ライフサイエンスコーパス: play an essential role in

1 They play an essential role in accelerating high-energy elect

2 Our study shows that arginine methylation plays an essential role in accurate pre-mRNA splicing ne

3 The RAG recombinase (RAG1/2) plays an essential role in adaptive immunity by mediatin

4 Thus modular architecture plays an essential role, in addition to sequence motifs,

5 cium signaling pathways in endothelial cells play an essential role in affecting barrier function and

6 thione, suggesting that thiols in DOM likely played an essential role in affecting microbial Hg uptak

7 ar factors to infect cells, and the ribosome plays an essential role in all viral infections.

8 -affinity IgE receptors (FcepsilonRI), which play an essential role in allergic diseases.

9 a striking capability of the auditory system-plays an essential role in animals' survival (e.g., dete

10 these findings demonstrate that mTOR signals play an essential role in antigen-specific humoral immun

11 Natural killer (NK) cells play an essential role in antiviral immunity, but knowle

12 These data show that CIAF1 plays an essential role in assembling the peripheral mat

13 entiation (LTP) in the lateral amygdala (LA) plays an essential role in auditory fear conditioning, i

14 Fingerprint biometrics play an essential role in authentication.

15 Nanomaterials can play an essential role in bacterial sensing owing to the

16 ys involving inorganic polyphosphate (PolyP) play an essential role in bacterial stress adaptation an

17 integrated MMTV (Wnt)/beta-catenin signaling plays an essential role in BBB formation and maintenance

18 The timing of thoughts and perceptions plays an essential role in belief formation.

19 he structure of toxic intermediate oligomers plays an essential role in better understanding their ne

20 is an important environmental variable that plays an essential role in biological adaptation for man

21 lasmodium falciparum EPAC (PfEpac), does not play an essential role in blood stages.

22 ells, might contribute to immune evasion and play an essential role in bone lesions frequently found

23 timate relationship with the CNS, where they play an essential role in both health and disease.

24 Molecular catalysis plays an essential role in both natural and artificial p

25 Our study demonstrates that KIB1 plays an essential role in BR signaling by inhibiting BI

26 ular vesicles (EVs) released by neural cells play an essential role in brain homeostasis and the cros

27 ption factor important for memory formation, plays an essential role in brain epigenetic programming.

28 Glucose transporters play an essential role in cancer cell proliferation and

29 ells and inflammation in the intestine, thus playing an essential role in cancer prevention or cancer

30 DNA methylation plays an essential role in cancer.

31 These data reveal PodJ plays an essential role in CC and LC tethering to the OP

32 n the future - help to pinpoint factors that play an essential role in cell migration.

33 nduced nuclear export of NR4A1 in TNBC cells plays an essential role in cell migration, SMAD7 degrada

34 many proteins in eukaryotic cells, and thus play an essential role in cellular information transfer.

35 Mitochondria play an essential role in cellular metabolism, generatio

36 The microscopic viscosity plays an essential role in cellular biophysics by contro

37 e AAA+ ATPase, p97, also referred to as VCP, plays an essential role in cellular homeostasis by regul

38 Cohesin plays an essential role in chromatin loop extrusion, but

39 AR domain containing proteins PACSIN1 and -2 play an essential role in ciliogenesis, similar to their

40 obus pallidus external segment (GPe) circuit plays an essential role in classical fear conditioning.

41 ype of synaptic glutamate receptors (AMPARs) plays an essential role in cognition.

42 ic connectivity of adult-born neurons, which play an essential role in cognitive function.

43 HSCs play an essential role in ConA-induced liver injury dire

44 the cytochrome P450 (CYP) 26 enzymes, which play an essential role in controlling retinoid gradients

45 Together, these results show that OTUB1 plays an essential role in controlling the stability of

46 tin regulation through histone modifications plays an essential role in coordinated expression of mul

47 Traveling waves play an essential role in coordinating mitosis over larg

48 These findings show that macrophages play an essential role in coordinating the epimorphic re

49 Replication studies play an essential role in corroborating research finding

50 Acetylcholine (ACh) plays an essential role in cortical information processi

51 Collectively, our data show that Sema3E plays an essential role in dampening the early inflammat

52 Families play an essential role in deceased organ procurement.

53 CaMKIIalpha plays an essential role in decoding Ca(2+) signaling in

54 n that the plant hormone salicylic acid (SA) plays an essential role in defense, whether the master r

