ライフサイエンスコーパス: play an essential role in

1 Biomarkers play an essential role in accelerating drug development.

2 e of the fusion glycoprotein of many viruses plays an essential role in activation; however, cleavage

3 apt to changes in oxygen availability, which plays an essential role in adaptation to a wide variety

4 The RAG recombinase (RAG1/2) plays an essential role in adaptive immunity by mediatin

5 thione, suggesting that thiols in DOM likely played an essential role in affecting microbial Hg uptak

6 The conclusions are that TRPC3 channels plays an essential role in AIAD via the PKC-alpha/Ikappa

7 eptors within the mesolimbic dopamine system play an essential role in alcohol relapse.

8 Mn(2+) ion plays an essential role in all forms of life.

9 ar factors to infect cells, and the ribosome plays an essential role in all viral infections.

10 (CF) gene, encodes for the CFTR protein that plays an essential role in anion regulation and tissue h

11 study, we demonstrated that GM-CSF signaling plays an essential role in antifungal defense against As

12 these findings demonstrate that mTOR signals play an essential role in antigen-specific humoral immun

13 Natural killer (NK) cells play an essential role in antiviral immunity, but knowle

14 tant to the anti-inflammatory reflex arc and plays an essential role in arresting MDSC proliferation.

15 creases in prefrontal acetylcholine release, plays an essential role in attention by mediating such c

16 entiation (LTP) in the lateral amygdala (LA) plays an essential role in auditory fear conditioning, i

17 GM-CSF) produced by T helper 17 (Th17) cells plays an essential role in autoimmune diseases.

18 BTK plays an essential role in B cell receptor (BCR)-mediate

19 integrated MMTV (Wnt)/beta-catenin signaling plays an essential role in BBB formation and maintenance

20 processes that regulate histone acetylation play an essential role in behavioral and molecular respo

21 The timing of thoughts and perceptions plays an essential role in belief formation.

22 h as electrostatic forces and hydrogen bonds play an essential role in biological molecular recogniti

23 is an important environmental variable that plays an essential role in biological adaptation for man

24 s post-translational modification (PTM) that plays an essential role in biological regulation.

25 Biomarker profiling using mass spectrometry plays an essential role in biological studies and is hig

26 oliferation in the regenerating limb and may play an essential role in blastema formation, thus provi

27 ntricular nucleus of the hypothalamus (PVH), play an essential role in blood pressure (BP) control.

28 metalloproteinase 13 (Mmp13, collagenase-3) plays an essential role in bone metabolism and mineral h

29 timate relationship with the CNS, where they play an essential role in both health and disease.

30 Accordingly, EVs play an essential role in both primary tumor growth and

31 Our study demonstrates that KIB1 plays an essential role in BR signaling by inhibiting BI

32 Microtubules play an essential role in breaking cellular symmetry.

33 Such proximity of the two metal ions may play an essential role in catalysis by generating a high

34 Glycoprotein D (gD) plays an essential role in cell entry of many simplexvir

35 nduced nuclear export of NR4A1 in TNBC cells plays an essential role in cell migration, SMAD7 degrada

36 narily conserved in all kingdoms of life and play an essential role in cellular ion homeostasis.

37 The microscopic viscosity plays an essential role in cellular biophysics by contro

38 Endosomal trafficking of signaling proteins plays an essential role in cellular homeostasis.

39 SOX9 is an HMG-box transcription factor that plays an essential role in chondrocyte development by di

40 structural and functional support to HCs and play an essential role in cochlear development, homeosta

41 cated that glial glutamate transporter EAAT2 plays an essential role in cognitive functions and that

42 tes both acute and chronic tissue damage and plays an essential role in collagen reorganization durin

43 HSCs play an essential role in ConA-induced liver injury dire

44 decapping machinery is highly conserved and plays an essential role in controlling mRNA stability, a

45 6), located at the mouth of the VhChiP pore, plays an essential role in controlling the channel's ion

46 glucose-responsive transcription factor that plays an essential role in converting excess carbohydrat

47 e IF-anchoring protein desmoplakin (DP) that play an essential role in coordinating cytoskeletal dyna

