ライフサイエンスコーパス: plasmalemmal

1 Mucosal epithelial cells thus express a plasmalemmal 5-HT transporter identical to that of serot

2 The dendritic plasmalemmal 5HT3A labeling was prominent within and nea

3 data demonstrate no major role for impaired plasmalemmal action potential conduction in the excitati

4 action-induced muscle injury causes impaired plasmalemmal action potential conduction, which could ex

5 MEND is blocked by siRNA knockdown of the plasmalemmal acyl transferase, DHHC5.

6 idually mediate the formation of functional, plasmalemmal alpha4betadelta GABARs.

7 ied by a respective decrease and increase in plasmalemmal and cytoplamic NK3R densities in AVP-labele

8 s moderately expressing p-mTOR (Ser 2448) in plasmalemmal and cytoplasmic compartments.

9 ere immunogold-silver labeled to examine the plasmalemmal and cytoplasmic distribution of these recep

10 nal profiles M2R immunogold was localized to plasmalemmal and cytoplasmic regions and showed a simila

11 t ER-alpha immunoreactivity (IR) was seen in plasmalemmal and cytoplasmic regions of spine heads, wit

12 (betagamma) subunits, stably associates with plasmalemmal and cytosolic caveolin.

13 disorders of acid-base transporters involve plasmalemmal and organellar transporters of H(+), HCO3(-

14 gold labeling for NBAT was distributed along plasmalemmal and vacuolar membranes within somata, dendr

15 Plasmalemmal and vesicular gamma-aminobutyric acid (GABA

16 ophins retain functional domains and mediate plasmalemmal assembly of the dystrophin-associated glyco

17 encoding the Kir6.2 and SUR1 subunits of the plasmalemmal ATP-sensitive K+ (KATP) channel.

18 e of the thymocytes undergoing apoptosis had plasmalemmal bound galectin-9.

19 ntracytoplasmic vesicles, in contrast to the plasmalemmal budding of HIV-1 typically seen with infect

20 microdomain that develops rapidly near open plasmalemmal Ca(2+) channels like voltage-gated L-type (

21 global Ca(2+) transients, with no change in plasmalemmal Ca(2+) current.

22 t was found to be able to substitute for the plasmalemmal Ca(2+) exchange function, thus rendering th

23 ble from those in the absence of Ca(2+) when plasmalemmal Ca(2+) extrusion was suppressed.

24 ca2 knockout (KO) is compensated by enhanced plasmalemmal Ca(2+) fluxes.

25 rved that, in primary mesothelial cells, the plasmalemmal Ca(2+) influx played a pivotal role.

26 NFAT1 is stimulated by sub-plasmalemmal Ca(2+) microdomains, whereas NFAT4 addition

27 In the absence of store depletion, plasmalemmal Ca(2+) permeability in resting muscle is ve

28 uggest that an important fraction of resting plasmalemmal Ca(2+) permeability is mediated by the Orai

29 ce of store-operated Ca(2+) entry (SOCE) via plasmalemmal Ca(2+) release-activated Ca(2+) (CRAC) chan

30 igger store-operated Ca(2+) entry (SOCE) via plasmalemmal Ca(2+)-selective Orai1 channels.

31 ng1 interfered with downstream IP3-dependent plasmalemmal Ca2+ entry without affecting the release of

32 selective for NCX: L-type Ca2+ currents and plasmalemmal Ca2+ pumps were not affected.

33 n inhibitory effect on Ca2+ extrusion by the plasmalemmal Ca2+-ATPase.

34 es of Ca2+ from the SR (sparks), stimulating plasmalemmal Ca2+-sensitive K+ (BK) channels, determines

35 ve terminals by exposure to veratridine or a plasmalemmal [Ca2+]o receptor agonist (Gd3+).

