ライフサイエンスコーパス: pleiotropic effect

1 e anticoagulant tolerance in M. spretus as a pleiotropic effect.

2 er a balancing selection due to antagonistic pleiotropic effect.

3 bipolar disorder, suggesting that they have pleiotropic effects.

4 by the vast array of neuropeptides and their pleiotropic effects.

5 SCZ although with incomplete penetrance and pleiotropic effects.

6 nd thrombosis; however, it also has multiple pleiotropic effects.

7 lation, leading to the potential of cellular pleiotropic effects.

8 pes in case-control studies and in detecting pleiotropic effects.

9 ircadian clock is independent from the other pleiotropic effects.

10 an important anti-inflammatory cytokine with pleiotropic effects.

11 ost-translationally, may explain many of the pleiotropic effects.

12 mm CuSO4, a condition that did not generate pleiotropic effects.

13 the discovery of loci with small but common pleiotropic effects.

14 a universal calcium-sensing protein that has pleiotropic effects.

15 y; 233 (16.9%) genes and 77 (4.6%) SNPs show pleiotropic effects.

16 y dependent on SPI1, but FliZ has additional pleiotropic effects.

17 pires to promote aggressive behavior through pleiotropic effects.

18 actors may face the challenge of undesirable pleiotropic effects.

19 llenge to reconcile how it orchestrates such pleiotropic effects.

20 dependent of LDL-cholesterol lowering called pleiotropic effects.

21 studies showing the T1128C polymorphism has pleiotropic effects.

22 new possibilities, including the analysis of pleiotropic effects.

23 locus discovery and providing suggestions of pleiotropic effects.

24 network suggesting complex interactions and pleiotropic effects.

25 phenotypes are heritable with no measurable pleiotropic effects.

26 hted median approach provided no evidence of pleiotropic effects.

27 s of different effectors as well as by their pleiotropic effects.

28 n D supplementation in inducing bactericidal pleiotropic effects.

29 s well as IL-5, demonstrating that IL-33 has pleiotropic effects.

30 and plasticity overlapped, suggesting major pleiotropic effects.

31 ene fusions, multiple RNA splice variants or pleiotropic effects.

32 unded, derived from their lipid lowering and pleiotropic effects.

33 sessment of potential simvastatin-associated pleiotropic effects.

34 e are eQTL with univariate and multivariate (pleiotropic) effects.

35 y tests whether common genetic variants with pleiotropic effects account for some of the correlated a

36 ies, including variants in NPAS3 that showed pleiotropic effects across schizophrenia, bipolar disord

37 A new study examines the question of pleiotropic effects acting on both electro-encephalograp

38 tive oxygen species production, and causes a pleiotropic effect affecting several biological processe

39 The genetic markers did not show evidence of pleiotropic effects and accounting for tobacco exposure

40 o one founder, we could validate examples of pleiotropic effects and complex allelic series at a locu

41 However, pleiotropic effects and poor bioavailability make exogen

42 ed due to several limitations, including its pleiotropic effects and short half-life.

43 its that protect the ejaculate have positive pleiotropic effects and/or because female counteradaptat

44 bers of traits declared significant, overall pleiotropic effects, and extent of apparent modularity o

45 ies for drug targets can inform indications, pleiotropic effects, and pharmacological mechanisms.

46 S, but the molecular targets mediating these pleiotropic effects are incompletely understood.

47 g levels of lipid mediators, suggesting that pleiotropic effects are not associated with eicosanoid p

48 e mechanisms by which estrogen confers these pleiotropic effects are undergoing active investigation.

49 chanisms by which mutant GFAP leads to these pleiotropic effects are unknown.

50 or blocker, has recently been shown to exert pleiotropic effects as a partial agonist of nuclear pero

51 It is thought that PP-IPs exert their pleiotropic effects as allosteric regulators and through

52 nts for the dominant gene action and diverse pleiotropic effects associated with the Li1 mutation.

53 gour in the production of the signal, and of pleiotropic effects between colour and defences.