48 These findings show that macrophages play an essential role in coordinating the epimorphic re

49 This demonstrated that neither PLP1 nor ADRP plays an essential role in coronavirus RNA synthesis.

50 Prefrontal serotonin (5-HT)2A receptors play an essential role in cortical network activity, but

51 n that the plant hormone salicylic acid (SA) plays an essential role in defense, whether the master r

52 s, magneto-optical studies have historically played an essential role in determining the fundamental

53 tructure of the RNA molecule-and its absence-plays an essential role in determining capsid structure

54 s, the detailed shape of a catalytic swimmer plays an essential role in determining its direction of

55 mposition of the methyllysine-binding pocket plays an essential role in determining the selectivity o

56 RBM10 is an RNA-binding protein that plays an essential role in development and is frequently

57 cisions.Polycomb repressive complex 2 (PRC2) plays an essential role in development by modifying chro

58 Cell signaling plays an essential role in development, and knowledge of

59 transcription factor of Hippo pathway which plays an essential role in development, cell growth, org

60 Mammalian DNA methylation plays an essential role in development.

61 B vitamins play an essential role in DNA synthesis and methylation,

62 s a single-stranded DNA-binding protein that plays an essential role in DNA metabolism.

63 ription factor IIH complex in eukaryotes and plays an essential role in DNA repair in the nucleotide

64 ALPK3, a gene encoding a nuclear kinase that plays an essential role in early differentiation of card

65 Knowledge of catalytic residues can play an essential role in elucidating mechanistic detail

66 re consistent with the conclusion that PSB27 plays an essential role in enabling plants to adapt to f

67 s (PMNs) are innate immune system cells that play an essential role in eradicating invading pathogens

68 In zebrafish and cultured cells, NCOA4 plays an essential role in erythroid differentiation.

69 Germline stem cells play an essential role in establishing the fertility of

70 ate lentiviruses encode the Nef protein that plays an essential role in establishing persistent infec

71 e (PQ) pool in these organelles, and that it plays an essential role in etioplast metabolism by parti

72 ) release channel (ryanodine receptor, RyR2) plays an essential role in excitation-contraction coupli

73 et al. argue that "cultural group selection plays an essential role in explaining human cooperation.

74 M3 muscarinic receptors (M3Rs) are known to play an essential role in facilitating insulin release a

75 Recent data indicate that FIT2 plays an essential role in fat storage in an in vivo con

76 at rotational dynamics of diatomic molecules play an essential role in filamentation-induced supercon

77 r mathematical analysis shows that microRNAs play an essential role in fine-tuning and providing robu

78 The fusion peptides (FP) play an essential role in fusion of viral envelope with

79 totail, in addition to the gH/gL ectodomain, plays an essential role in gB activation, potentially ac

80 Covalent histone modifications play an essential role in gene regulation and cellular s

81 er genes is called a hub gene, which usually plays an essential role in gene regulation and biologica

82 peculiar 'conveyor belt neurogenesis' could play an essential role in generating the topographically

83 er of Buc and that maternal kif5Ba (Mkif5Ba) plays an essential role in germline specification in viv

84 Hydrates play an essential role in global energy systems, as both

85 Glycogen branching enzyme 1 (GBE1) plays an essential role in glycogen biosynthesis by gene

86 HBV covalently closed circular DNA (cccDNA) plays an essential role in HBV persistence and replicati

87 t of a Bmp-Gata2 positive-feedback loop that plays an essential role in hematopoietic specification.

88 Platelets play an essential role in hemostasis and thrombosis.

89 ng epithelial cells and alveolar macrophages play an essential role in host defense against acute lun

90 Conventional dendritic cells (cDCs) play an essential role in host immunity by initiating ad

91 rther revealed that its Lys and Phe residues play an essential role in how MARCKS-ED detects and bind

92 These data demonstrate that FAK plays an essential role in HSC activation and liver fibr

93 , we showed that A-kinase anchoring proteins play an essential role in ICAM-4 activation.

