that the placenta and fetus were more susceptible to ZIKV infecti

87 naling had increased ZIKV replication in the placenta and fetus when infected at E12, and reciprocall

88 ase as well as bacterial transmission to the placenta and fetus.

89 fatty acid regulation) was hypomethylated in placenta and hypermethylated in cord blood.

90 arisons with microarray datasets from mutant placenta and in vitro differentiated trophoblast stem ce

91 o identify novel imprinted DMRs in the human placenta and investigated the dynamics of these imprinte

92 Development of the human placenta and its different epithelial trophoblasts is cr

93 ic acid [poly(I:C)] on TRP metabolism in the placenta and its impact on fetal neurodevelopment.

94 we performed yeast-two-hybrid screenings of placenta and lung cancer cDNA libraries, which demonstra

95 Associations were observed between placenta and maternal toenail Se (beta = 63.49; P < 0.00

96 ping preventative treatments that target the placenta and not the fetus to reduce risk of psychiatric

97 ancy, we sequenced miRNAs in triads of human placenta and of maternal and fetal blood and found large

98 However, its effects within the placenta and on pregnancy outcomes remain largely unknow

99 ns in fruit development: while TAG1 controls placenta and seed formation, TAGL1 participates in cutic

100 n women and transfer to the child across the placenta and through breastfeeding.

101 methylation status of specific genes in the placenta and thus supports a potentially novel mechanism

102 We show that TRPM6 activity in the placenta and yolk sac is essential for embryonic develop

103 in the accumulation of target transcripts in placenta and/or yolk sac, and that some of these would b

104 of imprinting (LOI) of IGF2 and H19 genes in placentas and cord blood of 90 mother-child dyads in ass

105 ong 47 placentas heterozygous for H19 and 37 placentas and cord blood tissues heterozygous for IGF2 a

106 mary cell types from mid- and late-gestation placentas and explants from first-trimester chorionic vi

107 Guided by these studies, we analyzed mouse placentas and identified a population with this phenotyp

108 fferentially expressed genes in preeclamptic placentas and intersected them with the list of human im

109 tal tissues (eg, amniotic fluid, cord blood, placenta, and brain).

110 cs of contrast entry and distribution in the placenta, and clearance from circulation.

111 in trophoblast and endothelial cells in the placenta, and endothelial, microglial and neural progeni

112 terface that comprises the maternal decidua, placenta, and fetal membranes.

113 y in the gastrointestinal tract, kidney, and placenta, and glycosylation seems essential for reaching

114 ating AMPK) were present in murine and human placenta, and hypoxia increased LKB1 and AMPK-alpha1 and

115 urified neurons and glia, T lymphocytes, and placenta, and identify 795 hap-ASM differentially methyl

116 hylation is uniquely distributed within term placenta, and is associated with gene expression.

117 demonstrated in vertebrate-specific tissues, placenta, and parathyroid glands, begging questions on t

118 (+)-naloxone, and cytokine expression in the placenta, and uterine myometrium and decidua, was also a

119 ant vasculogenesis in embryos, yolk sacs and placentas, and die between embryonic day 10.5 and 11.5.

120 ontrol ZIKV infection in the brains, testes, placentas, and fetuses of mice.

121 morphology, reduced junctional zone, smaller placentas, and impaired spiral artery remodeling with fe

122 The ZFP36L3 protein is a rodent-specific, placenta- and yolk sac-specific member of the tristetrap

123 estration and consequent inflammation in the placenta are common attributes of placental malaria.

124 Current ultrasound methods to evaluate the placenta are indirect and insensitive.

125 r network of large organs, such as the human placenta are limited, preventing adequate comparison of

126 Two hypotheses regarding the role of the placenta are possible: one is that the placenta directly

127 Results suggest that transcripts in placenta are under tight genetic control, and that place

128 isolated from early-gestation (6-8 wk) human placentas are bipotential, a phenotype that is lost with

129 We discovered that PHT cells from full-term placentas are refractory to ZIKV infection.

130 Placenta arsenic levels were associated with 163 differe

131 acental growth and function and identify the placenta as critical in integrating both intrinsic and e

132 persist in the mid- to late- gestation mouse placenta as well as a cell surface protein that can be u

133 LTR, with sites of expression including the placenta as well as other tissues and rather unexpectedl

134 immunohistochemical findings in preeclamptic placenta as well as uncomplicated placenta.

135 aorta, lungs, and wound healing, tumors, and placenta, as well.

