ライフサイエンスコーパス: play an important role in

1 Long-range intrachromosomal interactions play an important role in 3D chromosome structure and fu

2 Since ROS plays an important role in a variety of inflammation, ou

3 ing pathway of cellular MKK2 phosphorylation plays an important role in abiotic stress tolerance that

4 Genetics plays an important role in accounting for such interindi

5 ckout studies indicated that thrombospodin-1 played an important role in ACM-exerted synaptogenic eff

6 ur study suggests that DNA methylation might play an important role in AF arrhythmogenesis.

7 ses to frost, thus suggesting that frost may play an important role in affecting plant communities un

8 Host inflammatory and immune responses play an important role in aggressive periodontitis (AgP)

9 ith others via speech and music, and it also plays an important role in alerting and orienting us to

10 Dysfunction of microglia is known to play an important role in Alzheimer's disease (AD).

11 Vgamma9Vdelta2 T cell activation plays an important role in antitumor and antimicrobial i

12 Because HLA-E plays an important role in antiviral immunity by regulat

13 n.Calcium dependent protein kinase 1 (CDPK1) plays an important role in asexual development of Plasmo

14 turally uncharacterized C-terminal tail that plays an important role in autophosphorylation and signa

15 Toll-like receptors (TLRs) play an important role in B cell-mediated immune respons

16 he ability to form a stable head of foam and plays an important role in beer staling.

17 tain 1,4-linked N-acetyl-d-galactosamine and play an important role in biofilm formation by these org

18 d receptors related to CXCL1-CXCR2 signaling plays an important role in BMSC-produced antihyperalgesi

19 Vitamin D plays an important role in both the innate and adaptive

20 n B1, a key component of the nuclear lamina, plays an important role in brain development.

21 NAADP plays an important role in calcium signalling in the hea

22 ten deregulated in cancer and are thought to play an important role in cancer development.

23 ions of regulatory elements in tumors likely play an important role in cancer development.Cancer driv

24 y after starvation and physical exercise and played an important role in cancer growth.

25 nd mechanical indices, and its dysregulation plays an important role in cardiac disease pathogenesis.

26 y conserved feature of eukaryotic cells that play an important role in cell division.

27 ol, and the inhibition of SIRT2 activity may play an important role in cell gluconeogenesis.

28 al modification of the p53 signaling pathway plays an important role in cell cycle progression and st

29 a helix-loop-helix transcription factor that plays an important role in cell proliferation and differ

30 he glutaminolysis pathway, which is known to play an important role in cellular energetics, stress de

31 of molecules in the cellular plasma membrane plays an important role in cellular signaling.

32 Moreover, CYP3A plays an important role in chemical metabolism, toxicity

33 f non-neuronal cells, which are now known to play an important role in chronic pain processing.

34 Thus, UBQLN1 plays an important role in clearing mislocalized mitocho

35 ials across different therapeutic approaches play an important role in clinical decision making, trea

36 clinical indications where viral testing may play an important role in clinical management.

37 Purpose Hereditary factors play an important role in colorectal cancer (CRC) risk,

38 The plant cell wall plays an important role in communication, defense, organ

39 or male meiotic cell wall formation and thus plays an important role in consolidating the male gameto

40 ing engenders an antiviral state that likely plays an important role in constraining HIV-1 transmissi

41 gulates necroptosis and inflammation and may play an important role in contributing to a variety of h

42 ers, driven by different solvent processings play an important role in controlling the activation ene

43 Our data suggest that interorgan signaling plays an important role in controlling OB-ISCs in homeos

44 both microtubules and organelles, and hence plays an important role in controlling organelle transpo

45 Gene expression regulation plays an important role in controlling plant phenotypes

46 that the oxygen pressure (PO2) during growth plays an important role in controlling the interfacial t

47 Trafficking of mGluRs plays an important role in controlling the precise local

48 suggest that interspecies recombination may play an important role in CoV evolution and the emergenc

49 and clinical laboratory analysis continue to play an important role in defining these conditions, gen

