ライフサイエンスコーパス: play a major role in

1 erentiate into IL-13-producing Tc2 cells and play a major role in a bleomycin-induced model of fibros

2 tiffness sensing by living cells is known to play a major role in a variety of cell mechanobiological

3 Transcriptional deregulation plays a major role in acute myeloid leukemia, and theref

4 Cerebral vessels play a major role in AD, as Abeta is cleared from the br

5 pendent of payload dose or plasma clearance, plays a major role in ADC efficacy.Significance: This st

6 ated by the reaction between FC and .OH/Cl., played a major role in addition to .OH and Cl. in degrad

7 Phosphorylation plays a major role in adhesion signalling; however, a fu

8 The middle domain of Abeta1-42 plays a major role in aggregation, whereas the N-terminu

9 ceptor (IP3R), and Ryanodine receptor (RyR), plays a major role in agonist-induced intracellular calc

10 sts that CD8+ T cells and CD94+ NK cells may play a major role in AIM.

11 Intracortical interactions play a major role in all aspects of the visual functions

12 hat different C-type lectin receptors on DCs play a major role in allergen recognition and uptake.

13 tide (oAbeta) and tau proteins are likely to play a major role in Alzheimer's disease (AD).

14 WMI in vivo suggesting that the ISR does not play a major role in, and is not a likely therapeutic ta

15 Type I interferons have been shown to play a major role in anti-cancer immunity.

16 Natural killer (NK) cells play a major role in anti-viral immunity as first line d

17 r knowledge, that the piRNA pathway does not play a major role in antiviral defense in adult Drosophi

18 s an interferon (IFN) effector system, which plays a major role in antiviral defense.

19 ng force during active protrusion, and NMIIB plays a major role in applying force on the nucleus to f

20 The HIV-1 envelope protein gp120 plays a major role in binding and budding in the central

21 ses under the control of an external trigger play a major role in biological signal transduction proc

22 Gene expression stochasticity plays a major role in biology, creating non-genetic cell

23 iated neural adaptations are thought to have played a major role in bird diversification [4-8], where

24 main, from which the C-domain is supposed to play a major role in blood pressure regulation and is th

25 By contrast, genetic factors play a major role in both the presence and intensity of

26 constitute potent innate lymphoid cells that play a major role in both tumor immunosurveillance and v

27 Sequence variation within enhancers plays a major role in both evolution and disease, yet it

28 While the Cu transporter ATP7A plays a major role in both intestinal Cu mobilization to

29 Organic matter (OM) plays a major role in both terrestrial and oceanic bioge

30 s with 5'-3' exoribonuclease 2 (XRN2), which plays a major role in both the maturation of rRNA and th

31 head Box P (FOXP) transcriptional repressors play a major role in brain development and their dysfunc

32 Our results also revealed that Pol V played a major role in bypassing alpha-dC, alpha-dG and

33 ansient receptor potential isoform 4 (TRPV4) plays a major role in Ca(2+) /cation signalling, cytoske

34 purinergic receptors by secreted nucleotides plays a major role in calcium mobilization and the subse

35 Myeloid-derived suppressor cells (MDSCs) play a major role in cancer.

36 h larger than previously thought and thus it plays a major role in carbon cycling.

37 that control the extent of growth in mitosis play a major role in cell size control in budding yeast.

38 Although the unfolded protein response (UPR) plays a major role in certain microbial infectivity, its

39 dicating that ophiolite emplacement may have played a major role in changing global climate.

40 protease separase (EXTRA SPINDLE POLES, ESP) plays a major role in chromatid disjunction and cell exp

41 hese data suggest that the classical pathway plays a major role in complement activation in patients

42 Recent studies show that cities might play a major role in contemporary evolution by accelerat

43 Here we show that GrvR plays a major role in control of ace expression and E. f

44 e invertebrate homologue of norepinephrine), plays a major role in controlled sugar consumption.

45 -interacting bHLH transcription factors that play a major role in controlling JA responses in vegetat

46 ur work demonstrates that SPT small subunits play a major role in controlling SPT activity and substr

47 populations, the arcuate melanocortin system plays a major role in controlling homeostatic functions.

