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1 ulation of a G-protein coupled receptor with platelet activating factor.
2 significantly inhibited the biosynthesis of platelet activating factor.
3 ripeptides and possibly leukotriene B(4) and platelet activating factor.
4 hingomyelin (SM) to ceramide and inactivates platelet activating factor.
5 y alcohols, which are possible precursors of platelet activating factor.
6 trates for the production of eicosanoids and platelet-activating factor.
7 -containing lipids, such as lyso-PC, PC, and platelet-activating factor.
8 2-AG) are unaffected by LPS but increased by platelet-activating factor.
9 human epithelial cells via the receptor for platelet-activating factor.
10 ector cells, and the mediators histamine and platelet-activating factor.
11 ins in whole blood and dampened responses to platelet-activating factor.
12 ed priming of this response by TNF-alpha and platelet-activating factor.
13 is induced by administration of histamine or platelet-activating factor.
14 rmation was also reversed by the addition of platelet-activating factor.
15 owing to elevated levels of pro-inflammatory platelet-activating factors.
20 toxic injury via activation of receptors for platelet-activating factor, a proinflammatory signaling
21 tic oxidatively truncated phospholipids, and platelet-activating factor, a remarkably potent and plei
24 with the HDL-associated enzymes paraoxonase, platelet activating factor acetylhydrolase (PAF), and gl
25 nts, the most potent effect was observed for platelet activating factor acetylhydrolase alpha (Paf-AH
26 gulation of expression of the plasma form of platelet-activating factor acetylhydrolase (PAF AH) in t
29 or was inactivated by alkaline hydrolysis or platelet-activating factor acetylhydrolase (PAF-AH) trea
30 the possibility that the activity represents platelet-activating factor acetylhydrolase (PAF-AH), an
32 t that the cytoplasmic PLA(2) enzyme complex platelet-activating factor acetylhydrolase (PAFAH) Ib, w
36 lycopene), and antioxidant enzyme activity (platelet-activating factor acetylhydrolase [PAF-AH] and
37 A recent report demonstrates that plasma platelet-activating factor acetylhydrolase activity incr
38 om allergy, such as suggesting that baseline platelet-activating factor acetylhydrolase activity leve
39 ll dense low-density lipoproteins, increased platelet-activating factor acetylhydrolase activity, and
41 lesterolemic human plasma with a recombinant platelet-activating factor acetylhydrolase completely ab
42 izygous mutations in the human gene encoding platelet-activating factor acetylhydrolase IB subunit al
44 imal study, transfection of tumor cells with platelet-activating factor acetylhydrolase inhibited tum
45 nt controversy over whether paraoxonase 1 or platelet-activating factor acetylhydrolase is responsibl
46 rpose of this study was to determine whether platelet-activating factor acetylhydrolase Sse and strep
47 creened by enzymatic assays for SpeB and the platelet-activating factor acetylhydrolase Sse, and a ne
48 of lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase), the express
49 coding complement component receptor 2/CD21, platelet-activating factor acetylhydrolase, and oxidized
50 tions in the relative levels of paraoxonase, platelet-activating factor acetylhydrolase, ceruloplasmi
51 n-associated phospholipase A2, also known as platelet-activating factor acetylhydrolase, is a new ris
52 lation and elongation protein zeta-1 (FEZ1), platelet-activating factor acetylhydrolase, isoform Ib,
53 e inconclusive in determining whether plasma platelet-activating factor acetylhydrolase, or lipoprote
54 nzymes, BChE and a new extracellular form of platelet-activating factor acetylhydrolase, PAFAH1b2.
