ライフサイエンスコーパス: pleiotropic

1 strain to CaCO3 was suggested significantly pleiotropic.

2 s, that is, that the genetic architecture is pleiotropic.

3 ses to genes that have been determined to be pleiotropic across cancer types, genes affected by expre

4 y modulate the size of one organ despite the pleiotropic action of most known growth regulators.

5 review we summarize how platelets drive such pleiotropic actions and attempt to reconcile the paradox

6 sialic acids may be a general mechanism for pleiotropic actions of soluble klotho.

7 that provides a fascinating glimpse into the pleiotropic activities of a ubiquitously expressed multi

8 criptional activator/repressor with presumed pleiotropic activities.

9 rosis, identifying a novel function for this pleiotropic adipokine in regulation of tissue remodeling

10 easing plasma levels of adiponectin (APN), a pleiotropic adipokine, provides therapeutic benefit to p

11 Some of the parental mutations were pleiotropic, affecting multiple morphogenetic reactions.

12 ative to young ages or when selection favors pleiotropic alleles with beneficial effects early in lif

13 A key issue for high dimensional pleiotropic analysis is to effectively extract informati

14 ods and computational algorithms for genetic pleiotropic analysis, we proposed a new statistic method

15 he protein kinase casein kinase 2 (CK2) is a pleiotropic and constitutively active kinase that plays

16 acid, a hormone-like compound, which exerts pleiotropic and dominant effects on gastrointestinal imm

17 We suggest that a gene as pleiotropic and highly regulated as MET, together with i

18 p53 tumor suppressor pathway, which induces pleiotropic and often antagonistic cellular responses, w

19 single-nucleotide polymorphisms (SNPs) have pleiotropic and opposite effects on glycemic traits.

20 However, DELLA mutants are pleiotropic and the developmental basis for their effect

21 appeared highly specific, the possibility of pleiotropic associations cannot be entirely excluded.

22 To account for potential pleiotropic associations of certain SNPs with risk facto

23 No pleiotropic associations were identified.

24 , genes, or biological pathways; to test for pleiotropic associations with other psychiatric traits;

25 related to serum calcium levels and without pleiotropic associations with potential confounders were

26 Eight established non-HLA risk loci showed pleiotropic associations.

27 rowth factors and cytokines are functionally pleiotropic because their receptors are expressed on div

28 To date, no individual drug with pleiotropic beneficial effects is available for CF.

29 d promotes genomic instability, but how this pleiotropic biomarker is regulated at the protein level

30 potential of miRNAs is underscored by their pleiotropic capacities, putatively targeting multiple pa

31 , in which we demonstrated highly penetrant, pleiotropic cardiac anomalies.

32 Macrophages are pleiotropic cells capable of performing a broad spectrum

33 , we focused on TGFbeta because of its known pleiotropic cellular effects.

34 ltitude of signaling pathways resulting in a pleiotropic cellular response.

35 sKlotho elicits pleiotropic cellular responses with a poorly understood

36 s, causing human mitochondrial diseases with pleiotropic clinical manifestations.

37 Defects in cilia centrosomal genes cause pleiotropic clinical phenotypes, collectively called cil

38 by noncircadian mechanisms; clock genes have pleiotropic, clock-independent functions; and brain lesi

39 ere, we applied a recently developed genetic pleiotropic conditional false discovery rate (cFDR) appr

40 The primary outcome was the pleiotropic (conjunction) false discovery rate P value.

41 Initial genotype also affects the pleiotropic consequences of adaptation for fitness in a

42 vercome enhancer robustness and may minimize pleiotropic consequences of enhancer evolution.

43 poprotein metabolism and we assess potential pleiotropic consequences of genetically elevated lipopro

44 r across life stages, potentially mitigating pleiotropic constraints and enabling independent environ

45 ing to a failure of selection, due to either pleiotropic constraints or declining strength of selecti

46 rasting effects on antagonistic coevolution: Pleiotropic constraints stabilize the dynamics of arms r

47 d, if traits involved in IRSC are subject to pleiotropic constraints.

48 IL-10 is a pleiotropic cytokine expressed during malaria, a disease

49 nown to affect AD development, including the pleiotropic cytokine IL-4.

