ライフサイエンスコーパス: plant sterol

1 als but is a key step in the biosynthesis of plant sterols.

2 hereditary phytosterolemia and were rich in plant sterols.

3 erol absorption because it is independent of plant sterols.

4 ABCG5/G8 knockout mice a diet enriched with plant sterols.

5 absorption and promote excretion of dietary plant sterols.

6 f odds (LOD) score of 9.9, designated plasma plant sterol 14 (Plast14).

7 supplementation with orange juice containing plant sterols (2 g/d) significantly reduced LDL choleste

8 -binding cassette transporters G5/8 regulate plant sterol absorption and also the secretion into bile

9 The aim of this study was to examine whether plant sterols affect CRP concentrations and the lipoprot

10 y sterols and decreased hepatic excretion of plant sterols and cholesterol.

11 Eskimo woman had consumed a diet very low in plant sterols and moderate to low in cholesterol content

12 ol absorption is a selective process in that plant sterols and other non-cholesterol sterols are abso

13 by very high levels of sitosterol and other plant sterols and premature atherothrombotic vascular di

14 itro and ex vivo studies have suggested that plant sterols and stanols can shift the T helper (Th) 1/

15 Plant sterols and steroid hormones, the brassinosteroids

16 micronutrients such as copper and magnesium, plant sterols, and phytochemicals.

17 e these new data support the conclusion that plant sterols are excluded from the body because they ar

18 In contrast, plant sterols are relatively poorly esterified by ACAT,

19 It is not known why plant sterols are so assiduously excluded from the body.

20 Plant sterols are structural components of cell membrane

21 Plant sterols are synthesized via the isoprenoid pathway

22 -400 mg of non-cholesterol sterols, of which plant sterols are the major constituents.

23 timibe inhibits the intestinal absorption of plant sterols as well as cholesterol, leading to reducti

24 omplex (G5G8) that opposes the absorption of plant sterols but is also expressed in liver where it pr

25 d hepatobiliary secretion of cholesterol and plant sterols by 1.5-2-fold, increased the amount of int

26 The reason for poor absorption of plant sterols by the body is still unknown.

27 altered substrate specificity: transport of plant sterols by the heterodimer was preserved, whereas

28 Respectively, cholestanol/cholesterol and plant sterols campesterol/cholesterol and sitosterol/cho

29 One theory holds that plant sterols can directly promote atherosclerosis, but

30 The side chain in plant sterols can have either a methyl or ethyl addition

31 ificant and progressive reductions in plasma plant sterol concentrations in patients with sitosterole

32 effective in milligram doses, lowers plasma plant sterol concentrations in sitosterolemic subjects,

33 Serum plant sterol concentrations increased from baseline (0.4

34 Reductions in plant sterol concentrations were similar irrespective of

35 complexity of grapevine, we investigated the plant sterol content of berry and seed tissues at pre-ve

36 phenolics, carotenoids, coumarins, saponins, plant sterols, curcumins, and phthalides have been ident

37 mo ligands previously identified include the plant sterol cyclopamine (and its therapeutically useful

38 the output of Americans consuming 250-400 mg plant sterols/d.

39 n Abcg5- and Abcg8-deficient mice fed a high plant sterol diet resulted in accumulation of free stero

40 These data indicate that selected dietary plant sterols disrupt cholesterol homeostasis by affecti

41 results are discussed within the context of plant sterol distribution and metabolism.

42 However, plant sterols do not exchange with UC and are secreted i

43 ied the degradation of cholesterol and three plant sterols during a 360 min heating treatment (180 de

44 e demonstrate that both stereoisomers of the plant sterol, (E)- and (Z)-GS, bind to the steroid recep

45 Dietary plant sterols effectively reduce LDL cholesterol when in

46 The interest in plant sterols enriched foods has recently enhanced due t

47 Plant sterol-enriched functional foods are widely used f

48 f stearidonic acid (SDA) and 0.65 g/100mL of plant sterol esters (PSE) were prepared without or with

49 A reduced-fat spread containing plant sterol esters incorporated into a low-fat diet is

50 Plant sterol esters reduce cholesterol absorption and lo

51 type (WT) littermates were challenged with a plant sterol-free low fat or high fat (HF) diet.

52 p promoting active efflux of cholesterol and plant sterols from enterocytes back into the intestinal

53 heterodimer that transports cholesterol and plant sterols from hepatocytes into bile.

54 e appear to hyperabsorb both cholesterol and plant sterols from the intestine.

55 The plant sterol guggulsterone (GS) is the active agent in t

56 The plant sterol guggulsterone [4,17(20)-pregnadiene-3,16-di

57 ults for the first time demonstrate that the plant sterol guggulsterone suppresses ocular inflammatio

58 either VLDL or LDL there was no increase in plant sterols in bile, but with perfusion of HDL, the se

59 and G8 are known to cause an accumulation of plant sterols in blood and tissues (sitosterolemia).

60 Plasma plant sterols in F(2)s displayed a unimodal distribution

61 ped a phenotype that included high levels of plant sterols in many tissues, liver abnormalities, and

62 Here we show that accumulation of plant sterols in mice lacking ABCG5 and ABCG8 (G5G8-/- m

63 up to 27%, and decreased the accumulation of plant sterols in plasma by approximately 25%.

