ライフサイエンスコーパス: plague

1 ing from food-borne illnesses to the bubonic plague.

2 the causative agent of bubonic and pneumonic plague.

3 antly attenuated in a mouse model of bubonic plague.

4 ouse and rat models of bubonic and pneumonic plague.

5 O92 in mouse models of bubonic and pneumonic plague.

6 However, they are susceptible to plague.

7 r in the lungs during experimental pneumonic plague.

8 for Yersinia pestis, the causative agent of plague.

9 t on the progression or outcome of pneumonic plague.

10 uses the fatal respiratory disease pneumonic plague.

11 otic infections, including enterocolitis and plague.

12 e invasive infection associated with bubonic plague.

13 s of Yersinia pestis, the causative agent of plague.

14 Yersinia pestis is the causative agent of plague.

15 d virulence and the emergence of the bubonic plague.

16 11 or 12 LD50 in a mouse model of pneumonic plague.

17 otential vaccine candidate against pneumonic plague.

18 otected from developing subsequent pneumonic plague.

19 N-gamma in protecting mice against pneumonic plague.

20 uction of bubonic, septicemic, and pneumonic plague.

21 the causative agent of bubonic and pneumonic plague.

22 r lysozyme resistance and the development of plague.

23 inst Yersinia pestis, the etiologic agent of plague.

24 tes to disease in the mouse model of bubonic plague.

25 m in Yersinia pestis, the causative agent of plague.

26 d pneumonic animal models (mouse and rat) of plague.

27 completely attenuated in an in vivo model of plague.

28 ice weakened T cell-mediated defense against plague.

29 ecules to slow down the rapid progression of plague.

30 nate immune response necessary for surviving plague.

31 important role in determining the outcome of plague.

32 e III secretion generated protection against plague.

33 or development of both bubonic and pneumonic plague.

34 important role in the progression of bubonic plague.

35 ic roles for these pathways during pneumonic plague.

36 y in murine models of systemic and pneumonic plague.

37 hromatosis who died from laboratory-acquired plague.

38 rium Yersinia pestis, the causative agent of plague.

39 iniosis, Far East scarlet-like fever and the plague.

40 significantly increased survival of bubonic plague.

41 Yersinia pestis results in primary pneumonic plague.

42 tibody therapy in the mouse model of bubonic plague.

43 and biological threats, such as anthrax and plague.

44 Yersinia pestis causes bubonic plague, a fulminant disease where host immune responses

45 am-negative bacterium Yersinia pestis causes plague, a rapidly progressing and often fatal disease.

46 torical images labelled as depictions of the plague, although artistic and textual evidence shows tha

47 t numerous major public health problems have plagued American Indian communities for generations, Ame

48 the causative agent of bubonic and pneumonic plague, an acute and often fatal disease in humans.

49 study bacterial dissemination during bubonic plague and compare this model with an s.c. inoculations

50 d elsewhere that Mus spretus SEG mice resist plague and develop an immune response characterized by a

51 Yersinia pestis is the etiological agent of plague and has caused human pandemics with millions of d

52 s genus are A. astaci, the cause of crayfish plague and its close relative, A. invadans, which causes

53 is the impact of incidental setbacks such as plague and volcanism, which are seen to have compounded

54 7 contributed to the lethality of septicemic plague and was associated with the suppression of neutro

55 ffected by the Pla protease during pneumonic plague, and although A2AP participates in immune modulat

56 ally in protecting animals against pneumonic plague, and we have demonstrated an immunological basis

57 igor and is subject to the inaccuracies that plague anecdotal decision-making.

58 ypass a fundamental limitation that has long plagued applications of directed C-H activation in medic

59 les of these pathways in the pathogenesis of plague are not understood.

