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4 cluding FeCo alloys and Co4 N nanoparticles, plays a critical role in achieving this promising OER pe
5 me functions at the apex of this pathway and plays a critical role in activating the C-terminus of ub
6 lateral, representation of the sensory space plays a critical role in acuity and fine discrimination
7 ndings reveal that Ag-specific CD4 TRM cells play a critical role in adaptive immunity against reinfe
8 ulin (CaM)-rich environments, oncogenic KRAS plays a critical role in adenocarcinomas by promoting PI
9 hat delta-secretase phosphorylation by SRPK2 plays a critical role in aggravating AD pathogenesis.
11 ficking via chemokine receptors such as CCR5 plays a critical role in alloreactive responses, and pre
13 havior [1-4], and the striatum in particular plays a critical role in arbitrating between competing c
14 external lateral parabrachial nucleus (PBel) play a critical role in arousal to elevated CO2 or hypox
17 The prefrontal cortex (PFC) is thought to play a critical role in behavioral flexibility by monito
20 Bioinformatics and computational biology play a critical role in bioscience and biomedical resear
21 egulator AMP-activated protein kinase (AMPK) plays a critical role in blocking modifications to the c
23 s, the building block of microtubules (MTs), play a critical role in both supporting and regulating n
24 ing for cellular fitness through competition plays a critical role in both development and disease.
26 ctions; (2) dissolution of available calcite plays a critical role in buffering pH; (3) high salinity
27 anilloid subfamily member 6 (TRPV6) channels play a critical role in calcium uptake in epithelial tis
29 e of glycolysis pyruvate kinase (PKM), which plays a critical role in cancer cell metabolism and tumo
33 ested the hypothesis that 5-HT2CR in the BLA plays a critical role in CeA plasticity and neuropathic
36 he mitochondria-associated ER membrane (MAM) plays a critical role in cellular energetics and calcium
38 In conclusion, our study suggests that I-PTH plays a critical role in cellular proliferation, proteog
42 rovide evidence demonstrating that APC(Cdh1) plays a critical role in choosing the repair pathways in
48 activity.IMPORTANCE The antiviral kinase PKR plays a critical role in controlling HCMV replication.
50 a;-P branch of the unfolded protein response plays a critical role in controlling protein synthesis r
51 ANCE STATEMENT The extracellular environment plays a critical role in coordinating neuronal migration
54 scholars comprising journal editorial boards play a critical role in defining the trajectory of knowl
55 we report that the MARCH5 C-terminal domain plays a critical role in degradation of MARCH5 substrate
56 ken together, our results indicate that AAO4 plays a critical role in delaying senescence in siliques
57 demonstrates that antigenic site B residues play a critical role in determining both the unique anti
58 ecent research suggests evolution could also play a critical role in determining expansion speed but
59 wave motions of the tectorial membrane (TM) play a critical role in determining the frequency select
60 nalogous to the Allee effect in ecology, can play a critical role in determining the time until tumou
61 interface between electrolyte and electrode plays a critical role in determining battery performance
63 work demonstrates that the mechanics of inks plays a critical role in developing 3D printing technolo
64 aenorhabditis elegans UBCH7 homolog, UBC-18, plays a critical role in developmental processes through
66 isodic memory, the hippocampus is thought to play a critical role in disambiguating (pattern separati
68 Human retinoid X receptor alpha (hRXRalpha) plays a critical role in DNA binding and transcriptional
70 ed protein response, and ORMDL3 was found to play a critical role in driving the activating transcrip
74 The forkhead box transcription factor FOXC1 plays a critical role in embryogenesis and the developme
75 its function in caveolae biogenesis, Cavin-2 plays a critical role in endothelial cell maintenance an
78 monitoring of such biomarkers can therefore play a critical role in enhancing AD therapies by allowi
79 addition, our studies also revealed that PA plays a critical role in enhancing interactions between
80 Beijing shows that atmospheric water vapour plays a critical role in enhancing the heavy haze events
82 Thus, despite their size, small-bodied bees play a critical role in facilitating long-distance polle
87 alterations in floral resource phenology can play a critical role in governing bee population respons
88 Taken together, we conclude that autophagy plays a critical role in growth, asexual/sexual sporulat
90 atitis B virus (HBV)-encoded X protein (HBx) plays a critical role in HBV-related hepatocarcinoma dev
91 alization that the microbiota-gut-brain axis plays a critical role in health and disease, including n
99 mania is encountered, suggests that they may play a critical role in immune responses to Leishmania.
