ライフサイエンスコーパス: player

1 -6 and therefore represents an oncogenic key player.

2 sorders is emerging with RAC1 as the central player.

3 se (PD), where alpha-synuclein is also a key player.

4 nd 110 of 111 National Football League (99%) players.

5 and direction of information flow among the players.

6 an integrated way, considering all relevant players.

7 morbidity and lower diabetes amongst former players.

8 ia and Gammaproteobacteria, the likely major players.

9 ursor, integrating known and novel molecular players.

10 es and their regulators functioning as major players.

11 ize unravelling among a majority of rational players.

12 ization with direct feedback from commercial players.

13 betes was significantly lower amongst former players, (0.28, 95% CI 0.11-0.66), whereas osteoarthriti

14 CTE was neuropathologically diagnosed in 177 players (87%; median age at death, 67 years [interquarti

15 simultaneously catalytic amounts of two key players, a silicon-based Lewis superacid and a nucleophi

16 different outcomes, and the beliefs of each player about their opponent.

17 cate the transcription factor Sox11 as a key player after optic nerve injury-in DLK signaling of RGC

18 former collegiate and professional football players (age range, 52-65 years) provided informed conse

19 omographic data from 12 active or former NFL players and 11 matched control participants, the NFL pla

20 this article, we describe the key microbial players and biological pathways regulating dryland N2 O

21 In this review, we describe the key players and connections at play in type 2 responses and

22 n a cohort of National Football League (NFL) players and control participants, and to report measures

23 tform for phenotype-based discovery of novel players and inhibitors in the IIS-PI3K-Akt-Tor signaling

24 to identifying and characterizing molecular players and interactions in the PAR network have begun t

25 ated in cirrhosis and HCC, but the molecular players and signaling pathways contributing to these pro

26 y snow and ice algae, which are the critical players and the dominant primary colonisers and net prod

27 Morbidity and HrQoL differ between players and the general population, with higher musculos

28 found to be similar for high school football players and their nonplaying counterparts from mid-1950s

29 Fourteen high-frequency poker players, and 14 matched non-gambler controls, performed

30 thropic sponsors of research, major industry players, and collaborations among some of these entities

31 tube and flat panel display televisions, DVD players, and headphones.

32 was considered the loudest under the ear by players, and on average, violins that were quieter under

33 HITS also allows for data linkage with other player- and game-level data to inform the development of

34 ate (proposers) incur a cost, while their co-players are not necessarily required to pay any, allowin

35 Additional key players are the cell membrane-associated iron transporte

36 nterior cingulate cortex activation in poker players, as compared to controls, during reactive inhibi

37 ing the identity of the underlying molecular players, as well as other signals conveyed by voltage an

38 Its cell-to-cell variability, a key player associated with cancer cell survival and recurren

39 eague Baseball and the Major League Baseball Players Association reached an agreement regarding the d

40 trategies, we find that approximately 40% of players behave as resilient cooperators who avoid unrave

41 characterise retired professional ice hockey players' cognitive and psychosocial functioning in relat

42 tional anisotropy and mean diffusivity in 13 players compared with 15 control participants.

43 quality of life (HrQoL) amongst former rugby players, compared to an age-standardised general populat

44 eeming relatively quiet under the ear of the player-compared with new violins.

45 In contrast, these young players did not differ from control participants in regi

46 understanding of the cellular and molecular players enabling each of these steps is key to uncoverin

47 were 1000 rounds in each game made up of 18 players engaged in pairwise relationship with their neig

48 Under certain conditions, poor players exhibit cooperative behavior in two types of chi

49 ucture and motility position it as a crucial player for cellular integrity and survival.

50 r T cells and cytotoxic CD8+ T cells are key players for adaptive immune responses against acute infe

51 robiome on innate and adaptive immunological players from epithelial cells and antigen-presenting cel

52 ancient Homo sapiens subpopulations in a one-player game against nature.

