ライフサイエンスコーパス: pleckstrin

1 l with the PKC (protein kinase C) substrate, pleckstrin.

2 ignaling pathway compensates for the loss of pleckstrin.

3 ired actin assembly present in cells lacking pleckstrin.

4 Pleckstrin accounts for 1% of the total protein in these

5 (fibrillin 3 [FBN3], myosin IXA [MYO9A], and pleckstrin and Sec7 domain containing 3 [PSD3]) were ide

6 retion, phosphorylation of the PKC substrate pleckstrin, and Ca(2+) mobilization were unaffected in J

7 Overexpressed pleckstrin can affect polyphosphoinositide second messen

8 biquitination of the Dishevelled, Egl-10 and Pleckstrin (DEP) domain of the Wnt pathway protein Dishe

9 onformational changes in the dishevelled/Egl/pleckstrin (DEP) domain, a conserved structural motif th

10 which requires its dishevelled, Egl-10, and pleckstrin (DEP) domain, acts by promoting LIN-17 phosph

11 nslocation requires the Dishevelled, Egl-10, Pleckstrin (DEP) domain, but the molecular entity that s

12 n Gbeta5 and N-terminal Dishevelled, EGL-10, Pleckstrin/DEP Helical Extension (DEP/DHEY) domains are

13 This identified FERM, Rho/ArhGEF, and Pleckstrin domain protein 1 (Farp1) as strongly reduced

14 he protein Farp1 [FERM, RhoGEF (ARHGEF), and pleckstrin domain protein 1], a Rac1 activator previousl

15 ositol polyphosphate-5-phosphatase (INPP5D), pleckstrin domain-containing A3 (PHLDA3), sulfatase 2 (S

16 ation domains, but not the disheveled-Egl-10-pleckstrin domain.

17 of Epac1 at Ser-108 in the Disheveled/Egl-10/pleckstrin domain.

18 Platelets lacking pleckstrin exhibit a marked defect in exocytosis of delt

19 e mice containing a null mutation within the pleckstrin gene.

20 rotein membrane translocation via binding to pleckstrin homolog (PH) domains within target proteins.

21 Expression of Dbl homology-pleckstrin homology (DH-PH) region of ITSN-2L (DH-PH(ITS

22 x) and catalytic Dbl homology and C-terminal pleckstrin homology (DH-PHc) domain.

23 the small GTPases through their Dbl homology/pleckstrin homology (DH.PH) domains.

24 he homotrimer formation, whereas neither the pleckstrin homology (Golgi-binding) nor the START (ceram

25 D-12, an approximately 82 kDa protein with a pleckstrin homology (PH) and proline-rich domain, by int

26 PS interacts with specific residues in the pleckstrin homology (PH) and regulatory (RD) domains of

27 ng to a premature stop codon and loss of the pleckstrin homology (PH) and Src homology 2 (SH2) domain

28 pha-syntrophin lacking portions of the first pleckstrin homology (PH) domain (DeltaPH1a or DeltaPH1b)

29 Recombinant ORP4L and a variant without a pleckstrin homology (PH) domain (ORP4S) bind 25-hydroxyc

30 ciation of 5-HT6 receptor with neurofibromin Pleckstrin Homology (PH) domain also inhibits receptor c

31 The Dok7 structure consists of a Pleckstrin Homology (PH) domain and a Phosphotyrosine Bi

32 s leukocyte function, we have focused on its pleckstrin homology (PH) domain and find that deletion o

33 , a Ser473-specific Akt phosphatase, through pleckstrin homology (PH) domain binding.

34 ls that this region harbours a non-canonical pleckstrin homology (PH) domain connected to a 16-leucin

35 in binding activity and/or the COOH-terminal pleckstrin homology (PH) domain for their assembly compe

36 MAPK signaling and requires interaction of a pleckstrin homology (PH) domain in Ste5 with phosphatidy

37 These ArfGEFs carry a pleckstrin homology (PH) domain in tandem with their cat

38 osphate (PIP3) antagonists (PITs) that block pleckstrin homology (PH) domain interaction, including a

39 ,4,5-triphosphate (PIP3) binding function of pleckstrin homology (PH) domain is essential for the act