50 oduce various soluble factors, including the pleiotropic cytokine IL-6, regulating cellular processes

51 The pleiotropic cytokine interleukin 2 (IL2) disrupts the bl

52 IL-9 is a pleiotropic cytokine involved in various (patho)physiolo

53 This chaperone is identified as the pleiotropic cytokine macrophage migration inhibitory fac

54 IL-10 is a key pleiotropic cytokine that can both promote and curb Th2-

55 Interferon-gamma (IFN-gamma) is a pleiotropic cytokine that exerts anti-tumor and anti-ost

56 phage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been implicated in a broad

57 Interleukin-15 is a pleiotropic cytokine that is critical for the developmen

58 resulting in increased production of IL-6, a pleiotropic cytokine that is implicated in inflammatory

59 Osteopontin is a pleiotropic cytokine that is involved in several disease

60 phage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engag

61 hage colony-stimulating factor (GM-CSF) is a pleiotropic cytokine that plays a critical role in regul

62 IL-2 is a pleiotropic cytokine that promotes the differentiation o

63 GM-CSF is a pleiotropic cytokine that promotes the differentiation,

64 IL-6 is a pleiotropic cytokine with a wide range of biologic effec

65 ogical function of interleukin-10 (IL-10), a pleiotropic cytokine with an essential role in inflammat

66 IL6 is a pleiotropic cytokine with both pro- and anti-inflammator

67 IL-6 is a pleiotropic cytokine with complex roles in inflammation

68 Interleukin (IL)-15 is a pleiotropic cytokine, which is structurally close to IL-

69 lating factor) and IL-2 (interleukin-2), two pleiotropic cytokines of the mammalian immune system.

70 Type I IFNs are pleiotropic cytokines that are instrumental in combating

71 Type I interferons (IFNs) are pleiotropic cytokines well recognized for their role in

72 th factor-beta (TGF-beta) family ligands are pleiotropic cytokines.

73 iR160-resistant version of OsARF18 exhibited pleiotropic defects in growth and development, including

74 lar function, as loss of GapR causes severe, pleiotropic defects in growth, cell division, DNA replic

75 tectable phenotypes, deletion of TRX2 caused pleiotropic defects in growth, conidiation, light sensin

76 deficiency is a new mendelian disorder with pleiotropic defects of hematopoietic and nonhematopoieti

77 udies confirm FLI1 heterozygosity results in pleiotropic defects similar to those noted with other cr

78 PR/Cas9 elimination of SlBOP function causes pleiotropic defects, most notably simplification of infl

79 stem function and suggests how dissection of pleiotropic DELLA functions could unlock further yield g

80 A hypomorphic dsp1-1 mutation causes pleiotropic developmental defects, impairs the 3' end pr

81 us types of DNA lesions (DNA-Pt) and trigger pleiotropic DNA damage responses.

82 ant ATP-binding cassette transporter family, pleiotropic drug resistance (PDR) transporters play esse

83 The Gal11/Med15 KIX domain engages pleiotropic drug resistance transcription factor (Pdr1)

84 lar and genetic interactions leading to this pleiotropic effect have not yet been fully explored.

85 The basis of pleiotropic effect is rather complex, attributable to a

86 tion is crucial to understanding the complex pleiotropic effect of cancer genes and provides a possib

87 ormed heterogeneity tests to disentangle the pleiotropic effect of IVs.

88 The pleiotropic effect of Usp9X during Ag-receptor signaling

89 The locus also has a pleiotropic effect on grain width (1.5%) during late gra

90 nnel/pump/connexin transcripts, indicating a pleiotropic effect on the electrical phenotype of myofib

91 The genetic markers did not show evidence of pleiotropic effects and accounting for tobacco exposure

92 ed due to several limitations, including its pleiotropic effects and short half-life.

93 nts for the dominant gene action and diverse pleiotropic effects associated with the Li1 mutation.

94 Vitamin D has various cardiovascular pleiotropic effects by activating its nuclear receptor i

95 However, pleiotropic effects can complicate analyses.

96 ch reduced RCO protein stability, preventing pleiotropic effects caused by its altered gene expressio

97 ject of intense investigation because of its pleiotropic effects controlling a broad spectrum of cell

98 However, toxicities associated with their pleiotropic effects could contribute to the ineffectiven

99 Matricellular proteins mediate pleiotropic effects during tissue injury and repair.

100 Our results identified pleiotropic effects for an IRD-causing variant and provi

101 Among these loci, only four exhibited pleiotropic effects for PC and WSPC, explaining the low

102 sperm nutritional quality but cause negative pleiotropic effects for reasons that are not fully under

103 have been identified to alter cell size, but pleiotropic effects have largely hampered our ability to

104 attracted enormous attention owing to their pleiotropic effects in early host defense to infection a

105 We identify variants with pleiotropic effects in eight loci, including seven estab

106 e has an important role in kidney injury and pleiotropic effects in fibrosis.