48 s suggest that oligomer decomposition likely plays a major role in controlling SOA evaporation, and s

49 cerol at the endoplasmic reticulum membrane, plays a major role in controlling the utilization of pho

50 This intramembrane protease plays a major role in converting prelamin A to mature la

51 cal coupling between beta-cells in the islet plays a major role in coordinating a pulsatile secretory

52 ns that Agr functionality and PSM production play a major role in defining different forms of S. aure

53 osity, uniparental isodisomy or hemizygosity play a major role in defining HL risk in predominantly o

54 ers and other cellular factors is thought to play a major role in defining the specific spatiotempora

55 ue virus-infected individuals are thought to play a major role in dengue virus transmission.

56 r network within the parasitophorous vacuole play a major role in determining antigenicity of Toxopla

57 idogenic polypeptides with cellular surfaces play a major role in determining disease onset.

58 riables, suggesting that host factors likely play a major role in determining disease severity.

59 tural property of soil, and that root traits play a major role in determining diversity effects.

60 ntramolecular vibrations of the ground state play a major role in determining the line shape of such

61 We found xylem conduit dimensions play a major role in determining the susceptibility of t

62 ow and the effective duration of inhibition, played a major role in determining the trough positions

63 ional capacity during development, and input plays a major role in determining functional specializat

64 train generated by the gastrulating mesoderm plays a major role in determining the global axis of pla

65 omal escape in living cells.Hydrogen bonding plays a major role in determining the tridimensional str

66 e further demonstrate that myocilin does not play a major role in DEX-induced OHT in mice.

67 evening complex (EC) of the circadian clock plays a major role in directly coordinating the expressi

68 The host protein, PrP(C), plays a major role in disease transmission.

69 e between monomeric subunits of the tetramer plays a major role in distinguishing these functional st

70 Europe has played a major role in dog evolution, harbouring the old

71 he activity of direct GBSs and may therefore play a major role in driving gene activation in response

72 systems, we demonstrate that plate tectonics played a major role in driving tropical marine shallow r

73 Polo-like kinase-1 (PLK1) plays a major role in driving mitotic events, including

74 at the transmembrane form of EqCXCL16 likely plays a major role in EAV host cell entry processes, pos

75 from hypoxia in vitro, it does not appear to play a major role in either MCH or SAH-induced DWMI and

76 teries, and pseudocapacitors are expected to play a major role in energy conversion/storage in the ne

77 Colour polymorphisms have played a major role in enhancing current understanding o

78 Our data reveal that CIZ1 plays a major role in ensuring stable association of Xis

79 Chromatin regulators play a major role in establishing and maintaining gene e

80 (proBDNF)-dependent p75NTR signaling pathway plays a major role in excitability and persistent activi

81 While NMDA receptors play a major role in excitotoxicity, it is thought to be

82 first describe what appraisal is and why it plays a major role in explaining how different individua

83 established that the HMW1 and HMW2 adhesins play a major role in facilitating colonization of the up

84 Image quantization played a major role in feature repeatability.

85 Because suction plays a major role in fluid entry to the lymphatics and

86 Oocyte-derived, TGF-beta family proteins play a major role in follicular development and molecula

87 are dominated by minute microorganisms that play a major role in food webs and biogeochemical cycles

88 c degradation produced by reactive carbonyls plays a major role in food quality and safety.

89 In addition to playing a major role in fork progression during leading

90 kel-cell associated afferents are thought to play a major role in form perception by encoding surface

91 tic brain injury (TBI), ischemia and hypoxia play a major role in further worsening of the damage, a

92 fy source contributions of Zn and Cu and can play a major role in future air quality studies.

93 us, herbivory-driven volatiles are likely to play a major role in future biosphere-vegetation feedbac

94 ely ignored in morphology prediction but can play a major role in gelation, each scaffold needed to b

95 ome (BLM) helicase and exonuclease 1 (EXO1), play a major role in generating these DNA fragments and

96 We conclude that, on early Mars, tsunamis played a major role in generating and resurfacing coasta

97 Group II introns have played a major role in genome evolution, as they are lik

98 Peat mosses of the genus Sphagnum play a major role in global carbon storage and dominate

99 ntibodies indicated that this apolipoprotein plays a major role in HCV-HS interaction.

