ライフサイエンスコーパス: play a key role in

1 Thermoelectric power generation can play a key role in a sustainable energy future by conver

2 Matrix metalloproteinases (MMPs) play a key role in abdominal aortic aneurysm (AAA) devel

3 generate electricity from the waste heat can play a key role in achieving a global sustainable energy

4 IL-10 might play a key role in acquisition of tolerance in patients

5 Interleukin 15 plays a key role in activation of leukemic LGL.

6 ults suggest that epicardial Hippo signaling plays a key role in adaptive immune regulation during th

7 ear that antigen presentation in lymph nodes plays a key role in adaptive immunity, the cellular mech

8 e kinase (ATM) to the damaged site, where it plays a key role in advancing the DNA damage checkpoint

9 xpression of multiple mesenchymal genes that play a key role in airway branching and alveolar formati

10 Bronchial fibroblasts play a key role in airway remodelling in asthma.

11 PD, indicating that disrupted GSL clearance plays a key role in alpha-syn aggregation.

12 , homocysteine (Hcy), and glutathione (GSH), play a key role in an extensive range of physiological p

13 yl-CoA with acetaldehyde as intermediate and play a key role in anaerobic redox balance in many ferme

14 Complement may play a key role in antibody-mediated rejection.

15 , suggesting that these biological processes play a key role in antigenicity.

16 vo production of IFN-beta in response to VSV plays a key role in antiviral defense during infection.

17 re, for the first time, we show that Zdhhc13 plays a key role in anxiety-related behaviors and motor

18 sphorylation mediated by PK4 kinase activity plays a key role in artemisinin resistance in recrudesce

19 poral development of extraocular motoneurons plays a key role in assembling a functional oculomotor c

20 Mast cells (MCs) play a key role in asthma where their numbers are increa

21 They can play a key role in astrophysical and ionospheric chemist

22 Endothelial cells (EC) play a key role in atherosclerosis.

23 Dicarboxylic acids play a key role in atmospheric particle nucleation.

24 The IPS plays a key role in attention orienting and may contribu

25 family is an important class of enzymes that plays a key role in bacterial resistance to antibiotics.

26 ed that N-cadherin expression in mural cells plays a key role in barrier function, as CRISPR-mediated

27 ngiopoietin 1 (Ang-1) is agonistic for Tie2, plays a key role in blood vessel maturation and stabilit

28 Here, we report that PPARgamma plays a key role in both T cells and dendritic cells (DC

29 Chronic inflammation plays a key role in both type 1 and type 2 diabetes.

30 human infants, we have shown that TNF-alpha plays a key role in brain inflammation, including recrui

31 erm birth.Inflammation mediated by microglia plays a key role in brain injury associated with preterm

32 reviews several data-driven approaches which play a key role in bringing forward a sea change.

33 Projection neurons play a key role in carrying long-distance information be

34 Our data demonstrate that PAR2 signaling plays a key role in CE-induced AHR and airway inflammati

35 in (RIP) homotypic interaction motifs (RHIM) play a key role in cell death and inflammatory signallin

36 B) is a family of transcription factors that play a key role in cell survival and proliferation in ma

37 Cyclin D and CDK4/6 play a key role in cell-cycle progression by phosphoryla

38 ferlin is a large transmembrane protein that plays a key role in cell membrane repair and underlies a

39 extracellular matrix or to surrounding cells plays a key role in cell proliferation and differentiati

40 Our results demonstrate that NO plays a key role in cell wall remodelling in trichoblast

41 Epigenetics plays a key role in cellular development and function.

42 The liver plays a key role in cholesterol metabolism.

43 Polycomb-repressive complexes PRC1 and PRC2 play a key role in chromosome silencing induced by the n

44 Airborne nanoparticles play a key role in climate effects as well as impacting

45 directed genetic screen we find that vision plays a key role in cluster dynamics.