54 Their inhibition is predicted to have pleiotropic effects, but it is unclear whether this will

55 Vitamin D has various cardiovascular pleiotropic effects by activating its nuclear receptor i

56 own lipid-lowering capacities, statins exert pleiotropic effects by direct inhibition of the mevalona

57 te for TF evolution that alleviates negative pleiotropic effects by modularly gaining new binding sit

58 However, pleiotropic effects can complicate analyses.

59 ch reduced RCO protein stability, preventing pleiotropic effects caused by its altered gene expressio

60 To eliminate pleiotropic effects caused by o2, the 22-kDa alpha-zein,

61 es of intramolecular regulation have limited pleiotropic effects compared with changes to interaction

62 ject of intense investigation because of its pleiotropic effects controlling a broad spectrum of cell

63 However, toxicities associated with their pleiotropic effects could contribute to the ineffectiven

64 ppaB activity blocks heart regeneration with pleiotropic effects, decreasing both cardiomyocyte proli

65 A systematic evaluation of pleiotropic effects demonstrated a high tendency for lep

66 nia; however, it is unknown if this reflects pleiotropic effects, direct causality or some shared thi

67 Deletion of qseC leads to pleiotropic effects due to unregulated activation of the

68 This pattern is consistent with SirT1 having pleiotropic effects during cancer development (anti-prol

69 Epidermal growth factor (EGF) exerts pleiotropic effects during oncogenesis, including the st

70 Matricellular proteins mediate pleiotropic effects during tissue injury and repair.

71 92 components as the molecular basis for its pleiotropic effects during tumorigenesis.

72 Given the pleiotropic effects exerted by estrogens, other response

73 view, we discuss how KAP1 might execute such pleiotropic effects, focusing on genomic targeting mecha

74 Explaining the lack of more pleiotropic effects following a global block of SUMO con

75 Our results identified pleiotropic effects for an IRD-causing variant and provi

76 Among these loci, only four exhibited pleiotropic effects for PC and WSPC, explaining the low

77 sperm nutritional quality but cause negative pleiotropic effects for reasons that are not fully under

78 s vitamin D receptors and that vitamin D has pleiotropic effects has prompted an increased interest i

79 lar and genetic interactions leading to this pleiotropic effect have not yet been fully explored.

80 have been identified to alter cell size, but pleiotropic effects have largely hampered our ability to

81 renia (SCZ) and autism and often demonstrate pleiotropic effects; however, their frequencies in the g

82 seC, the constitutively active QseB leads to pleiotropic effects, impairing bacterial metabolism, and

83 SGCE mutations are likely to have a pleiotropic effect in causing both motor and specific ps

84 Here we report that this mutation induces pleiotropic effects in Coro1A protein, including the exa

85 TGF-beta1 has pleiotropic effects in different disease models and gene

86 sphatase of regenerating liver-3 (PRL-3) has pleiotropic effects in driving cancer progression, yet t

87 attracted enormous attention owing to their pleiotropic effects in early host defense to infection a

88 We identify variants with pleiotropic effects in eight loci, including seven estab

89 e has an important role in kidney injury and pleiotropic effects in fibrosis.

90 s bone mineralization and is associated with pleiotropic effects in many cell types, including putati

91 These cumulative defects led to pleiotropic effects in mitochondria such as decreased mt

92 receptor 1 (AdipoR1) mediates adiponectin's pleiotropic effects in muscle and liver and plays an imp

93 investigate multiple outcomes for additional pleiotropic effects in the 8q24 region.

94 IFNgamma) is one such cytokine that produces pleiotropic effects in the brain.

95 r decidual breakdown, evidence that VEGF has pleiotropic effects in the endometrium.

96 itamin A has been shown to have dominant and pleiotropic effects in the intestine.

97 Critically, pleiotropic effects in the mutated library are most like

98 mmunodeficiency virus, type 1 (HIV-1) exerts pleiotropic effects in the viral replication cycle.

99 esting that deletion of qseC confers similar pleiotropic effects in these two different pathogens.