60 ue in 1896 suggest that, only a decade after plague arrived, a heritable, plague-resistant phenotype

61 receptors for Yersinia pestis, the agent of plague, as shown by overexpression studies showing induc

62 screened them in a mouse model of pneumonic plague at a dose equivalent to 5 50% lethal doses (LD50)

63 The plague bacillus Yersinia pestis is unique among the path

64 Yersinia pestis (the plague bacillus) and its ancestor, Yersinia pseudotuberc

65 Yersina pestis, the bubonic plague bacterium, is coated with a polymeric protein hyd

66 A common issue plaguing battery anodes is the large consumption of lith

67 Emphasis is given to plague because of the considerable number of studies gen

68 of 2-component regulatory systems (2CSs) in plague because the latter are known to be key players in

69 t Y. pestis was capable of causing pneumonic plague before it evolved to optimally cause invasive inf

70 Yersinia pestis, the causative agent of plague, binds host cells to deliver cytotoxic Yop protei

71 B resolves many of the issues that routinely plague biomedical researchers intending to work with dat

72 component of T cell-mediated defense against plague but can be dispensable for Ab-mediated defense.

73 ponent for the integrated management of both plagues, but local eradication successes have been limit

74 Physicians who understood plague by its classic features, however, contested Novy'

75 of all-solid-state rechargeable batteries is plagued by a large interfacial resistance between a soli

76 Nevertheless, such formulations have been plagued by a local acidic microenvironment and protein-p

77 usly been limited to low synthesis rates and plagued by an unidentified deactivation pathway.

78 Unfortunately, tree ring analysis can be plagued by biases, resulting in spurious growth trends.

79 tient population which tends to be older and plagued by comorbidities such as diabetes mellitus and h

80 daveric biologic mesh has been expensive and plagued by complications such as seroma, infection, and

81 However, these efforts are plagued by conceptual difficulties derived from disparat

82 We report that the current evidence base is plagued by considerable methodologic heterogeneity in al

83 increase cardiac output, their use has been plagued by excessive mortality due to increased tachycar

84 he computational and statistical methods are plagued by fundamental identifiability issues, instabili

85 However, the field has been plagued by heterogeneity in the distributions of synthes

86 of diffuse large B-cell lymphoma (DLBCL) is plagued by heterogeneous responses to standard therapy,

87 h comparative genomics has consistently been plagued by high false-positive rates and divergent predi

88 ever, the current Ag-NW thin films are often plagued by high NW-NW contact resistance and poor long-t

89 The target article is plagued by imprecision, making it largely impossible to

90 ired cell types using this approach is often plagued by inefficiency, slow conversion, and an inabili

91 d structure formation even for small RNAs is plagued by intractably large state spaces.

92 nsity and long operation lifetimes, they are plagued by limited energy density.

93 In practice, cell performance is plagued by low practical capacity and poor cycling.

94 However, their use is plagued by major side effects, such as a loss of pain-re

95 However, their use is plagued by major side effects, such as analgesic toleran

96 ensely popular methodology, which is however plagued by mathematical intractability.

97 bility, and sensitivity of those systems are plagued by network leakage.

98 ct DNA and RNA (collectively xNA) are easily plagued by noise, false positives, and false negatives,

99 The literature on tumor markers is plagued by nonpublication bias, selective reporting, and

100 applicable to several other material systems plagued by polydispersity, defects, and grain boundary r

101 However, their application is plagued by poor chemical and structural stability.

102 ic vehicle operations, but their adoption is plagued by poor cycle life due to the structural and che

103 p polymeric alternatives, however, have been plagued by poor retention and off-target toxicity due to

104 d work has been reported on Mg/S system, all plagued by poor reversibility attributed to the formatio

105 wever, conventional transgenesis methods are plagued by position effects: the regulatory environment

106 he most important antibiotic classes but are plagued by problems of resistance, and the development o

107 use analyses based on observational data are plagued by problems of reverse causation and self-select

108 often rely on statistical phylogenetic tests plagued by profound flaws.

109 ardiac performance after such treatments are plagued by relatively low detection ability.

110 ailable for only half of all studies and are plagued by selective reporting of methods and results.

