ライフサイエンスコーパス: plasmalogen

1 to hydrolyse plasmenylcholine phospholipids (plasmalogens).

2 is specific for the sn-2-deacylated form of plasmalogen.

3 s) and a nearly 35% decrease in ethanolamine plasmalogen.

4 ty acids in plasma and deficient erythrocyte plasmalogens.

5 single step in the biosynthetic pathway for plasmalogens.

6 the introduction of the ether bond found in plasmalogens.

7 orous acid targeting the vinyl ether bond of plasmalogens.

8 egraded in response to the cellular level of plasmalogens.

9 m reactive chlorinating species targeting of plasmalogens.

10 d eosinophils attack the vinyl ether bond of plasmalogens.

11 in arachidonic acid-containing ethanolamine plasmalogens.

12 neutrophils, attack the vinyl ether bond of plasmalogens.

13 s present in the sn-1 position of neutrophil plasmalogens.

14 iosynthesis, resulted in decreased levels of plasmalogens (16-30%).

15 in sphingomyelin (78.3 and 117.5mug/ml) and plasmalogens (27.3 and 24mug/ml), possibly important for

16 not only from PAF to lysoplasmalogen forming plasmalogen analogs of PAF, but also to sphingosine prod

17 ids with putative health benefits, including plasmalogens, and should aid in selecting appropriate in

18 ing progressive accumulation of cholesterol, plasmalogens, and sphingolipids.

19 Plasmalogens are a phospholipid molecular subclass that

20 Plasmalogens are a subclass of glycerophospholipids that

21 The present studies demonstrate that plasmalogens are attacked by MPO-derived reactive chlori

22 We determined that plasmalogens are crucial for Schwann cell development an

23 rative strategies for the total synthesis of plasmalogens are enabled by this simple transformation.

24 iosynthesis of ether phospholipids, of which plasmalogens are the most abundant form in nervous tissu

25 spholipid causes neuropathology, implicating plasmalogens as regulators of membrane and cell signalin

26 on in the rate of biosynthesis and levels of plasmalogens, as determined using short- and long-term l

27 oteins, including the peroxisomal enzymes of plasmalogen biosynthesis and peroxisomal 3-ketoacyl thio

28 clinical features associated with defects in plasmalogen biosynthesis to include FAR1 deficiency as a

29 ation of a mutant CHO cell line defective in plasmalogen biosynthesis which contains intact, function

30 ansferase (DHAP-AT), a peroxisomal enzyme of plasmalogen biosynthesis, and we identify the mutations

31 entification of mutations in another gene in plasmalogen biosynthesis, fatty acyl-CoA reductase 1 (FA

32 AGPS and FAR1, encoding enzymes involved in plasmalogen biosynthesis.

33 e acyltransferase (DHAP-AT), first enzyme in plasmalogens biosynthesis, resulted in decreased levels

34 n PEX7, GNPAT, and AGPS, all involved in the plasmalogen-biosynthesis pathway, have been described in

35 s to their respective fatty alcohols for the plasmalogen-biosynthesis pathway.

36 ate the targeting of the vinyl ether bond of plasmalogens by the reactive brominating species produce

37 ate the targeting of the vinyl ether bond of plasmalogens by the reactive brominating species produce

38 ime the targeting of the vinyl ether bond of plasmalogens by the reactive chlorinating species produc

39 Plasmalogen concentrations were lower in VAT than in SAT

40 ery-long-chain fatty acid beta-oxidation and plasmalogen concentrations, and a decrease in very-long-

41 Plasmalogens constitute a significant fraction of cardia

42 Plasmalogens contain a vinyl ether bond linking the sn-1

43 s confirmed 34- and 20-fold increases in the plasmalogen cooxidation products, unsaturated lysophosph

44 ell development and differentiation and that plasmalogen defects impaired radial sorting, myelination

45 dels of RCDP and analyzed the consequence of plasmalogen deficiency in peripheral nerves.

46 Schwann cell defects, effectively bypassing plasmalogen deficiency.

47 viving population, we have isolated a unique plasmalogen-deficient Chinese hamster ovary (CHO) cell l

48 Unlike previously described plasmalogen-deficient mutants, NZel-1 contained peroxiso

49 transmembrane domain of Far1 is required for plasmalogen-dependent modulation of Far1 stability.

50 y human coronary artery endothelial cells to plasmalogen-derived lysophosphatidylcholine molecular sp

51 chanism that targets the vinyl ether bond of plasmalogens during neutrophil activation resulting in t

52 such as in asthma, might selectively target plasmalogens for oxidation.

53 Our results demonstrate the requirement of plasmalogens for the correct and timely differentiation

54 2-chlorooctadecanal, respectively, from the plasmalogen glycerol backbone.

55 Lysophosphatidic acid (LPA), plasmalogen-glycerophosphate (alkenyl-GP) and, cyclic-ph

56 Arachidonic acid was observed primarily in plasmalogen glycerophosphoethanolamine (GPE), whereas li

57 sed to examine the fate of diacyl, ether, or plasmalogen glycerophosphoethanolamine (GPEtn) species a

58 way of oxidative degradation of arachidonoyl plasmalogen GPE suggesting a unique role for this plasma

59 Plasmalogens (i.e. plasmenylcholines or plasmenylethanol

60 ials, to generate glycerophosphocholine-type plasmalogens in 4% overall yield.