107 Critically, pleiotropic effects in the mutated library are most like

108 ar composition and that its absence produces pleiotropic effects in this component of the plant extra

109 To discover putative effectors for the pleiotropic effects of AEE788, proteome-wide changes in

110 h blood CO levels but likely result from the pleiotropic effects of CO on cellular mitochondrial resp

111 Given a broad spectrum of pleiotropic effects of coxibs, our intention was to narr

112 Investigating the pleiotropic effects of genetic variants can increase sta

113 ling are well characterized in many tissues, pleiotropic effects of GPCR agonists limit investigation

114 stemic evaluation of GWAS data supported the pleiotropic effects of RGS1 and RASGRP1 variants in medi

115 We assessed whether the pleiotropic effects of statins can reduce delirium in in

116 The pleiotropic effects of statins, such as immunomodulation

117 We propose that pleiotropic effects of the HPT axis may favour longevity

118 analysis to demonstrate genetic factors with pleiotropic effects on bone mineral density and lean mas

119 Atorvastatin (ATV) has shown pleiotropic effects on bone tissue, and osteoporosis can

120 nalysis could mean that there are genes with pleiotropic effects on both traits, or that separate gen

121 sity in children, and show genetic loci with pleiotropic effects on both traits.

122 th factor 21 (FGF21), a peptide hormone with pleiotropic effects on carbohydrate and lipid metabolism

123 summary, there are genomic regions exerting pleiotropic effects on cardiovascular disease risk facto

124 s well as 16 undefined associated loci, have pleiotropic effects on different traits.

125 t directly on the traits, or indirectly from pleiotropic effects on fitness.

126 ion of transformed progenitors, but also has pleiotropic effects on hematopoiesis.

127 serum total bile acid concentrations and had pleiotropic effects on liver mass, serum cholesterol, an

128 id receptors (GRs), this steroid hormone has pleiotropic effects on many cell types.

129 Although C1QBP has been reported to exert pleiotropic effects on many cellular processes, we repor

130 luding caloric restriction impose beneficial pleiotropic effects on metabolism.

131 hift in the gut microbiome could explain its pleiotropic effects on multiple complex diseases includi

132 Nitric oxide (NO) exerts pleiotropic effects on plant development; however, its i

133 ame genetic region-either a single gene with pleiotropic effects or linked genes-influences distinct

134 y produced 1,25-dihydroxyvitamin D3 may have pleiotropic effects outside of bone.

135 In addition to lipid lowering, statins have pleiotropic effects that improve endothelial function, a

136 at protein interacts, were used to elucidate pleiotropic effects that may alter the flux of intermedi

137 with eGFR in the UCLEB sample, but has known pleiotropic effects that prevent us from drawing a causa

138 ivergence, suggesting that the nature of the pleiotropic effects was adaptive.

139 ies for drug targets can inform indications, pleiotropic effects, and pharmacological mechanisms.

140 Their inhibition is predicted to have pleiotropic effects, but it is unclear whether this will

141 the control of local translation, which has pleiotropic effects, in particular on synaptic function.

142 in a model species Nicotiana benthamiana had pleiotropic effects, including but not limited to severe

143 miR-24 tightly controls VWF levels through pleiotropic effects, including direct binding to the 3'

144 ophosphate (cAMP) is a second messenger with pleiotropic effects, including regulating neuroinflammat

145 ata indicate that PIM kinases in cHL exhibit pleiotropic effects, orchestrating tumor immune escape a

146 r Kal in autoantibody-induced arthritis with pleiotropic effects, which suggests that it is a new tar

147 pires to promote aggressive behavior through pleiotropic effects.

148 dependent of LDL-cholesterol lowering called pleiotropic effects.

149 new possibilities, including the analysis of pleiotropic effects.

150 locus discovery and providing suggestions of pleiotropic effects.

151 network suggesting complex interactions and pleiotropic effects.

152 phenotypes are heritable with no measurable pleiotropic effects.

153 hted median approach provided no evidence of pleiotropic effects.

