ライフサイエンスコーパス: plasmodial

1 l population had only a minor effect on anti-plasmodial activity.

2 For this reason, plasmodial ADA accepts a wider range of substrates, as i

3 highlight a drastic conformational change in plasmodial ADA upon substrate binding that has not been

4 e comparison of inhibitor complexes with the plasmodial and human enzymes.

5 is natural difference in specificity between plasmodial and mammalian ADA has not been well understoo

6 MP potency and selectivity toward bacterial, plasmodial, and cancerous cells while enabling the targe

7 , T cells from infected mice stimulated with plasmodial antigen triggered 5-10-fold increases in p24

8 he identified gene, pypag-1, encoded a novel plasmodial antigen.

9 Unlike many characterized plasmodial antigens, blocks of tandemly repeated amino a

10 e need a deeper understanding of fundamental plasmodial bioregulatory mechanisms to successfully subv

11 The characterization of plasmodial CDKs has identified them as a leading antimal

12 Physarum polycephalum, when transplanted, by plasmodial coalescence, into an S-phase plasmodium, fail

13 the vector Anopheles, thus perpetuating the plasmodial cycle.

14 FP2 and related plasmodial cysteine proteases have an unusual 14-aa moti

15 for folding of falcipain-2 and four related plasmodial cysteine proteases was inclusion of a 14-15-r

16 es represent the first crystal structures of plasmodial cysteine proteases with small molecule inhibi

17 ned in silico against the homology models of plasmodial cysteine proteases, falcipain-2, and falcipai

18 insights into the intricacies characterising Plasmodial developmental biology.

19 DSM265 is a novel antimalarial that inhibits plasmodial dihydroorotate dehydrogenase, an enzyme essen

20 We have previously reported that plasmodial DNA is the primary driver of systemic inflamm

21 afted with primate tissue make two important plasmodial dormancy-related questions researchable.

22 The plasmodial enzyme adenosine deaminase (ADA) plays a cent

23 The plasmodial enzyme dipeptidyl aminopeptidase 1 (DPAP1) wa

24 Plasmodial enzymes for the synthesis of PABA via the shi

25 s, we propose a specific role for one of the plasmodial enzymes, aminopeptidase P, in the catabolism

26 This channel, the plasmodial erythrocyte surface anion channel (PESAC), li

27 id foundation for the ongoing elucidation of plasmodial gene expression.

28 strategy may be widely applicable to modify plasmodial genes and perform structure-function analyses

29 ort the relative susceptibility of human and plasmodial GRs to a series of tricyclic inhibitors as we

30 yte modification by the parasite may involve plasmodial heat shock proteins and be vastly more comple

31 rties of Hs-18Pf-SAHH, the human enzyme with plasmodial helix 18, and Tc-18Hs-SAHH, the trypanosomal

32 n is seen as an additional substrate only in plasmodial homogenates.

33 ms in the pfmdr1 gene, the gene encoding the plasmodial homologue of mammalian multidrug resistance t

34 m-infected RBCs appeared to be suppressed by plasmodial infection, as both increased after antimalari

35 Ape plasmodial infections were highly prevalent, widely dist

36 consistent with recent observations that the plasmodial MAPKs are not true orthologues of the ERK1/2,

37 f the mode of activation and function of the plasmodial MAPKs.

38 Invasion of erythrocytes by Plasmodial merozoites is a composite process involving t

39 , epoxyazadiradione inhibited both huMIF and plasmodial MIF, thus bearing an immense therapeutic pote

40 is not directly exchanged for protons by the plasmodial Na+/H+ exchanger.

41 insight into this process, we have studied a plasmodial ortholog of the lysosomal exopeptidase cathep

42 Dependence of the plasmodial parasites on selenium suggests possible strat

43 fic inhibitors that could potentially target plasmodial PI4KIIIbeta to combat malaria.

44 alytic domain with extensions from six other plasmodial proteases folded normally and had kinetic par

45 Recent advances in the characterization of plasmodial proteases should facilitate the analysis of t

46 A number of plasmodial proteases that appear to be responsible for k

47 nose) and FP2(arm) are found only in related plasmodial proteases, suggesting that they confer malari

48 on of the domains of falcipain-2 and related plasmodial proteases.

49 re we report the characterization of a novel plasmodial protein kinase, PfPK7, whose top scores in bl

50 rotein kinase family, similar to a few other plasmodial protein kinases.

51 Given the involvement of sugar binding plasmodial proteins in host invasion, we set out to iden

52 Because they occur in almost all families of plasmodial proteins, the occurrence of LCRs cannot be as

53 the parasite without inhibiting secretion of plasmodial proteins.

54 Sequence alignment showed that the plasmodial sequence has 47% identity with human IRP1.

55 stent with the differences between human and plasmodial sequences in the Q2 pocket receiving this gro

56 ns to bacterial flow through porous media or plasmodial shuttle streaming in slime molds.

57 Plasmodial slime molds grow as networks and use flexible

58 Furthermore, if spore stages as well as plasmodial stages were detected in tissue, stool specime

59 Recent studies implicate the plasmodial surface anion channel (PSAC) and a role in pa

60 ty to ions and nutrients, as mediated by the plasmodial surface anion channel (PSAC) and recently lin

61 The plasmodial surface anion channel (PSAC) increases erythr

62 The plasmodial surface anion channel (PSAC) is an unusual io

63 The plasmodial surface anion channel (PSAC) is an unusual sm

64 The plasmodial surface anion channel (PSAC) may mediate thes

65 The plasmodial surface anion channel (PSAC) mediates this tr

66 The plasmodial surface anion channel (PSAC), an unusual volt

67 The plasmodial surface anion channel (PSAC), recently identi

68 n unusual voltage-dependent ion channel, the plasmodial surface anion channel (PSAC), which may accou

69 echanism involving genes responsible for the plasmodial surface anion channel, a nutrient channel tha

70 pathways, essential biological processes for plasmodial survival.

71 Plasmodial transglutaminase of Physarum polycephalum was

72 The internalized host proteins and a plasmodial transmembrane resident parasitophorous vacuol

73 sident proteins are detected as rafts in the plasmodial vacuole, (2) a voltage-gated channel in the i

74 This is a plasmodial, vegetative stage of acellular slime mould.