94 t Leishmania challenge suggesting that IL-23 plays an essential role in IL-17-mediated protection by

95 CD40 interacts with CD40L and plays an essential role in immune regulation and homeost

96 onclude that intestinal epithelium PPARgamma plays an essential role in increasing SNS activity under

97 Gut-derived bacterial LPS plays an essential role in inducing intestinal and syste

98 The RIP kinases (RIPKs) play an essential role in inflammatory signaling and inf

99 of chronic rhinosinusitis (CRS), PROMs will play an essential role in informing and tailoring the ri

100 species (ROS) produced by overexpressed MAOA plays an essential role in inhibiting apoptosis and acti

101 Primary sensory neurons in the DRG play an essential role in initiating pain by detecting p

102 barrier abnormalities have been suggested to play an essential role in initiation of early atopic der

103 (RCs) resulting from incomplete cytokinesis play an essential role in intercellular communication in

104 promotes chloride and bicarbonate secretion, playing an essential role in ion and acid-base homeostas

105 m that neutrophil recruitment and activation play an essential role in IR stress, and that targeting

106 Pru p 3 usually carries a lipid ligand that play an essential role in its function in plants.

107 d dominant tolerance and that Foxp3Treg cell played an essential role in its maintenance.

108 ates, we find that assembly of the Rbfox CTD plays an essential role in its normal splicing function.

109 sarcoma-associated herpesvirus (KSHV) ORF57 plays an essential role in KSHV lytic infection by promo

110 covery provides new insight that IL-13/STAT6 plays an essential role in KSHV pathogenesis.

111 feature of their ligand-induced behavior and plays an essential role in lateral cross-activation of t

112 sults demonstrate that temporal organization plays an essential role in learners' sensitivity to the

113 ikimate esterase (CSE) was recently shown to play an essential role in lignin biosynthesis in Arabido

114 Here, we reveal that E2F1 plays an essential role in liver physiopathology through

115 Biological membranes play an essential role in living organisms by providing

116 We conclude that fumarate accumulation plays an essential role in low temperature sensing in Ar

117 Efficient lysosomal Ca(2+) release plays an essential role in lysosomal trafficking.

118 Mitochondria play an essential role in maintaining cellular homeostas

119 human skin microbiome has been suggested to play an essential role in maintaining health by contribu

120 Nitrate respiration was further shown to play an essential role in maintaining high cell viabilit

121 ed to promote telomere homeostasis, but also plays an essential role in maintaining a stable genome.

122 Collectively, these data suggest that REEP6 plays an essential role in maintaining cGMP homeostasis

123 It is clear that IL-10 plays an essential role in maintaining homeostasis in th

124 Therefore, we predict that KCNQ3 plays an essential role in maintaining the sAHP under lo

125 H3K4me2 recruits the SET3C complex, which plays an essential role in maintaining this mark.

126 gest that female-derived GPI-anchored ENODLs play an essential role in male-female communication and

127 Electrostatic interactions play an essential role in many analytical applications i

128 ersible post-translational modification that plays an essential role in many cellular processes, incl

129 Myeloid cells are known to play an essential role in mediating epithelial inflammat

130 tor-beta (TGF-beta) family of growth factors plays an essential role in mediating cellular growth and

131 rom -135 to -123 of the LPCAT3 promoter that plays an essential role in mediating PPARdelta-induced t

132 cell culture and of guinea pigs that the SSP plays an essential role in mediating the membrane fusion

133 These results indicate that PIF4 plays an essential role in mediating the regulatory effe

134 together, our data suggest that the GPC SSP plays an essential role in mediating viral entry and als

135 Glutamine synthetase (GS) plays an essential role in metabolism by catalyzing the

136 Tumor-associated macrophages (TAMs) play an essential role in metastasis.

137 The augmin complex plays an essential role in microtubule (MT)-dependent MT

138 ts indicate that the KDM3A-KLF2-IRF4 pathway plays an essential role in MM cell survival and homing t

139 n the bone marrow and splenic vascular niche play an essential role in modulating the physiology of a

140 hat regulation at a translational level also plays an essential role in modulating gene expression.

141 gether, these results demonstrate that ZNF24 plays an essential role in modulating the angiogenic pot

142 We found that H3.3 plays an essential role in mouse development.

143 Here, we discover that neurotrophin 4 (NT4) plays an essential role in mucus overproduction after ea

144 to be regulated by the Notch receptor, which plays an essential role in myogenesis.

145 Antibodies are thought to play an essential role in naturally acquired immunity to

146 isengagement of UNC5C with polymerized TUBB3 plays an essential role in netrin-1/UNC5C-mediated axon

147 gulator of the canonical Wnt pathway, CTNNB1 plays an essential role in neurodevelopment.