53 detailed case study in the context of a two-player game with antisocial behavior and retaliatory pun

54 consisting of a simple online game in which players have to find a target hidden on a board, to inve

55 level of play, with all 3 former high school players having mild pathology and the majority of former

56 onal (5 [56%]), and professional (101 [86%]) players having severe pathology.

57 KEY MESSAGE: This work adds a new player, HER2, downstream of the perception of E-2-hexena

58 sociated immunopathology, and identifies key players, i.e. TLR2 and CTLA4, involved in this mechanism

59 ing amyloid beta precursor protein), a major player in Alzheimer's disease that is known to have immu

60 The amyloid precursor protein (APP), a key player in Alzheimer's disease, belongs to the family of

61 The central player in bacterial cell division, FtsZ, is essential in

62 ive bacteria and is believed to be a crucial player in bacterial chromatin organization via its DNA-b

63 that FtsZ, a protein already known as a key player in bacterial cytokinesis, had the "tubulin signat

64 ll, these results suggest that CfcR is a key player in biofilm formation regulation by the Rsm protei

65 ing for the first time neuronal MeCP2, a key player in brain development, to immune activation and de

66 mmalian IP3Rs, IP3R3 appears to be the major player in Ca(2+)-dependent apoptosis.

67 nscriptional mechanism, has emerged as a new player in cancer biology.

68 3 is increasingly recognized as an important player in cancer development, progression, and metastasi

69 MDC1 is a central player in checkpoint activation and subsequent DNA repai

70 maintenance protein 10 (Mcm10), an important player in CMG activation, increases the number of produc

71 igmatic type of nervous system cell as a key player in conditions ranging from neurodevelopmental dis

72 otubule-severing enzyme katanin as a central player in controlling the organizational state of the ar

73 pathology, implicating c-Jun as a potential player in demyelinating neuropathies.

74 inflammation is believed to be an important player in disease pathogenesis.

75 RAD51D is a key player in DNA repair by homologous recombination (HR), a

76 AMP-activated kinase (AMPK) is a key player in energy sensing and metabolic reprogramming und

77 rginine methylation on histones is a central player in epigenetics and in gene activation and repress

78 amage, and this study identifies NO as a key player in establishing this balance during M. tuberculos

79 Caspase-8 is a key player in extrinsic apoptosis and its activity is often

80 ndings highlight miR-142-3p as key molecular player in IL-1beta-mediated synaptic dysfunction, possib

81 these findings place ST6Gal-I as a critical player in imparting gemcitabine resistance and as a pote

82 NF-kappaB is a major player in inflammatory diseases that acts by regulating

83 NF-kappaB is a key player in inflammatory diseases, including multiple scle

84 unoreceptor that has emerged as an important player in inflammatory disorders besides its well-establ

85 NLRP3 inflammasome is a critical player in innate immunity.

86 Thus, Coro1A represents an important novel player in integrin biology, with key functions in PMN tr

87 d epithelial cells into the RNE is a crucial player in its formation.

88 lectively, these data identify LDIP as a new player in LD biology that modulates both LD size and cel

89 hese results suggest that CD63 is a critical player in LMP1 exosomal trafficking and LMP1-mediated en

90 s as a thylakoid Mn transporter and is a key player in maintaining Mn homeostasis in Synechocystis sp

91 eta-catenin signaling pathway is a prominent player in many developmental processes, including gastru

92 lusively, this work validates PSD95 as a key player in memory and establishes epigenetic editing as a

93 nin gene-related peptide (CGRP) is a central player in migraine pathogenesis, yet its site(s) of acti

94 citonin gene-related peptide (CGRP) is a key player in migraine.

95 gh levels of energy, and so iron, a critical player in mitochondrial respiration, is an important com

96 Polo-like kinase 1 (Plk1) is a key player in mitosis and a target for drug development as i

97 Bruton tyrosine kinase (Btk) is a central player in multiple signaling pathways of lymphoid and my

98 dly reduced the activity of NF-kappaB, a key player in muscle inflammation and myogenesis.