36 Inhibition of plasmalemmal calcium channels diminished the magnitude a

37 store-operated calcium entry (SOCE) through plasmalemmal calcium channels that open in response to s

38 ne adenylyl cyclases synthesize a restricted plasmalemmal cAMP pool that is intensely endothelial bar

39 contrast to the barrier-enhancing actions of plasmalemmal cAMP, the ExoY cytosolic cAMP pool induced

40 number of distinct noncoated pits resembling plasmalemmal caveolae also accumulated in anti-dynamin a

41 ll surface signal-transducing domains termed plasmalemmal caveolae and interacts with caveolin, an in

42 proaches revealed that MARCKS is targeted to plasmalemmal caveolae and undergoes subcellular transloc

43 Plasmalemmal caveolae are membrane microdomains that are

44 herichia coli, was specifically localized to plasmalemmal caveolae in BMMCs.

45 ve previously shown that eNOS is targeted to plasmalemmal caveolae in endothelial cells.

46 ynthase (eNOS) interacts reversibly with the plasmalemmal caveolae structural protein, caveolin-1.

47 cells, eNOS has been shown to be targeted to plasmalemmal caveolae, a process that is dependent on my

48 for eNOS palmitoylation and localization to plasmalemmal caveolae, and suggest further that sequence

49 Caveolin-1, a principal component of plasmalemmal caveolae, has been reported as a potentiall

50 (cav-1), the principle structural protein of plasmalemmal caveolae, regulates inflammatory signaling

51 sible subcellular targeting of the enzyme to plasmalemmal caveolae.

52 mice lack caveolin-1 protein expression and plasmalemmal caveolae.

53 ogical evidence that dynamin associates with plasmalemmal caveolae.

54 e efficient subcellular targeting of eNOS to plasmalemmal caveolae.

55 ducing domains in the plasma membrane termed plasmalemmal caveolae.

56 re of enzyme docking to caveolin proteins in plasmalemmal caveolae.

57 ion of Ca2+-dependent signal transduction in plasmalemmal caveolae.

58 caveolin-1 are associated within endothelial plasmalemmal caveolae.

59 d signal-transducing membrane domains termed plasmalemmal caveolae.

60 Thus, acylation targets eNOS to plasmalemmal caveolae.

61 hatidylinositol 4,5-bisphosphate (PIP(2)) in plasmalemmal caveolae.

62 de synthase (eNOS) promotes its targeting to plasmalemmal caveolae; agonist-promoted depalmitoylation

63 well as abundant glial processes also showed plasmalemmal CB1R and were mainly without muOR immunorea

64 studies illustrate that DTBI evokes evolving plasmalemmal changes that highlight mechanical and poten

65 rmacological agents to determine the role of plasmalemmal channels in Ca(2)(+) homeostasis.

66 shown to form nonselective, high-conductance plasmalemmal channels permeable to ATP, thereby offering

67 inct pathways that include diffusion through plasmalemmal channels, translocation by multiple transpo

68 Depletion of plasmalemmal cholesterol influences the distribution of

69 xtracellular matrix (ECM) glycoproteins, and plasmalemmal Cl(-) transporters - could help the identif

70 these pathways and substances was to repair plasmalemmal damage in eukaryotic cells.

71 of vesicles have been observed at regions of plasmalemmal damage in many cell types.

72 is induced by Ca2+ inflow resulting from the plasmalemmal damage.

73 l DAT gold particles (per square micron) and plasmalemmal DAT gold particles (per micron) than those

74 tified as cholinergic targets, 35% contained plasmalemmal DAT, and 65% were without detectable DAT im

75 ssion of the alpha4 subunit is necessary for plasmalemmal delta subunit localization at pubertal onse

76 ugh there was already a reduction in the NR1 plasmalemmal density at this time point.

77 The plasmalemmal dihydropyridine receptor (DHPR) is the volt

78 in injury (DTBI) is associated with neuronal plasmalemmal disruption, leading to either necrosis or r

79 To assess plasmalemmal disruption, rats (n = 21) received intracer

80 o, but independent of, neurons demonstrating plasmalemmal disruption.

81 to identify injury-induced neuronal somatic plasmalemmal disruption.

82 Ca(2+) influx through plasmalemmal disruptions activates calpain, vesicle accu

83 As suggested by their restricted plasmalemmal distribution, the high ouabain-affinity Na+

84 ne apparatus, whereas MOR showed a prominent plasmalemmal distribution.