148 , we hypothesized that BET proteins may also play an essential role in neutrophil-dominant allergic a

149 Here, we demonstrate that RIPK3 plays an essential role in NKT cell function via activat

150 We conclude that Ulk4 plays an essential role in normal brain development and

151 (2+) uptake in photoreceptors is complex and plays an essential role in normal function.

152 that although its N-terminal variable domain plays an essential role in optimizing Ca(2+)-dependent R

153 follicle transit-amplifying cells (HF-TACs) play an essential role in orchestrating dermal adipogene

154 Platelets play an essential role in other biological processes (im

155 Therefore, TRIM21 plays an essential role in p62-regulated redox homeostas

156 ion and trafficking of integrin beta1, which plays an essential role in PDA migration and metastasis.

157 during peroxisomal protein import processes play an essential role in peroxisome functionality.

158 ulence factor of Mycobacterium tuberculosis, plays an essential role in phagosome rupture and bacteri

159 ence of Mycobacterium tuberculosis (Mtb) and plays an essential role in phagosome rupture and translo

160 Brassinosteroids (BRs) play an essential role in plant growth and development,

161 significant influence on evolution and also plays an essential role in plant breeding, because a suc

162 lly, a genetic analysis indicated that SECE2 plays an essential role in plant growth and development.

163 suggest that phosphoinositide binding by H7 plays an essential role in poxvirus membrane biogenesis.

164 It has been implicated to play an essential role in preventing the increased forma

165 eractions of Cav2.1 with other proteins, and plays an essential role in preventing a complex neurolog

166 ed by the xeroderma pigmentosum (XP-V) gene, plays an essential role in preventing cutaneous cancer c

167 ) MnxG protein from marine Bacillus bacteria plays an essential role in producing MnOx minerals by ox

168 The orexin (hypocretin) neurons play an essential role in promoting arousal, and loss of

169 GSK3beta plays an essential role in promoting cell death and is e

170 We concluded that ASK1 plays an essential role in promoting OTA-induced renal c

171 ) is a second messenger adaptor protein that plays an essential role in propagating TNF-alpha-mediate

172 eins, which cannot be predicted de novo, may play an essential role in rapid light adaptation and pho

173 Therefore, mechanically activated Piezo1 plays an essential role in RBC volume homeostasis.

174 Methyl-CpG binding domain (MBD) proteins play an essential role in recruitment of NuRD complexes

175 Here we show that TRIM21 plays an essential role in redox regulation by directly

176 rdiac voltage-gated sodium channels (Nav1.5) play an essential role in regulating cardiac electric ac

177 Epigenetic complexes play an essential role in regulating chromatin structure

178 Chromatin dynamics play an essential role in regulating DNA transaction pro

179 Integrin beta1 is known to play an essential role in regulating macrophage migratio

180 CaV2.1 channels play an essential role in regulating synaptic signaling.

181 15, contributes to developmental programs by playing an essential role in regulating age-dependent li

182 These data support the conclusion that FIT2 plays an essential role in regulating intestinal health

183 These results suggest that SIRT1 plays an essential role in regulating mood-related behav

184 Cytokinin plays an essential role in regulating shoot apical meris

185 Our research indicates that EPHB4 plays an essential role in regulating small artery contr

186 Overall, the WRKY family plays an essential role in regulating the biosynthesis o

187 Immune cell-expressed beta2AR plays an essential role in regulating the early inflamma

188 CCCTC-binding factor (CTCF) plays an essential role in regulating the structure of c

189 Metabolic reprogramming in stromal cells plays an essential role in regulating tumour growth.

190 ant component of virus-host interactions and plays an essential role in regulating viral replication.

191 long-range communication relays, with lipids playing an essential role in regulation.

192 Nuclear factor kappaB (NF-kappaB) plays an essential role in regulation of innate immunity

193 he glycoprotein hormone receptor family that plays an essential role in reproduction.