100 Simultaneously, FANCD2-but not FANCI-plays a major role in HDR-mediated replication restart a

101 anucleated megakaryocyte (MK)-derived cells, play a major role in hemostasis and arterial thrombosis.

102 Platelet activity plays a major role in hemostasis with increased platelet

103 er, our work demonstrates that Tregs in skin play a major role in HF biology by promoting the functio

104 of the high-risk human papillomavirus (HPV) plays a major role in HPV-induced carcinogenesis.

105 cal cancer and encode an E7 oncoprotein that plays a major role in HPV-induced carcinogenesis.

106 The immune system plays a major role in human health and disease, and unde

107 The environment plays a major role in human health, yet tools to study t

108 The hematopoietic system plays a major role in human health.

109 NK cells play a major role in immune defense against human and mu

110 Complement plays a major role in inflammatory diseases, but its inv

111 sruption of olivocerebellar signalling could play a major role in initiating motor disease.

112 Fibroblast-like synoviocytes (FLS) play a major role in invasive joint destruction in rheum

113 Our data are consistent with Plasmodium VITs playing a major role in iron detoxification and, thus, n

114 encodes a mechanosensitive ion channel that plays a major role in light-touch mechanosensation and h

115 We speculate that distension of the MPA may play a major role in limiting full aortic expansion duri

116 Finally, we show that Rqh1 plays a major role in limiting Exo1-dependent direct rep

117 The enzyme playing a major role in lipid metabolism is subject to p

118 upport the notion that CD8(+) T cells do not play a major role in maintaining HSV-1 latency and react

119 ted with very-low-density lipoprotein (VLDL) play a major role in maintaining overall lipid homeostas

120 Calcium homeostasis plays a major role in maintaining neuronal function unde

121 Saliva plays a major role in maintaining oral health.

122 and testis-specific Ig superfamily protein) plays a major role in male fertility in mice.

123 Atmospheric aerosol nanoparticles play a major role in many atmospheric processes and in p

124 Complement activation plays a major role in many acute and chronic inflammator

125 rate that NKG2D expression by CD8(+) T cells plays a major role in mediating GVHD and GVT effects by

126 These results strongly suggest that PspA plays a major role in mediating the immunosuppressive pr

127 attachment protein receptor (SNARE) proteins play a major role in membrane fusion and contribute to c

128 s and their associated rhizosphere organisms play a major role in mineral weathering driving calcium

129 In all cases, enthalpy-entropy compensation plays a major role in minimizing the magnitude of "heavy

130 polysaccharides and glucosides, glucose also plays a major role in modern food products, particularly

131 ave revealed that magnesium and calcium ions play a major role in modulating the ability of these enz

132 tive constraints on the eukaryotic cell have played a major role in modulating the evolution of the m

133 The chemokine receptors CCR2 and CX3CR1 play a major role in monocyte recruitment and differenti

134 Cholinergic interneurons (CHIs) play a major role in motor and learning functions of the

135 is enzyme is accessible in the cytoplasm and plays a major role in mRNA decay.

136 Serendipity has played a major role in my contributions to investigative

137 We find that neutrophils play a major role in myelin clearance not only in Ccr2(-

138 PSA also plays a major role in nervous system regeneration follow

139 yses, our data indicate that CpG methylation plays a major role in neuroepigenetics, and that the mou

140 s have been extensively studied because they play a major role in neuronal firing and bursting.

141 Among these, the MYC oncogene plays a major role in NOTCH1-induced transformation.

142 hibitory circuits in the olfactory bulb (OB) play a major role in odor processing, especially during

143 For these patients, immunosuppression plays a major role in oncogenesis by both impairement of

144 essential micronutrients for animals as they play a major role in one carbon metabolism.

145 that specialized, secreted enterotoxins may play a major role in one of these strategies.

146 While the Hippo signaling pathway plays a major role in organ growth control, how it sense

147 munodeficiency virus drug resistance (HIVDR) plays a major role in pediatric HIV treatment failure be

148 (+)CD25(+)Foxp3(+) regulatory T (Treg) cells play a major role in peripheral tolerance.