154 s of different effectors as well as by their pleiotropic effects.

155 mm CuSO4, a condition that did not generate pleiotropic effects.

156 iate methods to discover novel, reproducible pleiotropic effects.Multivariate analysis methods can un

157 Bone has recently emerged as a pleiotropic endocrine organ that secretes at least two h

158 ntiaging membrane protein alpha-klotho, is a pleiotropic endocrine/paracrine factor with no known rec

159 analysis framework, we observed significant pleiotropic enrichment between obesity and T2D.

160 used to visually demonstrate the strength of pleiotropic enrichment.

161 3) catalyzes the oxidation of retinal to the pleiotropic factor retinoic acid using NAD(+).

162 Thyroid hormone is a pleiotropic factor that controls many cellular processes

163 hydrocarbon receptor (AHR) is emerging as a pleiotropic factor, modulating pathways beyond its estab

164 lution compared to standard single trait and pleiotropic fine mapping strategies.

165 els represent osmo-mechano-TRP channels with pleiotropic function and wide-spread expression.

166 idely expressed during development and has a pleiotropic function, whether Egr3 functions primarily i

167 ch as cell envelope modifications, suggest a pleiotropic functionality of the Mce systems that are pa

168 NEK1 shows pleiotropic functions and has been found to be mutated i

169 GRCD genes show both specialized and pleiotropic functions contributing to organ differentiat

170 These data identify pleiotropic functions for RIPK3 in the restriction of vi

171 t6A and its derivatives have pleiotropic functions in protein synthesis including ami

172 se A (BVR) and Akt isozymes have overlapping pleiotropic functions in the insulin/PI3K/MAPK pathway.

173 These pleiotropic functions mainly rely on NGAL's siderophore-

174 or specification process, and illustrate the pleiotropic functions of Forkhead TFs in different aspec

175 Thus, pleiotropic functions of TWIST control vascular disease

176 (IFN)-inducible gene encoding a protein with pleiotropic functions, acting both as a soluble molecule

177 ranscription Factor 4 (TCF4) is a clinically pleiotropic gene associated with schizophrenia and Pitt-

178 nding, suggesting the presence of additional pleiotropic genes associated with both ALS and neuropsyc

179 e how tissue-specific regulatory elements in pleiotropic genes contribute to organ-specific evolution

180 on test may facilitate identification of the pleiotropic genes contributing to the risk for alcohol d

181 Last, pleiotropic genes have a DFE that is less variable than

182 nally interacting networks, we found that 43 pleiotropic genes were interacting in a network with an

183 oposes a multivariate method for identifying pleiotropic genes while adjusting for cryptic relatednes

184 servation is that positional displacement of pleiotropic genes will affect the genetic regulation and

185 es, mapped core bioprocesses, and identified pleiotropic genes, whereas positive interactions often m

186 is association was not because of measurable pleiotropic genetic effects, which suggests that environ

187 We explore the potential for pleiotropic genetic variants to generate bias, revise ex

188 TGF-beta is a pleiotropic growth factor with dual (protective and detr

189 production of lysophosphatidic acid (LPA), a pleiotropic growth-factor-like lysophospholipid.

190 The well-known pleiotropic health benefits of green tea are mainly attr

191 manipulating part of the JA regulon to avoid pleiotropic host responses while promoting pathogen prol

192 A bivariate mapping model identified 11 pleiotropic hQTLs that determine the covariation of shoo

193 Ciliopathies are pleiotropic human diseases resulting from defects of the

194 tions in the genomic locus for MRP RNA cause pleiotropic human diseases, including cartilage hair hyp

195 conserved among eumetazoans yet flexible and pleiotropic in its effects.

196 lationship between the foraging gene and its pleiotropic influence on these feeding-related traits.

197 Disclosure of pleiotropic information did not increase anxiety or depr

198 out disclosing secondary findings, including pleiotropic information.

199 03146) was identified as a complex effect or pleiotropic instrument, and removal of this variant resu

200 Ibrutinib, a pleiotropic kinase inhibitor that targets BTK, is highly

201 Galectin-3 (Gal3), a pleiotropic lectin, is produced by monocytic cells and m

202 chromosome 12pter, a region that also showed pleiotropic linkage to two additional activity phenotype

203 c FTD is a polygenic disorder where multiple pleiotropic loci with small effects contribute to increa

204 -of-function ACTB mutations cause a distinct pleiotropic malformation syndrome with intellectual disa

205 ts in PBX1 cause intellectual disability and pleiotropic malformations resembling those in Pbx1 mutan

206 tiple organs leading to BM failure and other pleiotropic manifestations.