194 rane ERAD substrates, but unlike Hrd1, which plays an essential role in retrotranslocation and ubiqui

195 , a quality control process in mitochondria, plays an essential role in self-renewing expansion of Ti

196 These data suggest that mitochondria play an essential role in sesamol-induced HepG2 cells de

197 by monoamine neurotransmitters is thought to play an essential role in shaping computational neurodyn

198 Neural stem cells (NSCs) play an essential role in shaping the developing brain,

199 A conserved signaling network appears to play an essential role in signaling by responding to del

200 e also find that the catalytic center of bRT plays an essential role in site-specific cleavage of TR

201 study provides the first evidence that GLI3R plays an essential role in SMO-independent Hh signaling

202 NMDA receptors (NMDARs) play an essential role in some forms of synaptic plastic

203 primary means to generate genomic novelties, playing an essential role in speciation and adaptation.

204 Although optic flow plays an essential role in speed determination, it is le

205 raints imposed by a tetradentate P4N2 ligand play an essential role in stabilizing square planar Fe c

206 We conclude that sorbitol plays an essential role in stamen development and pollen

207 ahydrofolate dehydrogenase 1-like (MTHFD1L), plays an essential role in support of cancer growth.

208 Attention plays an essential role in supporting other cognitive fu

209 nse to low oxygen or inflammatory stress and plays an essential role in survival and function of immu

210 the AKAP7/PKA complex in the MF projections plays an essential role in synaptic plasticity and conte

211 by medullary thymic epithelial cells (mTECs) plays an essential role in T cell tolerance.

212 Random number generation plays an essential role in technology with important app

213 LNa, we reveal that only FLNa, but not FLNb, plays an essential role in tetherin turnover.

214 DCs play an essential role in TH cell differentiation, and w

215 rly-responding, pro-inflammatory macrophages play an essential role in the amplification of inflammat

216 ical coupling reactions in plants and, thus, play an essential role in the biosynthesis of biological

217 ntative of a class of assembly proteins that play an essential role in the biosynthesis of the active

218 ssertion that FRH helicase activity does not play an essential role in the clock, but rather FRH acts

219 Gangliosides (sialylated glycolipids) play an essential role in the CNS by regulating recognit

220 e argue that single filament techniques will play an essential role in the coming years as we try to

221 (vascular smooth muscle cells and pericytes) play an essential role in the development of the vascula

222 They play an essential role in the development of various org

223 armacological and functional genomic screens play an essential role in the discovery and characteriza

224 Macrophages play an essential role in the early immune response to M

225 It is well known that neutrophils play an essential role in the early phase of hepatic isc

226 l photosensitizer binding protein, which may play an essential role in the enrichment of ALA-induced

227 ed that unfavourable haemodynamic conditions play an essential role in the formation and development

228 Cholesterol crystals (CC) play an essential role in the formation of atherosclerot

229 These small RNAs play an essential role in the grasses, spatially definin

230 Neutrophils play an essential role in the initial stages of inflamma

231 in mouse oocytes, eggs and embryos that may play an essential role in the initiation of embryo devel

232 Heterotrimeric G proteins play an essential role in the initiation of G protein-co

233 These membrane proteins play an essential role in the insertion of the new SPB i

234 e CTD state of phosphorylation also does not play an essential role in the interaction between empty

235 stent with the idea that FKBP8 and Hsp90beta play an essential role in the late phase of CLC-1 qualit

236 Regulatory T (Treg) cells play an essential role in the maintenance of immune home

237 esting that electrons near the Fermi surface play an essential role in the mixed-valence physics of t

238 immune cells and their migration to the skin play an essential role in the pathogenesis of AD.

239 ions in estrogen-mediated cellular signaling play an essential role in the pathogenesis of endometrio

240 uring adulthood and genetic risk factors may play an essential role in the persistence of the disorde

241 cruited at the site of sterile muscle damage play an essential role in the regeneration of the tissue

242 Epigenetic modifications of histone tails play an essential role in the regulation of eukaryotic t

243 r with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation

244 Temperature-induced lipocalins (TILs) play an essential role in the response of plants to diff

245 Acinar cells play an essential role in the secretory function of exoc

246 e uniaxial strain state of shock compression play an essential role in the transformation.