46 ention.SIGNIFICANCE STATEMENT Working memory plays a key role in cognition, and working memory is imp

47 This important unidentified block could play a key role in constraining HIV-1 transmission.IMPOR

48 Insults to the airway epithelium play a key role in constrictive bronchiolitis after lung

49 Our data illustrate that [Mg(2+)]i plays a key role in control of HBV infection.

50 Soil microbes play a key role in controlling ecosystem functions and p

51 The optic lobe is thought to play a key role in controlling the expansion of the chro

52 s support a model in which this IDR of Med13 plays a key role in controlling a molecular switch that

53 indicate that MrpL35, with its partner Mrp7, play a key role in coordinating the synthesis of the Cox

54 es changes in the filter conformation, which play a key role in defining both selectivity and permeat

55 figurations of these entanglements appear to play a key role in determining the polymerization rates

56 ll (cubic zinc-blende or hexagonal wurtzite) plays a key role in determining the photoluminescence pr

57 Calcium plays a key role in determining the specificity of a vas

58 odeling shows that the elastic strain energy plays a key role in determining the total formation ener

59 RK pathway, the serine/threonine kinase BRAF plays a key role in development and homeostasis and repr

60 Chronic inflammation plays a key role in development of many liver diseases.

61 networks and their underlying metric spaces play a key role in dictating the existence of multi-frac

62 While chemical communication plays a key role in diverse natural processes, the intel

63 imosomal protein from Gram-positive bacteria plays a key role in DNA replication and restart as a loa

64 its introduction in 2009, this technique has played a key role in driving biological discovery, and y

65 r filopodia or phagocytic cup formation, but plays a key role in driving macrophage lamellipodial spr

66 , NMDA receptor-mediated AMPK inhibition may play a key role in early brain metabolic defects in AD.

67 the redox non-innocence of the pyridine can play a key role in enabling high regioselectivity for di

68 ne of the central processes in cell biology, playing a key role in endocytosis, exocytosis, and vesic

69 suggested that reactive oxygen species (ROS) play a key role in epigenetic regulation of miR-663.

70 Chromatin accessibility plays a key role in epigenetic regulation of gene activa

71 e data demonstrate that the cAMP-PKA pathway plays a key role in epigenetic regulation of key profibr

72 basic building block of the chromatin fiber, plays a key role in epigenetic regulatory processes that

73 up the oral microbiome are now understood to play a key role in establishment and maintenance of oral

74 rietal and right fusiform areas was shown to play a key role in ET characterization.

75 eous catalysts in which the chelating ligand plays a key role in facilitating the catalytic reaction

76 nuclear GSK3beta by Ser(389) phosphorylation plays a key role in fear response, revealing new potenti

77 Among these, chemotherapy plays a key role in fighting cancer.

78 ay be an integrated oral sensory region that plays a key role in flavor perception.

79 ization of contractile cytoskeletal networks plays a key role in force generation, while on the tissu

80 troma stimulated CRC development and growth, played a key role in formation of the immune-privileged

81 low temperature of the supersonic expansion plays a key role in forming these complexes.

82 Voltage-gated sodium (Nav) channels play a key role in generating action potentials which le

83 coelastic properties, which we speculate may play a key role in generating heterogeneous mechanical s

84 an orthogonal pattern of growth orientations plays a key role in generating out-of-plane deformations

85 Single-stranded DNA-binding proteins (SSBs) play a key role in genome maintenance, binding and organ

86 n for the short-range collision complex that plays a key role in governing the reaction outcome.

87 atrol, pterostilbene, piceids and viniferins play a key role in grapevine (Vitis vinifera) leaf defen

88 that the immediate-early 2 (IE2) protein may play a key role in HCMV-caused neurodevelopmental disord

89 The medial prefrontal cortex plays a key role in higher order cognitive functions lik

90 This protein plays a key role in HIV infection by facilitating the nu

91 rominent corepressor is TOPLESS (TPL), which plays a key role in hormone signaling and development.

92 Neutrophils play a key role in host defenses and have recently been

93 Complement plays a key role in host defense, but its dysregulation

94 Friction plays a key role in how ruptures unzip faults in the Ear

95 ement of sulfate groups along the GAG chain, plays a key role in HSV binding, we tested two native GA

96 d/l-Amino acid mixtures play a key role in human physiology and pathology; thus,

97 t pathology, dysbiosis, and inflammation and plays a key role in hypertension.