40 The pleckstrin homology (PH) domain is one of the most wides

41 mbrane docking mechanism of a representative pleckstrin homology (PH) domain isolated from the genera

42 e recruitment of the Akt phosphatase PHLPP1 (pleckstrin homology (PH) domain leucine-rich repeat prot

43 The pleckstrin homology (PH) domain located in the N-termina

44 to discover novel compounds that bind to the pleckstrin homology (PH) domain of AKT, thereby inhibiti

45 Bem4p interacted with the pleckstrin homology (PH) domain of Cdc24p, which functio

46 brane-inserting variable loop 1 (VL1) of the pleckstrin homology (PH) domain of dynamin-1 and demonst

47 Moreover, we identified the pleckstrin homology (PH) domain of G protein-coupled rec

48 In the present study, we aim to target the pleckstrin homology (PH) domain of GAB1 for cancer treat

49 The pleckstrin homology (PH) domain of human Fapp1, which bi

50 The pleckstrin homology (PH) domain of Lbc is located at the

51 The pleckstrin homology (PH) domain of P-REX2 inhibits PTEN

52 hosphatidylinositol 3,4-bisphosphate, to the pleckstrin homology (PH) domain of PDK1 is known to be e

53 RH domain, activated RhoA also binds to the pleckstrin homology (PH) domain of PDZRhoGEF.

54 other PI(4,5)P2-binding proteins such as the pleckstrin homology (PH) domain of phospholipase Cdelta1

55 The N-terminal pleckstrin homology (PH) domain of PLCbeta2 mediates bot

56 The pleckstrin homology (PH) domain of the general receptor

57 inositol 3,4,5-trisphosphate (PIP(3)) to the Pleckstrin Homology (PH) domain of the Tec family protei

58 ARAP3 by analyzing neutrophils from an ARAP3 pleckstrin homology (PH) domain point mutation knock-in

59 dent Arf GTPase exchange factors with a Sec7-pleckstrin homology (PH) domain tandem.

60 CERT's N-terminal pleckstrin homology (PH) domain targets it to the Golgi

61 Dynamins 1, 2, and 3 contain a pleckstrin homology (PH) domain that binds phosphoinosit

62 the kindlin FERM domain contains an inserted pleckstrin homology (PH) domain that recognizes membrane

63 ecruited to the Golgi through binding of its pleckstrin homology (PH) domain to phosphatidylinositol

64 itions, an intramolecular interaction of the pleckstrin homology (PH) domain with the von Willebrand

65 ng with the NMR data, we identify a putative pleckstrin homology (PH) domain within BR, and show that

66 The kindlin FERM domain is interrupted by a pleckstrin homology (PH) domain within its F2 subdomain.

67 This interaction involves a tripartite pleckstrin homology (PH) domain within Rgc2 and a partia

68 t attributed to the first 42 residues of the pleckstrin homology (PH) domain, a region that is critic

69 Brag2 contains a pleckstrin homology (PH) domain, and its nucleotide exch

70 daptor protein, phosphotyrosine interaction, pleckstrin homology (PH) domain, and leucine zipper-cont

71 proteins, one with and the other without the pleckstrin homology (PH) domain, as substrates for mTORC

72 a PtdIns(3,4,5)P(3)-binding protein, the AKT-pleckstrin homology (PH) domain, at the leading edge; he

73 basic region (BR), which contains a putative pleckstrin homology (PH) domain, followed by two Gly/Pro

74 ssociation with adaptor protein containing a pleckstrin homology (PH) domain, phosphotyrosine-binding

75 mma and the Alexa Fluor 594-labeled PLC-beta pleckstrin homology (PH) domain, we demonstrate that the

76 GD1 contains a phosphoinositide (PI) binding pleckstrin homology (PH) domain, we focused on genetic i

77 hat recruitment to the NKIS is mediated by a pleckstrin homology (PH) domain-containing binding partn

78 Here, we report that mutations in the pleckstrin homology (PH) domain-containing protein AtPH1

79 Drosophila melted encodes a pleckstrin homology (PH) domain-containing protein that

80 We report a conserved armadillo and pleckstrin homology (PH) domain-containing protein, term

81 in Dictyostelium discoideum, including five pleckstrin homology (PH) domain-containing proteins.

