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1 However, identifying brain areas that play a causal role in decision making has proved challen

2 In contrast, ritual human sacrifice does play a causal role in promoting and sustaining the evolu

3 s involving receptors for axon guidance cues play a central role in controlling growth cone behaviour

4 The amygdala may, therefore, play a central role in RL.

5 hey function as the cellular power plant and play a central role in the early stages of programmed ce

6 Ohr also appeared to play a central role in the peroxynitrite response, becau

7 Reactive oxygen species (ROS) play a critical role in cell signaling and proliferation

8 Cytokines play a critical role in directing the discrete and gradu

9 n transporting materials (ETMs) used in PSCs play a critical role in PSCs performance.

10 Venom peptide toxins such as conotoxins play a critical role in the characterization of nicotini

11 ining Yxxphi motif, but not dileucine motif, play a critical role in the earliest stages of AP2 activ

12 opose the hypothesis that SIRT1 may actually play a crucial causal role in overload-induced hypertrop

13 These play a crucial role in auditory perception as well as at

14 Neutrophils play a crucial role in host defense.

15 Nematode effectors play a crucial role in initializing and sustaining succe

16 ippocampal replays have been demonstrated to play a crucial role in memory.

17 and magnetic behaviours, have been proven to play a crucial role in photovoltaic properties of ferroe

18 Many ALS/FTD linked genes play a direct role in autophagy/lysosomal degradation, o

19 Transparent conducting electrodes play a fundamental role in far-field PhotoVoltaic system

20 l protein ligand TPD1 (TAPETUM DETERMINANT1) play a fundamental role in somatic and reproductive cell

21 ggest that small external electrical signals play a greater role in determining the chemosensitive re

22 in brain inhibitory circuits are thought to play a key role during the "critical period" of brain de

23 in (RIP) homotypic interaction motifs (RHIM) play a key role in cell death and inflammatory signallin

24 es changes in the filter conformation, which play a key role in defining both selectivity and permeat

25 d/l-Amino acid mixtures play a key role in human physiology and pathology; thus,

26 d activity-dependent mechanisms are known to play a key role in learning and memory.

27 nterspecific social information transfer can play a key role in many aspects of animal ecology from f

28 A (SAUR) genes promote elongation growth and play a key role in PM H(+)-ATPase activation by inhibiti

29 Accumulating evidence indicates that T cells play a key role in the pathology of lymphedema by promot

30 endent up-regulation of Cox-1 expression may play a key role in tissue homeostasis and wound healing

31 socioeconomic status and health-care access play a key role.

32 We found xylem conduit dimensions play a major role in determining the susceptibility of t

33 Genetic factors play a major role in the etiology of epilepsy disorders.

34 rly Americans, private insurance will likely play a major role.

35 rch has indicated that secreted proteins may play a major role.

36 e, hence suggesting that the H channel could play a more general role as a dielectric well.

37 Nevertheless, OsNHX1 seems to play a particular role in shoots in response to drought.

38 rocesses in human cells, and protein kinases play a pivotal role in health and disease.

39 growth factor beta (TGF-beta), is thought to play a pivotal role.

40 he dorsoventral organization of nIII and may play a primary role in determining motoneuron identity.

41 6-32 region, suggesting that this region may play a regulatory role.

42 ggest that the proangiogenic factor MMP9 may play a role as a biomarker associated with the developme

43 examining whether carbon disulfide (CS2) may play a role as an endogenously generated bioregulator an

44 For hydration water to play a role beyond modulating global protein solubility

45 SNF may play a role in both by supplying N to leaf tissues for a

46 ther related diseases.The gut microbiota may play a role in cardiovascular diseases.

47 formational restriction of the substrate may play a role in catalysis.

48 The results indicate that LRX proteins might play a role in cell wall-plasma membrane communication,

49 oral studies suggest that vestibular signals play a role in dissociating object motion and self-motio

50 This phenomenon may play a role in immune cartilage destruction; however, th

51 We thus hypothesized that dlBST could play a role in LID hyperkinetic manifestations.

52 NA polymerase epsilon (Pol epsilon) may also play a role in MMR.

53 in human blood suggested that cavitation may play a role in PUT.