55 ated phospholipase A2 (Lp-PLA2), also called platelet-activating factor acetylhydrolase, plays in ath
61 ory cellular metabolite up-regulated by Tat, platelet-activating factor, also induced oxidative stres
63 In hippocampal slices exposed to a stable platelet-activating factor analogue, tetanic stimulation
64 mesangial cell line induced upregulation of platelet activating factor and the fibrotic marker TGF-b
66 on anaphylaxis suggest an important role for platelet-activating factor and its relationship to the n
67 flammatory mediators (tumor necrosis factor, platelet-activating factor and prostaglandins), studies
70 ith N-formyl-methionyl-leucyl-phenylalanine, platelet activating factor, and leukotriene B4 was phosp
71 ory G protein-coupled chemoattractants fMLP, platelet-activating factor, and IL-8 elicit unique patte
73 production induced by TNF-alpha, GM-CSF, and platelet-activating factor, and this loss of pyk2 activi
74 locked by a combination of antihistamine and platelet-activating factor antagonist (but neither alone
75 e mediated by the autocrine activity, not of platelet-activating factor, but rather of endogenous CCR
76 d to surrogate PMNs respond to activation by platelet activating factor by initiating translation and
77 Tsujimura et al. report that the release of platelet-activating factor by basophils stimulated with
78 uding vascular endothelial growth factor and platelet-activating factor; by contrast, endothelial cel
79 d immunoglobulins (IgG, IgA), cytokines with platelet activating factor, calcium ionophore, or phorbo
80 irway eosinophils to chemoattractants (FMLP, platelet-activating factor, CCL11, CCL5, CXCL8) with res
82 as prior exposure to a p38-activating agent (platelet-activating factor) diminished the TNFalpha-indu
84 some of these peptides (eg, endothelin-1 and platelet-activating factor) has decreased mortality and
85 when elicited by leukotriene B4, C5a, FMLP, platelet-activating factor, IL-8, or RANTES chemotactic
86 surfactant phospholipids and biosynthesis of platelet-activating factor in noninflammatory remodeling
88 via CD14-, NF-kappaB-, and p44/42-dependent, platelet-activating factor-independent activation of the
89 ogen synthase kinase 3beta inhibitor, blocks platelet activating factor-induced activation of glycoge
92 ependent manner, LXs significantly inhibited platelet-activating factor-induced increases in leukocyt
96 duction of prostaglandins, leukotrienes, and platelet-activating factor, is present in EAE lesions.
97 ional studies demonstrated that RGS1 impairs platelet activating factor-mediated increases in intrace
98 gosine blocks thapsigargin-, ionomycin-, and platelet-activating factor-mediated SOCE despite normal
99 ceptor antagonists, or overexpression of the platelet-activating factor metabolizing enzyme acetylhyd
100 depletion by the G protein-coupled agonists platelet-activating factor or fMLP, but abolished agonis
101 tional state, and subsequent activation with platelet-activating factor or formyl-methionyl-leucyl-ph
103 ormally sensitive to substance P, but not to platelet-activating factor or serotonin, suggesting that
104 merous chemoattractants, such as chemokines, platelet-activating factor, or FMLP, through a process k
106 mediators, including TNF-alpha, GM-CSF, and platelet-activating factor, overcomes the adhesion-media
108 alyzes the hydrolytic inactivation of plasma platelet activating factor (PAF) and is also known as PA
111 as well as resveratrol and quercetin, on the platelet activating factor (PAF) biosynthetic enzymes, a
112 plexed with the physiological ligand GM2 and platelet activating factor (PAF) have shown binding at t
117 dministered with either the HIV-1 neurotoxin platelet activating factor (PAF) or the regulatory HIV-1
118 th BN52021, WEB-2170, and WEB-2086 (specific platelet activating factor (PAF) receptor antagonists),
119 Both LPS and BLP stimulated the synthesis of platelet activating factor (PAF), a potent lipid mediato
120 rved that tumor necrosis factor (TNF)-alpha, platelet activating factor (PAF), and lipopolysaccharide
121 rmyl-methionyl-leucyl-phenylalanine (fMLP)), platelet activating factor (PAF), leukotriene B4 (LTB(4)
122 mbination with uridine 5'-diphosphate (UDP), platelet activating factor (PAF), or lysophosphatidic ac