100 ediated excitatory drive in the hypothalamus plays a critical role in increased sympathetic output in
101 mmune sensor for cyclic dinucleotides (CDNs) playing a critical role in infection, inflammation, and
102 These data strongly suggest that MZ B cells play a critical role in initiating FVIII inhibitor forma
104 +) in the pre- and postsynaptic compartments play a critical role in initiating plastic changes in bi
105 amily of critical transcription factors that play a critical role in innate immune responses and infl
107 restricts clathrin-mediated endocytosis and plays a critical role in iron/transferrin uptake in vivo
108 These findings demonstrate that codon bias plays a critical role in KRAS-driven resistance and prov
109 ds of transcripts and isoforms, and both may play a critical role in lifespan extension through insul
111 d mediator, 15-epi lipoxin A4 (15-epi LXA4), plays a critical role in limiting neutrophil activation
116 erall, these results indicated that Amd1 may play a critical role in maintaining ascus wall integrity
119 in both sexes; however, D5 receptors seem to play a critical role in males whereas females rely more
120 1, in a genetic background-dependent manner, plays a critical role in mammalian eyelid development an
121 human leukocyte antigen (HLA) region, which plays a critical role in many diseases and traits but is
123 sea-level fluctuations and seamount location play a critical role in marine evolution, mainly by inte
126 ence that the hippocampal dentate gyrus (DG) plays a critical role in memory, it remains unclear whet
127 of all protein-tyrosine phosphatases (PTPs), play a critical role in metastatic progression of cancer
129 a clean-energy future, CO2 separations will play a critical role in mitigating current greenhouse ga
130 ells into the blood and other bodily fluids, play a critical role in modulating the tumor microenviro
131 These findings establish that cholesterol plays a critical role in modulating GIRK activity in the
132 receptor (NMDAR)-mediated Ca(2+) signalling plays a critical role in modulating hypothalamic neurose
136 oss of excitatory cholinergic modulation may play a critical role in mPFC deactivation in neuropathic
137 enes, ALP, Runx2, and type I collagen, which play a critical role in MSC to osteoblast transition and
139 gnaling mediated by Lys(63) ubiquitin chains plays a critical role in multiple pathways that are key
141 an increasing recognition that inflammation plays a critical role in neurodegenerative diseases of t
144 B-binding protein (CBP) and its paralog p300 play a critical role in numerous cellular processes.
146 FICANCE STATEMENT Prefrontal cortex activity plays a critical role in operant learning, but the under
148 CH2, a B-cell-specific transcription factor, plays a critical role in oxidative stress-mediated drug
149 onstrate that regulation of iron utilization plays a critical role in P. aeruginosa's ability to surv
150 ural transcription factor Neurogenin3 (Ngn3) plays a critical role in pancreatic endocrine cell diffe
151 the first direct evidence that Kir channels play a critical role in physiological endothelial respon
153 ganglia (TG), and TG-resident CD8(+) T cells play a critical role in preventing its reactivation.
155 ta(+) intestinal intraepithelial lymphocytes play a critical role in promoting intestinal homeostasis
156 contact the peptidyl-tRNA in the P site and play a critical role in promoting the synthesis of polyp
157 ivo, indicating that tissue microenvironment plays a critical role in promoting AML cell survival.
158 lectively, these data demonstrate that IL-33 plays a critical role in promoting ILC2 egress from the
161 main in coronavirus polyproteins, and it may play a critical role in protease regulation and stabilit
165 urons of the peripheral nervous system (PNS) play a critical role in regulating the immune system dur
166 ter (NADW) and Antarctic Bottom Water (AABW) played a critical role in regulating hemispheric and glo
168 ace between ingested nutrients and the body, plays a critical role in regulating energy homeostasis.
