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1 and resensitize resistant ovarian tumors to platinum.
2 nd compared to the state-of-the-art catalyst platinum.
3 her transition metal catalysts also, such as platinum.
4 more endergonic on tungsten carbide than on platinum.
5 production of rare elements such as gold and platinum.
6 ce and auxiliary electrodes were composed of platinum.
7 ast 6 months following last infused cycle of platinum.
10 n our approach allows the differentiation of platinum accumulation within each part of the morphology
12 kinase-anchoring protein 12 (AKAP12) impeded platinum adduct clearance and prevented cAMP-mediated en
13 tinum and gold against Enterococcus faecium, platinum against Klebsiella pneumoniae and platinum and
14 otherapy with a fluorinated pyrimidine and a platinum agent, followed by later treatment with taxanes
15 mble of pre-cyclization conformations of the platinum-alkene reactant complex, only a subset of which
16 e useful for the future design of structured platinum alloy nanocatalysts.Core-shell platinum alloy n
17 ured platinum alloy nanocatalysts.Core-shell platinum alloy nanoparticles are promising catalysts for
20 g electrode and counter electrode consist of platinum and are functionalized by drop casting of three
24 energetically less costly for gold than for platinum and explains the propensity of gold to facilita
26 robial inhibitory concentration demonstrated platinum and gold against Enterococcus faecium, platinum
28 nt for precious group metals as for example, platinum and opens up new ways in finding cost-efficient
30 ombination and increased sensitivity to both platinum and PARP inhibitor chemotherapy compared to Trp
31 , platinum against Klebsiella pneumoniae and platinum and silver against Acinetobacter baumannii were
33 rogrammed death 1 receptor antibody, in this platinum- and cetuximab-pretreated population with poor
34 eaction coordinates for polycyclization, for platinum- and enzyme-promoted polycyclization reactions
35 sm of action of these clinically established platinum anti-cancer agents, as well as more recently de
37 aditional electrodes, such as carbon or gold/platinum, are costly and difficult to microfabricate.
38 s, crucial for oxidation catalysts.Improving platinum as an oxidation catalyst requires understanding
40 talyst can be prepared by simple doping of a platinum atom into a molecule-like gold nanocluster.
41 ngle-pyridinic-nitrogen-atom-anchored single-platinum-atom centres, which are tolerant to carbon mono
42 the 3D coordinates of 6,569 iron and 16,627 platinum atoms in an iron-platinum nanoparticle, and cor
43 HER) as an alternative to currently utilised platinum based electrodes (with in electrolysers) is als
45 ) randomly assigned to clinical trials using platinum-based chemoradiotherapy (NRG Oncology Radiation
47 e technology to oral ceritinib 750 mg/day or platinum-based chemotherapy ([cisplatin 75 mg/m(2) or ca
48 logram of body weight once every 2 weeks) or platinum-based chemotherapy (administered once every 3 w
52 sensitive to clonogenic killing mediated by platinum-based chemotherapy and IR ( approximately 70%-8
53 with urothelial carcinoma progressing after platinum-based chemotherapy and unselected for PD-L1 exp
54 ve as an efficacious and safe alternative to platinum-based chemotherapy before autologous stem cell
56 gainst VEGF, improves outcomes when added to platinum-based chemotherapy in advanced-stage non-squamo
57 acebo after response to second-line or later platinum-based chemotherapy in patients with high-grade,
59 OBS) after primary cytoreductive surgery and platinum-based chemotherapy in women with stage II to IV
60 disease progression on or after one previous platinum-based chemotherapy regimen in the metastatic se
62 arcinoma, had received at least two previous platinum-based chemotherapy regimens, had achieved compl
63 t had progressed after at least one previous platinum-based chemotherapy were enrolled from 80 cancer
64 rothelial carcinoma who had progressed after platinum-based chemotherapy were randomly assigned (1:1)
65 nd disease progression during or after prior platinum-based chemotherapy were randomly assigned 1:1 t
66 e status (0 vs 1), previous radiosensitising platinum-based chemotherapy, and disease status (recurre
67 : treatment with primary surgery followed by platinum-based chemotherapy, stage II to IV disease, at
68 and a clinical complete response to primary platinum-based chemotherapy, who had been disease-free f
83 hod, different substrate-materials-supported platinum-based nanowires are obtained, which paves the w
85 gression-free interval after the penultimate platinum-based regimen, and best response to the most re
86 d complete or partial response to their last platinum-based regimen, had a cancer antigen 125 concent