100 ar composition and that its absence produces pleiotropic effects in this component of the plant extra

101 allistatin is a plasma protein that exhibits pleiotropic effects in vasodilation, anti-angiogenesis,

102 L and screened it in vitro for those showing pleiotropic effects in virulence phenotypes (reduced swa

103 the control of local translation, which has pleiotropic effects, in particular on synaptic function.

104 lbene, found in grapes and berries, exhibits pleiotropic effects, including anti-inflammatory, antiox

105 in a model species Nicotiana benthamiana had pleiotropic effects, including but not limited to severe

106 miR-24 tightly controls VWF levels through pleiotropic effects, including direct binding to the 3'

107 In addition, miR-mdh-1 plants exhibit strong pleiotropic effects, including dwarfism, reductions in c

108 7-H1) (CD274) is a cosignaling molecule with pleiotropic effects, including hindering antitumor immun

109 Deletion of BbcreA resulted in pleiotropic effects, including nutrient toxicity, leadin

110 ophosphate (cAMP) is a second messenger with pleiotropic effects, including regulating neuroinflammat

111 poptosis (TWEAK) and its receptor Fn14 exert pleiotropic effects, including regulation of myogenesis.

112 The basis of pleiotropic effect is rather complex, attributable to a

113 How CD30 generates these pleiotropic effects is currently unknown.

114 IL-2, a cytokine with pleiotropic effects, is critical for immune cell activat

115 However, because of their pleiotropic effects, it has been difficult to ascribe a

116 ption of individual factors often results in pleiotropic effects, making it difficult to discern regu

117 These pleiotropic effects may contribute to the effects of DPP

118 astatin is a cholesterol-lowering drug whose pleiotropic effects may have a therapeutic impact on bon

119 Such pleiotropic effects may underlie the corolla dimorphism

120 iate methods to discover novel, reproducible pleiotropic effects.Multivariate analysis methods can un

121 These results, along with the pleiotropic effects observed in nfc101/nfc102 downregula

122 ur results expose a potentially antagonistic pleiotropic effect of AFPs: beneficial freezing avoidanc

123 ic mutant of the ARP2/3 complex suggested no pleiotropic effect of ARPC2 beyond its function in the c

124 tion is crucial to understanding the complex pleiotropic effect of cancer genes and provides a possib

125 In lieu of the pleiotropic effect of CD8alpha(+) DCs in HSV-1 latency,

126 may therefore be due, at least in part, to a pleiotropic effect of high-dose statin therapy.

127 Microarray data analysis showed a pleiotropic effect of htrA on the transcriptome of C. di

128 ormed heterogeneity tests to disentangle the pleiotropic effect of IVs.

129 This pleiotropic effect of sitagliptin may explain the reduct

130 EDH in the MCA, and represents a beneficial pleiotropic effect of statin treatment.

131 sociated complications and tests whether the pleiotropic effect of statins on glycemic control is Rho

132 at CCDC88B is the morbid gene underlying the pleiotropic effect of the 11q13 locus on inflammation.

133 nclusion, the authors have observed a strong pleiotropic effect of the 8q24 region in a large prospec

134 fect on HDL levels, but it could represent a pleiotropic effect of the same functional component.

135 These studies illustrate the pleiotropic effect of TNF in both activation and down-mo

136 The pleiotropic effect of Usp9X during Ag-receptor signaling

137 apped on this chromosome region are likely a pleiotropic effect of VRN-1 rather than the effect of a

138 ial sources for these discrepancies were the pleiotropic effects of a general blockade of specific in

139 To discover putative effectors for the pleiotropic effects of AEE788, proteome-wide changes in

140 ed females are incompatible) and deleterious pleiotropic effects of altering early embryonic developm

141 These data demonstrate the pleiotropic effects of anti-PD-L1 therapy on both virus-

142 The pleiotropic effects of beta-catenin in MM correlate with

143 ature degradation, steady activation, and/or pleiotropic effects of cAMP agonists and antagonists; (i

144 Here, we investigated the pleiotropic effects of chirality alleles on shell shape

145 The pleiotropic effects of cholesterol include alterations i

146 h blood CO levels but likely result from the pleiotropic effects of CO on cellular mitochondrial resp

147 Given a broad spectrum of pleiotropic effects of coxibs, our intention was to narr

148 t on the mode of application, and the potent pleiotropic effects of cytokines like IL-2 may lead to s

149 These findings explain the pleiotropic effects of deletion of YME1 and suggest an i

150 eve significant expression knockdown and the pleiotropic effects of EB1 and APC gene knockdown.

