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1 0 and increased follicle-stimulating hormone plasma concentration.
2 not necessarily lead to high in vivo unbound plasma concentration.
3 on of erlotinib, without affecting erlotinib plasma concentration.
4 ection when reaching or exceeding a critical plasma concentration.
5 fluorescein angiography, CBCs, and melphalan plasma concentration.
6 with i.v. delivery with substantially lower plasma concentrations.
7 diet diary estimates of vitamin C intake and plasma concentrations.
8 n elevation of IL13 levels and decreased IL6 plasma concentrations.
9 ite all subjects achieving target nifedipine plasma concentrations.
10 s to be below the level of human therapeutic plasma concentrations.
11 ing outcomes were correlated with dabigatran plasma concentrations.
12 s experienced potentially toxic piperacillin plasma concentrations.
13 asing fatty acid chain length and the target plasma concentrations (0.5-1.0ng/mL over a month-long pe
14 n glucuronide reach peak nanomolar per liter plasma concentrations 1.6-2.3 h after intake, indicating
15 ile the zeolite nanoparticles exposed to low plasma concentration (10%) exhibited a high selective ad
17 up displayed marked increases in DHA and EPA plasma concentrations (2.6- and 3.5-fold), as well as de
18 nd a pharmacokinetics study documents a peak plasma concentration 30 min after dosing, with the agent
20 splant center (n = 211) confirmed that CXCL9 plasma concentrations above the median were associated w
24 recommended dose of 1500 mg BID may achieve plasma concentrations adequate to treat TE in HIV-infect
25 mine rifampicin, isoniazid, and pyrazinamide plasma concentrations after 7-8 weeks of therapy, and PK
27 n had minimal impact on DRV maximum observed plasma concentration and area under the curve; DRV Ctrou
31 rmally cleared by tubular secretion with the plasma concentrations and clearance rates of urea and cr
32 tal muscle in relation to dietary intake and plasma concentrations and compared this relation with as
33 oncentrations in CSF were similar to unbound plasma concentrations and exceeded the in vitro 50% inhi
34 roprotein convertase subtilisin/kexin type 9 plasma concentrations and fatty acid compositions did no
35 We generated a qAOP network based on drug plasma concentrations and focused on immunodepression, s
36 ely correlated with proinflammatory cytokine plasma concentrations and had lower surface IgG levels t
38 us Abdominis Plane blocks can result in high plasma concentrations and local anesthetic systemic toxi
39 een brain-derived neurotrophic factor (BDNF) plasma concentrations and the BDNF Val66Met nucleotide p
41 tential, binding potential relative to total plasma concentration, and binding potential relative to
43 nsic clearance leads to high in vivo unbound plasma concentration, and low efflux transport activity
44 circulating ghrelin levels, increased GLP-1 plasma concentration, and remodeling of gut microbiome d
45 Concomitant LPV/r use markedly increased TFV plasma concentrations, and AUC0-48 h was 67% higher with
46 tigate the impact of ticagrelor on adenosine plasma concentration (APC) in acute coronary syndrome (A
47 we introduce the "cortisol equivalents fish plasma concentration" approach, through which an increas
51 ELISA and INAA we report the half-life, peak plasma concentrations, area under the curve, ability to
52 well as 2) pretreatment tHcy and 3) albumin plasma concentrations as being significant contributors
53 that accounted well for the time profiles of plasma concentrations as well as effects on tremor sever
54 l dosing guided by pharmacokinetics achieved plasma concentrations associated with improved cardiac f
55 he plasma concentration-time curve (AUC) and plasma concentration at 12 hours after intake (C12h) pla
57 e more likely to have detectable piperaquine plasma concentrations at baseline compared with non-recr
59 tion, and binding potential relative to free plasma concentration: BPND, BPP, BPF, respectively).