82 osphate [PI(3,4)P2] and consequently recruit pleckstrin homology (PH) domain-containing signaling pro

83 Vav3 coactivates AR in a Vav3 pleckstrin homology (PH) domain-dependent but GEF-indepe

84 Intramolecular pleckstrin homology (PH) domain-kinase domain (KD) inter

85 Pleckstrin homology (PH) domain-mediated protein recruit

86 sicle scission via membrane insertion of its pleckstrin homology (PH) domain.

87 tes Akt-Thr308 and Ser473 independent of the pleckstrin homology (PH) domain.

88 pyrimidine analogues targeting site-2 of the pleckstrin homology (PH) domain.

89 eletion causing early termination within the pleckstrin homology (PH) domain.

90 rough the catalytic Sec7 domain, but via the pleckstrin homology (PH) domain.

91 nhibited by the Dbl homology (DH)-associated pleckstrin homology (PH) domain; activated Galpha(q) rel

92 ined ab initio and defines a new subclass of pleckstrin homology (PH) domains along with a new family

93 other processes by recruiting proteins with pleckstrin homology (PH) domains and possibly other doma

94 Pleckstrin homology (PH) domains are lipid-binding modul

95 Pleckstrin homology (PH) domains are protein domains tha

96 Pleckstrin homology (PH) domains have been identified on

97 Several pleckstrin homology (PH) domains have been reported to i

98 Pleckstrin homology (PH) domains mediate protein-membran

99 olism relies on selective recruitment of the pleckstrin homology (PH) domains of FAPP proteins to the

100 Here, we have found that the pleckstrin homology (PH) domains of PLCbeta2 and PLCbeta

101 c site on SOS, and the Dbl homology (DH) and Pleckstrin homology (PH) domains of SOS (the DH-PH unit)

102 with GDP-Ras and with the Dbl homology (DH)/pleckstrin homology (PH) domains of SOS, bringing GDP-Ra

103 escent protein (YFP) chimeras of enzymes and pleckstrin homology (PH) domains specific for their subs

104 es and typically possess tandem Dbl (DH) and pleckstrin homology (PH) domains that act in concert to

105 The mechanism of interaction of pleckstrin homology (PH) domains with phosphatidylinosit

106 ne (PM) through its Ras association (RA) and pleckstrin homology (PH) domains, both of which were req

107 ASAP1 contains a tandem of BAR, pleckstrin homology (PH), and Arf GAP domains and contri

108 EFA6R shares the catalytic Sec7, pleckstrin homology (PH), and coiled coil (CC) domains o

109 AGAP1 is composed of G-protein-like (GLD), pleckstrin homology (PH), Arf GAP, and ankyrin repeat do

110 or protein APPL1 (adaptor protein containing pleckstrin homology (PH), phosphotyrosine binding (PTB),

111 re of the complex of Rac2 bound to the split pleckstrin homology (spPH) domain of phospholipase C-gam

112 5 effector APPL1 (Adaptor Protein containing pleckstrin homology [PH] domain, PTB domain and Leucine

113 AIP1 via its pleckstrin homology and C2 domains binds to phosphatidyl

114 al cell spreading: it binds paxillin via the pleckstrin homology and F0 domains to activate Rac1, and

115 3BP2 is a pleckstrin homology and Src homology 2 domain-containing

116 Grb10 is a pleckstrin homology and Src homology 2 domain-containing

117 The binding was mediated by the pleckstrin homology and the kinase domains of AKT and wa

118 ouse embryo fibroblasts showed that both the pleckstrin homology and the Pro/Arg-rich domains determi

119 In contrast, the N-terminal pleckstrin homology and/or coiled-coil domains of GRF1 a

120 subunit of FACT (Spt16-M) to reveal a double pleckstrin homology architecture.