85 ny neuronal profiles showed endomembrane and plasmalemmal distributions of one or both receptors.

86 These specialized plasmalemmal domains are enriched in G protein-coupled r

87 (METH) both rapidly (within hours) decrease plasmalemmal dopamine (DA) uptake and cause long-term de

88 of antipeptide antisera against M5R and the plasmalemmal dopamine transporter (DAT) in single sectio

89 ically released dopamine is regulated by the plasmalemmal dopamine transporter (DAT), an integral mem

90 minals differ in levels of expression of the plasmalemmal dopamine transporter (DAT).

91 fferent method for the isolation of PVs from plasmalemmal fragments obtained by a silica-coating proc

92 We show that ET-1, which activates plasmalemmal G protein-coupled receptors and InsP3 produ

93 Postnatal expression of the plasmalemmal GABA transporter-1 (GAT-1), GAT-3, and the

94 f chronic unpredictable stress increased the plasmalemmal glial-glutamate transporter 2 (EAAT2) and i

95 PF cells express a plasmalemmal heptahelical receptor (CaR) that binds Ca2+

96 he plasmalemma to repair small (1-30 microm) plasmalemmal holes or a complete transection of the plas

97 Plasmalemmal immunogold particles representing alpha(1)1

98 n surface area of intracellular cisterns and plasmalemmal infoldings.

99 the plasma membrane and reseal laser-induced plasmalemmal injuries and that are small enough to be in

100 caused immediate, scattered neuronal somatic plasmalemmal injury to all of the extracellular HMWTs us

101 both A-type potassium channel synthesis and plasmalemmal insertion of vesicles bearing these potassi

102 ll surface proteins located primarily in the plasmalemmal invaginations called caveolae.

103 Many of these long plasmalemmal invaginations had clathrin-coated pits alon

104 ndocytosis and induced the formation of long plasmalemmal invaginations with attached clathrin-coated

105 eolin-1 (Cav-1) is the structural protein of plasmalemmal invaginations, termed caveolae, which funct

106 f guidance cue receptors leads to opening of plasmalemmal ion channels remains largely unknown.

107 that overexpress specific calcium permeable plasmalemmal ion channels with available selective pharm

108 e flagella, a process that probably involves plasmalemmal ion channels.

109 ling in neurons is based on the operation of plasmalemmal ion pumps and carriers that establish trans

110 recognize membrane proteins localized to the plasmalemmal junction between migrating neurons and adja

111 In addition, sub-plasmalemmal ('junctional') components of the ER (jER) a

112 s paralleled by a decrease in both total and plasmalemmal KCC2 protein.

113 tained both dextrans, demonstrating enduring plasmalemmal leakage, with many demonstrating necrosis.

114 From these and other data, we propose that plasmalemmal lesions in most eukaryotic cells (including

115 le alpha4 knockout (KO) mice were tested for plasmalemmal levels of the delta subunit within dendriti

116 The decline in plasmalemmal localization is manifested as decreased res

117 Increased plasmalemmal localization of alpha4betadelta GABA(A) rec

118 At pubertal onset, plasmalemmal localization of the delta subunit is reduce

119 and C2E domains are dispensable for correct plasmalemmal localization.

120 but showed a more prominent, size-dependent plasmalemmal location in nondopaminergic dendrites.

121 owed diffuse staining around a predominantly plasmalemmal location.

122 activity in striatal vesicle subcellular and plasmalemmal membrane fractions, respectively.

123 Plasmalemmal membrane labeling for MOR1 was more frequen

124 Metabolism of anionic phospholipids in plasmalemmal membrane may be a novel and general mechani

125 rter antagonist, reversed alterations in the plasmalemmal membrane potential (V(m)) and pH.

126 site, Abeta concentrates APP molecules into plasmalemmal membrane protein clusters.