136 s an enigmatic inflammatory condition of the placenta associated with fetal growth restriction and st

137 lopment of methods for detecting fetuses and placentas at risk as a means of reducing preterm brain i

138 sh border of syncytiotrophoblast of infected placentas; (b) amounts of megalin and Dab2 were strongly

139 e is known about the cellular changes in the placenta brought about by these drugs.

140 l tissues, up-regulated in stem cells and in placenta but also in cancer and HIV-1 infection.

141 localise and prevent oxidative stress in the placenta but not in the fetus.

142 sterial genes important for infection of the placenta but not maternal liver.

143 or megalin, which is abundantly expressed in placenta but was not previously analyzed in pregnancy ou

144 e proliferation or increase apoptosis in the placentas but induced extensive apoptosis in the brain.

145 pment, and are widely expressed in the human placenta, but their regulatory control by DNA methylatio

146 Viruses can gain access to the decidua and placenta by ascending from the lower reproductive tract

147 man IgGs are actively transferred across the placenta by binding the neonatal Fc receptor (FcRn) expr

148 imprinted DMRs were identified in the human placenta by comparing methylation between diandric and d

149 ely activated in either the pituitary or the placenta by distinct components of a remote locus contro

150 onfirm that preeclampsia is a disease of the placenta by generating and analyzing genome-wide molecul

151 tes and expression of 29 candidate miRNAs in placenta by qRT-PCR.

152 erved a protective effect of PD-L1-Fc on the placenta by reversing placental damages.

153 n Time-To-Plateau (TTP) were obtained in the placentas by voxel-wise fitting of the time series.

154 rall, the present study shows that the mouse placenta can integrate signals of oxygen and nutrient av

155 Maternal antibodies transported across the placenta can provide vital immunity against infectious p

156 ics are frequently inefficient and cross the placenta causing fetal side effects.

157 rations of Cd, Pb, Hg, Mn, Se, and Zn in 750 placentas collected from women enrolled in the New Hamps

158 ential amino acid content was also higher in placenta compared to other components.

159 n alterations, which were exacerbated in the placenta compared to the embryo.

160 (>40-fold) expression of C19MC miRNA in the placenta, compared with other organs, that resembled C19

161 ithin trophoblasts of the maternal and fetal placenta, consistent with a trans-placental infection ro

162 n the volume of maternal blood spaces in the placenta, consistent with increased flow.

163 te sequencing was performed with a subset of placentas, cord blood samples, and buccal samples collec

164 (VSASL) and 3D image acquisition with whole-placenta coverage.

165 Using human first trimester placenta, decidua, primary dNK cells, and macrophages, w

166 nificant interest in elucidating the role of placenta-derived exosomes (PdEs) during pregnancy, the e

167 ceptor mRNA was unexpectedly decreased in KO placentas, despite an increase in its stability in KO st

168 guide trophoblast cell fate decisions during placenta development remain ill defined.

169 ssor Prdm1/Blimp1, an essential regulator of placenta development, were identified in ChIP-seq experi

170 f the placenta are possible: one is that the placenta directly conveys the Zika virus to the early em

171 Stem villus arteries in human IUGR placentas displaying absent or reversed end-diastolic fl

172 regnancy is relatively short, and although a placenta does form, it is present for only a few days be

173 sexual transmission, an ability to cross the placenta during pregnancy and infect the developing fetu

174 d ESCs contributed to the development of the placenta, embryolemma and umbilical cord at 13.5 dpc and

175 ssion of TCblR/CD320 in the labyrinth of the placenta, embryonic brain, and spinal column in wild-typ

176 rted in extragonadal tissues including bone, placenta, endometrium, liver, and blood vessels from a n

177 another member of this small group of genes, Placenta Expressed Transcript 1 (Plet1), for its functio

178 onstrate that the anatomically simple tammar placenta expresses a dynamic molecular program that is r

179 In the placenta, expression is limited to the trophoblast linea

180 d to align regions of interest of the entire placenta, fetal liver, and maternal liver.

181 tter appear to be analogous to the primitive placenta formed during implantation.

182 amniochorionic membranes from mid-gestation placentas formed foci of infection, and interferon-beta

183 lopment, serotonin (5-HT) synthesized in the placenta from maternal l-tryptophan (TRP) reaches the fe

184 Finally, TRAbs cross the placenta from the mother to the fetus and can cause feta

185 Placentas from AMA women exhibited increased syncytial n

186 E17.5 embryos and placentas from FASD dams were smaller.

187 Placentas from male fetuses were heavier (1082 +/- 2 mg,

188 at epithelial cells in amniotic membranes of placentas from newborns with intrauterine growth restric

189 4 was one of the most downregulated genes in placentas from preeclamptic women.