121 ns multiple domains, including an N-terminal pleckstrin homology coiled-coiled extension (PHn-CC-Ex)

122 Here, we show that Pleckstrin homology containing family member 5 (Plekhg5)

123 n addition to the PX domain, a region in the pleckstrin homology domain (Ile-306-Ala-310) aids in the

124 hy values among the Akt isoforms in both the pleckstrin homology domain (P domain) and regulatory dom

125 mediated by direct interactions between its pleckstrin homology domain (PHD) and phosphatidylinosito

126 mediated by direct interactions between its pleckstrin homology domain (PHD) and phosphatidylinosito

127 FRET analyses detect large movements of the pleckstrin homology domain (PHD) from a 'closed' conform

128 4,5)P2 lipid sensor, phospholipase C delta 1 pleckstrin homology domain (PLC delta1-PH), is completel

129 Single mutations in the putative pleckstrin homology domain abolish binding of the tail d

130 different from that of other CDPKs; it has a pleckstrin homology domain adjacent to the kinase domain

131 SAP3 was biochemically similar to ASAP1: the pleckstrin homology domain affected function of the cata

132 rin-phosphoinositide recognition through its pleckstrin homology domain all result in failure to buil

133 Ect2 membrane association requires a pleckstrin homology domain and a polybasic cluster that

134 ys show that both a conserved surface on the pleckstrin homology domain and an intact TPR region are

135 ctly inhibits Akt through binding to the Akt pleckstrin homology domain and blocking Akt membrane tra

136 Mechanistically, AMOTL2 binds to AKT pleckstrin homology domain and interrupts AKT's membrane

137 Pleckstrin homology domain and leucine rich repeat prote

138 In this study, we identified pleckstrin homology domain and leucine-rich repeat prote

139 in the linker region between the N-terminal pleckstrin homology domain and the catalytic kinase doma

140 106, we identified two regions on its double-pleckstrin homology domain architecture that mediated hi

141 n2 chimeras, we identified the lipid-binding pleckstrin homology domain as being responsible for the

142 ransferase pulldown analyses identified Akt1 pleckstrin homology domain as the interactive domain.

143 tic domain for its GEF activity, whereas the pleckstrin homology domain assists in the PX-mediated ac

144 vity and localization of mTORC2 via the Sin1 pleckstrin homology domain at the plasma membrane is PI3

145 The non-pleckstrin homology domain beta-spectrin (beta2SP) (the

146 latory region promotes ASK1 activity via its pleckstrin homology domain but also facilitates ASK1 aut

147 PLEKHA7 (pleckstrin homology domain containing family A member 7)

148 Herein, we show that Pleckstrin homology domain containing protein family mem

149 oned on top of a long helical stalk with the pleckstrin homology domain flexibly attached on its oppo

150 in inhibited TRPV1, a PI(3,4,5)P(3)-specific pleckstrin homology domain had no effect.

151 A putative pleckstrin homology domain has been identified in the my

152 In place of the pleckstrin homology domain in dynamin, however, Drp1 con

153 Although a PI(4,5)P(2)-specific pleckstrin homology domain inhibited TRPV1, a PI(3,4,5)P

154 together with an N-terminal F0 domain and a pleckstrin homology domain inserted in the F2 domain.

155 proximal to mitochondria, and the C-terminal pleckstrin homology domain is associated with the plasma

156 at in vivo Itk exists as a monomer, with the pleckstrin homology domain less than 80 A from the C ter

157 The recent discovery of the PHLPP (pleckstrin homology domain leucine-rich repeat protein p

158 (PP1) or the hydrophobic motif phosphatase, pleckstrin homology domain leucine-rich repeat protein p

159 The pleckstrin homology domain leucine-rich repeat protein p

160 Here we show that the pleckstrin homology domain leucine-rich repeat protein p

161 s, promotes dephosphorylation of Akt through pleckstrin homology domain leucine-rich repeats protein

162 examined the phospholipid binding profile of pleckstrin homology domain localizing mutations.

163 tol 4,5-bisphosphate [PtdIns(4,5)P(2)] via a pleckstrin homology domain located in the myo1c tail, wh

164 t on a conserved FYVE domain, its C-terminal pleckstrin homology domain mediates recruitment to membr

165 All mutations increased kinase activity, and pleckstrin homology domain mutants exhibited enhanced ph

166 Our results show that FAK binds the pleckstrin homology domain of AGAP2, and the binding is

167 ompetitor nor substrate mimetic, it binds to pleckstrin homology domain of Akt and blocks Akt membran

168 nase domain interacted specifically with the pleckstrin homology domain of BchC1.

169 In vitro, the pleckstrin homology domain of Cb binds phosphoinositides

170 inding in its active, GTP-bound state to the pleckstrin homology domain of Cb.