151 alysis (HEFT) that identifies individual and pleiotropic effects of eQTL in the presence of hidden fa

152 Additional analyses identified the pleiotropic effects of eSNPs from the published GWAS cat

153 e uptake, further expanding the profound and pleiotropic effects of FOX transcription factors on adip

154 These studies highlight the pleiotropic effects of genes that determine autoimmune d

155 Investigating the pleiotropic effects of genetic variants can increase sta

156 ling are well characterized in many tissues, pleiotropic effects of GPCR agonists limit investigation

157 The pleiotropic effects of histamine are mediated by four G

158 ry diseases may have arisen, in part, due to pleiotropic effects of host resistance to pathogens over

159 To determine whether pleiotropic effects of hyperactive Shh signaling link th

160 sial, and any effects could be confounded by pleiotropic effects of hypolipidemic treatment.

161 int in the control of both the metabolic and pleiotropic effects of insulin.

162 mation about the patterns of inheritance and pleiotropic effects of loci involved in pigmentation.

163 We also show multiple pleiotropic effects of major Heliconius patterning loci

164 can modulate autoimmune disease without the pleiotropic effects of nonselective reagents and, thus,

165 ependent deacetylase that exerts many of the pleiotropic effects of oxidative metabolism.

166 The molecular mechanism for these pleiotropic effects of PDGFs has not been fully describe

167 The pleiotropic effects of proteasome inhibition include the

168 nd decipher the basis for specificity in the pleiotropic effects of RET, we characterized development

169 inoid receptors is involved in mediating the pleiotropic effects of retinoids.

170 stemic evaluation of GWAS data supported the pleiotropic effects of RGS1 and RASGRP1 variants in medi

171 in restriction and choline deficiency on the pleiotropic effects of rodent ketogenic diets, we studie

172 with SSc, provided further insight into the pleiotropic effects of shared autoimmune risk factors, a

173 understanding of the beneficial and harmful pleiotropic effects of statin therapy.

174 gs may provide a better understanding of the pleiotropic effects of statins as well as molecular mech

175 We assessed whether the pleiotropic effects of statins can reduce delirium in in

176 The pleiotropic effects of statins, 3-hydroxy-3 methylglutar

177 The pleiotropic effects of statins, such as immunomodulation

178 ecreases in plasma LDL cholesterol and other pleiotropic effects of statins.

179 The pleiotropic effects of TGF-beta1 on tendon cells and tis

180 This study reveals the pleiotropic effects of the FGFR2 Y394C mutation evidence

181 evolution, the results illustrate the wider pleiotropic effects of the genes, or haplotypes, that in

182 However, because pleiotropic effects of the genetic variants studied cann

183 We propose that pleiotropic effects of the HPT axis may favour longevity

184 The pleiotropic effects of the mutant gene also include cogn

185 We also detected pleiotropic effects of these adaptations on a wide range

186 ether, these findings support the well-known pleiotropic effects of these CNVs suggesting shared abno

187 ls and even that of their offspring, but the pleiotropic effects of these factors have posed a challe

188 l complexity of tubulinopathies reflects the pleiotropic effects of tubulins and their specific spati

189 discoveries expand our understanding of the pleiotropic effects of type I IFNs during infection and

190 further research is required to explore the 'pleiotropic' effects of nicotinic acid and will ultimate

191 Both BCF and IR suggested a pleiotropic effect on 17q25 (univariate LOD 3.2, P = 0.0

192 ion to metabolism, suggesting that THC had a pleiotropic effect on gene expression in immune cells.