50 e competitive network structure may likewise play an important role in determining community-level fu

51 ng of synaptic receptor proteins at synapses plays an important role in determining receptor concentr

52 gar preferences, indicating that residue 153 plays an important role in determining sugar donor speci

53 orientation of the catalyst and chromophore plays an important role in determining the device effici

54 the hypothesis that T cells to Phl p 12 can play an important role in development of allergic sympto

55 Runx2 may play an important role in development of osteoarthritis

56 Collective cell migration plays an important role in development.

57 Bile plays an important role in digestion, absorption of fats

58 owever, factors other than somatic mutations play an important role in disease initiation as well as

59 as a type of genomic/genetic variation that plays an important role in disease susceptibility.

60 Molecular size plays an important role in dissolved organic matter (DOM

61 omain structure in all eukaryotes, with CTCF playing an important role in domain formation in mammals

62 nton reaction and manganese peroxidase might play an important role in DR5B dye degradation.

63 Local atmospheric forcing therefore plays an important role in driving oceanic variability c

64 G protein-coupled receptors (GPCRs) play an important role in drug therapy and represent one

65 elicate balance between entropy and polarity plays an important role in drugs' potency.

66 These data confirm that Armc5 plays an important role in early mouse embryonic develop

67 e mutual regulation between p53 and LMP1 may play an important role in EBV infection and latency and

68 y of calcium-dependent endopeptidases, which plays an important role in ECM remodelling.

69 y, and that their compensatory herbivory may play an important role in ecosystem resilience.

70 uctor nanomaterial-molecular interfaces will play an important role in emerging photonic and optoelec

71 rated the observation that clathrin does not play an important role in endocytosis in A. nidulans.

72 The results suggest that miR-542-3p plays an important role in endometrial decidualization b

73 ein kinase) is a heterotrimeric protein that plays an important role in energy homeostasis and cardio

74 thin the vicinity of the dsDNA, is likely to play an important role in ensuring that a high interacti

75 a zinc domain and a winged helix domain and plays an important role in enzyme activity.

76 orin- (AQP) 3, a water and glycerol channel, plays an important role in epidermal function, with stud

77 erm alterations over weeks, months and years play an important role in epilepsy.

78 annot sustain an outbreak on their own, they play an important role in establishing new foci of infec

79 We argue that scientists can play an important role in facilitating change by connect

80 miRNAs play an important role in fine-tuning host immune homeos

81 Multiple residues within the S1 helix also play an important role in fine-tuning the voltage depend

82 ation that regulates chromatin structure and plays an important role in gene transcription.

83 DNA is an ongoing process in eukaryotes and plays an important role in genomic variability.

84 important concept-believed, for example, to play an important role in glass formation-the microscopi

85 ents glucose-induced insulin secretion, thus playing an important role in glucose control.

86 Glutathione degradation plays an important role in glutathione and redox homeost

87 ic interactions-screened by ions in solution-play an important role in governing their ability to fol

88 argued that radiative cooling by water vapor plays an important role in governing the depth and ampli

89 or component of primary cell walls, where it plays an important role in growth regulation.

90 a/inhibitory kappaB kinase epsilon signaling plays an important role in HDM-induced glycolysis and pa

91 The human microbiota, which plays an important role in health and disease, uses comp

92 hat high-parental expression-level dominance plays an important role in heterosis.

93 and support the hypothesis that these cells play an important role in HHV-8 infection and pathogenes

94 The viral genotype has been shown to play an important role in HIV pathogenesis following tra

95 ion, the sensitivity to visceral sensations, plays an important role in homeostasis and guiding motiv

96 ate immune responses, and changes in NS1 can play an important role in host adaptation.

97 IgA is predominantly recognized to play an important role in host defense at mucosal sites,

98 White blood cells (WBCs) play an important role in host immune responses early in

99 Gut microbiota plays an important role in host health and nutrient dige

100 Interleukin-22 (IL-22) plays an important role in host immunity and tissue home

101 ence has revealed that intestinal microbiota play an important role in human health and disease, incl

102 Legumes play an important role in human health, sustainable food

103 rant activation of the Wnt signaling pathway plays an important role in human cancer development.