111 Doing so at the nanoscale has thus far been plagued by significant scalability problems, particularl

112 ct outcomes of mitral regurgitation (MR) are plagued by small size, inconsistent etiologies, and lack

113 Until now PCCT has been plagued by strong artifacts when dense materials like bo

114 Such markets are plagued by strong incentives for fraudulent behavior of

115 ncluding hop (Humulus lupulus) are routinely plagued by T. urticae infestations.

116 The current status of CCS is that it is plagued by technical uncertainties, infrastructure, fina

117 a combination of BRAF and MEK inhibitors is plagued by the development of drug resistance.

118 quest for catalyst optimization in vitro is plagued by the elusive description of the active sites o

119 opment of a competitive magnesium battery is plagued by the existing notion of poor magnesium mobilit

120 ses in a field of inquiry that has been long plagued by the limited availability of research specimen

121 Current treatment options are plagued by toxicity, lengthy treatment regimens, and gro

122 roteins in heterogeneous media are generally plagued by two distinct obstacles: lack of sensitivity d

123 ersion of one amide to another, is typically plagued by unfavourable kinetic and thermodynamic factor

124 One human plague case was reported in Oregon in September 2010 and

125 etermined the geographic pattern of sporadic plague cases.

126 Host survival during plague, caused by the Gram-negative bacterium Yersinia p

127 nsequently, several pathogens, including the plague causing bacterium Yersinia pestis, avoid activati

128 Two fundamental challenges plague clinical translation of vaccine-adjuvants: reduci

129 izing on extensive archival data from Indian Plague Commission investigations.

130 ate side-effects and proarrhythmic potential plaguing CPVT pharmacological management today.

131 The species of weeds that plague crops today are a consequence of the historical p

132 s that may bridge zoonotic and anthroponotic plague cycles.

133 the cost of quality control of manufacturing plague development of Li-ion rechargeable batteries that

134 Plague develops as a consequence of bacterial neutraliza

135 ociated with bacteremia or those relevant to plague diagnosis.

136 biologically relevant i.d. model of bubonic plague differs significantly from the s.c. model in mult

137 mely high-prevalence outbreak (61%) of white-plague disease at 14 sites off southeastern Florida.

138 a annularis corals during a concurrent white plague disease outbreak and bleaching event.

139 White-plague disease was observed near Virginia Key, Florida,

140 is causes bubonic, pneumonic, and septicemic plague, diseases that are rapidly lethal to most mammals

141 One problem plaguing drug development efforts is the lack of a suita

142 highlighted a significant role for pneumonic plague during outbreaks of Y. pestis infections.

143 atical model coupling environmentally forced plague dynamics with evolutionary selection of rats, cap

144 3 and 4 pathogens, such as anthrax, bubonic plague, Ebola and Marburg fever.

145 climate fluctuations that preceded regional plague epidemics, based on a dataset of 7,711 georeferen

146 g commensal rats of cities undergoing severe plague epidemics.

147 Yersinia pestis, the causative agent of plague, evolved from the gastrointestinal pathogen Yersi

148 Yersinia pestis, the causative agent of plague, expresses the plasminogen activator protease Pla

149 Potential and limitations of inferring plague foci and dynamics using epidemiological data is d

150 en due to either the presence of now-extinct plague foci in Europe itself, or successive disease intr

151 e ports indicates the absence of a permanent plague focus in the inland areas of Europe.

152 e of a previously uncharacterized historical plague focus that persisted for at least three centuries

153 we describe the characteristics of pneumonic plague, focusing on its disease progression and pathogen

154 Yersinia pestis, the cause of the disease plague, forms biofilms to enhance flea-to-mammal transmi

155 s from one of the last European outbreaks of plague, from 1722 in Marseille, France.