98 ind that none of these residues in isolation plays a key role in IAPP self-assembly, whereas simultan

99 The adenylate cyclase toxin-hemolysin (CyaA) plays a key role in immune evasion and virulence of the

100 for the hypothesis that oxidative stress may play a key role in impacting TRN PV neurons at early sta

101 13A5), a sodium-coupled citrate transporter, plays a key role in importing citrate from the circulati

102 ugh intestinal barrier disruption presumably plays a key role in inflammatory bowel disease (IBD) dev

103 nisms of proteostasis in skeletal muscle and plays a key role in initiating sarcopenia.

104 Natural killer (NK) cells play a key role in innate immunity by detecting alterati

105 Facial emotion perception plays a key role in interpersonal communication and is a

106 nsic, Caspase-1 and -8 inflammasome response plays a key role in intestinal immune defense and pathol

107 bsiding volcano-tectonic barriers would have played a key role in Late Cretaceous climate changes.

108 d activity-dependent mechanisms are known to play a key role in learning and memory.

109 folding that holds chromosome pairs together plays a key role in limiting the levels of double-strand

110 Patterns of gene flow play a key role in maintaining genetic homogeneity in a

111 ecule (CAM) localized at neuronal membranes, playing a key role in maintaining the mechanical integri

112 Our study demonstrates that dispersal plays a key role in maintaining local and regional patte

113 T. brucei telomerase plays a key role in maintaining telomere length, and T.

114 nslational regulation of L1 retrotransposons plays a key role in maintaining trans-generational genom

115 nterspecific social information transfer can play a key role in many aspects of animal ecology from f

116 Matrix metalloproteinases (MMPs) play a key role in many diseases like cancer, atheroscle

117 ameter-growth cessation in trees will likely play a key role in mediating species and ecosystem respo

118 protein kinase catalytic subunit (DNA-PKcs) plays a key role in mediating non-homologous end joining

119 reactive oxygen species (ROS) in the kidney plays a key role in mediating renal injury in diabetes.

120 The transcription factor STAT6 plays a key role in mediating signaling downstream of th

121 These findings indicate that Grx1 induction plays a key role in mediating the protective effect of l

122 hese data provide in vivo evidence that TIA1 plays a key role in mediating toxicity and further sugge

123 t the RSC is very active during PS and could play a key role in memory consolidation taking place dur

124 lian target of rapamycin complex 1 (mTORC1), plays a key role in metabolism and binds chromatin; howe

125 n regions are rich in androgen receptors and play a key role in modulating aggressive behavior in ani

126 ential expression of restriction factors may play a key role in modulating the susceptibility of diff

127 The let-7 miRNA family plays a key role in modulating inflammatory responses.

128 vertebrate, we show that the gut microbiota plays a key role in modulating vertebrate life span.

129 Sharks are charismatic predators that play a key role in most marine food webs.

130 udies of MhsT and LeuT, we propose that TM5i plays a key role in Na2 binding and release associated w

131 first time that local mRNA sequence context plays a key role in near-cognate aminoacyl-tRNA selectio

132 nd mammalian target of rapamycin and as such plays a key role in neuronal function and survival.

133 p97 is a "segregase" that plays a key role in numerous ubiquitin (Ub)-dependent pa

134 Membrane transporters play a key role in obtaining sufficient quantities of ma

135 As an essential micronutrient, iron plays a key role in oceanic biogeochemistry.

136 the G protein coupled receptor (GPCR) S1pr2, plays a key role in pancreas development linking lineage

137 The L3 region may therefore play a key role in pathogenicity.

138 PAR1 activation has been suggested to play a key role in pathological states like thrombosis,

139 Inflammatory processes play a key role in pathophysiology of many neurologic di

140 her disease, especially glucosylsphingosine, play a key role in PD pathology in the brain.

141 Tfh cells play a key role in peanut allergy, and the IL-1 pathway

142 Therefore, this spider may play a key role in pest suppression.

143 Our studies reveal that TLR2 plays a key role in platelet hyperreactivity and the pro

144 A (SAUR) genes promote elongation growth and play a key role in PM H(+)-ATPase activation by inhibiti

145 Here, we demonstrate that microtubules play a key role in poleward movement of acentric chromos

146 RNA-binding proteins play a key role in post-transcriptional processes.

147 e human cell lines, suggesting that it could play a key role in pre-mRNA splicing.

148 loop L1 is highly sensitive to magnesium and plays a key role in pre-organization.