55 These two cell types play an essential role in determining HBV clearance/tole

56 tructure of the RNA molecule-and its absence-plays an essential role in determining capsid structure

57 onstrate that domain-specific working memory plays an essential role in determining individual capaci

58 s, the detailed shape of a catalytic swimmer plays an essential role in determining its direction of

59 g NMJ.SIGNIFICANCE STATEMENT The AP waveform plays an essential role in determining the behavior of n

60 mposition of the methyllysine-binding pocket plays an essential role in determining the selectivity o

61 The linkage between the helices plays an essential role in determining the structural to

62 As such, diffusion of ethene and propene plays an essential role in determining the ultimate prod

63 ctor receptor 1 (TNFR1) after ligand binding plays an essential role in determining whether cells exh

64 RBM10 is an RNA-binding protein that plays an essential role in development and is frequently

65 cisions.Polycomb repressive complex 2 (PRC2) plays an essential role in development by modifying chro

66 Cell signaling plays an essential role in development, and knowledge of

67 transcription factor of Hippo pathway which plays an essential role in development, cell growth, org

68 (EMT) is a fundamental cellular process and plays an essential role in development, tissue regenerat

69 lthough this miRNA family is hypothesized to play an essential role in differentiation, a triple knoc

70 g lipid in eukaryotic cell plasma membranes, playing an essential role in diverse cellular processes.

71 conserved group of nucleic acid enzymes that play an essential role in DNA repair, replication, and r

72 ation of molecular targets among known drugs plays an essential role in drug repurposing and understa

73 Knowledge of catalytic residues can play an essential role in elucidating mechanistic detail

74 nant extracellular enamel matrix protein and plays an essential role in enamel formation (amelogenesi

75 We also show that a MARF1 RRM plays an essential role in enhancing its endonuclease ac

76 HIV-1 Nef plays an essential role in enhancing virion infectivity

77 resent findings suggest that SREBP signaling plays an essential role in epidermal differentiation, sk

78 The Hippo-YAP signaling pathway plays an essential role in epithelial cells during intes

79 a highly dynamic property of chromatin that plays an essential role in establishing and maintaining

80 ate lentiviruses encode the Nef protein that plays an essential role in establishing persistent infec

81 netic sequence database retrieval benchmarks play an essential role in evaluating the performance of

82 udding yeast, WASp-mediated actin nucleation plays an essential role in fission yeast endocytosis.

83 In the liver, they play an essential role in for example bile formation or

84 The Wnt receptor Fzd7 plays an essential role in gastric tumorigenesis irrespe

85 t that non-coding constraint mutations could play an essential role in GBM, underscoring the need to

86 This study reveals that MBNL1 plays an essential role in GBM stemness and tumor progre

87 er genes is called a hub gene, which usually plays an essential role in gene regulation and biologica

88 Biotin plays an essential role in growth of mycobacteria.

89 t market prices in the near future, it could play an essential role in hedging against future climate

90 e family of HDGF-related proteins (HRPs) and plays an essential role in hepatocellular carcinoma path

91 We conclude that, in early plants, H3K27me3 played an essential role in heterochromatin function, su

92 C-C chemokine receptor 5 (CCR5) plays an essential role in HIV pathogenesis as the major

93 Macrophages play an essential role in host defense and display remar

94 apoptosis, and necroptosis (PANoptosis) and plays an essential role in host defense against influenz

95 These data demonstrate that FAK plays an essential role in HSC activation and liver fibr

96 , we showed that A-kinase anchoring proteins play an essential role in ICAM-4 activation.