247 , the TREM-1-mediated innate immune response played an essential role in the activation of neutrophil

248 Photonic microsystems played an essential role in the development of integrate

249 Visual field testing has played an essential role in the diagnosis and management

250 s reveal that the coevolution of these sites played an essential role in the evolution of simian neur

251 is the major component of the cytoskeleton, playing an essential role in the structure and motility

252 st acts as a co-factor of the TCP-1 complex, playing an essential role in the Tubulin-folding process

253 urvival of motor neuron (SMN) protein, which plays an essential role in the biogenesis of spliceosoma

254 findings indicate that the helicase activity plays an essential role in the catalytic efficiency of R

255 Autophagy plays an essential role in the cellular homeostasis of n

256 p35, phosphorylates multiple substrates and plays an essential role in the development and function

257 is induced by prenatal inflammatory exposure plays an essential role in the development of EH through

258 These findings show that EH plays an essential role in the Drosophila CNS in the con

259 s studies demonstrate that the glycosylation plays an essential role in the flagellar assembly and mo

260 pressing the neuropeptide neuromedin S (NMS) plays an essential role in the generation of daily rhyth

261 Solid organic matter (OM) plays an essential role in the generation, migration, st

262 response marker, since protein glycosylation plays an essential role in the inflammatory cascade.

263 e nanoscale organization of collagen fibrils plays an essential role in the mechanics of these gels a

264 It plays an essential role in the membrane attack complex (

265 that in mice on the C57Bl/6 background EMX1 plays an essential role in the midline crossing of an ax

266 gether, these results demonstrate that SIRT1 plays an essential role in the NAc in regulating mood-re

267 Myelin plays an essential role in the nervous system and its di

268 cially impairment of its phagocytic ability, plays an essential role in the pathogenesis of age-relat

269 horylation of protein kinase C (Pkc1), which plays an essential role in the pathways that link the ce

270 PfCRT also plays an essential role in the physiology of the parasit

271 tal and modelling results indicate that ArnS plays an essential role in the precisely controlled expr

272 of TNF superfamily signalling complexes and plays an essential role in the regulation and homeostasi

273 gulation, is recruited to the HPV genome and plays an essential role in the regulation of early viral

274 Greatwall (Gwl) kinase plays an essential role in the regulation of mitotic ent

275 Zinc plays an essential role in the regulation of pancreatic

276 In Arabidopsis thaliana, CONSTANS (CO) plays an essential role in the regulation of photoperiod

277 strate that FATTY ACYL-COA REDUCTASE (AsFAR) plays an essential role in the reproduction of the bug A

278 The PhoQ/PhoP two-component system plays an essential role in the response of enterobacteri

279 cific POU-homeo domain transcription factor, plays an essential role in the specification of the soma

280 Our study suggests that the NP RNase plays an essential role in the suppression of host innat

281 The retroviral enzyme integrase plays an essential role in the virus replication cycle b

282 ng activity to Axin in vitro, but SAMP1 also plays an essential role in the Wnt destruction complex i

283 IRF8), which is highly expressed in B cells, played an essential role in this regulation.

284 mTECs), the Autoimmune regulator (Aire) gene plays an essential role in this process by driving the e

285 We demonstrate that Notch signaling plays an essential role in this process, enabling neural

286 hancer elements, and transcription machinery plays an essential role in tissue development and regene

287 Here, we demonstrate that STAT1 plays an essential role in TLR-mediated antibody respons

288 MITF-BRG1 interplay thus plays an essential role in transcription regulation in m

289 Reactive oxygen species (ROS) play an essential role in transformation.

290 Methyl-CpG binding proteins play an essential role in translating DNA methylation ma

291 PAF plays an essential role in UV-induced immune suppression

292 derived vesicles present in body fluids that play an essential role in various cellular processes, su

293 involved in diverse biological processes and play an essential role in various human diseases.

294 Nucleosome plays an essential role in various cellular processes, s

295 V1 interneurons are inhibitory neurons that play an essential role in vertebrate locomotion.

296 The Hedgehog (Hh) signaling pathway plays an essential role in vertebrate embryonic tissue p

297 oach, we revealed that both studied proteins play an essential role in viral stability.

298 ZIKV nonstructural protein 1 (NS1) plays an essential role in viral replication and immune

299 hoprotein P is a multifunctional protein: it plays an essential role in viral transcription and repli

300 nodeficiency virus type 1 (HIV-1), gp120(SU) plays an essential role in virus binding to target CD4+