149 The strength of the CNF framework played a key role in preventing the collapse of pores du

150 Although this event is thought to play a key role in priming RAF activation, the underlyin

151 s that 8-oxo-purine ribonucleotides may have played a key role in primordial nucleic acids prior to t

152 on of these modes demonstrating that sulfate plays a key role in producing highly acidic fine aerosol

153 sable elements in prokaryotic genomes, which play a key role in prokaryotic genome organization and e

154 The tau protein is thus widely felt to play a key role in promoting neurodegeneration.

155 encircling the anterior portion of the eye, plays a key role in promoting aqueous humor outflow and

156 This virulence pathway plays a key role in promoting bacterial survival and the

157 ein, we show that focal-adhesion-kinse (FAK) plays a key role in promoting hepatic stellate cells (HS

158 rfamily of GTPases, and Ras-PI3K interaction plays a key role in promoting tumor formation and mainte

159 dial (lch5) organ of Drosophila larvae-which plays a key role in proprioceptive locomotion control.

160 servations confirm that catchment morphology plays a key role in providing refuges with low groundwat

161 Neural activity plays a key role in pruning aberrant synapses in various

162 c structure and strong electron correlations plays a key role in realizing robust superconductivity w

163 Inter-domain dynamics and interactions play a key role in recognition and can be analysed by te

164 DNA localization plays a key role in recognition, as highlighted by Toll-

165 SF3b1 plays a key role in recruiting the U2 snRNP to the BS.

166 Clinical laboratories play a key role in reducing this burden, as the timely i

167 t, a dynamic process which has been shown to play a key role in regulating both cellular adhesive pro

168 -cells of pancreatic islets, K(ATP) channels play a key role in regulating glucose-dependent insulin

169 C1 neurons play a key role in regulating inspiratory modulation of

170 Inflammatory cytokines are known to play a key role in regulating protease expression in can

171 Protein kinases play a key role in regulating the activity of focal adhe

172 rier transport of Abeta, suggesting it might play a key role in regulating the balance between Abeta

173 CANCE STATEMENT CaV1 L-type calcium channels play a key role in regulating the output of central neur

174 Transcription factors play a key role in regulating these decisions and operat

175 modification of proteins by phosphorylation plays a key role in regulating all aspects of eukaryotic

176 SK channels in spines by backpropagating APs plays a key role in regulating both EPSP amplitude and S

177 The sulfur biogeochemical cycle plays a key role in regulating Earth's surface redox thr

178 te nucleus of the mammalian hypothalamus and plays a key role in regulating food consumption and ener

179 nating from the ventral tegmental area (VTA) plays a key role in regulating reward-seeking behaviors.

180 CREB-H, an ER-anchored transcription factor, plays a key role in regulating secretion in metabolic pa

181 n convertase subtilisin/kexin type 9 (PCSK9) plays a key role in regulating the levels of plasma low-

182 of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating this critical decision.

183 of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating this decision.

184 The 3D structure of the genome plays a key role in regulatory control of the cell.

185 Salt marshes play a key role in removing excess anthropogenic nitroge

186 nd adipose tissues, is the metabolic center, playing a key role in reproduction.

187 The tree root-mycorhizosphere plays a key role in resource uptake, but also in the ada

188 Here we show that the Eda pathway also plays a key role in root development.

189 gical interactions have been acknowledged to play a key role in shaping biodiversity.

190 RNA-binding proteins play a key role in shaping gene expression profiles duri

191 man and Syme's research in 1979 continues to play a key role in shaping recent efforts to uncover the

192 Rhizodeposits play a key role in shaping rhizosphere microbial communi

193 activation of the cAMP/pkA signaling pathway play a key role in spontaneous lizard retinal axon regen

194 This pathway plays a key role in stability of mushroom spines and is

195 The surface tension (gamma) of xylem sap plays a key role in stabilizing air-water interfaces at

196 The solvent plays a key role in stabilizing the leaving glutathione

197 rovide direct evidence that epithelial cells play a key role in stimulating connective tissue healing

198 KOR/dynorphin mechanisms in this brain area play a key role in stress-induced alcohol seeking.

199 inking segment, and the chromodomains, which play a key role in substrate discrimination.