54 ructure, has been increasingly recognized to play a role in regulating executive function, the dysfun

55 Bacteria may play a role in regulating harmful algal blooms, but litt

56 healthy children, suggesting that HOXA4 may play a role in regulating human growth by epigenetic mec

57 Peripheral blood monocytes play a role in sarcoidosis inflammation.

58 es and dendrite morphology, studied in vivo, play a role in selective sensory processing in the M-cel

59 ry mechanisms of olfactory transduction also play a role in setting the resting sensitivity in OSNs.

60 Trace minerals (TM) play a role in skin integrity and wound healing.

61 Respiratory virus (RV) has been suggested to play a role in the pathogenesis.

62 , the dialogue between these two areas could play a role in the regulation of emotions and in procedu

63 bservation was that the ASGR also appears to play a role in the uptake of unconjugated phosphorothioa

64 iple aspects of autoimmune disorders and may play a role in triggering disease.

65 he proliferation of HIV-1-infected cells may play a role in viral persistence, but little is known ab

66 vidual changes in a variety of species might play a role over evolutionary timescales.

67 ment of synaptic inputs onto dendrites could play a significant role in cortical computations, but ho

68 ations, such as cytosine methylation of DNA, play a significant role in mediating gene expression in

69 This treatment can play a significant role in preventing glaucoma vision lo

70 We conclude that EEFs can play a significant role in sustainable agricultural prod

71 this correlation, we hypothesize that lipids play a so far unrecognized role in organ development.

72 In the experiment, subjects repeatedly play a strategic game that has an optimal strategy.

73 ing value or salience, the signal appears to play a versatile and active role in adaptive sensorimoto

74 es afforded by supramolecular chemistry will play a vital role in the future of the drug delivery fie

75 ion, with prominent theories arguing that it played a critical role in the evolution of vocal communi

76 d that the lysine-specific demethylase KDM3A played a dual role in breast cancer cell invasion and ap

77 Both Husk and Ash provided K, which also played a role in yield improvement.

78 fibrils into a load-bearing network, thereby playing a central role in wall mechanics and growth, but

79 nce shows that warm semi-arid ecosystems are playing a disproportionate role in the interannual varia

80 GTPase TC10 as an immunomodulatory molecule playing a role in physiological B cell responses.

81 Our results suggest that PPC plays a causal role specifically in visual decision maki

82 Analysis of nod-1 sectors suggests that NOD plays a cell-autonomous function in the leaf.

83 hetic nervous system control of inflammation plays a central role in hypertension.

84 Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in br

85 ption-EXport) is a multiprotein complex that plays a central role in the coordination of synthesis, p

86 es in the exon-1 region of mutant huntingtin plays a central role in the pathogenesis of Huntington's

87 hat delta-secretase phosphorylation by SRPK2 plays a critical role in aggravating AD pathogenesis.

88 NM myosin II plays a critical role in airway SM contraction that is i

89 he mitochondria-associated ER membrane (MAM) plays a critical role in cellular energetics and calcium

90 Epigenetic regulation of chromatin plays a critical role in controlling embryonic stem (ES)

91 activity.IMPORTANCE The antiviral kinase PKR plays a critical role in controlling HCMV replication.

92 The forkhead box transcription factor FOXC1 plays a critical role in embryogenesis and the developme

93 its function in caveolae biogenesis, Cavin-2 plays a critical role in endothelial cell maintenance an

94 atitis B virus (HBV)-encoded X protein (HBx) plays a critical role in HBV-related hepatocarcinoma dev

95 Here, we show that BMP signaling plays a critical role in looping morphogenesis of the av

96 P1 subunit of the Lassa glycoprotein complex plays a critical role in receptor recognition.

97 CE Recently, it has been reported that GSDMD plays a critical role in regulating lipopolysaccharide a

98 Cytochrome P450 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing

99 ain (SMMHC; encoded by CBFB-MYH11) and RUNX1 plays a critical role in the pathogenesis of this leukem

100 IgE production plays a crucial role in protective as well as pathogenic

101 These results indicate that SP110b plays a crucial role in shaping the inflammatory milieu

102 ls and their neoplastic extracellular matrix plays a decisive role in malignant progression of carcin

103 ns as a retromer component with CSC and also plays a distinct role in the regulation of endosome dyna

104 mbient conditions if absorptive partitioning plays a dominant role.