61 We also observed reduced plasmalogens in red blood cells in one individual to a r

62 vous tissue and myelin; however, the role of plasmalogens in the peripheral nervous system is poorly

63 rected the in situ levels of fatty acids and plasmalogens in these mutant cell lines.

64 Plasmalogen insufficiency resulted in defective protein

65 dy demonstrates that the vinyl ether bond of plasmalogens is a molecular target of the reactive chlor

66 at the enzyme may be important in regulating plasmalogen levels in animal cells.

67 The total plasmalogen levels were significantly decreased in NASH

68 by a mechanism that is dependent on cellular plasmalogen levels.

69 cies promote selective oxidative cleavage of plasmalogens, liberating alpha-chloro fatty aldehydes an

70 ts lacked all ether phospholipids, including plasmalogens, LPG, and GIPLs.

71 eroxidase target the vinyl ether bond of the plasmalogen, lysoplasmenylcholine (1-O-hexadec-1'-enyl-s

72 ds) and lack of products (like bile acids or plasmalogens), many peroxisomal defects lead to detrimen

73 decanal was dependent on the presence of the plasmalogen masked aldehyde (i.e. the vinyl ether) in th

74 ct of FABP on plasmalogen mass, ethanolamine plasmalogen mass was reduced 30% in gene-ablated mice.

75 Consistent with a reported effect of FABP on plasmalogen mass, ethanolamine plasmalogen mass was redu

76 e, is arrhythmogenic, but the effects of the plasmalogen metabolite, lysoplasmenylcholine (LPLC), are

77 alogen GPE suggesting a unique role for this plasmalogen molecular species glycerophospholipid.

78 s found that the abundant arachidonoyl GPEtn plasmalogen molecular species were uniquely reduced in r

79 vide a universal scan for diacyl, ether, and plasmalogen PE lipids that cannot be readily observed ot

80 PE plasmalogen, PE with two unsaturated fatty acids, and ly

81 are acid sensitive suggestive that they are plasmalogen PEs possessing a double bond at the 1-positi

82 undertaken to define the role of PLA(2) and plasmalogen phospholipid hydrolysis in PAF synthesis in

83 resulted in inhibition of iPLA(2) activity, plasmalogen phospholipid hydrolysis, production of choli

84 d by its use in syntheses of an anti-oxidant plasmalogen phospholipid, found in electrically active t

85 kD CaIPLA2 with preferential activity toward plasmalogen phospholipids has been recently purified fro

86 tion of iPLA(2) and associated hydrolysis of plasmalogen phospholipids was accompanied by increased l

87 sary for peroxisome growth, the synthesis of plasmalogen phospholipids, and the maintenance of cellul

88 active chlorinating species (RCS) target the plasmalogen pool of LDL isolated from peripheral human b

89 rinated aldehydes from both LDL and monocyte plasmalogen pools that may have important effects during

90 -mediated targeting of both monocyte and LDL plasmalogen pools was demonstrated in phorbol myristate

91 Plasmalogen rather than diacyl phospholipids are the pre

92 eactive chlorinating species attack membrane plasmalogens releasing alpha-chloro fatty aldehydes incl

93 The vinyl ether bond of plasmalogens renders them susceptible to oxidation.

94 ivated neutrophils targeted endothelial cell plasmalogens resulting in 2-chlorohexadecanal production

95 il peroxidase target the vinyl ether bond of plasmalogens resulting in the production of a neutral li

96 eloperoxidase target the vinyl ether bond of plasmalogens, resulting in the production of a neutral l

97 Plasmalogen subclass masses were also reduced, suggestin

98 K 293T cells resulted in decreased levels of plasmalogens, suggesting that the enzyme may be importan

99 Expression of Far1 increased plasmalogen synthesis in wild-type Chinese hamster ovary

100 ting that Far1 is a rate-limiting enzyme for plasmalogen synthesis.

101 ed, suggesting that H-FABP may augment brain plasmalogen synthesis.

102 l targets tissue- and lipoprotein-associated plasmalogens to generate alpha-chlorinated fatty aldehyd

103 ly, 2-BrHDA was preferentially produced from plasmalogen treated with hypochlorous acid in the presen

104 An improved synthesis of plasmalogen type lipids is described.

105 ng species targeting the vinyl ether bond of plasmalogens utilizing a cell-free system.

106 oduced by eosinophil peroxidase attacked the plasmalogen vinyl ether bond at acidic pH.

107 s, reactive brominating species attacked the plasmalogen vinyl ether bond at neutral pH.

108 Targeting of the LDL plasmalogen vinyl ether bond was dependent on the presen

109 The vinyl ether bond of LDL plasmalogens was targeted by MPO-derived RCS, resulting

110 her phospholipids also known as ethanolamine plasmalogen whose functions are not well characterized.