171 fuse B-cell lymphoma homology domain and the pleckstrin homology domain of Cb.

172 cteristics, are comparable with those of the pleckstrin homology domain of cytohesin-3 (general recep

173 The pleckstrin homology domain of dynamin is essential for t

174 tidylinositol 4,5-bisphosphate, binds to the pleckstrin homology domain of GEP100.

175 K-SYK) oncogene consists of the Tec homology-pleckstrin homology domain of ITK and the kinase domain

176 we identify a stable interaction between the pleckstrin homology domain of Kal7 and the juxtamembrane

177 Moreover, deletion of the pleckstrin homology domain of kindlin-1 also failed to r

178 This interaction involves the pleckstrin homology domain of kindlin-3 and blades 5-7 o

179 t, and mutational analysis revealed that the pleckstrin homology domain of P-Rex1 is required.

180 Herein, we show that the pleckstrin homology domain of p63RhoGEF is not involved

181 2-O-Bn-InsP5 interacts specifically with the pleckstrin homology domain of PDK1 and impairs formation

182 The pleckstrin homology domain of PdkA is sufficient to loca

183 5)P(2) at a slower rate (2.0 s(-1)) than the pleckstrin homology domain of phospholipase C-delta (13

184 eins/domains, such as the PI(4,5)P2-specific pleckstrin homology domain of phospholipase Cdelta1 (PHP

185 In contrast to the pleckstrin homology domain of PLCdelta1 it does not have

186 ation in living cells and compared it to the pleckstrin homology domain of PLCdelta1.

187 that generate the specific PI ligand for the pleckstrin homology domain of SFC/VAN3, phosphatidylinos

188 A single point mutation in the pleckstrin homology domain of SKAP55 (R131M) blocks the

189 t of ADAP to LFA-1 integrin complexes by the pleckstrin homology domain of SKAP55, and this recruitme

190 the E17K-transforming point mutation in the pleckstrin homology domain of the Akt1 oncoprotein.

191 5)P3)-mediated membrane translocation of the pleckstrin homology domain of the kinase Akt and thus au

192 -anchoring patches when it was attached to a pleckstrin homology domain or a CAAX motif.

193 ment in Golgi PI-4P that was detected with a pleckstrin homology domain probe.

194 acterized the lipid-binding specificity of a pleckstrin homology domain protein.

195 formationally "opens" CB2SH3+ and allows the pleckstrin homology domain to properly bind lipids depen

196 hemoattractant-elicited translocation of the pleckstrin homology domain to the membrane and substanti

197 er than the interaction of the adhesion of a pleckstrin homology domain with phosphatidylinositol 4,5

198 Itk has an N-terminal pleckstrin homology domain, a Tec Homology domain with a

199 e signaling domains, a GTPase-like domain, a pleckstrin homology domain, and an ArfGAP domain, and ex

200 tructurally similar to PLCdelta1, it lacks a pleckstrin homology domain, and it remains unclear how P

201 es PIP3 binding to basic residues in the Akt pleckstrin homology domain, aPKCs lack this domain.

202 e exchange factor (rhoGEF) domain and tandem pleckstrin homology domain, consistent with a role in rh

203 IQGAP1 C-terminal domain and the cytohesin-3 pleckstrin homology domain, each tagged with enhanced gr

204 do not require Net1A catalytic activity, its pleckstrin homology domain, or its regulatory C terminus

205 s recruitment of Itk to the membrane via its pleckstrin homology domain, phosphorylation of Itk by th

206 requires recruitment to the membrane via its pleckstrin homology domain, phosphorylation of Itk by th

207 5 effector APPL1 (adaptor protein containing pleckstrin homology domain, phosphotyrosine binding doma

208 tivating protein (ARF GAP) with a PI-binding pleckstrin homology domain, result in discontinuous vein

209 and is inhibited by SifA binding to the SKIP pleckstrin homology domain, suggesting that SifA may be

210 Along with an N-terminal pleckstrin homology domain, the central domain affects n

211 Fragments of CynA lacking the pleckstrin homology domain, which are normally found in

212 We show that SKIP's pleckstrin homology domain, which directly binds SifA, a

213 pholipids due to a lack of the lipid-binding pleckstrin homology domain, which is used for lipid-medi