200 inding site distal to the active center that plays a key role in substrate DNA binding and catalytic

201 Social dynamics (rank and affiliation) played a key role in success rates.

202 Our results show that superspreaders play a key role in sustaining onward transmission of the

203 Amyloid-beta (Abeta) peptides play a key role in synaptic damage and memory deficits i

204 The alphaLbeta2 integrin LFA-1 is known to play a key role in T lymphocyte migration, which is nece

205 llular pool of LFA-1 in naive CD8(+) T cells plays a key role in T cell activation and differentiatio

206 Reactive oxygen species (ROS) play a key role in the acclimation process of plants to

207 ne structure of the fatty acids was found to play a key role in the binding of a glycolipid to the ca

208 nt of the basal ganglia and is well known to play a key role in the control of motor function via bal

209 Prefibillar species have been proposed to play a key role in the cytotoxicity of amyloid fibrils a

210 ergence and integration network suggested to play a key role in the definition of peripersonal space.

211 Cell transmembrane receptors play a key role in the detection of environmental stimul

212 Transcription factors play a key role in the development of diverse cancers, a

213 y sensorimotor experience, and therefore may play a key role in the development of imitative capaciti

214 Centrioles play a key role in the development of the fly.

215 dorsolateral prefrontal cortex (dlPFC) would play a key role in the effect of anxiety on BPS.

216 The dimensions of the target molecule play a key role in the efficiency of the synapse formati

217 expressed within or around organ primordia, play a key role in the formation, shaping, and subdivisi

218 principal neurons of the mammalian brain and play a key role in the function of nerve cell circuits.

219 We conclude that FN3K may play a key role in the GGap and thus diabetes complicati

220 Wetlands play a key role in the immobilization of metallic contam

221 mmune responses against HIV-1.IMPORTANCE DCs play a key role in the induction of immune responses aga

222 developmental and peroxisomal processes that play a key role in the maturation and stability of corti

223 energy densities, all-solid-state batteries play a key role in the next generation energy storage de

224 Arbuscular mycorrhizal (AM) fungi play a key role in the nutrition of tropical trees, yet

225 an electron and a hole in a solid material, play a key role in the optical properties of insulators

226 , a degenerative process that is believed to play a key role in the pathogenesis of many diseases, ar

227 (+) T cells within the CNS are considered to play a key role in the pathogenesis of multiple sclerosi

228 Accumulating evidence indicates that T cells play a key role in the pathology of lymphedema by promot

229 the specific arrangement of the linkers can play a key role in the photophysical properties of MOFs.

230 Platelets play a key role in the physiological hemostasis or patho

231 gnaling cooperate with the 3 MPN drivers and play a key role in the PMF pathogenesis.

232 Village health workers (VHWs) play a key role in the provision of community-based serv

233 ion by electrocatalytic water splitting will play a key role in the realization of a sustainable ener

234 differentiation, indicating that macrophages play a key role in the redifferentiation of the blastema

235 The NMDAR is thought to play a key role in the refinement of connectivity in dev

236 c BRDT members, are epigenetic "readers" and play a key role in the regulation of gene transcription.

237 We conclude that adipose tissue eosinophils play a key role in the regulation of normal PVAT anti-co

238 r species for influenza A viruses (IAVs) and play a key role in the transmission of IAVs between spec

239 Immunomodulatory interventions play a key role in the treatment of infections and cance

240 Peroxisomes are thought to have played a key role in the evolution of metabolic networks

241 Selection breeding has played a key role in the improvement of seed yield and q

242 ducing organelles of bacterial ancestry that played a key role in the origin and early evolution of c

243 indicates that a reduction of insolation is playing a key role in the link between the weakening of

244 toskeletal changes and inflammation, thereby playing a key role in the mechanisms of disease progress

245 the GDP-binding pocket identified Arg(93) as playing a key role in the nucleotide interaction and rev

246 ion of reactive oxygen species (ROS) in vivo plays a key role in the ageing process has been extensiv

247 itment of NMII to the secretory granules but plays a key role in the assembly and activation of NMII

248 unit of the NADH: ubiquinone oxidoreductase, plays a key role in the assembly and activity of complex

249 system promotes depressive-like behavior and plays a key role in the aversive effects of stress.

