ライフサイエンスコーパス: platensimycin

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1 to develop a concise asymmetric synthesis of platensimycin.

2 and biologically related but different from platensimycin.

3 used in the synthesis of the antibiotic (-)-platensimycin.

4 lay a key role in the biological activity of platensimycin.

5 oxy group, led to the oxatetracyclic core of platensimycin.

6 Platensimycin (1a) is a novel broad spectrum Gram-positi

7 An enantioselective synthesis of platensimycin, a novel antibiotic natural product that i

8 Here we report the discovery of platensimycin, a previously unknown class of antibiotics

9 logical evaluation of two distinct series of platensimycin analogues with varying degrees of complexi

10 The total syntheses of platensimycin and its congeners, platensimycins B(1) and

11 The secondary metabolites platensimycin and platencin, isolated from the bacterial

12 ate synthase involved in the biosynthesis of platensimycin and platencin.

13 yntheses of platensimycin and its congeners, platensimycins B(1) and B(3), platensic acid, methyl pla

14 Recently we reported the discovery of platensimycin by screening natural product extracts usin

15 Platensimycin demonstrates strong, broad-spectrum Gram-p

16 Treatment with platensimycin eradicates Staphylococcus aureus infection

17 analogue of the recently reported antibiotic platensimycin has been accomplished.

18 Platencin, though structurally similar to platensimycin, has been found to operate through a sligh

19 Direct binding assays show that platensimycin interacts specifically with the acyl-enzym

20 while the substituted benzoic acid domain of platensimycin is a highly conserved structural motif wit

21 Platensimycin is the flagship member of a new and growin

22 Platensimycin is the most potent inhibitor reported for

23 Chronic administration of platensimycin led to a net reduction in liver triglyceri

24 ings refine our present understanding of the platensimycin pharmacophore and establish certain struct

25 Platensimycin, platencin, and phomallenic acids, newly d

26 Platensimycin (PTM) and platencin (PTN) are highly funct

27 Platensimycin (PTM) and platencin (PTN) are potent and s

28 Platensimycin (PTM) is a recently discovered broad-spect

29 Because of its unique mode of action, platensimycin shows no cross-resistance to other key ant

30 inhibitors of mammalian fatty acid synthase, platensimycin specifically inhibits fatty acid synthesis

31 95 and 3.91 microg/ml, respectively, whereas platensimycin targets only FabF (IC50 = 0.13 microg/ml)

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