149 Thus, IL-15 plays a major role in peripheral maintenance of NK cells

150 working through the androgen receptor (AR), plays a major role in physiological process and disease

151 in neutrophils, a cell type that is known to play a major role in pneumococcal clearance.

152 Our data suggest that ER stress plays a major role in podocyte injury in DN and RTN1A mi

153 There is little doubt evolution has played a major role in preventing the control of infecti

154 Antibiotic prophylaxis plays a major role in preventing surgical site infection

155 vices, but that mental health services could play a major role in primary and secondary prevention of

156 t regulation of endogenous survival pathways plays a major role in progression of chronic lymphocytic

157 The DNA mismatch repair (MMR) system plays a major role in promoting genome stability and sup

158 Here we show that ANGPTL3 plays a major role in promoting uptake of circulating ve

159 NK cells play a major role in protection against tumor recurrence

160 these circumstances, (*)OH and CO3(*-) would play a major role in PRP phototransformation.

161 tress, and mitochondrial-dependent apoptosis plays a major role in radiation-induced tissue damage.

162 These cells play a major role in rebuilding tumor-associated lymphat

163 ralizing antibodies, and EIII is believed to play a major role in receptor binding.

164 G protein-coupled receptor phosphorylation plays a major role in receptor desensitization and arres

165 A family of CBF transcription factors plays a major role in reconfiguring the plant transcript

166 2) is a negatively charged phospholipid that plays a major role in recruiting and regulating proteins

167 nvolved in endocannabinoid biosynthesis thus play a major role in regulating the activity of this sys

168 constituents of the extracellular matrix and play a major role in regulating the development and func

169 and Hsp90 cell signaling pathways appear to play a major role in regulating these cellular and struc

170 Forest stand age plays a major role in regulating carbon fluxes in boreal

171 ATP-binding cassette transporter A1 plays a major role in regulating microdomain cholesterol

172 We find that TRAPPIII plays a major role in regulating Rab activation and traf

173 We find that oocyte-derived methylation plays a major role in regulating trophoblast development

174 ucleosome core particle (NCP) is believed to play a major role in regulation of gene expression.

175 We show that lymphocytes play a major role in remyelination whose efficacy is sig

176 logous recombination (HR) DNA repair pathway plays a major role in repairing DSBs induced by HZE part

177 stochemistry analysis demonstrate that NCoR1 plays a major role in repressing developmental maturatio

178 In mouse embryonic stem cells where TRIM28 plays a major role in repressing endogenous retroviruses

179 Lysosome exocytosis plays a major role in resealing plasma membrane (PM) dis

180 Perineuronal nets (PNNs) are thought to play a major role in restricting synaptic plasticity dur

181 t ataxia-telangiectasia mutated kinase (ATM) plays a major role in restricting the replication of SSB

182 Abscisic acid (ABA) signaling plays a major role in root system development, regulatin

183 channels composed of subunit connexins, can play a major role in secondary cell death by forming con

184 The RIG-I-like receptors (RLRs) play a major role in sensing RNA virus infection to init

185 data provide convincing evidence that HMGB4 plays a major role in sensitizing TGCTs to cisplatin, co

186 1 and Notch2 receptors on HBCs, is likely to play a major role in setting the level of p63 expression

187 The electrode surface plays a major role in several plasma-related technical f

188 viduals (i.e. individual heterogeneity), can play a major role in shaping demographic trajectories in

189 Our results suggest that flow and mixing play a major role in shaping the microbiota of the colon

190 pecies' evolution in the past and could also play a major role in shaping their evolution in the futu

191 e found no evidence that geographic location played a major role in shaping RNA virus diversity, and

192 These results suggest that climatic changes played a major role in shaping species' evolution in the

193 have evolved multiple times, only viviparity played a major role in shaping the patterns of diversity

194 systems, and suggests that sexual selection plays a major role in shaping sex chromosome dosage comp

195 H-NS is a NAP that also plays a major role in silencing pathogen genes.

196 Surprisingly, cohesin rings do not play a major role in sister telomere cohesion.

197 However, reduced GDNF expression does not play a major role in SMA pathology as viral-mediated GDN

198 e yet resistant layer called exosporium that plays a major role in spore adhesion and virulence.