88 ed longer progression-free survival than did platinum-based therapy in patients with treatment-naive,
89 key mechanism associated with resistance to platinum-based therapy, a finding that we subsequently e
90 e kinase inhibitors, mitotic inhibitors, and platinum-based therapy, there is a need to stratify pati
92 of [3](2+) occurs through abstraction of the platinum-bound chloride ligand by the adjacent Lewis aci
95 ation was stratified by response to previous platinum chemotherapy (complete vs partial) and length o
97 er-intuitive core-shell formation process in platinum-cobalt nanoparticles at elevated temperature un
98 n (FIC) studies demonstrated that the silver/platinum combination against Enterococcus faecium, and s
100 led to clinical implementation of effective platinum complexes in the clinic have fueled multidiscip
103 , high-performance electrocatalysts with low platinum consumption are desirable for use as cathode ma
104 ur methodology in rats using an experimental platinum-containing anti-cancer nanodrug and three FDA a
106 ive effect on the anti-tumor efficacy of the platinum-containing nanodrug, as well as animal survival
108 opy with glassy carbon working electrode and platinum counter/reference electrode at a potential of 0
109 wed the atom-by-atom fabrication of isolated platinum deposits, ranging from single atoms to 9-atom c
110 (rituximab, dexamethasone, cytarabine, and a platinum derivative [R-DHAP]), the overall response rate
115 of health and language were collected in the PLATINUM Diversity cohort, which included 1501 patients
117 the superiority of nonplatinum therapy over platinum doublet therapy for ERCC1-positive NSCLC as wel
118 chemotherapy (one or two lines, including a platinum doublet) and crizotinib and had subsequent dise
119 y 3 weeks (35 cycles) or investigator-choice platinum-doublet chemotherapy (4-6 cycles or until docum
120 ated an epigenetic signature associated with platinum drug resensitization that may offer utility in
121 parameter most consistently associated with platinum drug resistance, emphasizing the need to direct
122 insights into the vital role of RAD6/TLS in platinum drug tolerance and reveal clinical benefits of
124 D6B depletion were associated with decreased platinum drug-induced proliferating cell nuclear antigen
125 1-mutant cancer cells is being targeted with platinum drugs and poly (ADP-ribose) polymerase (PARP) i
128 carboplatin derivative to quantify and track platinum drugs in tumors using PET has the potential to
129 lation can sensitize ovarian cancer cells to platinum drugs, in large part by altering gene expressio
131 n of methanol from the reduction of CO2 on a platinum electrode triggered great interest and exciteme
132 ave developed simple sensors containing only platinum electrodes for the detection of heavy metal con
134 ternative catalysts to noble metals, such as platinum, for the hydrogen evolution reaction (HER).
135 otherapy (complete vs partial) and length of platinum-free interval (6-12 months vs >/=12 months) and
138 the greatest bactericidal activity was again platinum gold and palladium against all three bacteria.
140 ested in combinations using ZoI assays, gold/platinum, gold/palladium and platinum/palladium were ind
141 ny other elements (e.g., Ni, Co, Au, Se, and platinum group elements) are significantly less abundant
142 It remains a grand challenge to replace platinum group metal (PGM) catalysts with earth-abundant
145 work on phosphorescent, low molecular weight platinum(II) complex as an oxygen sensing probe to study
146 platinum(IV) complex, the in situ generated platinum(II) complex has good affinity for G-quadruplex
151 ), silver(I), mercury(II), copper(I and II), platinum(II), and cationic gold(I) are effective for rea
152 (III), gold(III), nickel(II), palladium(II), platinum(II), rhodium(III), iridium(III), and ruthenium(
153 e synthesis and in-depth characterization of platinum(II)-crosslinked single-chain nanoparticles (Pt(
154 ssemble into heavy elements such as gold and platinum in a process known as rapid neutron capture (r-
155 to approximately 2.5 mum for phosphorus and platinum in HCT116 colon cancer spheroids upon treatment
156 435 is necessary for cAMP-enhanced repair of platinum-induced damage and protection against cisplatin
162 tissue, cisplatin-resistant tumors excluded platinum ions from tumor areas in contrast to cisplatin-
163 detection technique which involves reducing platinum ions to platinum metal species followed by an e
164 nally, the detection method demonstrates the platinum is dissolved into the solution as an ionic spec
168 emorial Center in Mumbai, India, reached its platinum jubilee milestone (75 years), which was celebra
169 to 680 mW cm(-2) at 80 degrees C with a low platinum loading of 0.09 mgPt cm(-2), corresponding to a
170 way as to include an interaction between the platinum metal center and the surface oxygen atoms.