193 The locus also has a pleiotropic effect on grain width (1.5%) during late gra

194 Disruption of the CIN1 gene had a pleiotropic effect on growth, normal cytokinesis, intrac

195 an expression pattern can potentially have a pleiotropic effect on the assembly rate and lysis time,

196 nnel/pump/connexin transcripts, indicating a pleiotropic effect on the electrical phenotype of myofib

197 lecule, such as a hormone, can have dramatic pleiotropic effects on a broad range of diverse developm

198 n an intricate signaling network that exerts pleiotropic effects on a host of substrates.

199 se data suggest that Sept5 deficiency exerts pleiotropic effects on a select set of affective behavio

200 Reactive oxygen species (ROS) exert pleiotropic effects on a wide array of signaling protein

201 TGF-beta has pleiotropic effects on adaptive immunity, especially in

202 osomal dominant mutations with antagonistic, pleiotropic effects on all three of these biological pro

203 We analyze models with pleiotropic effects on all traits at all loci but by var

204 of dipeptidyl peptidase-4 (DPP-4) have shown pleiotropic effects on bone metabolism and anti-inflamma

205 analysis to demonstrate genetic factors with pleiotropic effects on bone mineral density and lean mas

206 Atorvastatin (ATV) has shown pleiotropic effects on bone tissue, and osteoporosis can

207 IL-21 is a class I cytokine that exerts pleiotropic effects on both innate and adaptive immune r

208 me 4p15 (logarithm of odds = 3.5) exhibiting pleiotropic effects on both the endophenotype (lymphocyt

209 nalysis could mean that there are genes with pleiotropic effects on both traits, or that separate gen

210 sity in children, and show genetic loci with pleiotropic effects on both traits.

211 th factor 21 (FGF21), a peptide hormone with pleiotropic effects on carbohydrate and lipid metabolism

212 summary, there are genomic regions exerting pleiotropic effects on cardiovascular disease risk facto

213 a, and suggest that sensitivity is driven by pleiotropic effects on cell growth and apoptotic pathway

214 ocytoplasmic RNA-binding protein that exerts pleiotropic effects on cell growth and tumorigenesis.

215 (TGF-beta) is a key regulatory molecule with pleiotropic effects on cell growth, migration, and invas

216 non-essential amino acid, glutamine, exerts pleiotropic effects on cell metabolism, signalling and s

217 They exert pleiotropic effects on cells and are required for effici

218 However, these agents show pleiotropic effects on cells and can induce apoptosis th

219 meric with streptavidin (SA-4-1BBL) that has pleiotropic effects on cells of innate, adaptive, and re

220 r details of IFN signaling, catalogued their pleiotropic effects on cells, and harnessed their therap

221 However, despite their pleiotropic effects on cells, little is known about the

222 Despite pleiotropic effects on cells, the role of these epoxyeic

223 roteinase 1 (TIMP1), a secreted protein with pleiotropic effects on cellular growth, survival and int

224 C pathway, activated protein C (aPC), exerts pleiotropic effects on coagulation, fibrinolysis, and in

225 Thyroid hormone has pleiotropic effects on cochlear development, and genomic

226 These data demonstrate that LytA has pleiotropic effects on complement activation, a finding

227 variation at a pathway locus also indicated pleiotropic effects on contractility and blood pressure.

228 onogenesis by hnRNP K occurs largely through pleiotropic effects on cytoskeletal-associated targets.

229 s well as 16 undefined associated loci, have pleiotropic effects on different traits.

230 rnally derived genes (unless a gene also has pleiotropic effects on fitness of asymmetric kin).

231 ent of fitness or because the mutations have pleiotropic effects on fitness.

232 t directly on the traits, or indirectly from pleiotropic effects on fitness.

233 The pleiotropic effects on gene transcription in response to

234 t affect the nucleolus organizer region have pleiotropic effects on genome regulation and development

235 th levels of GGT; ADRB2 haplotypes displayed pleiotropic effects on GGT and triglyceride levels.

236 oups of related taxa, and some have putative pleiotropic effects on groups of distantly related organ

237 ion of transformed progenitors, but also has pleiotropic effects on hematopoiesis.