199 Although Myc transcription factors play a major role in stem cell self-renewal and pluripot

200 mational dynamics at the mouth of the pocket play a major role in steroid receptor activation.

201 ges in gene transcription have been shown to play a major role in stress responses and adaptation.

202 cies studied, suggesting that the host taxon plays a major role in structuring virus diversity.

203 ed to as resting-state studies, have come to play a major role in studies of the human brain in healt

204 specializations and suggest that they do not play a major role in synapse formation.SIGNIFICANCE STAT

205 -terminal domain of the large subunit (p58C) plays a major role in template-primer binding and also d

206 of this bark beetle-vectored fungus and may play a major role in the ability of I. typographus to co

207 However, glial activity does not appear to play a major role in the acute regulation of barrier fun

208 port while glial activity does not appear to play a major role in the acute regulation of barrier fun

209 of the peptide fractions, and Tyr seemed to play a major role in the antioxidant activity.

210 Biogenic selenium (Se) emissions play a major role in the biogeochemical cycle of this es

211 at nucleotide excision repair is unlikely to play a major role in the cellular response to ribonucleo

212 of defense against bacterial infections and play a major role in the clearance of apoptotic cells.

213 Clouds play a major role in the climate system, but large uncer

214 so suggest that the phenyl ring interactions play a major role in the crystallization mechanism.

215 Genetic factors play a major role in the development of addiction.

216 Technical factors play a major role in the development of BCs, particularl

217 oth inflammation signals and ceramide, could play a major role in the development of insulin resistan

218 s originating from host-parasite interaction play a major role in the disease pathology and allied co

219 Nutritional symbionts play a major role in the ecology and evolution of insect

220 focusing in stenosed vessels, is observed to play a major role in the enhancement.

221 Genetic factors play a major role in the etiology of epilepsy disorders.

222 suggesting that cytonuclear interactions can play a major role in the evolutionary dynamics ofA. thal

223 support for the notion that repulsive forces play a major role in the formation of lipid rafts.

224 Although sexual reproduction is believed to play a major role in the high diversification rates and

225 are highly immunostimulatory molecules that play a major role in the host defense against infections

226 lts support the idea that antibodies did not play a major role in the improvement, and that cell-medi

227 t in profound negative-affective states that play a major role in the maintenance of addiction.

228 Prokaryotic viruses play a major role in the microbial ecology and evolution

229 ults suggest that inflammation and ethnicity play a major role in the modulation of CRC risk.

230 infection, indicated that licensing did not play a major role in the NK cell antiviral response duri

231 eregulation of FOXC1 or its downstream genes play a major role in the pathogenesis of coarctation of

232 Several virulence factors are known to play a major role in the pathogenesis of cryptococcal in

233 Thus, ExMVs play a major role in the pathogenesis of infection and p

234 and many studies suggest that host genetics play a major role in the pathogenesis of most of them.

235 Endo-epicardial asynchrony may play a major role in the pathophysiology of AF and may o

236 MicroRNAs (miRNAs) play a major role in the post-transcriptional regulation

237 As mitochondria play a major role in the rapid buffering of cytosolic ca

238 ion experiments have revealed that KRAB-ZFPs play a major role in the recognition and transcriptional

239 modulate long-term depression expression and play a major role in the regulation of hippocampal learn

240 yaluronan-binding function of TSG-6 does not play a major role in the stabilization of the murine cum

241 ance of a minor transcript of BRCA2 that can play a major role in the survival of humans who are homo

242 oxo-amino-acids of the protein serum albumin play a major role in the translocation of protons via an

243 continental shelves around the Arctic Ocean play a major role in the ventilation of the deep basins

244 merized pigments, but not total polyphenols, played a major role in the determination of H2O2 levels,

245 ral to the description of diversity and have played a major role in the development of theories of bi

246 evolution and that aquatic habitats may have played a major role in the diversification of some early

247 ur projections suggest that (i) habitat loss played a major role in the European eel decline; (ii) th

248 t domesticated camelids called "chilihueque" played a major role in the island's society.

249 cts of initial differences in litter quality played a major role in the late stages of the process.