105 Our results demonstrate that MDC1 also plays a fundamentally significant role in maintenance of

106 This peroxidase function plays a key role during apoptosis.

107 The IPS plays a key role in attention orienting and may contribu

108 erm birth.Inflammation mediated by microglia plays a key role in brain injury associated with preterm

109 s support a model in which this IDR of Med13 plays a key role in controlling a molecular switch that

110 Calcium plays a key role in determining the specificity of a vas

111 ization of contractile cytoskeletal networks plays a key role in force generation, while on the tissu

112 Friction plays a key role in how ruptures unzip faults in the Ear

113 13A5), a sodium-coupled citrate transporter, plays a key role in importing citrate from the circulati

114 dial (lch5) organ of Drosophila larvae-which plays a key role in proprioceptive locomotion control.

115 te nucleus of the mammalian hypothalamus and plays a key role in regulating food consumption and ener

116 ll-specific transmembrane protein (DC-STAMP) plays a key role in the induction of osteoclast (OC) cel

117 ocalized in the ventral tegmental area (VTA) plays a key role in the reinforcing and addictive proper

118 eeping sigma(70)-holoenzyme (Esigma(70)) and plays a key role in the transcriptional reprogramming up

119 The lymphatic system plays a key role in tissue fluid homeostasis, immune cel

120 iator is a multi-unit molecular complex that plays a key role in transferring signals from transcript

121 partial unfolding of misfolded intermediates plays a key role.

122 We find that TRAPPIII plays a major role in regulating Rab activation and traf

123 n approach to assess whether DNA methylation plays a mediating and causal role in associations betwee

124 Thus, TRAF3 plays a negative role in platelet activation and in thro

125 n of gene expression by alternative splicing plays a pivotal role in brain, where it affects neuronal

126 Temperature plays a pivotal role in determining the distribution of

127 oblast-like pancreatic stellate cells (PSCs) plays a predominant role in the formation of desmoplasti

128 that an overexuberant systemic inflammation plays a primary role in ACLF progression.

129 Together, these results show that the dPul plays a primary role in action planning as opposed to vi

130 ion, scavenging sea-salt aerosol bound PFAS, plays a role as a significant input of PFCAs to the Mari

131 Ubiquitination of this site plays a role in AR stability and is critical for its tra

132 III PI3K Vacuolar protein sorting 34 (Vps34) plays a role in both canonical and noncanonical autophag

133 her the information in spike timing actually plays a role in brain function.

134 unohistochemistry, suggesting that GalNAc-T6 plays a role in colon carcinogenesis.

135 PEN3) ATP binding cassette (ABC) transporter plays a role in defense against numerous pathogens and i

136 To address whether this phenomenon plays a role in disease pathogenesis, we generated a kno

137 d polyubiquitination and that the proteasome plays a role in RIG-I degradation.

138 y, this work identifies a novel protein that plays a role in the assembly of the mitochondrial respir

139 is an important sorbent of metal(loid)s and plays a role in the attenuation of metal(loid) uptake in

140 present study demonstrates a mechanism that plays a role in the marked sexual dimorphism observed in

141 We have found that PDHK4 plays a role in the post-translational regulation of mut

142 nomic locus-specific amplification mechanism plays a role.

143 Therefore, the trkB.T1 receptor plays a significant pathophysiological role after SCI, a

144 LPA1 plays a significant role in maintenance of epithelial ba

145 Inflammation plays a significant role in the development of obesity-r

146 ng the Xenopus system, we show that RARbeta2 plays a specific role in somite number and size, restric

147 c-Jun N-terminal kinase (JNK) plays a vital role in malignant transformation of differ

148 Our results demonstrate that Scn8a plays a vital role in neuronal excitability and provide

149 n the membrane of olfactory sensory neurons, plays a vital role in their host seeking and risk aversi

150 The epigenetic reader BRD4 plays a vital role in transcriptional regulation, cellul

151 However, whether cytoplasmic Cl(-) plays additional roles in animal development and tissue

152 DAergic neuron SV endocytosis and that they play additive roles in facilitating each other's pathoge

153 pF/C (5,6) , but the porins do not appear to play an active role in phospholipid transport.