156 from Yersinia pestis, the causative agent of plague, from the closely related species Y. pseudotuberc

157 The economic crisis plaguing Greece was expected to impact consumption of ph

158 Importantly, recent epidemics of plague have highlighted a significant role for pneumonic

159 Recently developed in vivo models of plague have resulted in new ideas regarding bacterial sp

160 The debilitating choreic movements that plague HD patients have been attributed to striatal dege

161 es a fundamental problem that has previously plagued high-resolution Raman spectroscopy: fine spectra

162 verity, and difficulty of treating pneumonic plague highlight how differences in the route of disease

163 s essential for the development of pneumonic plague; however, the complete repertoire of substrates c

164 tolerable burden of malaria has for too long plagued humanity and the prospect of eradicating malaria

165 ost successful parasites, many of which have plagued humans throughout our history.

166 many of the practical limitations that have plagued hydrogen-bond donor catalysis and enables use of

167 in colonial India after the introduction of plague in 1896 suggest that, only a decade after plague

168 attenuated Y. pestis CO92 to evoke pneumonic plague in a mouse model while retaining the required imm

169 nuated in evoking both bubonic and pneumonic plague in a mouse model.

170 The data suggest that T cells combat plague in conjunction with neutrophils, which require he

171 been responsible for the many resurgences of plague in Europe following the Black Death.

172 trade routes were to blame for the spread of plague in European history, yet this relationship has ne

173 Yersinia, including Y. pestis, the agent of plague in humans, and Y. pseudotuberculosis, the related

174 ght ill-prepared societies off-guard-Bubonic plague in medieval times, AIDS in the 1980s, and Ebola t

175 ient sources, contributing to maintenance of plague in nature.

176 e routes played a dominant role in spreading plague in pre-industrial Europe.

177 specimen and Yersinia pestis ("Black Death" plague) in a medieval tooth, which represented only minu

178 oted strains of Y. pestis to cause pneumonic plague, indicating that Y. pestis was primed to infect t

179 biofilm in the foregut of fleas that feed on plague-infected animals or humans.

180 ic (subcutaneous) and pneumonic (intranasal) plague infection models.

181 Our results show that plague infection was endemic in the human populations of

182 Pneumonic plague is a deadly respiratory disease caused by Yersini

183 The 1900 San Francisco plague is a significant event in which citizens, physici

184 Plague is initiated by Yersinia pestis, a highly virulen

185 Pneumonic plague is the most severe manifestation of plague, with

186 The hallmark of bubonic plague is the presence of grotesquely swollen lymph node

187 Plague is transmitted by fleas or contaminated aerosols.

188 Yersinia pestis, the etiologic agent of plague, is a bacterium associated with wild rodents and

189 e of Yersinia pestis, the bacterial agent of plague, is a recent evolutionary adaptation.

190 Yersinia pestis, the causative agent of plague, is able to suppress production of inflammatory c

191 bacteria Yersinia pestis, causative agent of plague, is extremely virulent.

192 sample-to-sample variability that typically plagues MALDI-TOF, and is the first method developed to

193 Although high optical losses still plague many approaches, phonon polariton (PhP) materials

194 e the contexts of official wars continues to plague many parts of the world.

195 light on the practical limitations that have plagued many of the H-bond donor-catalyzed reactions dev

196 Indiscriminate antimicrobial use has plagued medicine since antibiotics were first introduced

197 estis, H. influenzae, and Proteus that cause plague, meningitis, and severe wound infections, respect

198 y pan-drug resistant Acinetobacter baumannii plague military and civilian healthcare systems.

199 to 100% survivability to mice in a pneumonic plague model at 20 to 50 LD50.

200 tant was still fully virulent in a pneumonic plague model but had an approximately 90-fold increase i

201 p or DeltamsbB single mutant, in a pneumonic plague model were significantly protected against a subs

202 In the murine plague model, TLR7 was a significant contributor to the

203 the Yfe(+) Feo(+) parent strain in a bubonic plague model.

204 Cardiotoxicity is a side effect that plagues modern drug design and is very often due to the

205 uated (40 to 100%) at 12 LD50 in a pneumonic plague mouse model.