104 ay is responsible for cell proliferation and plays an important role in hyperplastic growth, which ha

105 Genome-wide association studies (GWAS) have played an important role in identifying genetic variants

106 Toll-like receptors (TLRs) play an important role in immune responses to pathogens

107 e (GO) and reduced graphene oxide (rGO) have played an important role in immunoassays (IAs) and immun

108 y of tumor cells to cytotoxic treatments can play an important role in individualized cancer medicine

109 .The cytokine interleukin 1alpha (IL-1alpha) plays an important role in inflammatory processes.

110 SPHK2 plays an important role in kidney fibrogenesis by modula

111 Circadian clocks play an important role in lipid homeostasis, with impact

112 ms that regulate cell death and inflammation play an important role in liver disease and cancer.

113 and gas-filled pores in the soil and likely play an important role in long-distance microbial intera

114 of purpose in life, a modifiable factor, may play an important role in maintaining physical function

115 nd miR-200 families, through which IRE1alpha plays an important role in maintaining BMPC function und

116 The lysosome plays an important role in maintaining cellular nutrient

117 of 14-3-3zeta, suggesting that this residue plays an important role in maintaining structure across

118 Annotation with ontology terms can play an important role in making data driven classificat

119 CD40L plays an important role in malignant B cell biology, and

120 of water will also be reviewed because water plays an important role in many of the C1 transformation

121 -phosphate-containing molecules and IGF2 and plays an important role in many pathophysiological proce

122 Our work indicates that methylation plays an important role in marking DNA for transformatio

123 tage-gated sodium (Nav) channel subtype also plays an important role in mechanical pain signaling by

124 They play an important role in mediating neurovascular coupli

125 These data demonstrated that VHSV M plays an important role in mediating both virus-induced

126 p53-AMPK-FOXO3a-FOXM1 signaling cascade that plays an important role in mediating mutant p53s' gain-o

127 vel analysis has revealed that the MAPK Fus3 plays an important role in mediating this differentiatio

128 Epigenetic factors have been suggested to play an important role in metabolic memory by trapping a

129 ly active cells, bacterial 16S rRNA sequence plays an important role in microbial identification.

130 PAs) that reduce deforestation can therefore play an important role in mitigating climate change and

131 unctional studies revealed that SLC25A46 may play an important role in mitochondrial dynamics by medi

132 cohorts studied here, polygenic architecture plays an important role in modifying AD risk beyond APOE

133 demonstrate by the first time that the Igf1r plays an important role in murine asthma, mediating both

134 we provide evidence that glycosphingolipids play an important role in muscle innervation, which dege

135 uggest that the radicals present in soil can play an important role in natural remediation mechanisms

136 coactivator of the Notch signaling pathway, playing an important role in neural stem cell regulation

137 SOX1 plays an important role in neural development and neural

138 ostimulants-like cocaine and amphetamine-and plays an important role in neuropsychiatric disorders, i

139 nce the characteristics of Arbequina oil and play an important role in newly introduced cultivars.

140 As such, they play an important role in normal physiological processes

141 ization are not well understood, yet the ECM plays an important role in normal tissue homeostasis and

142 Dopaminergic signalling is established as playing an important role in novelty related modulation

143 Hydrophobicity plays an important role in numerous physicochemical proc

144 ved middepth radiocarbon age maximum and may play an important role in ocean carbon storage.

145 e that immune complex formation of serum IgA plays an important role in orchestration of inflammation

146 Imagery plays an important role in our life.

147 lular matrix glycosaminoglycan implicated in playing an important role in palatal shelf elevation-80%

148 Inflammatory response plays an important role in Parkinson disease (PD).

149 in macrophages affects cellular function and plays an important role in pathogenesis during infection

150 Immune destruction of hemopoietic stem cells plays an important role in pathogenesis, as shown by suc

151 These findings suggest that STAT3 signaling plays an important role in PD-1/PD-L1 regulation and the

152 ns and Staphylococcus species do not seem to play an important role in peri-implantitis.