207 loys the auxiliary protein HypX (hydrogenase pleiotropic maturation X) for CO ligand formation.

208 cts on the eukaryotic ribosome and implicate pleiotropic mechanisms of action beyond decoding.

209 CD38 antibodies have pleiotropic mechanisms of action including Fc-dependent

210 r findings define an immune component of the pleiotropic mechanisms through which IGFBP7 suppresses H

211 tase, a function that may explain its widely pleiotropic membrane-associated phenotypes across organi

212 dy sheds light onto the role of miR-206 as a pleiotropic modulator of different hallmarks of cancer,

213 Understanding the pleiotropic molecular determinants of neuronal [Cl(-)]i

214 a different perspective on the role of this pleiotropic molecule.

215 sitions, and multivariate analysis shows the pleiotropic morphological effects of modulating the leve

216 Clinically, chronic GVHD is a pleiotropic, multiorgan syndrome involving tissue inflam

217 Ataxia-telangiectasia (AT) is a pleiotropic multisystem disorder caused by mutations in

218 ng a detailed understanding of the nature of pleiotropic mutations and their phenotypic consequences

219 Pleiotropic mutations in drl1 affect leaf length and wid

220 l count-associated variation at another more pleiotropic myeloid enhancer near GATA2, highlighting re

221 This work reveals the pleiotropic nature of the biological functions targeted

222 ch are amplified by the highly polygenic and pleiotropic nature of these genetic contributions.

223 ur-alpha-deficient mice die after birth with pleiotropic neuronal defects.

224 ne system and functions are perhaps the most pleiotropic not only for development but also for the fu

225 ange of phenotypic cancer hallmarks, and the pleiotropic oncogenic functions of GRP78 may result from

226 rowth factor binding protein 2 (IGFBP2) is a pleiotropic oncogenic protein that has both extracellula

227 tent with oligogenic mechanisms resulting in pleiotropic outcomes.

228 Histamine has pleiotropic pathophysiological effects, but its role in

229 onic tissue damage and disability in EAE via pleiotropic pathways, but it is dispensable during early

230 KEY POINTS: Leptin, is a 16 kDa pleiotropic peptide not only primarily secreted by adipo

231 ABSTRACT: Leptin, is a 16 kDa pleiotropic peptide not only primary secreted by adipocy

232 to different retinal symptoms, demonstrating pleiotropic phenotype traits influenced by both underlyi

233 its are of limited value, due to their often pleiotropic phenotypes and the difficulties with disting

234 hality with defective neural development and pleiotropic phenotypes in multiple tissues.

235 in generation and in suppression of diverse pleiotropic phenotypes points to a common underlying mol

236 he mutation was semidominant and resulted in pleiotropic phenotypes with such features as short siliq

237 plants expressing VAP27-GFP fusions exhibit pleiotropic phenotypes, including defects in root hair m

238 atically increased brain O-GlcNAc levels and pleiotropic phenotypes, including early-onset obesity, g

239 to reduced relative m(6) A levels and shared pleiotropic phenotypes, which included aberrant vascular

240 nt developmental processes leading to severe pleiotropic phenotypes.

241 nes, providing a potential mechanism for the pleiotropic phenotypic effects.

242 Hydrogen sulfide (H2S) elicits pleiotropic physiological effects ranging from modulatio

243 pendently of T2D status, indicating possible pleiotropic physiological functions of melatonin, but in

244 tric oxide (NO) is a signaling molecule with pleiotropic physiological roles in normal cells and path

245 However, Jarid2 has also been shown to exert pleiotropic PRC2-independent actions during embryogenesi

246 ts, and provides a surprising link between a pleiotropic pre-mRNA splicing pathway and the precise co

247 trophin is released from COL VI and promotes pleiotropic pro-fibrotic effects.

248 Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory cytokine belonging to the I

249 IL-6 is a pleiotropic proinflammatory cytokine that is elevated in

250 rophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, in this process.