206 pment of a lethal infection in a septicaemic plague mouse model.

207 If low statistical power plagues neuroscience, then this reduces confidence in th

208 Thick haze plagued northeastern China in January 2013, strongly aff

209 f this critical point and the "sign problem" plaguing numerical quantum Monte Carlo (QMC) methods, it

210 ted understanding of the first pandemic, the Plague of Justinian (6-8th centuries).

211 e that the Y pestis lineages that caused the Plague of Justinian and the Black Death 800 years later

212 it was responsible for three pandemics: the Plague of Justinian in the 6(th) century AD, which persi

213 ublic health officials denied a diagnosis of plague on economic, political, and social grounds.

214 s when regeneration by mature hepatocytes is plagued or impaired.

215 tion of individuals with suspected smallpox, plague, or cholera.

216 lusions from RADseq data, a problem that has plagued other genetic marker types in the past.

217 ess that Pothos & Busemeyer (P&B) discuss as plaguing other models.

218 esultant lack of biochemical specificity has plagued our understanding of how biological electrophile

219 In particular, it plagues our ability to acquire, process, and model high-

220 Major trade routes decided the major plague outbreak hotspots, while navigable rivers determi

221 y modern period and the 6,656 geo-referenced plague outbreak records in AD1347-1760.

222 a dataset of 7,711 georeferenced historical plague outbreaks and 15 annually resolved tree-ring reco

223 Increased plague outbreaks and political conflicts, as well as dec

224 urthermore, the negative correlation between plague outbreaks and their distance from major trade por

225 es that may improve patient prognosis during plague outbreaks.

226 hereby avoiding decomposition reactions that plague oxidations of neutral cerium(III) compounds.

227 This epidemic marked the start of the second plague pandemic, which lasted in Europe until the early

228 sinia pestis has caused at least three human plague pandemics.

229 storical consequences as manifested by human plague pandemics.

230 lower ends of the height spectrum that have plagued past IBW equations.

231 A case study in Germany indicates that plague penetrated further into Europe through the local

232 fection supports innate host defense against plague, perhaps by providing a nondiffusible spatial cue

233 ) to address mispriming issues that commonly plague poly(A) site (pA) identification, and we used the

234 Plague presents an optimal system for interrogating such

235 ific insight into paleoviral infections that plagued primates deep in their evolutionary history.

236 ous cycle of tumor-stromal interactions that plagues prostate cancer patients.

237 sts, Yersinia pestis, the causative agent of plague, replicates as biofilm in the foregut of fleas th

238 Pneumonic plague represents the most severe form of disease caused

239 ds no support for the existence of permanent plague reservoirs in medieval Europe.

240 To locate these putative plague reservoirs, we studied the climate fluctuations t

241 Incorporating increased plague resistance among rats as a consequence of intense

242 lution based on experimental observations of plague resistance and reveal the buffering effect of suc

243 this study, we have further delineated this plague resistance locus to a region of less than 20 cM t

244 This programming plays a key role in the plague-resistance phenotype and may be similarly signifi

245 a decade after plague arrived, a heritable, plague-resistant phenotype had become prevalent among co

246 The reasons for plague's persistence and abrupt disappearance in Europe

247 ale food-borne illnesses, dysentery, bubonic plague, secondary hospital infections, and sexually tran

248 Together with plague, smallpox and typhus, epidemics of dysentery have

249 racterized by severe epidemic events such as plague, smallpox, or influenza that shaped the immune sy

250 cing the genomes, we find that these ancient plague strains are basal to all known Yersinia pestis.

251 the parasitic redox shuttle mechanism, that plagues sulfur-based electrode chemistries.

252 Yet, statistical artifacts commonly plague the analysis of relative abundance data.

253 tion Agreement, illegal logging continues to plague the region.