153 Mast cells play an important role in periodontitis, but the mechani

154 ess termed nonphotochemical quenching (NPQ), plays an important role in photoprotection.

155 DNA methylation plays an important role in physiological and pathologica

156 aerosols that absorb solar radiation and may play an important role in planetary radiative forcing an

157 t mice, suggesting that this interaction may play an important role in positioning of myonuclei and f

158 alth and suggest that race/ethnicity and BMI play an important role in pregnancy bone health.

159 owth by SF through tryptophan catabolism may play an important role in preventing inappropriate Th ce

160 gests that the sialylation status of PrP(Sc) plays an important role in prion lymphotropism.

161 onic template neurons in auditory cortex may play an important role in processing sounds with harmoni

162 Our results indicate AR plays an important role in promoting the growth of HER2

163 Thus, this orphan kinesin plays an important role in promoting trypanosome infecti

164 sional (3D) architecture of the cell nucleus plays an important role in protein dynamics and in regul

165 s from this study demonstrated that fMRI may play an important role in providing complementary inform

166 cases, suggesting that both mutations might play an important role in PTFL lymphomagenesis.

167 queezed states, Fock states and Bell states, plays an important role in quantum information processin

168 loud interactions (aerosol indirect effects) play an important role in regional meteorological variat

169 MicroRNAs play an important role in regulating ER stress.

170 Wetlands play an important role in regulating the atmospheric car

171 Gut microbiota play an important role in regulating the development of

172 set adhesion to primary human HSEC and could play an important role in regulating the inflammatory re

173 ependent Lys11-linkage ubiquitin conjugation plays an important role in regulating DNA damage-induced

174 Protein post-translation modification plays an important role in regulating DNA repair; howeve

175 r D6/ACKR2 is expressed on apoptotic PMN and plays an important role in regulating macrophage propert

176 tion in pentameric ligand-gated ion channels plays an important role in regulating neuronal excitabil

177 nce that the conformational flexibility also plays an important role in regulating protein associatio

178 , these results suggest that endogenous GDNF plays an important role in regulating the function of do

179 Altogether, these findings show that alphaBC plays an important role in regulating Wallerian degenera

180 ibition of B cell responses by rapamycin may play an important role in regulation of allograft-specif

181 e, the plasticity of electrical synapses may play an important role in regulation of state, synchrony

182 emonstrate that human ribonuclease H1 (RNH1) plays an important role in replication fork movement in

183 Similar mass drownings may have played an important role in rivers throughout the world

184 ith unknown function), and Argonaute (Ago1), plays an important role in RNAi-mediated heterochromatin

185 re professionals involved in this care might play an important role in safeguarding the trust of adol

186 Staphylococcus aureus plays an important role in sepsis, pneumonia, wound infe

187 KAP150, the most well-characterized isoform, plays an important role in several forms of neuronal pla

188 urthermore, fungal allergy has been shown to play an important role in severe asthma.

189 These results suggest that selective factors play an important role in shaping the gut community stru

190 medial nucleus of the trapezoid body (MNTB) plays an important role in sound localization.

191 is not known if neo-sex chromosome evolution plays an important role in speciation.

192 elate of sound repetition rate or frequency, plays an important role in speech perception, music perc

193 The gaseous phytohormone ethylene plays an important role in spike development in wheat (T

194 The bottom template is found to play an important role in stabilizing the beta roll stru

195 we conclude that electrostatic interactions play an important role in stabilizing these binding site

196 family, which has recently been reported to play an important role in store-operated Ca(2+) entry (S

197 HIV self-testing could play an important role in supporting HIV interventions t

198 understood, it has been shown that flagella play an important role in surface sensing by transmittin

199 netic association studies show that genetics play an important role in the attainment of education.