99 onfirm that SLN-based thermogenesis is a key player in muscle non-shivering thermogenesis (NST) and c

100 Our results establish SMCHD1 as a key player in nasal development and provide biochemical insi

101 Alpha synuclein (alpha-syn) is a central player in neurodegeneration, but the mechanisms triggeri

102 NAJ family of molecular chaperones, is a key player in neuronal proteostasis maintenance.

103 cycle gene loci, thereby representing a key player in oncogenesis and a viable target for cancer the

104 etastasis and identified STAT4 as a critical player in ovarian cancer metastasis.

105 ial ankyrin-repeat 1 (TRPA1) is an important player in pain and inflammatory pathways.

106 Thus, PAK4 could be an essential player in PDAC progression representing an interesting t

107 2), which was previously shown to be a major player in plasma-cell regulation, emphasizing the role o

108 stabilizes synaptic connections and is a key player in postsynaptic AMPA receptor endocytosis, provid

109 The DEAH-box helicase Prp43 is a key player in pre-mRNA splicing as well as the maturation of

110 esults implicate Rai1 as a novel and central player in processing non-visual light information, from

111 ondrial pyruvate carrier 1 (MPC1), a crucial player in pyruvate metabolism, is downregulated in colon

112 This work identifies BCR as a critical player in Rac1 regulation during OGD in hippocampal neur

113 in-derived neurotrophic factor (BDNF), a key player in regulating synaptic strength and learning, is

114 e major fat depot in humans and is a central player in regulating whole body metabolism.

115 Fe(II) is a key player in ROS formation in surrogate lung fluid (SLF) co

116 ly, these data establish SHP-1 as a critical player in setting the threshold downstream of TCR signal

117 pendent kinase inhibitor p21 is an important player in stress pathways exhibiting both tumor-suppress

118 An important player in subverting the host response to HCV infection

119 aptosomal-associated protein SNAP25 is a key player in synaptic vesicle docking and fusion and has be

120 our results suggest that retbindin is a key player in the acquisition and retention of flavins in th

121 Cholesterol is a key player in the complex interaction between viral and cell

122 Syndecan-1 is a critical player in the complex reciprocal interaction between MM

123 CFs in vitro and in vivo, identifying a new player in the development of cardiac fibrosis and potent

124 he importance of TGF-beta signaling as a key player in the development of ocular neovascularization a

125 These results highlight cIAP2 as a player in the DNA damage response as a posttranscription

126 s differentiation and identify PJA1 as a new player in the epigenetic control of muscle gene expressi

127 The amyloid beta peptide (Abeta) is a key player in the etiology of Alzheimer disease (AD), yet a

128 Our work implicates a novel player in the expression of LID, the kinase CK2: knock-o

129 Flash memories are currently the key player in the field, yet they fail to meet the commercia

130 opsis MKK4/MKK5-MPK6 cascade is an important player in the maternal control of embryogenesis.

131 The neurohormone oxytocin is a key player in the modulation of reproductive and social beha

132 suggest that Reelin signaling is a critical player in the modulation of synaptic function.

133 ly, our results unveil lipin-2 as a critical player in the negative regulation of NLRP3 inflammasome.

134 nhibits human myeloperoxidase (MPO), a major player in the oxidative defense of neutrophils.

135 ATX is a novel player in the pathogenesis of liver fibrosis and cancer

136 The formin-like protein INF2 is an important player in the polymerization of actin filaments.

137 ndings further establish UBIAD1 as a central player in the reductase ERAD pathway and regulation of i

138 ibosome factory, is emerging as an important player in the regulation of cell survival and recovery f

139 Izawa et al. (2017) identifies Vms1 as a key player in the regulation of ribosome quality control spe

140 moreover, they highlight HOTAIR as a crucial player in the Snail-mediated EMT.

141 P (c-di-GMP) has emerged as a key regulatory player in the transition between planktonic and sedentar

142 Fibroblasts are a main player in the tumor-inhibitory microenvironment.

143 We show that each player in this game-a "thief" and a "victim"-must balanc

144 rts (mitoNEET and NAF-1), and could be a key player in this pathway within the mitochondria.