60 fenamide is a prodrug that reduces tenofovir plasma concentrations by 90% compared with tenofovir dis
61 vel tenofovir prodrug that reduces tenofovir plasma concentrations by 90%, thereby decreasing off-tar
63 ed in a significant increase in mean maximum plasma concentration (C max ), elimination half-life and
64 ntration-time curve (AUC)(0-12h) and maximum plasma concentration (C(max)) for raltegravir + boceprev
66 of the study through a comparison of maximum plasma concentration (Cmax) and area under the concentra
68 o free lutein, PLGA-NP increased the maximal plasma concentration (Cmax) and area under the time-conc
70 on versus time curve (AUC), maximum observed plasma concentration (Cmax), and time above a threshold
71 id (63% and 70% lower geometric mean maximum plasma concentration [Cmax] and 77% and 82% lower AUC0-t
72 ion modeling, the egg intervention increased plasma concentrations compared with control by the follo
76 proximately 5 muM) approximating its unbound plasma concentration (determined by equilibrium dialysis
79 fore each weekly VRE session, to ensure peak plasma concentrations during the sessions in 25 patients
80 s showed that high-dose methotrexate maximum plasma concentration (estimate = 0; P = .48), median cle
81 en though the compounds reached steady state plasma concentrations exceeding their Ki values by >60-f
83 who are at the highest risk of unpredictable plasma concentration exposing them to overdose, toxicity
84 from time zero to last sampling and maximum plasma concentration exposure with short half-life (rang
85 avenous colistin is difficult to use because plasma concentrations for antibacterial effect overlap t
86 avenous colistin is difficult to use because plasma concentrations for antibacterial effect overlap t
87 ood containing the peak, midpoint, or trough plasma concentrations for meropenem, ceftolozane-tazobac
88 doses from breast milk and resultant infant plasma concentrations for tenofovir and emtricitabine we
89 e contractility assays over paroxetine and a plasma concentration higher than its IC50 for over 7 h.
90 interdigestive motility, motilin and ghrelin plasma concentrations, hunger and satiety ratings, and f
92 , giving the conversion formula: (creatinine plasma concentration in mumol/L) = (creatinine concentra
93 We investigated the determinants of sST2 plasma concentrations in 2,991 Framingham Offspring Coho
94 rapy (cART) impacted steady-state atovaquone plasma concentrations in human immunodeficiency virus (H
95 k, but there was an inverse association with plasma concentrations in men, with quintile 4 having sig
96 corroborated by increased insulin and IGF-1 plasma concentrations in multiple system atrophy patient
97 tose 1-phosphate (0.1 mM), (corresponding to plasma concentrations in patients on galactose-restricte
98 ral bioavailability (F = 50%) and sufficient plasma concentrations in rats, providing an excellent st
99 oncentration at 12 hours after intake (C12h) plasma concentrations in the third trimester were on ave
100 formance as a function of its measured blood plasma concentration: it reduced reflection impulsivity
102 he in vivo efficacy correlated well with the plasma concentration levels, and no acute toxicity sympt
103 transplantation (LT), immunoglobulin (Ig) G plasma concentrations<6 g/L are common and correlate wit
106 to note that the area under the curve of the plasma concentration of (-)-epicatechin metabolites over
107 ich the methylxanthines mediate an increased plasma concentration of (-)-epicatechin metabolites that
109 . in amyloid positive controls, SCD and MCI) plasma concentration of Abeta42 was just moderately decr
110 study was to determine whether a physiologic plasma concentration of alpha-ketoglutarate (alphaKG) in
113 ct of posture on blood pressure, heart rate, plasma concentration of catecholamines, vasopressin, end
114 pon peroral dosing to rodents led to maximum plasma concentration of CsA at 6 h as opposed to 24 h wi
115 In mice not treated with exogenous tPA, the plasma concentration of endogenous tPA increased 3-fold
118 Despite this, there was no difference in plasma concentration of IL-6 at baseline versus 24 (P =
120 e primary endpoint was the difference in the plasma concentration of interleukin-6 (IL-6) 24 and 48 h
121 status, insulin sensitivity, glucose uptake, plasma concentration of isoprostanes, and total antioxid
126 XR-knockout mice on a high-protein diet, the plasma concentration of newly formed urea was significan
131 es of kPhd2KO mice, accompanied by increased plasma concentration of vascular endothelial growth fact
132 mice, the addition of elacridar (at systemic plasma concentrations of >/=200 ng/mL) resulted in an in