127 ce between the endoplasmic reticulum and the plasmalemmal membrane was ruled out as a mechanism for t

128 Membrane/lipid rafts, plasmalemmal microdomains enriched in cholesterol, sphin

129 MLRs are plasmalemmal microdomains enriched in sphingolipids, cho

130 es to determine whether eNOS is localized to plasmalemmal microdomains implicated in signal transduct

131 Caveolae are plasmalemmal microdomains that are involved in vesicular

132 into sphingomyelin-rich and cholesterol-rich plasmalemmal microdomains, thereby acquiring resistance

133 ulum/polyribosomes, and accumulations of sub-plasmalemmal microfilaments containing spindle densities

134 e caused preferential Ca(2+) uptake into sub-plasmalemmal mitochondria.

135 The plasmalemmal monoamine transporters clear the extracellu

136 tibodies on distinct endocytic processes and plasmalemmal morphology were then assayed by fluorescenc

137 t newly enveloped VZV to late endosomes, and plasmalemmal MPRci are necessary for entry by cell-free

138 ac myocytes to eliminate any contribution of plasmalemmal Na(+) channels to the observed actions of t

139 gamma subunit is a specific component of the plasmalemmal Na(+),K(+)-ATPase.

140 was without effect, whereas the reverse mode plasmalemmal Na(+)/Ca(2+) exchange inhibitor KB R7943 re

141 presynaptic [Ca(2+)]i recovery, and blocking plasmalemmal Na(+)/Ca(2+) exchange produced only a small

142 mp, acting in proportion to their effects on plasmalemmal Na(+)/Ca(2+) exchange.

143 ncreases in cytosolic Ca(2+) mediated by the plasmalemmal Na(+)/Ca(2+) exchanger (NCX) operating in t

144 heart-enriched isoform, CHP3, regulates the plasmalemmal Na(+)/H(+) exchanger NHE1 isoform by enhanc

145 10-15% of PFC NE axons exhibit predominantly plasmalemmal NET and evident TH immunoreactivity.

146 However, the proportion of plasmalemmal NET nearly doubled from 29% in control anim

147 Plasmalemmal neurotransmitter transporters (NTTs) regula

148 es to induce Ca(2+) influx through expressed plasmalemmal nicotinic channels.

149 Immunoelectron microscopy revealed plasmalemmal OTR at enterocyte adherens junctions.

150 s and induced a significant increase in near plasmalemmal p47(phox) and a decrease in cytoplasmic p47

151 between young females and males in the near plasmalemmal p47(phox) on AVP dendrites seen in the pres

152 between young females and males in the near plasmalemmal p47(phox) on AVP dendrites seen in the pres

153 The plasmalemmal PA is synthesized by phosphorylation of dia

154 R) are functionally coupled to the overlying plasmalemmal (PL) microdomains in PL-jER units named 'PL

155 uclear region moving 3 times faster than the plasmalemmal pool, suggesting that protein-lipid or prot

156 Furthermore, the plasmalemmal presence of CD36 and intracellular lipid le

157 th insulin, we measured GLUT4 translocation, plasmalemmal presence of the fatty acid transporter CD36

158 t up to 20 spines shared a recycling pool of plasmalemmal proteins rather than maintaining independen

159 induces phosphorylation of endothelial cell plasmalemmal proteins residing in caveolae as detected b

160 membrane protein VAMP/synaptobrevin and the plasmalemmal proteins syntaxin and SNAP-25.

161 ar endosomal and lysosomal membranes to form plasmalemmal pseudopods.

162 st that endogenous calpain activity promotes plasmalemmal repair by vesicles or other membranes which

163 Plasmalemmal repair is necessary for survival of damaged

164 formation of a dye barrier (seal) to assess plasmalemmal repair, we now report that B104 hippocampal

165 To reveal plasmalemmal resealing or enduring disruption, rats were

166 sporter (DAT) plays an important role in the plasmalemmal reuptake of dopamine and, thus, in the term

167 gic neurons that have a limited capacity for plasmalemmal reuptake of dopamine, a characteristic of t

168 he 5-HT levels reflect vesicular release and plasmalemmal reuptake through the serotonin transporter

169 specific multiprotein complexes at discrete plasmalemmal, sarcoplasmic reticular and myofilament sit

170 The frequency and rate of plasmalemmal sealing are decreased by a small molecule i

171 undant parallel pathways of Ca(2+)-dependent plasmalemmal sealing of injured neurons mediated in part

172 ractions, proteins, and pathways involved in plasmalemmal sealing should suggest novel neuroprotectiv

173 endent, PKA-independent, pathway involved in plasmalemmal sealing.