171 allowed the quantification of the amount of platinum metal dissolved into the solution, from which t
172 que which involves reducing platinum ions to platinum metal species followed by an electrocatalytic a
173 similar potentials to those for reduction on platinum metal, suggesting a similar mechanism and kinet
174 measured the thermal conductance of gold and platinum metallic wires down to single-atom junctions.
175 In the present work, we used ceramic-based platinum microelectrode arrays (MEAs) to perform high-fr
181 evolution biocatalyst based on photosystem 1-platinum nanoparticle biocomplexes embedded into a speci
182 tion fine structure analysis confirm similar platinum nanoparticle shapes, sizes, lattice parameters,
183 69 iron and 16,627 platinum atoms in an iron-platinum nanoparticle, and correlate chemical order/diso
185 puttering and e-beam lithography techniques, platinum nanoparticles (Pt NPs) were deposited in a brid
187 acrylonitrile (PAN) nanofibrous web and then platinum nanoparticles (Pt-NP) decoration was performed
190 ease the rate of mass transfer of silver and platinum nanoparticles and improve their stochastic elec
191 lulose (NC)-based composites with silver and platinum nanoparticles as additive materials to fabricat
192 ticles is typically superior to that of pure platinum nanoparticles for the oxygen reduction reaction
195 osome payload (dextran, single-stranded DNA, platinum nanoparticles) is trafficked into the attached
196 ified and then was decorated with silver and platinum nanoparticles, respectively, by chemical reduct
199 possess a high density of interfaces between platinum-nickel and nickel sulfide components, which coo
203 d earth abundant metal catalyst which rivals platinum on a weight basis over hundreds of hours of ope
205 Ten permutations of noble and base metals (platinum, palladium, copper, nickel, and cobalt) were sy
206 ectrochemical genosensor based on Zinc oxide/platinum-palladium (ZnO/Pt-Pd) modified fluorine doped t
208 Antitumour activity was assessed in post-platinum patients who received at least one dose of avel
212 tive second-line treatment for patients with platinum-pretreated recurrent or metastatic squamous cel
213 quantum chemical computations on a series of platinum-promoted polycyclization reactions are describe
214 e demonstrate how atomically dispersed ionic platinum (Pt(2+)) on ceria (CeO2), which is already ther
219 o-electrocorticography (mu-ECoG) arrays with platinum (Pt) or glassy carbon (GC) electrodes were manu
220 ts are unique in their ability to trap ionic platinum (Pt), providing exceptional stability for isola
221 d as a promising alternative to their costly platinum (Pt)-based counterparts in polymer electrolyte
222 tretchable, and inexpensive devices based on platinum (Pt)-decorated graphite for glucose determinati
225 sm of action are available for patients with platinum-refractory advanced or metastatic urothelial ca
227 with small-cell lung cancer, all of whom had platinum-refractory disease, had a partial response or p
228 use of HDCT as third-line or later therapy, platinum-refractory disease, mediastinal primary tumor s
229 survival than chemotherapy in patients with platinum-refractory metastatic urothelial carcinoma over
230 r activity in the treatment of patients with platinum-refractory metastatic urothelial carcinoma; a m
232 py of investigator's choice in patients with platinum-refractory recurrent or metastatic squamous cel
233 The combination seems particularly active in platinum-refractory small-cell lung cancer, which tends
234 We used superresolution light microscopy and platinum replica transmission electron microscopy (TEM)
236 ioning, whole-cell mount, cell unroofing and platinum replication, and resin embedding and sectioning
237 g group 1 (ERCC1) protein is associated with platinum resistance and survival in non-small-cell lung
240 imary patient-derived platinum-sensitive and platinum- resistant ovarian cancer cells and ovarian can
241 argeting may improve therapeutic outcomes in platinum-resistant and recurrent ovarian cancer in part
244 phase 1 study, patients with progressive or platinum-resistant metastatic or recurrent NSCLC were en
246 red the responses of patients with recurrent platinum-resistant ovarian cancer who received carboplat
247 erived xenograft model of advanced-stage and platinum-resistant ovarian cancer, an MMAE-based NDC dou
248 manageable safety profile and was active in platinum-resistant ovarian cancer, with the strongest si
254 esting potentially predicting sensitivity to platinum salts and PARP inhibitors, the data regarding s
256 robust cell death in primary patient-derived platinum-sensitive and platinum- resistant ovarian cance
257 iagnosis and upon relapse from patients with platinum-sensitive HGSOC recurrence who were treated > 5
259 f a clinical efficacy trial in patients with platinum-sensitive or platinum-resistant relapsed SCLC.