133 d given injections of 1,25(OH)2D3, liver and plasma concentrations of 1,25(OH)2D3 increased and decre
134 significantly affecting extracellular pH or plasma concentrations of 1,25(OH)2D3, Ca(2+), and phosph
136 out cetrimide (5%, w/w)) resulted in average plasma concentrations of 2.6-16.2nM between 2 and 6h, wh
143 e intake significantly elevated mean +/- SEM plasma concentrations of 8 flavanone (1.75 +/- 0.35 mumo
144 a standardized breakfast was consumed, with plasma concentrations of acylated ghrelin, glucagon-like
150 xamined associations of baseline (1993-1997) plasma concentrations of apoC-III and subspecies of HDL
151 t BMI x genotype interactions for changes in plasma concentrations of arachidonic acid and DHA in pho
152 introduced early in complementary feeding on plasma concentrations of biomarkers in choline pathways,
153 tail skin temperatures) of rats, even though plasma concentrations of both antagonists well exceeded
154 h volunteer; meal 1 was designed to increase plasma concentrations of both TGRLs and nonesterified fa
156 als (CIs) comparing the extreme quartiles of plasma concentrations of C16:0, C22:0, C24:0, and C24:1
159 chemiluminescent competitive immunoassay and plasma concentrations of choline, betaine, dimethylglyci
166 Transpulmonary thermodilution-based EVLWi, plasma concentrations of epithelial (soluble receptor fo
167 reduced fetal weights by 13%, lowered fetal plasma concentrations of essential amino acids, and decr
168 e or a dose-matched hesperidin supplement on plasma concentrations of established and novel flavanone
169 l clots, is higher than that in gels made at plasma concentrations of fibrinogen (3-10 mg/mL), where
170 008) with measured first pregnancy trimester plasma concentrations of four PFASs (in nanograms/millil
175 of 15-yr-old children (n= 324), we measured plasma concentrations of homocysteine, choline, and beta
176 no significant intergroup difference in the plasma concentrations of IL-1beta, -8, -10, or -12 p70 o
178 d meat intake is associated with unfavorable plasma concentrations of inflammatory and glucose metabo
179 henotype 2) that was characterised by higher plasma concentrations of inflammatory biomarkers, a high
182 over 4 hours using MRI and blood glucose and plasma concentrations of insulin, peptide YY, and ghreli
183 ter syndrome-like phenotype, including lower plasma concentrations of K+ and H+ and compensatory upre
184 went peripheral venous sampling to determine plasma concentrations of key collagen precursors (procol
186 ndividuals displayed significantly increased plasma concentrations of LPCs containing mono- and polyu
187 otoxic events were accompanied by changes in plasma concentrations of macrophage-derived cytokine, eo
188 ty was evaluated using clinical outcomes and plasma concentrations of markers of inflammation, glucos
189 h ophthalmic issues had significantly higher plasma concentrations of metabolites that are associated
193 ction fraction </=40%, dyspnea, and elevated plasma concentrations of natriuretic peptides were rando
195 igh-risk individuals, we quantified baseline plasma concentrations of nine PFAS among 957 participant
197 type 2 diabetes is inversely correlated with plasma concentrations of odd-chain fatty acids [OCFAs; p
199 utic doses of ritonavir are used to increase plasma concentrations of other HIV drugs oxidized by CYP
203 que, and parasite biomass was estimated from plasma concentrations of Plasmodium falciparum histidine
204 and insulin-resistant subjects have elevated plasma concentrations of pro-NT, and in longitudinal stu
205 gal Candida species in the gut and increased plasma concentrations of prostaglandin E(2) (PGE(2)), wh
207 aimed to measure and validate differences in plasma concentrations of proteins that are associated wi
209 on, it is crucial to extend the knowledge on plasma concentrations of reactive key alpha-dicarbonyl c
215 sis of prior monkey studies, we suspect that plasma concentrations of tariquidar did not fully block
217 ingested with a meal, by pill count, and by plasma concentrations of tenofovir and FTC at week 4); a
218 or repeated measures) lowered postabsorptive plasma concentrations of tHcy by -11.7% +/- 3.0% (placeb
219 sma AnxA1 was also inversely correlated with plasma concentrations of the acute-phase protein, C-reac
220 a highly sensitive IL-2 assay, the observed plasma concentrations of the drug at 90 min exceeded the
223 tions were not accompanied by changes in the plasma concentrations of the gut-derived peptides cholec
224 release was achieved via NIR laser light and plasma concentrations of the model drug were determined
226 Furthermore, mice lacking Sarm1 had reduced plasma concentrations of the phophorylated axonal neurof