170 CE Recently, it has been reported that GSDMD plays a critical role in regulating lipopolysaccharide a
171 altogether demonstrating that primary cilia play a critical role in regulation of both the early odo
173 owever, it remains unknown whether autophagy plays a critical role in regulation of BACE1 trafficking
175 a novel mechanism of kappaOR regulation that plays a critical role in reinstatement of drug seeking.
176 te that Snapin-mediated retrograde transport plays a critical role in removing BACE1 from presynaptic
178 ane-bound ATP-dependent metalloprotease FtsH plays a critical role in resistance to various stressors
179 ly abundant features (e.g. species or genes) plays a critical role in revealing the contributors (i.e
181 2 (HER2), as a key prognostic tumor marker, plays a critical role in screening, early diagnosis and
182 -CpG-binding domain 3 (Mbd3) and the complex plays a critical role in self-renewal and neuronal diffe
183 e window at the start of the breeding season play a critical role in shaping the demography of a long
184 ween microbiota and the immune system likely plays a critical role in shaping beneficial plant-microb
185 rbacterial antagonism mediated by LXG toxins plays a critical role in shaping Firmicute-rich bacteria
186 ults suggest that local cellular environment plays a critical role in shaping terminal phenotypes of
187 exchange factor (GEF) Son of Sevenless (SOS) plays a critical role in signal transduction by activati
189 atory component of the local field potential-plays a critical role in spatial navigation and memory b
194 he disease in zebrafish revealed that ARPC1B plays a critical role in supporting T cell and thrombocy
195 empt reward delays at the decision point and play a critical role in suppressing impulsive choice by
198 helper (Tfh) cells and germinal centers (GC) play a critical role in the ability of the immune system
199 intermediate bound states that are likely to play a critical role in the assembly mechanisms of ssDNA
200 idence that hydrogen(s) present at C10 of AA play a critical role in the catalysis of prostaglandin a
201 Venom peptide toxins such as conotoxins play a critical role in the characterization of nicotini
202 lass I alpha-mannosidases were identified to play a critical role in the degradation process, includi
205 ining Yxxphi motif, but not dileucine motif, play a critical role in the earliest stages of AP2 activ
206 a pathogenic T-cell subset in SSc and likely play a critical role in the early stage of SSc skin dise
207 e of anxiety and depressive symptoms and may play a critical role in the emergence of psychiatric dis
208 ost genetic factors modulating such effects, play a critical role in the evolution of TEs both within
209 une-glia interactions at the sensory ganglia play a critical role in the genesis of herpetic neuralgi
210 es are ubiquitous in soils and sediments and play a critical role in the geochemical distribution of
211 ytoprotective enzyme heme oxygenase-1 (HO-1) play a critical role in the growth and progression of re
212 kin-10 (IL-10)-producing B cells (B10 cells) play a critical role in the immune system balance by neg
213 e macrophage (MPhi) has been demonstrated to play a critical role in the inflammatory phase of tissue
214 ally, these findings suggest that HT neurons play a critical role in the initiation of the perception
215 ectrical energy storage technology that will play a critical role in the large-scale deployment of in
216 er, the data indicate that P2X7R-induced ROS play a critical role in the P2X7R signaling pathway of t
217 that activated PFs (aPFs) and myofibroblasts play a critical role in the pathogenesis of liver fibros
219 tate, suggesting that these charged residues play a critical role in the protein translocation step t