250 The brain plays a key role in the controls of energy intake and ex

251 Local rank information plays a key role in the curve resolution of multicompone

252 The ventromedial prefrontal cortex plays a key role in the decision process, encoding both

253 While axon fasciculation plays a key role in the development of neural networks,

254 Neuronal activity plays a key role in the development of sensory circuits

255 with these entities is important as imaging plays a key role in the diagnostic workup, and prompt di

256 transporter 4 (Glut4) to the plasma membrane plays a key role in the dynamic regulation of glucose ho

257 results demonstrate that glutamate signaling plays a key role in the dynamics of SD, and that impaire

258 gamma production by these lymphocytes likely plays a key role in the early control of the parasite an

259 led by metals and ceramics, polymer-based AM plays a key role in the emerging AM of advanced multifun

260 The epigenetics landscape of cells plays a key role in the establishment of cell-type speci

261 ll-specific transmembrane protein (DC-STAMP) plays a key role in the induction of osteoclast (OC) cel

262 The autophagy-lysosomal system plays a key role in the maintenance of cellular homeosta

263 These results demonstrate that the CR plays a key role in the mechanotransduction complex in h

264 flammasome, a caspase-1 activation platform, plays a key role in the modulation of liver inflammation

265 Position 6 of the morphinan skeleton plays a key role in the mu-opioid receptor (MOR) activit

266 Protein arginine deiminase 2 (PAD2) plays a key role in the onset and progression of multipl

267 escence proves that the halide stoichiometry plays a key role in the optoelectronic properties of the

268 the endothelium by pro-inflammatory stimuli plays a key role in the pathogenesis of a multitude of v

269 Amyloid-beta (Abeta) plays a key role in the pathogenesis of Alzheimer's dise

270 Brain-derived neurotrophic factor (BDNF) plays a key role in the pathophysiology and treatment of

271 This programming plays a key role in the plague-resistance phenotype and

272 cription factor SHORT VEGETATIVE PHASE (SVP) plays a key role in the progression from vegetative to f

273 In addition, the pyrrole NH also plays a key role in the proton-coupled, two-electron oxi

274 way, indicating that the form of the oxidant plays a key role in the reaction mechanism.

275 Collectively, our data suggest that USP15 plays a key role in the regulation of dynamic protein-pr

276 mRNA splicing and export plays a key role in the regulation of gene expression, w

277 Nitric oxide signaling plays a key role in the regulation of vascular tone and

278 E STATEMENT Water channel aquaporin 4 (AQP4) plays a key role in the regulation of water homeostasis

279 Water channel aquaporin 4 (AQP4) plays a key role in the regulation of water homeostasis

280 ocalized in the ventral tegmental area (VTA) plays a key role in the reinforcing and addictive proper

281 We discovered that surface water on Cu plays a key role in the selectivity for hydrocarbon prod

282 nce of dibenzyl substituents at the nitrogen plays a key role in the stereochemical outcome of the re

283 eeping sigma(70)-holoenzyme (Esigma(70)) and plays a key role in the transcriptional reprogramming up

284 It is widely recognized that language plays a key role in the transmission of human culture, b

285 he ion to be incorporated into the ice phase plays a key role in the ultimate size of the ice grains

286 otic-enriched anionic lipid Cardiolipin (CL) plays a key-role in the TFDs delivery to bacteria.

287 se, and clearly demonstrated that the cervix plays a key role in their delayed parturition.

288 Because cGMP plays a key role in these processes, here we investigate

289 figuration, showing that secondary structure plays a key role in these processes.

290 The inflammatory mediators, COX-2 and PGE2, played a key role in this effect, as indicated by honoki

291 Tip-localized exocytosis plays a key role in this network by integrating guidance

292 RhoA signaling at adherens junctions plays a key role in this process by coupling cadherin-ba

293 endent up-regulation of Cox-1 expression may play a key role in tissue homeostasis and wound healing

294 served innate immune system is considered to play a key role in tissue injury recognition and the sub

295 The lymphatic system plays a key role in tissue fluid homeostasis, immune cel

296 The medial prefrontal cortex (mPFC) plays a key role in top-down control of the brain's stre

297 iator is a multi-unit molecular complex that plays a key role in transferring signals from transcript

298 ond those for the environment, indeed it may play a key role in transitioning towards a more sustaina

299 These domains have the potential to play a key role in transmitting epigenetic silencing of

300 Myeloid cells play a key role in tumor progression and metastasis by p