174 ate and palmitate and is targeted thereby to plasmalemmal signal-transducing domains termed caveolae.

175 rge dendrites, but was more often located at plasmalemmal sites in small dendrites, the majority of w

176 2- selectively produced by mitochondria near plasmalemmal sites of Ca2+ entry acts as a modulator to

177 these dendrites the MOR1 was at nonsynaptic plasmalemmal sites.

178 Phospholemman regulates the plasmalemmal sodium pump in excitable tissues.

179 lls per group, *, p < 0.01), and reduced the plasmalemmal staining of hERG.

180 lls per group; *, p < 0.01), and reduced the plasmalemmal staining of hERG.

181 tients with multiple sclerosis yielded faint plasmalemmal staining on both KIR4.1-expressing and non-

182 t activates extracellular Ca2+ entry via the plasmalemmal store-operated channel transient receptor p

183 nolabeling on endomembranes just beneath the plasmalemmal surface (+42.1 +/- 11.3%; p < 0.05) in non-

184 o controls had a reduced percentage of their plasmalemmal surface apposed to unmyelinated axon profil

185 DOR-immunoreactivity was associated with the plasmalemmal surface at or near the postsynaptic density

186 er than 5.5-fold (p < .0001) by altering its plasmalemmal surface expression; WNK3 did not affect ROM

187 eactivity was most often associated with the plasmalemmal surface near asymmetric synapses.

188 p75NTR-IR was most often associated with the plasmalemmal surface near postsynaptic densities; in den

189 concurrent increase in the percentage of the plasmalemmal surface occupied by active zones and the si

190 dy state distribution of GAT-3 at the apical plasmalemmal surface requires a protein-protein interact

191 these structures and was not limited to the plasmalemmal surface.

192 cles, and was less consistently found on the plasmalemmal surface.

193 f unmyelinated axons (from 15 to 35%) to the plasmalemmal surface; and (b) located primarily in the c

194 YNMLCFGIY1015 possible participation in Slo1 plasmalemmal targeting and demonstrate its role as a mai

195 in the amount, subcellular localization, or plasmalemmal targeting of DAT within individual dopamine

196 transport rate, cell surface stability, and plasmalemmal trafficking of KCC2 are rapidly and reversi

197 sites required for the vasopressin-mediated plasmalemmal translocation and activation of NKCC2 in vi

198 ytosis demonstrated that UCD38B bypasses the plasmalemmal uPAS complex and directly acts intracellula

199 In glial plasmalemmal vesicle (GPV) preparations from treated rat

200 binding protein G(i), and thereby activates plasmalemmal vesicle formation and the directed migratio

201 SOD with antibodies (Ab/SOD, size 10nm) to plasmalemmal vesicle-associated protein (Plvap) that is

202 et endothelial cell adhesion molecule 1, and plasmalemmal vesicle-associated protein).

203 We have demonstrated that the plasmalemmal vesicles (caveolae) of the continuous micro

204 Plasmalemmal vesicles (PVs) or caveolae are plasma membr

205 The vast majority of plasmalemmal vesicles carrying albumin also immunostaine

206 ecting a small fraction of the population of plasmalemmal vesicles of vascular endothelia are describ

207 ated muscle requires proper communication of plasmalemmal voltage-activated Ca2+ channels and Ca2+ re

208 d by alkaline incubation involves opening of plasmalemmal voltage-dependent Ca channels and Ca(2+) en

209 plasma membrane and to repair laser-induced plasmalemmal wounds in dysferlin-deficient human myoblas

210 levels, resealing kinetics of laser-induced plasmalemmal wounds, myotube formation, and cellular via

211 3, members of the Zip (Zrt/Irt-like protein) plasmalemmal Zn transporter family, are predominantly ex