64 protect against the accumulation of dietary plant sterols in plasma.

65 There was a significant accumulation of plant sterols in the brains of the Pdgfb(ret/ret) mice.

66 in which patients accumulate cholesterol and plant sterols in the circulation and develop premature C

67 s with this disease have very high levels of plant sterols in the plasma and develop tendon and tuber

68 s with this disease have very high levels of plant sterols in the plasma, and develop tendon and tube

69 Increased serum concentrations of plant sterols, including stigmasterol, during parenteral

70 Intercalation of plant sterols into the plasma membrane therefore results

71 ced-calorie orange juice beverage containing plant sterols is effective in reducing CRP and LDL chole

72 hich serve numerous biochemical functions in plants: sterols (isoprenoids with a C30 backbone) are es

73 nd ABO have been associated with circulating plant sterol levels and CVD, thereby suggesting atheroge

74 from this disease have very elevated plasma plant sterol levels and develop tendon and tuberous xant

75 er genes besides ABCG5ABCG8 influence plasma plant sterol levels and now become candidates to explain

76 candidates to explain differences in plasma plant sterol levels between humans.

77 Plasma plant sterol levels differ among humans due to genetic a

78 inhibitor of cholesterol absorption, reduces plant sterol levels in patients with sitosterolemia.

79 cross between F(1)s was performed and plasma plant sterol levels measured in 102 male and 99 female F

80 take yields a 2-fold increase in circulating plant sterol levels that equally represent markers of ch

81 A disease characterized by high plasma plant sterol levels, beta-sitosterolemia, was recently f

82 analysis of these mutants has revealed that plant sterols may be key signaling molecules influencing

83 evated cholesterol absorption rather than by plant sterols may therefore mediate the relationships of

84 no acid identity to recently isolated higher-plant sterol methyltransferases from soybean and Arabido

85 anges, we examined the effects of individual plant sterols on cholesterol metabolism in cultured adre

86 there is a paucity of data on the effect of plant sterols on CRP concentrations.

87 study evaluated the influence of esterified plant sterols on serum lipid concentrations in adults wi

88 D, thereby suggesting atherogenic effects of plant sterols or of cholesterol uptake.

89 Plant sterols, or phytosterols, are very similar in stru

90 The plant sterol output in the coprolite was only 0.4% of th

91 Plant sterols (phytosterols) and the drug ezetimibe redu

92 In plants, sterols play fundamental roles as membrane const

93 We analyzed plasma plant sterol (PPS) levels, a surrogate measure of choles

94 Cholestanol and plant sterols provide a measure of cholesterol absorptio

95 Plant sterol (PS) oxidation products (POP) derived from

96 Plant sterol (PS) supplementation is increasingly accept

97 Three plant sterol (PS)-enriched beverages, milk based fruit j

98 Benefits of plant sterols (PS) for cholesterol lowering are compromi

99 letate and linolenate) on a mixture of three plant sterols (PS: campesterol, stigmasterol and beta-si

100 The benefits of plant sterols (PSs) for cholesterol lowering are hampere

101 Plant sterols (PSs) lower LDL cholesterol, an establishe

102 inal domain similar in sequence to yeast and plant sterol reductases.

103 porter cause accumulation of cholesterol and plant sterols, resulting in premature coronary atheroscl

104 To determine which plant sterol(s) caused the metabolic changes, we examine

105 However, biliary plant sterol secretion was markedly different: with the

106 Using the unesterified plant sterol, sitostanol (SIT), as a nonexchangeable ana

107 CAT) 2 to differentiate cholesterol from the plant sterol, sitosterol, was compared with that of the

108 surrogate markers of cholesterol absorption (plant sterols: sitosterol, campesterol) and synthesis (c

109 l-related molecules (cholesterol precursors, plant sterols, some oxysterols, cholesterol sulfate, cho

110 The major plant sterol species is sitosterol; hence the name of th

111 ools of cholesterol and very elevated plasma plant-sterol species and frequently develop tendon and t

112 Serum plant sterols (stigmasterol, avenasterol, sitosterol, an

113 Phytosterols are plant sterols structurally similar to cholesterol that a

114 lemented by exogenous stigmasterol, the main plant sterol, suggesting that sterols are required for T

115 Plant sterol supplementation produces minimal increases

116 sterols but seems to have lower affinity to plant sterols than cholesterol.

117 similarly large for each of three individual plant sterols that was tracked.

118 The ratio of plasma campesterol (a plant sterol) to lathosterol (a cholesterol precursor) w

119 lacebo Bev) or with (1 g/240 mL; Sterol Bev) plant sterols twice a day with meals for 8 wk.

120 The increase in biliary plant sterols was detected 5-10 min after HDL was added

121 but with perfusion of HDL, the secretion of plant sterols was increased two- to threefold (P = 0.000

122 Serum plant sterols were higher in patients who were currently

123 In Sr-bI/Abcg5 dko plasma plant sterols were highest, while hepatic plant sterols

124 ma plant sterols were highest, while hepatic plant sterols were lower compared with Abcg5 ko (P < 0.0

125 lating perfusions, hepatic concentrations of plant sterols were not different after different lipopro

126 ease in the fractional absorption of dietary plant sterols, which was associated with an approximatel