145 Zap1 transcriptional activator is a central player in this process.

146 combination pathway, emerged as an important player in this process.

147 of microtubules and F-actin, as an essential player in this process.

148 , thus indicating that SOD3 might be a novel player in thyroid tumor stroma.

149 Recently, IL-12 emerged as a critical player in type 2 diabetes complications.

150 X-inactive specific transcript (XIST), a key player in X-chromosome inactivation that encodes an RNA

151 Myeloid cells, key players in atherosclerosis, take up and present antigens

152 Transporters are essential players in bacterial growth and survival, since they are

153 Epigenetic mechanisms have emerged as key players in cancer development which affect cellular stat

154 While endothelial cells are key players in cancer progression, the influence of tumor st

155 ormation of these muscles are also important players in cardiogenesis, expressed in the second heart

156 les, and exosomes, have emerged as important players in cell-to-cell communication in normal physiolo

157 nt protein receptor (SNARE) proteins are key players in cellular trafficking and coordinate vital cel

158 al inhibitory synaptic connections are major players in choosing, sequencing and maintaining behavior

159 eristics, pointing to basophils as important players in CU pathophysiology.

160 Mechanosensitive proteins are key players in cytoskeletal remodeling, muscle contraction,

161 nce points to inflammation as one of the key players in diabetes-mediating adverse effects to the neu

162 developmental signaling, are emerging as new players in driving epithelial dysfunction and allergic p

163 y, among the various oxidative stress combat players in E. coli, ubiquinone acts as the cell's first

164 e-exposure can enhance susceptibility of key players in ecosystem functioning to further (pulse) dist

165 in hand, chemical biologists have become key players in efforts toward understanding the complexity o

166 ls, these recognition elements will be major players in future biosensor development.

167 In summary, 3'-UTRs seem to be major players in gene regulation that enable local functions,

168 be controlled by the host, but also as major players in genome evolution and regulation.

169 g by Ephs and ephrins that make them pivotal players in health and disease.

170 sor genes and the immune system are critical players in inhibiting cancer initiation and/or progressi

171 re, we identified RIG-I and MDA5 as critical players in innate and adaptive immune responses against

172 M) family have recently emerged as important players in innate immunity and antivirus.

173 he protein polymer, the numerous and diverse players in intracellular pathways for disulfide formatio

174 or Kruppel homolog 1 (Kr-h1), one of the key players in juvenile hormone signaling.

175 cysteine aspartate proteases that are major players in key cellular processes, including apoptosis a

176 and its target DLST are important metabolic players in left ventricular dysfunction.

177 lipids have been largely overlooked as major players in lipid raft formation.

178 er of large-scale proteomics to identify key players in liver regeneration and the importance of post

179 Key players in mammalian iron trafficking include several ty

180 ntial for immune reconstitution, are central players in many physiological and pathological human pro

181 nucleus (IP), have been identified as major players in mediating the aversive effects of nicotine.

182 The central players in most cellular events are assemblies of macrom

183 Th17 cells are major players in multiple autoimmune diseases and are developm

184 microglia and astrocytes, which are central players in neuroinflammation.

185 Extracellular proteases have emerged as key players in neuroplasticity phenomena.

186 Thus, ceramides are vital players in numerous diseases including metabolic and car

187 into ecosystem models where they act as key players in nutrient cycling and trophic networks.

188 drocytes, we identified consistent molecular players in OA progression that replicated across indepen

189 rylation and reveal its interaction with key players in PD, opening up new research avenues for bette

190 s is due to defective association of crucial players in phototransduction cascade.

191 Ago) proteins in eukaryotes are known as key players in post-transcriptional gene silencing(1), while

192 proach in identifying previously unsuspected players in proteotoxic processes.

193 To identify key players in PSG organization, we performed high-throughpu

194 servations point to GRFs as new multifaceted players in Ribi gene regulation both during exponential

195 Though several players in signal perception have been identified, littl

196 these findings uncover AP-2 and clathrin as players in Slack channel regulation.