229 and rare (MAF <0.01) variants that influence plasma concentrations of these 4 hemostatic factors by m
230 bit different modulations in salivary and/or plasma concentrations of these parameters compared with
231 rotein (HDL), low-density lipoprotein (LDL), plasma concentrations of total cholesterol (TC) and trig
233 ween the dose of quercetin-3-O-glucoside and plasma concentrations of total quercetin (R(2) = 0.52, P
236 ence of arrhythmias was associated with high plasma concentrations of troponin-T and N-terminal brain
237 plasma and 24 h urine sodium and potassium, plasma concentrations of TXB2 (stable TXA2 metabolite) a
240 k syndrome and sepsis), we sought to analyze plasma concentrations of VEGFs and Angs in patients with
243 We determined whether dietary intakes and plasma concentrations of vitamin C were associated with
244 d cediranib area under the curve and maximum plasma concentration on the daily, but not intermittent,
246 centration was significantly associated with plasma concentration (P < .001) and cytochrome P450 2B6
247 d glutamine de novo synthesis (P < 0.02) and plasma concentrations (P < 0.03) in both fasting and fed
248 tudy was to analyze the impact of dabigatran plasma concentrations, patient demographics, and aspirin
250 e (using a dose that reproduced stress-level plasma concentrations) potentiated cocaine-primed reinst
251 ld male R92Q mice, ranolazine at therapeutic plasma concentrations prevented the development of HCM-r
253 gnificant increase in the leptin:adiponectin plasma concentration ratio in rats subjected to coronary
254 (range, n = 5) rilpivirine cord-to-maternal plasma concentration ratio was 0.50 (range, .35-.81).
257 lity and hunger ratings, motilin and ghrelin plasma concentrations, satiety, and caloric intake.Women
258 at BUP, NBUP, and MET at clinically relevant plasma concentrations significantly induced BCRP mRNA up
259 ic risk of Lp(a) is associated with elevated plasma concentration, small isoforms of apolipoprotein [
260 plasma concentration and fractional time of plasma concentration spent over 64 mg/L (4-fold the mini
261 entricular volumes that correlated with peak plasma concentrations, supporting a temporal association
262 ke palmitoylethanolamide, oleoylethanolamide plasma concentrations tended to be higher in nonhedonic
263 0.001) and an earlier time to reach maximal plasma concentration than that of cis isomers (28 +/- 7
264 ovir prodrug, results in 90% lower tenofovir plasma concentrations than does tenofovir disproxil fuma
266 spects of the use of these low doses and low plasma concentrations that require special attention.
267 lation to therapeutically relevant doses and plasma concentrations, there are specific aspects of the
268 th dosing regimens would reach target 3-hour plasma concentrations throughout the duration of the pre
270 platin continuous infusion of area under the plasma concentration-time curve 4.1 mg/mL per min per da
271 56 mg/m(2) resulted in higher area under the plasma concentration-time curve from time zero to last s
274 uated by the observed initial burst release, plasma concentration-time profiles, time at which maximu
275 icals and their metabolites to reach maximal plasma concentrations (Tmax) should be synchronised with
276 plied to individual compounds predicted fish plasma concentrations to be below the level of human the
277 onsteroidal anti-inflammatory drugs but with plasma concentrations too low to disrupt PG biosynthesis
279 Simulated median (interquartile range) day 7 plasma concentration was 29.4 (19.3-44.3) ng/ml in small
281 rutinib clinical trial revealed that exosome plasma concentration was significantly decreased followi
283 /PD) analysis in patients with isavuconazole plasma concentrations was conducted to establish the exp
284 The fish plasma model (FPM), which predicts plasma concentrations, was applied to evaluate the poten
287 in the WT/MCD and ob/control groups, whereas plasma concentrations were 4.8-fold higher in ob/MCD mic
288 ety was assessed every 4 weeks and pazopanib plasma concentrations were determined at weeks 4 and 24.
290 Drug-Coated Angioplasty Balloon), paclitaxel plasma concentrations were measured after last DCB deplo
296 more severe HF, as defined by high NT-proBNP plasma concentration, were at increased risk of VTE.
297 C-labeled total lycopene and lycopene-isomer plasma concentrations, which were measured with the use
298 he temporal profile of ghrelin or peptide YY plasma concentration with bedside functional assessment
300 avir using a dosing regimen that resulted in plasma concentrations within the therapeutic range for c
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