260 idered a new standard of care for women with platinum-sensitive ovarian cancer following a complete o
261 d progression-free survival in patients with platinum-sensitive ovarian cancer who had achieved a res
262 sed to identify patients with BRCA wild-type platinum-sensitive ovarian cancers who might benefit fro
264 h BRCA mutant or BRCA wild-type and LOH high platinum-sensitive ovarian carcinomas treated with rucap
266 In ARIEL2 Part 1, patients with recurrent, platinum-sensitive, high-grade ovarian carcinoma were cl
267 patients were aged 18 years or older, had a platinum-sensitive, high-grade serous or endometrioid ov
268 psule formulation to all-comer patients with platinum-sensitive, relapsed high-grade serous ovarian c
269 ted olaparib tablet maintenance treatment in platinum-sensitive, relapsed ovarian cancer patients wit
270 glucose oxidase-based biosensor, a sentinel platinum sensor, a laccase/tyrosinase-based biosensor an
271 , followed by the layer-by-layer growth of a platinum shell via Ostwald ripening during the oxygen an
272 l for atomic-scale design and control of the platinum shell, which is known to be the structural feat
273 ported cost-effective, efficient and durable platinum single-atom electrocatalyst with carbon monoxid
274 reveal that the main effective sites on such platinum single-atom electrocatalysts are single-pyridin
276 id interface revealed that the adsorption on platinum supported catalysts of 1-(1-naphthyl)-ethylamin
277 and efficient method to generate a family of platinum supramolecular square complexes, including prev
278 n the ability of the amines to adsorb on the platinum surface and their performance as chiral modifie
281 ve to drive the ORR or H2O2 reduction on the platinum surface, mainly using square wave potential pul
282 of the structure and degree of oxidation of platinum surfaces under operando conditions is essential
283 Although the combination of surgery and platinum-taxane chemotherapy provide an effective treatm
285 e OS for nonplatinum therapy was inferior to platinum therapy (median OS, 7.6 months [paclitaxel and
286 ss the safety profile in patients (both post-platinum therapy and cisplatin-naive) treated with avelu
287 ation potently sensitized resistant cells to platinum therapy and was effective in killing ovarian ca
288 atients with squamous histology who received platinum therapy compared with nonplatinum chemotherapy;
289 V = -0.071 +/- 0.003, comparable to that of platinum, theta Pt = 0.076 +/- 0.007, and is much larger
290 tment in a cohort of patients with advanced, platinum-treated non-small-cell lung cancer (NSCLC).
293 progression 6 to 12 months after their last platinum treatment were randomly assigned 1:1 to the exp
294 ion of CO2 into CO, whose high affinity with platinum triggers the formation of a Pt-CO film that pre
295 esolved electrochemical measurements using a platinum ultramicroelectrode (UME) as the working electr
299 ding of 0.09 mgPt cm(-2), corresponding to a platinum utilization of 0.13 gPt kW(-1) in the fuel cell
300 transmission information to create a phased "Platinum" variant catalog of 4.7 million single-nucleoti
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