123 incubated in H2O2 (70 micromol/L, 2 hours), platelet activating factor (PAF), prostaglandin E2 (PGE2
124 ion and chemoattraction, Mig potently blocks platelet activating factor (PAF)- and leukotriene B4 (LT
131 low density lipoprotein and comigrates with platelet-activating factor (PAF) acetylhydrolase on KBr
133 the PAFAH1B2 and PAFAH1B3 subunits of type I platelet-activating factor (PAF) acetylhydrolase, a phos
135 idized glycerophosphocholines (Ox-GPCs) with platelet-activating factor (PAF) activity produced non-e
137 er short-chained phospholipids--inflammatory platelet-activating factor (PAF) and apoptotic oxidative
139 genesis and photoimmune suppression, such as platelet-activating factor (PAF) and serotonin (5-HT) re
141 GS4, also blocked phosphorylation of PAFR by platelet-activating factor (PAF) and, unexpectedly, by p
146 models and human asthmatics have implicated platelet-activating factor (PAF) as an important inflamm
147 r wild-type control as experimental animals, platelet-activating factor (PAF) at 10(-7) m as the test
148 ponses to the inflammatory mediators C5a and platelet-activating factor (PAF) but did not respond to
150 at cigarette smoking leads to an increase in platelet-activating factor (PAF) content and PAF recepto
151 ured spleen and liver cytokine responses and platelet-activating factor (PAF) content in mice given C
152 -2) regulate surfactant protein-A (SP-A) and platelet-activating factor (PAF) expression, which incre
153 ittle, if any, role in neutrophil priming by platelet-activating factor (PAF) for OpZ-dependent respo
155 at exposure of neutrophils to E-selectin and platelet-activating factor (PAF) in combination induced
157 t studies have implicated the lipid mediator platelet-activating factor (PAF) in UVB-mediated systemi
158 models of LE that the phospholipid mediator platelet-activating factor (PAF) increases in LE and tha
180 Because the lipid mediator of inflammation, platelet-activating factor (PAF) is released by UV-irrad
181 Animal models show that the receptor for platelet-activating factor (PAF) is responsible for many
187 ry potential of the proinflammatory mediator platelet-activating factor (PAF) on the subcellular dist
188 urvival after anaphylaxis, administration of platelet-activating factor (PAF) or histamine, and expos
189 th Kindlin-2 siRNA showed enhanced basal and platelet-activating factor (PAF) or lipopolysaccharide-s
190 esulted from inhibitory signals generated by platelet-activating factor (PAF) or oxidized LDL that ac
194 regation was inhibited by antagonists of the platelet-activating factor (PAF) receptor but not inhibi
195 tor and that antagonists of 5-HT(2A) and the platelet-activating factor (PAF) receptor can block cis-
196 f intracellular Leishmania, we surmised that platelet-activating factor (PAF) receptor had a signific
198 onist of the PTX-sensitive G protein-coupled platelet-activating factor (PAF) receptor, blocked the a
199 Corneal stromal myofibroblasts express the platelet-activating factor (PAF) receptor, but its role
205 ne suppression are the binding of UV-induced platelet-activating factor (PAF) to its receptor and the
206 and the proinflammatory glycerophospholipid platelet-activating factor (PAF) were markedly reduced i
207 cell types with respect to the metabolism of platelet-activating factor (PAF), a biologically active
208 s by exploiting molecular mimicry to degrade platelet-activating factor (PAF), a host-derived inflamm
211 Recent studies suggest that the action of platelet-activating factor (PAF), a potent phospholipid
213 ated endocytosis (CME), we hypothesized that platelet-activating factor (PAF), an effective chemoattr
214 in corneal epithelial cells stimulated with platelet-activating factor (PAF), and interferes with th
215 as tumor necrosis factor-alpha (TNF-alpha), platelet-activating factor (PAF), and lipopolysaccharide
216 ctively induced by the addition of PGE(2) or platelet-activating factor (PAF), another lipid cytokine
217 UVB radiation generates the lipid mediator, platelet-activating factor (PAF), as well as oxidized ph
218 nergistic signaling induced by serotonin and platelet-activating factor (PAF), but not histamine.