222 The parathyroid glands acting through PTH play a critical role in the regulation of serum calcium.
223 on between acetylation and deacetylation may play a critical role in the resolution of bivalent prote
224 e channel subunit of MCUC, has been shown to play a critical role in the response to beta-adrenorecep
226 ion, with prominent theories arguing that it played a critical role in the evolution of vocal communi
227 results identify a mode of cIAP1 regulation playing a critical role in the cellular response to apop
228 ADCC), whereas terminal alpha2,6-sialylation plays a critical role in the anti-inflammatory activity
231 PM8 expression inhibits Rap1 GTPase and thus plays a critical role in the behavior of vascular endoth
232 ATR, a protein kinase in the PIKK family, plays a critical role in the cell DNA-damage response an
233 r factor (erythroid-derived 2)-like 2 (NRF2) plays a critical role in the cellular antioxidant respon
234 RESISTANCE LOCUS O (MLO) family of proteins, plays a critical role in the communication processes reg
236 IL-10) is an anti-inflammatory cytokine that plays a critical role in the control of immune responses
237 egrates diverse signals in the beta-cell and plays a critical role in the control of insulin secretio
238 ible and immiscible systems of binary alloys plays a critical role in the design of multicomponent al
239 ate p53beta in a synergistic manner, and NMD plays a critical role in the determination of the p53bet
240 FICANCE STATEMENT The central amygdala (CeA) plays a critical role in the development of alcohol depe
242 Together, these results suggest that Tshz1 plays a critical role in the development of ITCs and tha
243 the interaction of Src Kinase and integrins plays a critical role in the development of lung fibrosi
244 acteria and their metabolic products, likely plays a critical role in the development of obesity-asso
245 rocyte sequestration in the microvasculature plays a critical role in the development of severe disea
247 the ESCRT machinery, and in particular VPS4, plays a critical role in the early stages of PV infectio
248 o its function in selective autophagy, Atg20 plays a critical role in the efficient induction of nons
250 er, these data suggest that NCgl2760/Rv0227c plays a critical role in the elongation of the mannan ba
253 emodeling, a fundamental cellular mechanism, plays a critical role in the glucocorticoid-induced oste
256 estioned whether this alternative regulation plays a critical role in the hyperglycolytic phenotype o
257 and nectin-like adhesion molecules and thus plays a critical role in the innate immune response to m
260 ylation is potentiated by TxA2 and that TxA2 plays a critical role in the most proximal event of CLEC
262 iatric illness.SIGNIFICANCE STATEMENT Stress plays a critical role in the neurobiology of mood and an
265 ients with Alzheimer's disease, which likely plays a critical role in the pathogenesis of disease.
266 ain (SMMHC; encoded by CBFB-MYH11) and RUNX1 plays a critical role in the pathogenesis of this leukem
269 dence that the negatively charged C-terminus plays a critical role in the regulation of alpha-synucle
270 is involved in male cell differentiation and plays a critical role in the regulation of chromatin fun
271 y in KSHV RTA expression and function likely plays a critical role in the regulation of downstream vi
273 e receptor CXCR4 and its chief ligand CXCL12 plays a critical role in the retention and migration of
274 the nuclear pore by importins and exportins plays a critical role in the spatial regulation of prote
276 at signal peptides with the receptor complex plays a critical role in the transport process itself.
278 ons proved that the NPs chemical composition played a critical role in their in vivo biodistribution
279 Resection of double-strand breaks (DSBs) plays a critical role in their detection and appropriate
283 complex formation is not required but eIF4G plays a critical role in this translation mechanism.
284 affinity galactose-recognition element that plays a critical role in toxin attachment to cell surfac
285 port a model where the eVP30-eNP interaction plays a critical role in transcription initiation and pr
287 tion in mice.piRNAs are regulatory RNAs that play a critical role in transposon silencing and gametog
288 apoptosis (PUMA) and showed that these cells play a critical role in tumor progression that is indepe
289 arge body of literature has shown that FOXC1 plays a critical role in tumor development and metastasi
291 hromatin-remodeling factor Hmga2 in the skin plays a critical role in UVB-mediated melanomagenesis.
292 ators for gene expression and thus, they can play a critical role in various biological functions and
296 PORTANCE Hepatitis B virus (HBV) HBx protein plays a critical role in viral replication and hepatocar
297 long been hypothesized the fungal metabolism plays a critical role in virulence though specific nutri
300 of cortical circuit assembly are thought to play a critical role in vulnerability to schizophrenia (
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