250 Reactors have played a major role in the study of neutrino oscillation

251 Autotaxin (ATX) is a secreted enzyme playing a major role in the production of lysophosphatid

252 However, the unique His-Tyr-ligated PhuR plays a major role in the acquisition of heme.

253 ndicating that genomically incorporated 5-FU plays a major role in the antineoplastic effects of FdUr

254 rowding-induced myosin conformational change plays a major role in the changed kinetics of actomyosin

255 senger RNA (mRNA) and start codon choice and plays a major role in the control of translation efficie

256 the regulation of hepatic metabolism, which plays a major role in the development and progression of

257 no acid peptide hormone adrenomedullin (ADM) plays a major role in the development and regulation of

258 in kinase gamma (CaMKIIgamma) in macrophages plays a major role in the development of necrotic, thin-

259 ience.SIGNIFICANCE STATEMENT Neural activity plays a major role in the development of sensory circuit

260 SIGNIFICANCE STATEMENT: Neural activity plays a major role in the development of sensory circuit

261 lates immune responses against pathogens and plays a major role in the differentiation and maintenanc

262 UDP-glycosyltransferase (UGT) plays a major role in the diversity and reactivity of pl

263 egrins and actin filament anchoring and thus plays a major role in the establishment of the actin-ext

264 c role of glucagon released from alpha-cells plays a major role in the etiology of both type 1 and ty

265 KCNB1 channels with reactive oxygen species plays a major role in the etiology of mouse model of tra

266 This study shows that thiamine plays a major role in the formation of three key odorant

267 rest houses much of Earth's biodiversity and plays a major role in the global carbon budget, estimate

268 undant and ubiquitous phylum of archaea that plays a major role in the global nitrogen cycle.

269 aceous and woody species, because protoxylem plays a major role in the hydraulic systems of leaves, e

270 dsRNA produced during virus replication and plays a major role in the innate immunity response to vi

271 Splicing by group II introns plays a major role in the metabolism of plants, fungi, a

272 ration rate (kd), indicating that metabolism plays a major role in the overall elimination of these c

273 The oxidative stress response in the airways plays a major role in the pathogenesis of RSV.

274 Rgamma, or NR1F3) is a nuclear receptor that plays a major role in the production of interleukin (IL)

275 (mechanomiRs) in dystrophic skeletal muscle plays a major role in the progression of MD.

276 indicating that the BCR signaling threshold plays a major role in the regulation of central B cell t

277 Glucagon plays a major role in the regulation of glucose homeosta

278 ly accepted view, here we show that Poldelta plays a major role in the replication of both DNA strand

279 The MinCDE system plays a major role in the site selection of the division

280 Horizontal gene transfer (HGT) plays a major role in the spread of antibiotic resistanc

281 Integrin alpha4beta7 plays a major role in the trafficking of lymphocytes, in

282 preservation, the reduction of sulfite input plays a major role in the wine industry.

283 radial (cell-to-cell) transport of oxylipins plays a major role in the wound response.

284 s-such as interactions between the organisms-play a major role in their emergence(1,2).

285 uggesting that codivergence with their hosts played a major role in their diversification.

286 anding of interface and surface effects that play a major role in these systems.

287 Although cell surface cues play a major role in this process, few dendrite specific

288 high insulin levels in overweight women may play a major role in this relationship, due to insulin's

289 The viral protein kinase US3 plays a major role in this immune evasion mechanism, and

290 In mammals, macrophages are known to play a major role in tissue regeneration.

291 ive aging, the interdependency between cells plays a major role in tissue death, providing evidence o

292 The muscle segment homeogenes Msx1 and Msx2 play a major role in tooth and bone formation.

293 epressive complex 2 (PRC2) has been shown to play a major role in transcriptional silencing in part b

294 nhibition of activated PD-1(+) T lymphocytes plays a major role in tumor escape from immune system du

295 downregulation, the miR-140-5p/Pin1 axis may play a major role in tumorigenesis and offer promising t

296 8-oxoG plays a major role in tumorigenesis and human disease.

297 Akt plays a major role in tumorigenesis and the development

298 rmore, our data suggest that the macrophages play a major role in viral dissemination by carrying the

299 fection, NK cells migrate into follicles and play a major role in viral reservoir control in lymph no

300 that cross-species transmission events have played a major role in viral evolution.