190 riglyceride patterns were disrupted in human placentas from pregnancies with large-for-gestational ag

191 Placentas from preterm Nrf2(-/-) mice showed elevated le

192 y after birth, one 2-month-old baby, and two placentas from spontaneous abortions, from Brazil were s

193 Immunohistochemistry was performed on placentas from stillborn infants whose cause of death wa

194 we immunostained amniotic membranes from 51 placentas from symptomatic and asymptomatic congenital i

195 ed a genome-wide DNA methylation analysis in placentas from term infants born appropriate-for-gestati

196 nd Dab2 (p = 0.046) were reduced in infected placentas from women with LBW deliveries.

197 In the placenta, fructose induced de novo uric acid synthesis b

198 Previous studies showed that high levels of placenta growth factor (PlGF) correlated with increased

199 We hypothesized that placenta growth factor (PlGF), an erythroblast-secreted

200 Moreover, the placentas had increased lipids and altered expression of

201 Recent work has suggested that the placenta harbours microbial communities, however the loc

202 The placenta has a critical role in the deleterious and sex-

203 viation from monoallelic expression among 47 placentas heterozygous for H19 and 37 placentas and cord

204 o-hematopoietic transition in the embryo and placenta; however, the precursor cells to hemogenic endo

205 nd macrophages were increased throughout the placenta in stillbirths; pan-placental CD4(+) and CD8(+)

206 Here we review the novel involvement of the placenta in the transmission of the maternal adverse env

207 ZIKV infection of the placenta increases production of IFNbeta and expression

208 Primary AmEpCs isolated from mid-gestation placentas infected with pathogenic VR1814 proliferated a

209 Within the placenta, InsR deficiency elicited changes in gene expre

210 rome (APS) does not prevent life-threatening placenta insufficiency-associated complications such as

211 niversal PAMP for TLR2, traverses the murine placenta into the developing fetal brain.

212 These results suggest that bacteria from the placenta invade the fetal brain after maternal hypoxia.

213 ulthood may have an in utero origin, and the placenta is a key organ that plays a pivotal role in fet

214 The placenta is a vital organ for fetal growth and developme

215 site of materno-fetal nutrient transfer, the placenta is central to this interplay; however, the rela

216 s supposition that the metabolic rate of the placenta is dominated by the SCT contribution.

217 We propose that although a choriovitelline placenta is never established physically in the human, t

218 in hepatocytes, although their effect on the placenta is poorly understood.

219 The resulting placenta is reduced in size.

220 The placenta is the main determinant of fetal growth and dev

221 ying PE remain enigmatic and delivery of the placenta is the only known remedy.

222 The placenta is the principal organ nurturing the fetus duri

223 Viral tropism for the decidua and placenta is then dependent on viral entry receptor expre

224 Placental abruption (early separation of the placenta) is associated with preterm birth and perinatal

225 sical HLA molecule uniquely expressed in the placenta, is a central component of fetus-induced immune

226 While IR is impaired in GDM-placenta, it is unaffected in GDM-platelet.

227 However, since IgM does not cross the placenta, it may be a good marker of infection in neonat

228 Alternatively, the placenta itself might be mounting a response to the expo

229 ging revealed patchy perfusion of Egfl7(-/-) placentas marked by impeded blood conductance through si

230 lites, especially 25(OH)D3, suggest that the placenta may play an active role in modulating the vitam

231 ailability is mediated by coordinated muscle-placenta metabolic adjustments linked to internal clocks

232 ue plastic vessel networks of normal and FGR placentas (n = 12/group) were created by filling the ves

233 CXCL14) to test with qPCR in a larger set of placentas (n = 475) and found no differences between the

234 xation of imprinting (ROI) and LOI of H19 in placentas not associated with differences in methylation

235 fetal brain after hypoxia, but was found in placenta of all animals.

236 locytic MDSCs (GR-MDSCs) accumulate in human placenta of healthy pregnancies but are diminished in pa

237 ng pregnancy affects lipid metabolism in the placentas of overweight and obese women at term.

238 lipid content was significantly lower in the placentas of overweight and obese women supplemented wit

239 ns to fetal plasma or to secretions from the placenta or from model trophoblast barriers that had bee

240 egnancy, arising through malperfusion of the placenta or pregnancy at high altitude.

241 but no apparent morphological changes in the placenta or surviving offspring.

242 ltures, and/or by culture or staining of the placenta or umbilical cord.

243 was assessed based on intrapartum fever and placenta pathology.

244 eports for the first time non-invasive whole-placenta perfusion imaging in utero.