197 ew (quantum Nash) equilibrium points whereby players in some classical games are always outperformed

198 acterial plant litter decomposers as central players in stream ecosystems.

199 tify skin type 2 conventional DCs as crucial players in TH2 sensitization to common inhaled allergens

200 netic reprogramming and that they may be key players in the acquisition of cellular totipotency and t

201 These signals are potential key players in the activation of bulge melanocyte precursors

202 rized factors AK023948 and DHX9 as important players in the AKT pathway, and that their upregulation

203 Intermediate filaments (IFs) are key players in the control of cell morphology and structure

204 Macrophages (Mvarphis) are key players in the coordination of the lifesaving or detrime

205 Our study focuses on key players in the damage signaling pathway and highlights h

206 Monocytes are key players in the development and exacerbation of atheroscl

207 NA species have been identified as important players in the development of chronic diseases, includin

208 Hepatic stellate cells (HSCs) are key players in the development of liver fibrosis, but the ro

209 Long noncoding RNAs are emerging players in the epigenetic machinery with key roles in de

210 perties, ionic liquids have become essential players in the fields of synthesis and catalysis, extrac

211 Methanogenic archaea are major players in the global carbon cycle and in the biotechnol

212 emerged as important, yet poorly understood, players in the host's innate immune response to virus in

213 the brain, glial cells are implicated as key players in the onset and progression of AD and related d

214 Podocytes are increasingly recognized as key players in the pathogenesis of proteinuria in primary an

215 tides, which have been implicated as central players in the pathology of Alzheimer disease.

216 Astrocytes are key players in the pathology of multiple sclerosis and can a

217 lating the activation of TLRs, which are key players in the recognition of invading microbes.

218 cell cycle defects potentially unveiling new players in the regulation of these processes.

219 all major B cell subsets, yet the molecular players in these signaling events are not fully understo

220 Key players in this process are aminoacyl-tRNA synthetases (

221 ein transport, however the further molecular players in this process remain obscure.

222 examples to illustrate the key concepts and players in this process.

223 infection; however, which cell types are key players in this response remain unknown.

224 -activated chloride channels (CaCCs) are key players in transepithelial ion transport and fluid secre

225 Our results highlight RAC/PAK1 as major players in YAP1 regulation triggered by cell adhesion.

226 Some of the established players include the Rab GTPases, the SNARE complex prote

227 y, entanglement, or even discord between the players' input states.

228 Our results also show that these other players interact with the dopaminergic RL system, interf

229 In the competition condition, players' interests were directly opposed: the partner tr

230 In the cooperation condition, players' interests were matched: they had to make corres

231 that mammalian target of rapamycin is a key player involved in prevention of TH2 responses by flagel

232 Defining the microbial players involved in crop rotational effects in maize wil

233 We conclude that MMP9 and 2 are robust new players involved in human MSC immunoregulatory mechanism

234 okaryotes, yeasts, and plants, the molecular players involved in Pi sensing in mammals remain unknown

235 To identify molecular players involved in qH, we screened for suppressors of s

236 We discuss not only the players involved in these processes, but also the subcel

237 The key players involved in this process are mechanosensitive io

238 t and synaptic plasticity, but the molecular players involved in this process are not well defined.

239 a3 outside-in signaling, focusing on the key players involved, and how they cooperate to orchestrate

240 One integral player is IFN regulatory factor (IRF)-8, which promotes

241 a mechanistic scenario for how a microbiota player (Lactobacillus) may contribute to regulating meta

242 EGFR and associated signaling players may therefore represent promising targets for mi

243 Among 202 deceased former football players (median age at death, 66 years [interquartile ra

244 As players memorize more rounds, the dimension of the strat

245 ster rates of stimulus discrimination, poker players might have recruited more cognitive resources th

246 sectional study of former elite, male, rugby players (n = 259) was undertaken, and standardised morbi

247 ChIP sequencing of the major players NUT, ZNF532, BRD4, EP300, and H3K27ac revealed t

248 The Pat1 protein is a central player of eukaryotic mRNA decay that has also been impli

249 th their target mRNAs and therefore is a key player of post-transcriptional regulation network.