254 The problem of fraud continues to plague the wine industry, and detecting cases where the

255 fundamental catalytic limitations that have plagued the electrochemical production of hydrogen for d

256 ates and sequence composition bias have long plagued the mitochondrial phylogenetics.

257 One technical issue that has always plagued the post-processing of Illumina genotyping array

258 The main limitation plaguing the broader applicability of TDA is the lack of

259 A long-standing problem plaguing the field of transition metal catalyzed C-H fun

260 be achieved only if the systemic challenges plaguing the health system (poor coverage of early infan

261 tions is representative of systemic problems plaguing the regulation of chemicals in food.

262 e WT bacterium in a mouse model of pneumonic plague, the Deltalpp Deltaail double mutant and the Delt

263 dification is unnecessary to cause pneumonic plague, the substitution is instead needed to efficientl

264 long-ranged electrostatic interactions have plagued theory and simulation alike.

265 addition to the risk of natural exposure to plague, there is also the threat of a bioterrorist act,

266 DA-CuCN avoids polymerization that otherwise plagues these alkylations and generates a reactive metal

267 The Yersinia-flea interactions that enable plague transmission cycles have had profound historical

268 ion that is important for blockage-dependent plague transmission from fleas to mammals.

269 on our findings, we propose the mechanism of plague transmission in historical Europe, which is imper

270 conducting on wildlife infectious diseases: plague transmission in prairie dogs and lyssavirus dynam

271 posttranscriptional regulatory mechanisms in plague transmission.

272 s diseases of historical importance, such as plague, tuberculosis, and leprosy.

273 am-negative bacteria, including purveyors of plague, typhoid fever, whooping cough, sexually transmit

274 lored include tuberculosis, leprosy, bubonic plague, typhoid, syphilis, endemic and epidemic typhus,

275 hermal oxidation and corrosion problems that plague unprotected metal meshes, while also maintaining

276 finding solutions to the problems that have plagued us for centuries.

277 Yersinia pestis, the causative agent of plague, uses a type III secretion system (T3SS) to injec

278 Yersinia pestis, the causative agent of plague, utilizes a type III secretion system (T3SS) to i

279 Mice delivered with a single dose of F1-V plague vaccine containing both gene and protein in the T

280 ar Typhi strain to create a bivalent mucosal plague vaccine that produces both the protective F1 caps

281 tested and developed into a live attenuated plague vaccine(s).

282 but should not be exposed to live-attenuated plague vaccines.

283 Novy showed plague was present in the city but without its character

284 nce in mouse models of bubonic and pneumonic plague, we characterized an msbB in-frame deletion mutan

285 n providing the host with protection against plague, we developed a live-attenuated vaccine strain by

286 allergy, i.e., asthma and allergic rhinitis, plaguing westernized countries, with up to 8% of young c

287 ificant oral toxicity to the flea vectors of plague, whereas Y. pestis does not.

288 Conventional chemotherapy is plagued with adverse side effects because cancer treatme

289 versity remains methodically challenging and plagued with biases.

290 traditional biochemical fractionation can be plagued with contaminants and loss of key components.

291 ratios, up to 30:1 (over-labeling), normally plagued with energy migration and background fluorescenc

292 try and single-cell RNA-seq (scRNA-seq), are plagued with systematic errors that may severely affect

293 hough many are prone to radiation damage and plagued with temperature instabilities.

294 LD50 when tested in a mouse model of bubonic plague, with infection by 10/20 of the aforementioned mu

295 c plague is the most severe manifestation of plague, with mortality rates approaching 100% in the abs

296 trol malaria, typhus, body lice, and bubonic plague worldwide, until countries began restricting its

297 Flea-borne zoonoses such as plague (Yersinia pestis) and murine typhus (Rickettsia t

298 he catastrophic European Black Death/bubonic plague (Yersinia pestis).

299 The etiologic agent of bubonic plague, Yersinia pestis, senses self-produced, secreted

300 ns such as the Yersinia pestis, which causes plague, Yersinia pseudotuberculosis, Yersinia enterocoli