219 Leu-Phe (fMLP), adenosine diphosphate (ADP), platelet-activating factor (PAF), interleukin-8 (IL-8),
220 shown that the lipid inflammatory mediator, platelet-activating factor (PAF), synthesized by activat
221 mbrane inhibits hyperpermeability induced by platelet-activating factor (PAF), VEGF in ECV-CD8eNOSGFP
222 e calcium entry (SOCE) following the initial platelet-activating factor (PAF)-induced release of Ca(2
236 -alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor, PAF) and the generation of 2
237 diated responses, RGS4 and the receptors for platelet-activating factor (PAFR), formylated peptides (
239 phils were treated with fMLP with or without platelet-activating factor, PMA alone, or tumor necrosis
240 nitiates the biosynthesis of eicosanoids and platelet-activating factor, potent mediators of inflamma
241 Under the same experimental conditions, platelet-activating factor primed neutrophils for supero
242 factor, the ability of alpha-toxin to induce platelet-activating factor production was assessed, and
243 regation was blocked using a monoclonal anti-platelet activating factor receptor (PafR) antibody and
244 ine, an H1R antagonist, blocked EAE, and the platelet activating factor receptor antagonist CV6209 re
245 creased adherence mediated by binding to the platelet activating factor receptor on epithelial cells.
247 D synthase, histamine receptor type 1 (H1R), platelet activating factor receptor, Ig Fc epsilon recep
248 eir ability to generate oxidized lipids with platelet-activating factor receptor (PAF-R) agonist acti
250 er of melanoma metastasis, via activation of platelet-activating factor receptor (PAFR) and cAMP-resp
251 dditional recognition system mediated by the platelet-activating factor receptor (PAFr) and directed
252 e hypothesis that influenza up-regulates the platelet-activating factor receptor (PAFr) and thereby p
256 hibitors identified a prominent role for the platelet-activating factor receptor (PAFr) in hypoxia-as
259 f synaptic activity in a manner dependent on platelet-activating factor receptor (PAFR) signaling.
260 polymeric immunoglobulin receptor (pIgR) and platelet-activating factor receptor (PAFr) to attach and
261 iciency in interleukin 1alpha (IL-1alpha) or platelet-activating factor receptor (PAFR), an important
262 of A. baumannii binds to A549 cells through platelet-activating factor receptor (PAFR), resulting in
267 experiments revealed that L5 signals through platelet-activating factor receptor and lectin-like oxid
268 s demonstrate the differential expression of platelet-activating factor receptor and TLR-4 in uterine
269 nti-eotaxin and anti-RANTES mAbs, but not by platelet-activating factor receptor antagonists (CV6209,
270 s NK(2), calcitonin gene-related peptide, or platelet-activating factor receptor antagonists had no e
273 tion was assessed, and whether the epidermal platelet-activating factor receptor could augment toxin-
274 ctive effect resulted in part from decreased platelet-activating factor receptor expression on endoth
275 antibody or therapeutic agents that modulate platelet-activating factor receptor expression, may conf
276 stry studies demonstrate the presence of the platelet-activating factor receptor in both endometrial
277 nally, retroviral-mediated expression of the platelet-activating factor receptor into the platelet-ac
279 milar involvement for an unrelated GPCR (the platelet-activating factor receptor), indicating that it
280 Bacterial lipoteichoic acid activates the platelet-activating factor receptor, which is G protein-
281 rom the international phase III trial of the platelet-activating factor receptor-antagonist Lexipafan
282 platelet-activating factor receptor into the platelet-activating factor receptor-negative epithelial
283 ent studies used model systems consisting of platelet-activating factor receptor-positive and -negati
288 ity, we found that histamine, serotonin, and platelet-activating factor, small molecule vascular perm
289 hil, macrophage, and neutrophil secretion of platelet-activating factor subsequent to FcgammaR stimul
290 of PMN cationic entry after thapsigargin or platelet-activating factor suggested that SOCE occurs th
291 lus for the synthesis for the lipid mediator platelet-activating factor, the ability of alpha-toxin t
293 ructurally diverse neutrophil-priming agents platelet-activating factor, TNF-alpha, and the substance
294 rotein is rapidly synthesized in response to platelet activating factor under the control of a specia
296 nt chemicals (bradykinin, capsaicin, low pH, platelet-activating factor), whereas Adelta-fibres are r
297 5-hydroxytryptamine), platelet factor 4, and platelet-activating factor, which specifically stimulate
298 lpha-toxin resulted in significant levels of platelet-activating factor, which were approximately 50%
299 l, lipid mediators lysophosphatidic acid and platelet-activating factor, whose signals are implicated
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