97 This has played an essential role in identifying cases, informing

98 t Leishmania challenge suggesting that IL-23 plays an essential role in IL-17-mediated protection by

99 Power Pool (EAPP), hydropower is expected to play an essential role in improving electricity access i

100 ORTANCE The papillomavirus L2 capsid protein plays an essential role in infectious entry, where it di

101 We show that this modification plays an essential role in infectious entry, where it mo

102 species (ROS) produced by overexpressed MAOA plays an essential role in inhibiting apoptosis and acti

103 barrier abnormalities have been suggested to play an essential role in initiation of early atopic der

104 Dendritic cells (DC) play an essential role in innate immunity and radiation-

105 RIg, by interacting with complement in vivo, plays an essential role in intravascular clearance of bl

106 m that neutrophil recruitment and activation play an essential role in IR stress, and that targeting

107 Pru p 3 usually carries a lipid ligand that play an essential role in its function in plants.

108 erent genes have been recently recognized to play an essential role in its pathogenesis.

109 ates, we find that assembly of the Rbfox CTD plays an essential role in its normal splicing function.

110 TFF1, a secreted protein, plays an essential role in keeping the integrity of gast

111 esis.IMPORTANCE ORF45-induced RSK activation plays an essential role in KSHV lytic replication, and O

112 feature of their ligand-induced behavior and plays an essential role in lateral cross-activation of t

113 We show that Gcgr signaling plays an essential role in LDL-C (low-density lipoprotei

114 sults demonstrate that temporal organization plays an essential role in learners' sensitivity to the

115 The hippocampus plays an essential role in learning.

116 ikimate esterase (CSE) was recently shown to play an essential role in lignin biosynthesis in Arabido

117 crosomal triglyceride transfer protein (MTP) plays an essential role in lipid metabolism, especially

118 Podocytes are highly specialized cells that play an essential role in maintaining the integrity and

119 ed to promote telomere homeostasis, but also plays an essential role in maintaining a stable genome.

120 Collectively, these data suggest that REEP6 plays an essential role in maintaining cGMP homeostasis

121 Our data indicate that LRRK2 plays an essential role in maintaining nuclear envelope

122 The brain-gut-liver axis plays an essential role in maintaining overall glucose,

123 is a heritable epigenetic modification that plays an essential role in mammalian development.

124 Electrostatic interactions play an essential role in many analytical applications i

125 Solvents play an essential role in many areas of chemistry and is

126 Antibodies produced by memory B cells play an essential role in many of these responses.

127 Tunneling plays an essential role in many branches of physics and

128 pathogen interactions often means that l-Rha plays an essential role in many organisms.

129 Myeloid cells are known to play an essential role in mediating epithelial inflammat

130 x (V1) and extrastriate visual areas [22-26] play an essential role in mediating size constancy.

131 rom -135 to -123 of the LPCAT3 promoter that plays an essential role in mediating PPARdelta-induced t

132 Glutamine synthetase (GS) plays an essential role in metabolism by catalyzing the

133 Tumor-associated macrophages (TAMs) play an essential role in metastasis.

134 The augmin complex plays an essential role in microtubule (MT)-dependent MT

135 These results indicated that MCAT plays an essential role in mitochondrial function and ma

136 Here, we discover that neurotrophin 4 (NT4) plays an essential role in mucus overproduction after ea

137 to be regulated by the Notch receptor, which plays an essential role in myogenesis.

138 Antibodies are thought to play an essential role in naturally acquired immunity to

139 isengagement of UNC5C with polymerized TUBB3 plays an essential role in netrin-1/UNC5C-mediated axon

140 Inhibitory interneurons play an essential role in neural computations by utilizi

141 e an action potential in excitable cells and play an essential role in neuronal signaling.

142 hagy is a lysosomal degradation pathway that plays an essential role in neuronal homeostasis and is p

143 , we hypothesized that BET proteins may also play an essential role in neutrophil-dominant allergic a

144 (2+) uptake in photoreceptors is complex and plays an essential role in normal function.

145 The mammalian olfactory bulb (OB) plays an essential role in odor processing during the pe

146 that although its N-terminal variable domain plays an essential role in optimizing Ca(2+)-dependent R

147 While it is clear that the Z-ring plays an essential role in orchestrating cytokinesis, pr

148 DNA methylation plays an essential role in orchestrating these learning-

149 Fibroblasts play an essential role in organogenesis and the integrit

150 Together, our data demonstrate that N-WASP plays an essential role in P aeruginosa-induced vascular

151 Na(V) 1.6 plays an essential role in peripheral sensory neurons, s

152 Mitochondria are known to play an essential role in photoreceptor function and sur

153 Both these mechanisms play an essential role in physiological and diseases pro

154 molecules for gene regulation in plants and play an essential role in plant-pathogen interactions.