154 , we showed that A-kinase anchoring proteins play an essential role in ICAM-4 activation.

155 These membrane proteins play an essential role in the insertion of the new SPB i

156 systems and these compounds could therefore play an important role as environmental tracers.

157 ning either 3 (3R-Tau) or 4 repeats (4R-Tau) play an important role both during brain development and

158 Dysfunction of microglia is known to play an important role in Alzheimer's disease (AD).

159 owever, factors other than somatic mutations play an important role in disease initiation as well as

160 y, and that their compensatory herbivory may play an important role in ecosystem resilience.

161 rated the observation that clathrin does not play an important role in endocytosis in A. nidulans.

162 Toll-like receptors (TLRs) play an important role in immune responses to pathogens

163 y of tumor cells to cytotoxic treatments can play an important role in individualized cancer medicine

164 Circadian clocks play an important role in lipid homeostasis, with impact

165 Annotation with ontology terms can play an important role in making data driven classificat

166 unctional studies revealed that SLC25A46 may play an important role in mitochondrial dynamics by medi

167 we provide evidence that glycosphingolipids play an important role in muscle innervation, which dege

168 uggest that the radicals present in soil can play an important role in natural remediation mechanisms

169 nce the characteristics of Arbequina oil and play an important role in newly introduced cultivars.

170 The bottom template is found to play an important role in stabilizing the beta roll stru

171 of distinguishing these two conditions could play an important role in the clinical management of pat

172 RTE can play an important role in the differentiation between ma

173 These biomarkers therefore may play an important role in the monitoring and management

174 h target proteases or other proteins and may play an important role in the various beneficial functio

175 omoters and their distal regulatory elements play an important role in transcriptional regulation; ho

176 Antigen-presenting cells (APCs) play an important role in transplant rejection and toler

177 cate that iPLA2-dependent metabolic pathways play an important role in tumor initiation or progressio

178 suggesting that intracellular Ca(2+) buffers play an important role in vesicle recruitment in both lo

179 It is likely that TAVR will play an increasingly important role in the management of

180 We conclude that nucleoporins play an unanticipated regulatory role in NEBD, by recrui

181 Similar mass drownings may have played an important role in rivers throughout the world

182 cal analog of ion-selective electrodes, have played an increasingly important role in chemical and bi

183 novel mechanosensory mechanism in VSMCs and plays an active role in both the arteriolar myogenic res

184 rabies virus (PRV), have suggested that UL37 plays an essential albeit poorly defined role in intrace

185 The RAG recombinase (RAG1/2) plays an essential role in adaptive immunity by mediatin

186 tructure of the RNA molecule-and its absence-plays an essential role in determining capsid structure

187 s studies demonstrate that the glycosylation plays an essential role in the flagellar assembly and mo

188 l colonization has occurred, or if evolution plays an immediate role, governing the growth and expans

189 Since ROS plays an important role in a variety of inflammation, ou

190 Because HLA-E plays an important role in antiviral immunity by regulat

191 The plant cell wall plays an important role in communication, defense, organ

192 or male meiotic cell wall formation and thus plays an important role in consolidating the male gameto

193 ing engenders an antiviral state that likely plays an important role in constraining HIV-1 transmissi

194 Our data suggest that interorgan signaling plays an important role in controlling OB-ISCs in homeos

195 Trafficking of mGluRs plays an important role in controlling the precise local

196 as a type of genomic/genetic variation that plays an important role in disease susceptibility.

