ライフサイエンスコーパス: plakin

1 kin domain, which is a common feature of the plakins.

2 re mediated through different domains on the plakins.

3 unique epitopes in the tail domains of these plakins.

4 This is the first reported mutation of desmo-plakin and also the first inherited skin disorder in whi

5 tra exons encoding a second IFBD between the plakin and SR-containing rod domains of BPAG1-a.

6 mmary, proteomic analysis of uEVs identified plakins and complement as disease-associated proteins in

7 The interactions between plakins and components of specialized cell junctions suc

8 l actin binding proteins that are related to plakins and dystrophin and expressed in axons during dev

9 With similarities to both plakins and spectrins, trabeculin-alpha appears to have

10 Plakins are cytoskeletal linker proteins initially thoug

11 Plakins are large multi-domain proteins that interconnec

12 The plakins are multi-domain proteins that have been shown t

13 ctin binding domains; regions of homology to plakins at either end of the giant polypeptide; 29 copie

14 Most plakins contain a plakin domain formed by up to nine spe

15 -spectrin, suggesting that the SH3 domain of plakins contributes to the stability and rigidity of thi

16 ural and mechanistic insights into an entire plakin domain and provides a basis for understanding the

17 mino-acid N-terminal region of DP contains a plakin domain common to members of the plakin family.

18 Most plakins contain a plakin domain formed by up to nine spectrin repeats (SR1

19 ay scattering analysis shows that the entire plakin domain has an "L" shape, with a long arm and a sh

20 specific interactions with plakoglobin, the plakin domain of desmoplakin, plakophilin 1, and the cyt

21 ing (SAXS) to elucidate the structure of the plakin domain of plectin, extending our previous analysi

22 ins include an actin-binding domain (ABD), a plakin domain, a coiled coil (CC) rod domain, two differ

23 elucidate the architecture of desmoplakin's plakin domain, as well as its constituent tandem SRs.

24 een described previously and consists of the plakin domain, the CC rod domain, and the first IFBD.

25 BPAG1-a is composed of the ABD, the plakin domain, the SR-containing rod domain, and the MTB

26 esmosomes are mediated through the so-called plakin domain, which is a common feature of the plakins.

27 roteins, and spans what has been termed the "plakin domain," which includes residues 180-1022 and con

28 e regulates the interaction with the plectin plakin domain.

29 defined by limited proteolysis of the whole plakin domain.

30 Plakin domains contain multiple copies of spectrin repea

31 rvation, we propose that the architecture of plakin domains is defined by two pairs of spectrin repea

32 ontinuous versus segmented structures of the plakin domains of plectin and desmoplakin give insight i

33 The plakin domains of plectin and other plakins harbor bindi

34 -SR9 region, which is conserved in all other plakin domains, forms a rigid segment stabilized by uniq

35 actor 1, are likely to have similar extended plakin domains.

36 The plakin family member periplakin, identified in yeast two

37 Plakin family members envoplakin and periplakin have bee

38 Together this reveals how plakin family members form dynamic linkages with cytoske

39 oteins of the homologous tail region of five plakin family members, including the recently cloned per

40 ntibodies against unique epitopes in various plakin family members.

41 BPAG1 is a member of the plakin family of cytolinker proteins.

42 Periplakin is a member of the plakin family of cytolinkers that connect cytoskeletal n

43 -like repeats may enable some members of the plakin family of cytolinkers to laterally bind and stabi

44 1-e, also known as BP230) is a member of the plakin family of hemidesmosome cytoskeletal linker prote

45 ology to envoplakin and other members of the plakin family of intermediate filament connector molecul

46 far as autoantigens in PNP all belong to the plakin family of proteins and include desmoplakin, the 2

47 The members of the plakin family of proteins serve as epidermal cytolinkers

48 Periplakin, a member of the plakin family of proteins, has been recently characteriz

49 d that the 195-kD protein is a member of the plakin family of proteins, to which envoplakin, desmopla

50 phigoid antigen 1 (BPAG1) is a member of the plakin family of proteins.

51 This novel member of the plakin family was designated periplakin.

52 phigoid antigen 1 (BPAG1) is a member of the plakin family with cytoskeletal linker properties.

53 omes belong to the cadherin superfamily, the plakin family, and the armadillo repeat protein family.

54 ins a plakin domain common to members of the plakin family.

55 s in PPL being consistent with that of other plakin genes: 21 small exons, separated by large introns

56 ammalian orthologue of the Drosophila kakapo plakin genetically involved in epidermal-muscle adhesion

57 The plakin domains of plectin and other plakins harbor binding sites for junctional proteins.

58 While ACF7/kakapo is divergent from other plakins in its IF-binding domain, it has at least one ac

59 homologous region in the carboxy-terminus of plakins, including the newly characterized periplakin, s

60 Together, plakin, integrin, and hemicentin are founding components

61 ntains a putative actin-binding domain and a plakin-like domain that are highly homologous to dystoni

62 desmoplakin give insight into how different plakins might respond to tension and transmit mechanical

63 ciency in beta4 integrin or knockdown of the plakin protein Bullous Pemphigoid Antigen 1e (BPAG1e).

64 The plakin protein family serves to connect cell-cell and ce

65 ypothesis that the beta4 integrin-associated plakin protein, bullous pemphigoid antigen 1e (BPAG1e) f

66 ding SR is also observed in plectin, another plakin protein, but not in alpha-spectrin, suggesting th

67 Plakin proteins form critical connections between cell j

68 esmosomal proteins, is found in a variety of plakin proteins, and spans what has been termed the "pla

69 Envoplakin has a single plakin repeat domain (PRD) which recognizes intermediate

70 We find that the plakin repeats are inserted between the actin-binding do

71 in the shot locus, which encodes a series of plakin repeats similar to the COOH terminus of plakins s

72 emble an associated track of F-actin and the plakin Short Stop (shot).

73 akin repeats similar to the COOH terminus of plakins such as plectin and BPAG1e.

74 Other plakins, such as bullous pemphigoid antigen 1 and microt

75 ms with characteristics of both spectrin and plakin superfamilies.

76 Immunoblotting of equal amounts of each plakin tail-glutathione S-transferase fusion protein wit

77 contains F-actin, microtubules, and Shot, a plakin that binds F-actin and microtubules.

78 Plectin is a prototypical plakin that tethers intermediate filaments to membrane-a

79 we identify the integrin-binding cytolinker plakin (VAB-10A) and integrin (INA-1/PAT-3) as key BM-BM