155 significant influence on evolution and also plays an essential role in plant breeding, because a suc

156 Iron-sulfur (Fe-S) clusters play an essential role in plants as protein cofactors me

157 ts is the caseinolytic protease (Clp), which plays an essential role in plastid protein turnover.

158 mutation patterns for cancer classification plays an essential role in precision and personalized me

159 It has been implicated to play an essential role in preventing the increased forma

160 Model simulations indicate that MTHFS plays an essential role in preventing 5fTHF accumulation

161 uggesting that it is the fork structure that plays an essential role in PriA's selection of DNA subst

162 ) MnxG protein from marine Bacillus bacteria plays an essential role in producing MnOx minerals by ox

163 GSK3beta plays an essential role in promoting cell death and is e

164 k complex-associated protein named BOH2 that plays an essential role in promoting flagellum inheritan

165 ) is a second messenger adaptor protein that plays an essential role in propagating TNF-alpha-mediate

166 WDR77 plays an essential role in prostate tumorigenesis and ce

167 autophagy is an intracellular mechanism that plays an essential role in protein clearance.

168 aperones and nucleotide exchange factors and plays an essential role in protein quality control that

169 eins, which cannot be predicted de novo, may play an essential role in rapid light adaptation and pho

170 e phosphatase (PTP) SHP2, encoded by PTPN11, plays an essential role in RAS-mitogen-activated protein

171 and promote the synthesis of ubiquinone that plays an essential role in reducing oxidative stress and

172 Pancreatic islets play an essential role in regulating blood glucose level

173 Rab proteins play an essential role in regulating intracellular membr

174 re ubiquitous in science and technology, and play an essential role in regulating physical, biologica

175 CaV2.1 channels play an essential role in regulating synaptic signaling.

176 15, contributes to developmental programs by playing an essential role in regulating age-dependent li

177 ctivator of nuclear factor B ligand (RANKL), plays an essential role in regulating bone resorption.

178 The medial prefrontal cortex (mPFC) plays an essential role in regulating emotion, including

179 Recent evidence showed that Sema3E plays an essential role in regulating the activities of

180 ant component of virus-host interactions and plays an essential role in regulating viral replication.

181 antiporter that belongs to SLC30 family and plays an essential role in regulating Zn(2+) accumulatio

182 long-range communication relays, with lipids playing an essential role in regulation.

183 Drosophila reveal that RagC phosphorylation plays an essential role in regulation of cell growth.

184 e shown that the glomerular podocytes, which play an essential role in renal filtration, express the

185 The Polycomb system modifies chromatin and plays an essential role in repressing gene expression to

186 RP) receptor and conserved among eukaryotes, plays an essential role in sensing the ribosome during c

187 These data suggest that mitochondria play an essential role in sesamol-induced HepG2 cells de

188 Ras family proteins play an essential role in several cellular functions, in

189 5'-3' structure-specific endonuclease, which plays an essential role in several DNA repair pathways i

190 TATEMENT Dopamine transmission is thought to play an essential role in shaping large scale-neural net

191 Neural stem cells (NSCs) play an essential role in shaping the developing brain,

192 ults demonstrate that intrinsic conductances play an essential role in shaping the I/O relationship o

193 s that modulate inflammatory gene expression play an essential role in shaping the macrophage inflamm

194 The WUSCHEL-CLAVATA3 pathway genes play an essential role in shoot apical meristem maintena

195 A conserved signaling network appears to play an essential role in signaling by responding to del

196 e also find that the catalytic center of bRT plays an essential role in site-specific cleavage of TR

197 t line of defense against pathogens but also play an essential role in skin homeostasis.

198 study provides the first evidence that GLI3R plays an essential role in SMO-independent Hh signaling

199 Man-made continuous fibers play an essential role in society today.

200 ssed in meiotic and haploid germ cells which plays an essential role in spermatogenesis.