197 orin- (AQP) 3, a water and glycerol channel, plays an important role in epidermal function, with stud

198 argued that radiative cooling by water vapor plays an important role in governing the depth and ampli

199 -phosphate-containing molecules and IGF2 and plays an important role in many pathophysiological proce

200 demonstrate by the first time that the Igf1r plays an important role in murine asthma, mediating both

201 SOX1 plays an important role in neural development and neural

202 in macrophages affects cellular function and plays an important role in pathogenesis during infection

203 , these results suggest that endogenous GDNF plays an important role in regulating the function of do

204 Staphylococcus aureus plays an important role in sepsis, pneumonia, wound infe

205 This single site phosphorylation plays an important role in the control of transcriptiona

206 se separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple mem

207 that the KDM3 family of histone demethylases plays an important role in tumorigenic potential and sur

208 , translation initiation from non-AUG codons plays an important role in various gene regulation progr

209 of HIV-1 Gag protein is N-myristoylated and plays an important role in virus budding.

210 on reaction (OER), surface oxygen adsorption plays an indispensable role in the electrocatalysis.

211 s of B cells in humans; however, whether CD6 plays any role in intestinal I/R-induced injury and, if

212 ere are conflicting reports about whether it plays any role in regulating viral lytic reactivation.

213 Our results also highlight the critical role played by antigen density in regulating CAR function.

214 This overview emphasizes the important role played by cross-feeding of intermediary metabolites (in

215 similarities are still debated, and the role played by most organismal traits and their intraspecific

216 of mobility demonstrates the potential role played by polarons in charge transport in CH3NH3PbI3.

217 that include the Gata2 transcription factor play central roles in hematopoietic fate establishment.

218 Lipids play central roles in metabolism and cell signaling, and

219 Protein detection and quantification play critical roles in both basic research and clinical

220 H19 and Igf2 are linked imprinted genes that play critical roles in development.

221 f rice CCR4 and the PXLXP motif of rice CAF1 play critical roles in OsCCR4-OsCAF1 interaction.

222 NAs (miRNAs) are small, non-coding RNAs that play critical roles in the post-transcriptional regulati

223 In plants, regulated cell death (RCD) plays critical roles during development and is essential

224 The mitochondrial adaptor molecule MAVS plays critical roles in coordinating both virus-induced

225 iously imagined and that octamer deformation plays different roles based on the type of chromatin rem

226 odulatory effects could allow PMd and PMv to play distinct functions for the control of hand movement

227 eri interacting proteins, BB0238 and BB0323, play distinct roles in pathogen biology and infectivity

228 ow by mutation and overexpression that Doc2B plays distinct roles in two sequential priming steps in

229 ver, methylation may vary in specific RE and play diverse roles in disease development, thus averagin

230 e the Sema3 subfamily of signaling molecules plays diverse roles in the regulation of cell proliferat

231 Redox-active tyrosines (Ys) play essential roles in enzymes involved in primary meta

232 icated tail structures of DNA bacteriophages play essential roles in life cycles.

233 s isolated from natural sources are known to play important physiological roles in the human body.

234 ands of genes have been well demonstrated to play important roles in cancer progression.

235 protrude from the leading edge of cells and play important roles in cell motility.

236 d substitution geometry of lipophilic groups play important roles in compound-lipid interactions.

237 Recent evidence indicates that lncRNAs play important roles in directing the development of div

238 ier and Sherley explain how diverse seabirds play important roles in ecosystem functioning, global nu

239 Although R-loops play important roles in gene expression and recombinatio

240 to Hla and neutrophil bactericidal capacity play important roles in limiting S. aureus SSTI in femal

241 onstrated that long noncoding RNAs (lncRNAs) play important roles in many human diseases.

242 ier, the neural cell adhesion molecule NCAM, play important roles in many nervous system functions du

243 r members of the SnRK3 family, and that they play important roles in multiple signalling pathways in

244 ostasis and innate neuroimmune function, and play important roles in neurodegeneration and brain agin

245 prise a large fraction of the human proteome play important roles in numerous cellular functions.

246 Inhibitor of DNA binding (Id) proteins play important roles in regulating cardiac development v

247 l communities at different body sites, which play important roles in sensing the environment, protect

248 pecies of the Ixodidae family, are likely to play important roles in subverting host defenses, and co

249 The B7-CD28 family of ligands and receptors play important roles in T-cell co-stimulation and co-inh

250 Our results also show that PKR and OAS1 play important roles in the ISG15-mediated type I IFN se

251 oduct, prostaglandin E2 (PGE2), are known to play important roles in the modulation of both the host

252 tly mutated genes (non-SMGs), which may also play important roles in the prognosis of EC patients, ha

253 The influenza A virus M1 and M2 proteins play important roles in virus assembly and in the morpho

254 mands, funding challenges, and other factors play important roles, but a rigorous analysis of academi

255 urine tooth development, where Lrp4 and Wise play important roles.