214 hat PfCDPK7 interacts with PI(4,5)P2 via its pleckstrin homology domain, which may guide its subcellu

215 PHLDB1 contains a pleckstrin homology domain, which we show binds phosphat

216 These two lipid messengers bind to pleckstrin homology domain-containing effectors that reg

217 anoparticles (LNPs) encapsulating osteogenic pleckstrin homology domain-containing family O member 1

218 TEN in macrophage leads to activation of the pleckstrin homology domain-containing guanine-nucleotide

219 elective phosphoinositide sequestration with pleckstrin homology domain-containing phospholipase Cdel

220 Here, we identify a pleckstrin homology domain-containing protein (PHLDB3)-e

221 the ArfGAP with coiled-coil, Ank repeat, and pleckstrin homology domain-containing protein ACAP2 as a

222 We show that Pleckstrin homology domain-containing protein family mem

223 This pool of PI-4P specifically recruits pleckstrin homology domain-containing proteins involved

224 PIP3 recruits pleckstrin homology domain-containing proteins to the me

225 Here we assessed the prognostic impact of pleckstrin homology domain-interacting protein (PHIP) co

226 Here, we show that the activation of Pleckstrin homology domain-interacting protein (PHIP), p

227 formation by eps8 siRNA or overexpression of pleckstrin homology domain-truncated Eps8 (i.e. 261-p97(

228 EF contains a Dbl homology (DH) domain and a pleckstrin homology domain.

229 4.1-ezrin-radixin-moesin (FERM) domain and a pleckstrin homology domain.

230 sine 373 in the N-terminal part of Kindlin-3 pleckstrin homology domain.

231 minal tail region, which contains a putative pleckstrin homology domain.

232 tide repeat (TPR) region capped by a cryptic pleckstrin homology domain.

233 ed region in the upper lobe that resembles a pleckstrin homology domain.

234 interact with the DH domain but not with the pleckstrin homology domain.

235 on encompassing the N-terminal to C-terminal pleckstrin homology domains (PHn-PHc), are auto-inhibite

236 ones and reports that Pob3 and Rtt106 double pleckstrin homology domains bind histones H3-H4, we also

237 e we have measured the diffusive behavior of pleckstrin homology domains bound to phosphoinositide ph

238 engineered proteins containing one to three pleckstrin homology domains coupled by flexible linkers.

239 by fusion with tandem phospholipase C-delta1 pleckstrin homology domains or by co-expression with wil

240 pically possess tandem Dbl homology (DH) and pleckstrin homology domains that act in concert to catal

241 ition to the canonical Dbl homology (DH) and pleckstrin homology domains that carry out the guanine n

242 ide regulating TRPV1, we applied recombinant pleckstrin homology domains to inside-out excised patche

243 Using GFP-tagged pleckstrin homology domains to monitor PtdIns(3,4,5)P(3)

244 a membrane (PM) via the interaction of their pleckstrin homology domains with phosphatidylinositol 4-

245 ell membrane through interactions with their pleckstrin homology domains, allowing PDK1 to activate A

246 verlays with phospholipid binding in related pleckstrin homology domains, however, suggests that ISPs

247 ing regions, which lie between the motor and pleckstrin homology domains, reduced the instantaneous v

248 d a complex with p115 RhoGEF involving their pleckstrin homology domains.

249 of the characteristics of those observed in pleckstrin homology domains.

250 ral analysis revealed that both ISPs adopt a pleckstrin homology fold often associated with phospholi

251 surface properties that are present in other pleckstrin homology fold-based interaction modules.

252 Consistent with our finding that the double pleckstrin homology structure is common to these three h

253 f SHARPIN, which adopts the highly conserved pleckstrin homology superfold that is often used as a sc

254 e GST is glutathione S-transferase and PH is pleckstrin homology) and in vivo.

255 ture, but instead requires a neighboring PH (Pleckstrin Homology) domain to achieve these functions.

256 n1A/B bind directly to ROCK2 through its PH (Pleckstrin Homology) domain.