201 family of motor proteins have been shown to play an essential role in spindle formation by generatin

202 raints imposed by a tetradentate P4N2 ligand play an essential role in stabilizing square planar Fe c

203 otein in selenoprotein translation that also plays an essential role in stabilizing selenoprotein tra

204 We conclude that sorbitol plays an essential role in stamen development and pollen

205 ahydrofolate dehydrogenase 1-like (MTHFD1L), plays an essential role in support of cancer growth.

206 ptor REV-ERBalpha, which represses BMAL1 and plays an essential role in sustaining a functional clock

207 Irrigation plays an essential role in sustaining crop production in

208 UNC-13 proteins play an essential role in synaptic transmission by recru

209 Deregulation of MYC plays an essential role in T cell acute lymphoblastic le

210 The thymus is a primary lymphoid organ that plays an essential role in T lymphocyte maturation and s

211 BILBO1's N-terminal domain (NTD) plays an essential role in T. brucei FPC biogenesis and

212 with phosphatidylinositol-containing lipids play an essential role in targeting ExoU to host membran

213 The enhancer Ealpha plays an essential role in Tcra rearrangement by establi

214 DCs play an essential role in TH cell differentiation, and w

215 tional exchangeable pools) that is likely to play an essential role in the biogeochemical functioning

216 ntative of a class of assembly proteins that play an essential role in the biosynthesis of the active

217 AP-1 transcription factors play an essential role in the cardiomyocyte response to

218 Gangliosides (sialylated glycolipids) play an essential role in the CNS by regulating recognit

219 Therefore, thermodynamics does appear to play an essential role in the determination of the cell

220 range.SIGNIFICANCE STATEMENT Hensen's cells play an essential role in the development and homeostasi

221 Nutrients from dehydrated sewage sludge play an essential role in the development of many plants

222 ata suggest that adipocyte derived cytokines play an essential role in the development of obesity ind

223 (vascular smooth muscle cells and pericytes) play an essential role in the development of the vascula

224 They play an essential role in the development of various org

225 y(ADP-ribose)-polymerase (PARP)-1 and PARP-2 play an essential role in the DNA damage response.

226 Macrophages play an essential role in the early immune response agai

227 ) is a circulating cytokine that is known to play an essential role in the endothelial homeostasis an

228 ed that unfavourable haemodynamic conditions play an essential role in the formation and development

229 We conclude that electrostatic interactions play an essential role in the formation of the highly ef

230 Sediments play an essential role in the functioning of aquatic eco

231 These membrane proteins play an essential role in the insertion of the new SPB i

232 e CTD state of phosphorylation also does not play an essential role in the interaction between empty

233 Regulatory T (Treg) cells play an essential role in the maintenance of immune home

234 nt TRP channels of different subtypes, which play an essential role in the maintenance of skin functi

235 microdomains." Tetraspanins, including CD82, play an essential role in the pathogenesis of fungal inf

236 opressin (AVP) and its type-2 receptor (V2R) play an essential role in the regulation of salt and wat

237 Acinar cells play an essential role in the secretory function of exoc

238 These findings suggest that BMAL1 may play an essential role in the survival of DANs and maint

239 Results show that lipids play an essential role in the ZIKV assembly pathway reve

240 Visual field testing has played an essential role in the diagnosis and management

241 s reveal that the coevolution of these sites played an essential role in the evolution of simian neur

242 Most recently, molecular diagnostics have played an essential role in the global health response t

243 f eukaryotic translation elongation that has played an essential role in the study of protein synthes

244 essential part of the innate immune system, playing an essential role in the control of infectious d

245 hile the cerebral cortex is widely viewed as playing an essential role in the learning and performanc

246 High-intensity (HI) light plays an essential role in the adaptation to hot summer

247 m the cis-Golgi to the endoplasmic reticulum plays an essential role in the biogenesis of proANP cont

248 Autophagy plays an essential role in the cellular homeostasis of n

249 I protein arginine methyltransferase, PRMT5, plays an essential role in the control of cancer cell pr

250 p35, phosphorylates multiple substrates and plays an essential role in the development and function

251 k-A is a receptor tyrosine kinase (RTK) that plays an essential role in the development and functioni

252 gamma (RORgamma) is a nuclear receptor that plays an essential role in the development of T helper 1