251 Sirt6 has pleiotropic protective actions in podocytes, including a

252 ibbles Pseudokinase 3 gene (TRIB3) encodes a pleiotropic protein increasingly implicated in the regul

253 lly clarified, and it is rather defined as a pleiotropic protein likely acting as a dynamic cell surf

254 LR, encoded by GFER) is a widely distributed pleiotropic protein originally identified as a hepatic g

255 Interferon gamma (IFNgamma) is a pleiotropic protein secreted by immune cells.

256 ansforming growth factor beta (TGFbeta) is a pleiotropic protein secreted from essentially all cell t

257 and outline a conceptual framework for their pleiotropic recognition by single immune receptors.

258 Interestingly, the ss4 mutant displays a pleiotropic reduction in the activity of AMY3.

259 However, unlike the pleiotropic regulator BldD, we show that BldO functions

260 orghum Dwarf3 gene, an auxin transporter and pleiotropic regulator of both leaf inclination angle and

261 ollectively, our data suggest that ScmR is a pleiotropic regulator of secondary metabolism, virulence

262 BldO now joins pleiotropic repressor BldD to exert a multi-layer contro

263 TL, Hi-C and ChIP-seq data, we show that the pleiotropic risk loci are enriched for B-cell regulatory

264 on data, to improve fine-mapping accuracy at pleiotropic risk loci.

265 Next, we show that jointly modeling pleiotropic risk regions improves fine-mapping resolutio

266 est that multimeric KhpA/B may function as a pleiotropic RNA chaperone controlling pneumococcal cell

267 utant lacking all 6 mce operons suggesting a pleiotropic role for this system.

268 a receptor tyrosine kinase, MET, which has a pleiotropic role in embryogenesis and modifies a large n

269 This unveils a molecular rationale for the pleiotropic role of the protein quality control machiner

270 Previous studies have described the pleiotropic role of type I IFNs on innate and adaptive i

271 In contrast, we identified pleiotropic roles for DeltaNp63 in tumor development and

272 Our findings indicate that Sep4 plays pleiotropic roles in B. cinerea development and specific

273 r (BDNF) has drawn much attention due to its pleiotropic roles in the central nervous system and impl

274 Further investigation into pleiotropic roles of genes influencing both sleep and ne

275 ur findings extend the evidence of important pleiotropic roles of IL6 in tumorigenesis and drug resis

276 n is associated with side effects due to its pleiotropic roles.

277 odified nucleotide ppGpp ('magic spot') is a pleiotropic second messenger that mediates the response

278 cAMP is a pleiotropic second messenger with the ability to generat

279 uanosine analogue, (p)ppGpp, which acts as a pleiotropic secondary messenger.

280 CK2 is a highly conserved and pleiotropic serine/threonine kinase that promotes many p

281 limiting resources, and we hypothesize that pleiotropic signaling mechanisms regulate allocation of

282 nd activator of transcription 3 (STAT3) is a pleiotropic signaling mediator of many cytokines, includ

283 Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with its f

284 understanding, the molecular integration of pleiotropic signals coming from this complex and dynamic

285 After removing potentially pleiotropic single nucleotide polymorphisms (SNPs) possi

286 Pleiotropic SNPs at the HLA and MAPT loci associated wit

287 or prevent premature or ectopic activity of pleiotropic, soluble cytokines such as IL-4 or IL-13.

288 oss of primary cilia causes a group of human pleiotropic syndromes called Ciliopathies.

289 Interleukin (IL)-13 is a pleiotropic T helper type 2 cytokine frequently associat

290 t persists in the environment and produces a pleiotropic toxicity syndrome across vertebrate species

291 cal for canonical activation of NF-kappaB, a pleiotropic transcription factor controlling immunity, d

292 d that signaling involving MYC-an essential, pleiotropic transcription factor that regulates the expr

293 MYC is a highly pleiotropic transcription factor whose deregulation prom

294 MYC is a well-known highly pleiotropic transcription factor; however, the role of M

295 Steroid receptors are pleiotropic transcription factors that coordinate adapta

296 nse regulator of this signaling system, is a pleiotropic transcription regulator, which is involved i

297 molytic S. aureus phenotype, controlled by a pleiotropic transcriptional regulator/noncoding RNA viru

298 Promyelocytic leukemia (PML) is a pleiotropic tumor suppressor, but its role in tumor micr

299 nctions through independent model, where the pleiotropic variants directly affect lung function, not

300 ly occurring peptide hormone relaxin-2, is a pleiotropic vasodilating hormone that has been studied i