200 ), and soluble Abeta species are believed to play an important role in the clinical development of th

201 of distinguishing these two conditions could play an important role in the clinical management of pat

202 Regulatory T cells (Tregs) play an important role in the CNS during multiple infect

203 Self-assembly is likely to play an important role in the construction of the exospo

204 riptional regulators of gene expression that play an important role in the control of fundamental bio

205 ve stress and inflammation are considered to play an important role in the development and progressio

206 omyocytes and that changes in their activity play an important role in the development of ER stress d

207 elated activity has the properties needed to play an important role in the development of geniculocor

208 und to interact with a group of targets that play an important role in the development of this type o

209 RTE can play an important role in the differentiation between ma

210 XCR5-expressing conventional dendritic cells play an important role in the efficient propagation of o

211 cts the less affluent and whose failures may play an important role in the explanation of the increas

212 Human milk oligosaccharides (HMOs) play an important role in the health of an infant as sub

213 to be elicitors or pathogenic factors,which play an important role in the host-pathogen interaction

214 uch as CD11c(+) conventional dendritic cells play an important role in the initial propagation of pri

215 to become virulent for pigs.IMPORTANCE Swine play an important role in the interspecies transmission

216 of microscopic mechanisms, which could each play an important role in the migration of microorganism

217 era, studies suggest that microRNAs (miRNAs) play an important role in the molecular basis of caste d

218 These biomarkers therefore may play an important role in the monitoring and management

219 in the endoplasmic reticulum (ER) of AML and play an important role in the non-canonical activation o

220 Fatty acids and lipid mediator signaling play an important role in the pathogenesis of asthma, ye

221 ic modifications, including DNA methylation, play an important role in the pathogenesis of autoimmune

222 ironmental exposures in early life appear to play an important role in the pathogenesis of childhood

223 Cytokines play an important role in the pathogenesis of cirrhosis

224 I) is a potentially novel biomarker that may play an important role in the pathogenesis of diabetes,

225 n, which is found in normal brain aging, may play an important role in the pathogenesis of multiple n

226 Tissue-specific immune responses play an important role in the pathology of autoimmune di

227 Structural defects play an important role in the properties of MOFs and can

228 as an excellent PGP rhizobacterium that may play an important role in the recovery of burned holm-oa

229 loor and subsequent transport to nests, ants play an important role in the redistribution of nutrient

230 In the amygdala, neurons expressing SST play an important role in the regulation of anxiety, whi

231 rases (PMTs) and histone demethylases (KDMs) play an important role in the regulation of gene express

232 by synthetic or purified TLR ligands and may play an important role in the regulation of inflammation

233 erance induction, indicating that Treg cells play an important role in the regulation of peanut sensi

234 Peroxisomes are proposed to play an important role in the regulation of systemic inf

235 or reproductive isolation and may therefore play an important role in the speciation process.

236 Quantitative protein assays play an important role in the study of biological functi

237 We hypothesize that DNA methylation might play an important role in the susceptibility to develop

238 Innate and adaptive immune cells play an important role in the therapeutic activity of an

239 Prescription opioid analgesics play an important role in the treatment of postoperative

240 h target proteases or other proteins and may play an important role in the various beneficial functio

241 ptidyl prolyl cis/trans isomerases (PPIases) play an important role in the zipper-like triple-helix f

242 unt of attention from synthetic chemists and played an important role in the development of modern as

243 X-ray crystal structures have played an important role in the drug-design process, per

244 Hybridization has played an important role in the evolution of many lineag

245 een the electrodes and the SWCNTs might have played an important role in the gas sensing process.

246 lation and stratification, which have likely played an important role in the observed atmospheric car

247 associated changes in prey availability have played an important role in the population's recovery.

248 iments showed that the microenvironment also played an important role in the structure of the microbi

249 en together, our results suggest that PHLPP1 plays an important role in the assembly of kinetochores

250 This single site phosphorylation plays an important role in the control of transcriptiona

251 Transforming growth factor-beta (TGF-beta) plays an important role in the development and maintenan

252 gut are severely damaged by HIV-1, and this plays an important role in the development of AIDS.