257 taining the GEF (Sec7) and membrane-binding (pleckstrin homology) domains, revealing that it has a co

258 ic fluorescent reporter, PH-GFP (where PH is pleckstrin homology), detected an Ag-dependent enrichmen

259 lponin homology (CH) domain with the Acidic, pleckstrin homology, and DH domains.

260 ncover necessary contributions of the CDC25, Pleckstrin homology, and Ras-associating domains, but no

261 of functional domains, including N-terminal pleckstrin homology, coiled-coil, and calmodulin-binding

262 s best known for containing the 2 prototypic Pleckstrin homology, or PH, domains.

263 These behaviors require a pleckstrin homology-domain membrane tether and a WD40 cl

264 -mediated regulation required the N-terminal pleckstrin homology-GRAM domain and Cys413 within the ph

265 pollen tubes, SEC3a displayed amino-terminal Pleckstrin homology-like domain (SEC3a-N)-dependent suba

266 We report here the identification of pleckstrin homology-like domain family B member 1 (PHLDB

267 Pleckstrin Homology-Like Domain, Family A, member 1 (PHL

268 nd by mRNA expression of the p53 target gene pleckstrin homology-like domain, family A, member 3 ( PH

269 binding within a region predicted to adopt a pleckstrin homology-like fold in the N terminus of RME-8

270 Here, we report an important role for the pleckstrin homology-related domain family member, T-cell

271 independently of acetylation while a double pleckstrin-homology (PH) domain binds the K56-containing

272 Although the pleckstrin-homology (PH) domain is known to mediate phos

273 Introduction of the exogenous isolated pleckstrin-homology (PH) domain of p63RhoGEF (residues 3

274 hrin-coated vesicles and contains a putative pleckstrin-homology (PH) domain that has been shown to p

275 , including a Ras-associating (RA) domain, a pleckstrin-homology (PH) domain, a family-specific BPS (

276 Dok7 comprises a pleckstrin-homology (PH) domain, a phosphotyrosine-bindi

277 el role for the adaptor protein containing a pleckstrin-homology (PH) domain, phosphotyrosine-binding

278 Additionally, we identify an acylated pleckstrin-homology (PH) domain-containing protein (APH)

279 a key signaling molecule, acts by recruiting pleckstrin-homology (PH) domain-containing proteins to c

280 (DH) domain followed almost invariantly by a pleckstrin-homology (PH) domain.

281 rvations, we study the Dbl-homology (DH) and Pleckstrin-homology (PH) domains of Bcr-Abl p210, which

282 ignaling-like (RGSL), Dbl-homology (DH), and pleckstrin-homology (PH) domains.

283 sphatidylinositol-4,5-bisphosphate using the pleckstrin-homology domain (PHD) and engage in rapid mem

284 ) exchanger regulatory factor 1 (NHERF1) and pleckstrin-homology domain leucine-rich repeat protein p

285 We show that adaptor protein containing a pleckstrin-homology domain, a phosphotyrosine-binding do

286 T) in TGEF2 impaired inhibition by the TGEF2 pleckstrin-homology domain, resulting in dramatically in

287 radixin, moesin (FERM) domain bisected by a pleckstrin-homology domain.

288 hate (PIP(3)) through interaction with their pleckstrin-homology domains.

289 ted the phosphorylation and translocation of pleckstrin in response to the activation of receptor for

290 activation of PKC through RAGE binding, and pleckstrin is a critical molecule for proinflammatory cy

291 The results suggest that pleckstrin is involved in RAGE signaling and advanced gl

292 s study demonstrates that phosphorylation of pleckstrin is up-regulated in diabetic mononuclear phago

293 l characterization of Sac2 revealed a unique pleckstrin-like homology Sac2 domain conserved in all Sa

294 (Ubl) domain of parkin binds directly to the pleckstrin-like receptor for ubiquitin (Pru) domain with

295 hRpn13 contains an N-terminal pleckstrin-like receptor for ubiquitin domain that binds

296 which, like ubiquitin, binds the N-terminal pleckstrin-like receptor of ubiquitin (PRU) domain of RP

297 Pleckstrin-null platelets aggregate normally in response

298 Although pleckstrin-null platelets merged their granules in respo

299 These data show that pleckstrin regulates the fusion of granules to the cell

300 Pleckstrin, the platelet and leukocyte C kinase substrat