256 Our results suggest that chance events have played important and possibly opposing roles throughout

257 r of pro-inflammatory cytokine signaling and plays important roles in immune function, while abnormal

258 ceride lipase (ATGL)-mediated lipolysis that plays important roles in metabolism, tumor progression,

259 testing of the role that biotic interactions play in determining species ranges.

260 o to define the functional roles these genes play in disease.

261 her quality move selection and stronger self-play in the next iteration.

262 such as an overactive innate immune response play in the pathogenesis of this form of hepatic injury.

263 ght the diverse roles lipid constituents may play in the prion conversion process.IMPORTANCE Prion co

264 , politically unbiased yield estimates could play in understanding policy impacts.

265 and time and revealing the essential role it played in maintaining stability and functionality within

266 the role that layered hydroxides could have played in prebiotic peptide formation.

267 these studies demonstrate the role Ser-346/7 plays in arrestin recruitment and initiation of receptor

268 uman skeletal muscle and the role that ACSL6 plays in lipid synthesis in both rodent and human skelet

269 h the well-known regulatory roles that SIRT1 plays in modulating both anabolic and catabolic pathways

270 e the role that the frontopolar cortex (FPC) plays in motivating cognitive and physical effort exerti

271 sment of the role that the delta(13)C record plays in reconstructing the oxygenation of earth's surfa

272 hts the role that intracellular localization plays in specialized metabolism, and sets the stage for

273 Lipid nanodiscs are playing increasingly important roles in studies of the s

274 Hsp70 molecular chaperones play key roles in cellular protein homeostasis by bindin

275 s are also enriched in the brain, where they play key roles in neuronal development and neurotransmis

276 nserved between mouse and human and known to play key roles in neuronal function.

277 the network indicates calcium-related genes play key roles in P. euphratica response to salt shock.

278 oup B1 Sox genes as Sox2 and Sox19 appear to play major roles in neural development.

279 Sialic acids play many important roles in several physiological and p

280 ne such gene is Wilms' tumour 1 (WT1), which plays multiple roles in development, tissue homeostasis

281 e same individual, the effect of their inter-play on ToM abilities has not been investigated.

282 ng members of the RVE8 clade, RVE3 and RVE5, play only minor roles in the regulation of clock functio

283 These results indicate that MYBS1 and MYBS2 play opposite roles in regulating glucose and ABA signal

284 and how its effects on regeneration dynamics play out in long-term stand dynamics.

285 We have also shared a 'plug and play' pipeline to allow other researchers to easily use

286 rotein interactions (PPIs) of these subunits play pivotal roles in assembling the functional polymera

287 Conclusion Career duration and primary playing position seem to modify the effects of concussio

288 ecruitment to inflamed and damaged sites and plays prominent roles in inflammatory pathologies and ca

289 SOCS-3 and SOCS-4 appear to play regulatory roles in a number of keratinocyte and en

290 n, express four serine proteases (NSPs) that play roles in the control of cell-signaling pathways and

291 In malaria, CD36 plays several roles, including mediating parasite seques

292 Both genes play significant roles in type I interferon (IFN) produc

293 These results delineate that C3 plays specific roles in platelet activation independent

294 Direct band-gap semiconductors play the central role in optoelectronics.

295 to the critical power of self-focusing, Pcr, playing the role of the fundamental number-of-particles

296 the designed chiral binaphthyl-based ligand plays the essential role of a general base catalyst and

297 nal strain or a perpendicular magnetic field plays the role of the transverse field, thereby providin

298 ife cycle, so each arenavirus protein likely plays unappreciated accessory roles during infection.

299 and their receptors have been implicated in playing vital roles in ICH outcomes.

300 s Shock Acceleration (LDCSA) mechanism is at play, which combines an initial Collisionless Shock Acce