253 lly induced, chronic low-grade inflammation, plays an important role in the development of obesity, d

254 ctor I (NFI) family of transcription factors plays an important role in the development of the cerebr

255 We conclude that the C-terminus plays an important role in the efficient folding and reg

256 Altogether, our data suggest that ZNF143 plays an important role in the expression of C/EBPalpha

257 se separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple mem

258 Hence, the PH domain, but not the DH domain, plays an important role in the formation of the differen

259 Phase separation of these molecules likely plays an important role in the generation and stability

260 The transcription factor NF-kappaB plays an important role in the immune system, apoptosis

261 ly, we show that the enhanced angiotensin II plays an important role in the intracellular accumulatio

262 ibody to be produced in immune responses and plays an important role in the neutralization of bacteri

263 Dysregulation of microRNAs (miRNAs) plays an important role in the pathogenesis of chronic l

264 shows that early loss of beta-cell function plays an important role in the pathogenesis of T2D, espe

265 uction by multiple cell types in the airways plays an important role in the pathogenesis of type 2 ai

266 Their altered sensitivity plays an important role in the pathology of malignant hy

267 stitute a class of small noncoding RNAs that plays an important role in the post-transcriptional regu

268 autophagy, and removal of ataxin-3 protein, plays an important role in the protective effects of cal

269 Overall, these findings suggest that TRPC1 plays an important role in the regulation of adiposity v

270 ng enzyme in the matrix.Protein localization plays an important role in the regulation of cellular ph

271 Moreover, we found that chymase plays an important role in the regulation of FXIIIA via

272 t findings suggest that stem cell metabolism plays an important role in the regulation of stem cell a

273 roduction (GPP) of vegetation in urban areas plays an important role in the study of urban ecology.

274 Genetics plays an important role in the susceptibility to sporadi

275 g the concept that TRIF-dependent signalling plays an important role in the transcription of this cyt

276 ifferential radial thickening of guard cells plays an important role in the turgor-driven shape chang

277 slational lipid modification of Ras proteins plays an important role in their recruitment to the PM.

278 sults indicate that the BigLEN-GPR171 system plays an important role in these behaviors and could be

279 We found that, while glycosylation plays an important role in these orthologs, additional s

280 A liver-brain-pancreas neuronal relay plays an important role in this process.

281 rative arrest known as "cellular quiescence" plays an important role in tissue homeostasis and stem c

282 omoters and their distal regulatory elements play an important role in transcriptional regulation; ho

283 Antigen-presenting cells (APCs) play an important role in transplant rejection and toler

284 ultaneous liver-kidney (SLK) transplantation plays an important role in treating kidney failure in pa

285 sease specific, accurate and early diagnosis plays an important role in tremor management.

286 cate that iPLA2-dependent metabolic pathways play an important role in tumor initiation or progressio

287 The tumor microenvironment plays an important role in tumor growth and metastasis.

288 that the KDM3 family of histone demethylases plays an important role in tumorigenic potential and sur

289 ree of contact between Tyr residues and Kme3 plays an important role in tuning cation-pi-mediated Kme

290 However, pH rise driven by inorganic carbon played an important role in undermining ecosystem health

291 ulatory networks (GRNs) from expression data plays an important role in understanding the fundamental

292 Pre-existing serum antibodies play an important role in vaccine-mediated protection ag

293 pread and versatile silencing mechanism that plays an important role in various biological processes.

294 , translation initiation from non-AUG codons plays an important role in various gene regulation progr

295 MP) specific phosphodiesterase type 5 (PDE5) plays an important role in various pathologies including

296 suggesting that intracellular Ca(2+) buffers play an important role in vesicle recruitment in both lo

297 evidence suggests that the airway microbiota plays an important role in viral bronchiolitis pathobiol

298 of HIV-1 Gag protein is N-myristoylated and plays an important role in virus budding.

299 atalysts for oxygen evolution reaction (OER) plays an important role in water splitting.

300 The constitutive androstane receptor (CAR) plays an important role in xenobiotic metabolism, energy