245 Low 5-HT in the placenta persisted, but forebrain levels normalized by E

246 inflammasome activation specifically in the placenta, pharmacological inhibition of inflammasome or

247 eins known to be involved in trophoblast and placenta physiology.

248 Although it is known that the placenta plays a central role in development of preeclam

249 Furthermore, GR-MDSCs isolated from placenta polarized CD4(+) T cells toward a Th2 cytokine

250 ynamic than previously reported and that the placenta preferentially maintains maternal germline-deri

251 Metal contaminants cross the placenta, presenting a heightened risk of perturbing fet

252 lele, rs7216389-T and Gasdermin-B (GSDMB) in placenta (r2=27%) versus lung (r2=6%).

253 d in numerous fetal tissues, 2) ex vivo, the placenta released high amounts of apelin in late gestati

254 ly that trophoblasts isolated from full-term placentas resist infection by diverse viruses, including

255 Furthermore, the placenta responds to nutritional and metabolic signals i

256 describe the innate mechanisms by which the placenta restricts microbial access to the intrauterine

257 Placentas retained monoallelic allele-specific gene expr

258 l structure of aromatase purified from human placenta, revealing an androgen-specific active site.

259 The placenta richly expresses nonheme and heme Fe transport

260 Placenta RNA sequencing data at E14.5 indicated substant

261 Thus, the placenta's role has been a focus.

262 hroughput transcriptome analyses of multiple placenta samples from healthy controls and patients with

263 ion and had serum, urine, amniotic fluid, or placenta samples tested by real-time polymerase chain re

264 The molecular mechanisms by which the placenta senses and responds to environmental cues are p

265 The inflammatory response to placenta-sequestered parasites is associated with poor p

266 stational diabetes mellitus (GDM)-associated placenta, SERT is found entrapped in the cytoplasm of th

267 The placenta showed a reduction of 18% +/- 4 in mean apparen

268 otic epithelial cells (AmEpCs) from infected placentas, sometimes with aberrant morphology.

269 f STBEVs into primary HCAEC, and transfer of placenta specific miRNAs from STBEVs into the endoplasmi

270 We previously identified the protein placenta-specific 8 (PLAC8, onzin) in a genome-wide sear

271 The guinea pig, with a placenta structure similar to that in humans, is the onl

272 associated with altered miRNA expression in placenta, suggesting a potential mechanism of EDC toxici

273 into immune-sheltered spaces, including the placenta, testes and brain.

274 ved between GWAS SNPs and gene expression in placentas than what has been reported in other tissues,

275 ypoxia promotes damaging secretions from the placenta that affect fetal development and whether a mit

276 experimental models with a small, defective placenta that restricts delivery of nutrients and oxygen

277 al milieu are conveyed to the embryo via the placenta, the maternal-fetal intermediary responsible fo

278 removing a toxic aggregated protein from the placenta, they may also be delivering aggregated transth

279 The transcriptomes of 159 human placenta tissues were profiled by genome-wide RNA sequen

280 ther the effects of sildenafil transcend the placenta to affect the fetus is unknown.

281 tene induces a feed-forward mechanism in the placenta to enhance the assimilation of beta-carotene fo

282 uring pregnancy inhibited the ability of the placenta to esterify and store lipids.

283 acental mammals', but marsupials also have a placenta to mediate early embryonic development.

284 anomalies suggests that ZIKV may bypass the placenta to reach the fetus.

285 These medications can cross the placenta to the fetus, leading to postpartum neonatal ab

286 d high-throughput RNA sequencing of a Mabuya placenta transcriptome and screened for the presence of

287 hat is expressed in male germ line cells and placenta under normal physiological conditions.

288 However, while infection of the placenta was observed, the experimental challenge in thi

289 Mitochondrial DNA copy number in eoPE placentas was significantly higher than in samples from

290 Embryos and placentas were assessed for developmental defects at emb

291 Placentas were collected after delivery for examination.

292 of abnormal placental development; abnormal placentas were observed predominantly in abnormally deve

293 The maternal blood and the placentas were obtained at the time of cesarean section

294 r was not associated with methylation in the placenta, whereas arsenic levels quantified through mate

295 the effects of hypoxia on the growth of the placenta, which is the organ that interfaces between the

296 to form properly in the majority of abnormal placentas, which compromised the integration of the mate

297 ed genes were found in late-onset PE and GDM placentas, which may suggest that these conditions could

298 The cells from term placentas, which resist infection, do not express genes

299 ll as Mel 624 parental cells, and human term placenta whole tissue sections were used as controls and

300 e demonstrate that (1) both agents cross the placenta with rapidly detectable fetal serum concentrati