253 Neuroimaging plays an essential role in the diagnosis of these malfor

254 aluation through right heart catheterization plays an essential role in the diagnosis, categorization

255 s studies demonstrate that the glycosylation plays an essential role in the flagellar assembly and mo

256 rganizing factor 1 (EOF1, AAEL012336), which plays an essential role in the formation and melanizatio

257 Solid organic matter (OM) plays an essential role in the generation, migration, st

258 sely, PAD is exposed in pathological tau and plays an essential role in the inhibition of fast axonal

259 2, a member of the malate-aspartate shuttle, plays an essential role in the intracellular NAD(H) redo

260 We report here that the bacterial sRNA SsrA plays an essential role in the light-organ symbiosis bet

261 a master regulator of lysosomal biogenesis, plays an essential role in the lysosomal exocytosis of s

262 tural protein, nuclear protein 1 (NP1), that plays an essential role in the maturation of capsid prot

263 It plays an essential role in the membrane attack complex (

264 tion, tripartite motif 21 (TRIM21) E3 ligase plays an essential role in the p62-Keap1-Nrf2 axis pathw

265 cially impairment of its phagocytic ability, plays an essential role in the pathogenesis of age-relat

266 horylation of protein kinase C (Pkc1), which plays an essential role in the pathways that link the ce

267 PfCRT also plays an essential role in the physiology of the parasit

268 tal and modelling results indicate that ArnS plays an essential role in the precisely controlled expr

269 The surface ligand plays an essential role in the production of QDs, post-s

270 riptions in vascular endothelial cells (ECs) plays an essential role in the promotion of EC prolifera

271 otein of the extracellular matrix (ECM) that plays an essential role in the proper maintenance of ske

272 escribed as a counterregulatory hormone that plays an essential role in the protection against hypogl

273 The Insulin/IGF-1 signalling (IIS) pathway plays an essential role in the regulation of glucose and

274 review, now we report that IEC polarization plays an essential role in the regulation of IL-6/STAT3

275 Greatwall (Gwl) kinase plays an essential role in the regulation of mitotic ent

276 In Arabidopsis thaliana, CONSTANS (CO) plays an essential role in the regulation of photoperiod

277 or the first time, that choline availability plays an essential role in the regulation of temporal pr

278 strate that FATTY ACYL-COA REDUCTASE (AsFAR) plays an essential role in the reproduction of the bug A

279 The PhoQ/PhoP two-component system plays an essential role in the response of enterobacteri

280 and hydrogen (H(2)) into ammonia (NH(3)) gas plays an essential role in the synthesis of fertilizers

281 , such as the trifluoromethyl (CF(3)) group, plays an essential role in the synthesis of new pharmace

282 The TRPV1 cation nonselective ion channel plays an essential role in thermosensation and perceptio

283 Two HSV membrane proteins, gE/gI and US9, play an essential role in these processes.

284 esonance (SPR)-generated energetic electrons play an essential role in this photochemical process, th

285 The YidC insertase plays an essential role in this process, but the molecul

286 hancer elements, and transcription machinery plays an essential role in tissue development and regene

287 We found that p110beta plays an essential role in TPO-mediated (i) priming of p

288 Methyl-CpG binding proteins play an essential role in translating DNA methylation ma

289 e the most abundant cancer stromal cells and play an essential role in tumor immunosuppression, provi

290 lar heat shock protein-90alpha (eHsp90alpha) plays an essential role in tumour invasion and metastasi

291 derived vesicles present in body fluids that play an essential role in various cellular processes, su

292 involved in diverse biological processes and play an essential role in various human diseases.

293 e branched1 mutant, indicating that ba2 also plays an essential role in vegetative AM development.

294 oach, we revealed that both studied proteins play an essential role in viral stability.

295 s gH studied to date have been implicated in playing an essential role in viral infection of diverse

296 e only structural protein of the virion that plays an essential role in viral assembly.

297 and its engagement with human ACE2 receptor plays an essential role in viral entry into host cells.

298 ZIKV nonstructural protein 1 (NS1) plays an essential role in viral replication and immune

299 Long-range correlations play an essential role in wave transport through disorde

300 as diverged from other vertebrate ferlins to play an essential role in zebrafish skeletal and cardiac