250 that PIH1D3, a protein that emerges as a new player of the cytoplasmic pre-assembly pathway, is part

251 to the mammalian MCUC, and identifies a new player of the intracellular Ca(2+) regulation network in

252 ng liver de novo lipogenesis as a downstream player of the p63 network.

253 Players of American football may be at increased risk of

254 molecular mechanisms and critical functional players of DNA demethylation in this process remain larg

255 Key players of the ABA-signaling pathway are the ABA-binding

256 Contrary to the other key players of the core fusion machinery, gL has the most el

257 m of the disorders caused by variants in key players of the glutamatergic signaling pathway.

258 Toll-like receptors (TLRs) are major players of the innate immune system.

259 s for TSS emphasize the need to identify key players of the storm's initial wave.

260 Adipose tissue macrophages (ATMs) are key players orchestrating metabolic inflammation, and ER str

261 on of taste can be considered as a novel key player participating in the regulation of gut function.

262 young active (n = 4) or former (n = 10) NFL players recruited from across the United States, and 16

263 Players reported a mean (SD) of 7.0 (6.4) years (range,

264 Most of the major players required for cytokinesis are known, but the temp

265 Recent studies have identified the key players required for this process and showed that a comm

266 52 retired male Scottish international rugby players (RIRP) and 29 male controls who were similar in

267 d to decide either how much of a counterpart player's monetary endowment they wanted to take from the

268 We find that at moderate levels of player sensitivity cooperative behavior increases, but t

269 and 11 matched control participants, the NFL players showed higher total distribution volume in 8 of

270 Decoder dissects subnetworks to identify key players significantly impacting cell behaviour specific

271 Determining the real-time kinetics of single players such as RPA in the presence of multiple DNA proc

272 pposite was observed for former professional players (t29 = 3.883; adjusted P = .001).

273 ether, our findings reveal that Nf2 is a key player that orchestrates the differential growth of opti

274 The molecular players that are important for this fundamental biologic

275 microbiota-host mutualism, highlighting key players that could identify important therapeutics.

276 Rho GTPases are the major players that guide cells through structural reorganizati

277 at further characterization of the molecular players that regulate stage-specific gene expression and

278 While most of the key molecular players that regulate this process have been identified

279 If no initial information is given to the players, the search is optimized for cues that cover an

280 an ancestral scene involving three notional players: the needy other, the better-off other, and the

281 Participants were first included by other players, then excluded, and finally re-included.

282 ionships among the motion time series of the players to determine the magnitude and direction of info

283 Finally, strategies used by informed players turn into non-stationary processes in which the

284 ally, we discovered five novel plant defense players using a systems biology-fueled top-to-bottom app

285 Behavioral analyses revealed that poker players were faster than controls in categorizing pictur

286 energy expenditure and although experienced players were less active compared to novice counterparts

287 m the Wisconsin Longitudinal Study, football players were matched between March 1 and July 1, 2017, w

288 informant-reported athletic history and, for players who died in 2014 or later, clinical presentation

289 In a convenience sample of deceased football players who donated their brains for research, a high pr

290 It is known that learning of players who interact in a repeated game can be interpret

291 rugby union athletes (back three and centre players) who are most reliant on LM rather than total bo

292 Case series of 202 football players whose brains were donated for research.

293 l and clinical features of deceased football players with CTE.

294 Key players with highest expression of solute transporters w

295 Overall, former players with lower FA tended to have lower BOLD PSC acro

296 history and position was observed: Nonspeed players with more than three concussions had lower FA in

297 cussion history was observed; former college players with more than three concussions had lower FA in

298 However, players with real-swimming experience during the first t

299 oblems in HrQoL were reported amongst former players within the domains of mobility (p < 0.001), self

300 ed by specific immune genes that act as 'key players' within expression networks.