238 ighly pathogenic RNA viruses, likely mediate pleiotropic effects on host gene expression, presumably

239 , a small-molecule inhibitor of dynamin, has pleiotropic effects on HSV-1 and HSV-2 infection and imp

240 neuropsychiatric disorders, suggesting that pleiotropic effects on human complex traits may be wides

241 However, comparative studies of their pleiotropic effects on human T cell-mediated tumor rejec

242 ically promotes the autoimmunity through its pleiotropic effects on immune cells.

243 Since statins have pleiotropic effects on inflammation and coagulation that

244 Given TGF-beta's pleiotropic effects on inflammation and fibrogenesis, we

245 TLR7 activation by imiquimod has pleiotropic effects on innate immune cells, but its effe

246 ptor (PPAR)-gamma is a nuclear receptor with pleiotropic effects on lipid metabolism, inflammation, a

247 serum total bile acid concentrations and had pleiotropic effects on liver mass, serum cholesterol, an

248 TGF-beta has pleiotropic effects on many cell types at different stag

249 id receptors (GRs), this steroid hormone has pleiotropic effects on many cell types.

250 Although C1QBP has been reported to exert pleiotropic effects on many cellular processes, we repor

251 ression of RME1, a transcription factor with pleiotropic effects on meiosis and filamentous growth.

252 luding caloric restriction impose beneficial pleiotropic effects on metabolism.

253 hift in the gut microbiome could explain its pleiotropic effects on multiple complex diseases includi

254 BDNF has pleiotropic effects on neuronal development and synaptic

255 In conclusion, sumoylation exerts pleiotropic effects on p68/p72, which may have important

256 les, leaves, roots, and culms supporting the pleiotropic effects on plant architecture.

257 ain productivity of indica cultivars through pleiotropic effects on plant architecture.

258 pregulation of transposon expression and has pleiotropic effects on plant development.

259 Nitric oxide (NO) exerts pleiotropic effects on plant development; however, its i

260 The ADRB2 gene had pleiotropic effects on plasma levels of GGT and triglyce

261 Estrogens exert pleiotropic effects on reproductive traits, which includ

262 ) is critical for angiogenesis, but also has pleiotropic effects on several nonvascular cells.

263 , and loss of CCDC88B protein expression has pleiotropic effects on T lymphocyte functions, including

264 ften target proteins and pathways that exert pleiotropic effects on the cancer cell phenotype, and pa

265 Estrogen has pleiotropic effects on the cardiovascular system.

266 wever, because brefeldin A is known to exert pleiotropic effects on the entire endosomal system, the

267 uld facilitate finding new target genes with pleiotropic effects on the expression of ion channel pro

268 hat these lipid-signaling molecules can have pleiotropic effects on the fate and function of the immu

269 PCSK2 gene polymorphisms are associated with pleiotropic effects on various traits of glucose homeost

270 t gene for antiangiogenic therapy due to its pleiotropic effects on vascular and non-vascular cells.

271 ame genetic region-either a single gene with pleiotropic effects or linked genes-influences distinct

272 ata indicate that PIM kinases in cHL exhibit pleiotropic effects, orchestrating tumor immune escape a

273 y produced 1,25-dihydroxyvitamin D3 may have pleiotropic effects outside of bone.

274 te that loss of MAGP2 expression in vivo has pleiotropic effects potentially related to the ability o

275 phosphatidylcholine (q=0.008), suggesting a pleiotropic effect previously associated with a reduced

276 nto selenoproteins that have a wide range of pleiotropic effects, ranging from antioxidant and anti-i

277 ibe how such mechanisms might have generated pleiotropic effects responsible for tumor mitigation and

278 Of the pleiotropic effects, seed dormancy could contribute most

279 blished analytical approaches to identifying pleiotropic effects, sources of spurious cross-phenotype

280 five of which exhibited evidence suggesting pleiotropic effects (stay-green) between delayed senesce

281 Recently, statins have shown pleiotropic effects such as anti-inflammation and bone s

282 overexpression of these two proteins caused pleiotropic effects, such as hypersensitivity to puromyc

283 In this work we show that SCCRO has broader, pleiotropic effects that are essential for cullin neddyl

284 ts Cul4 and Ddb1, likely because these cause pleiotropic effects that block cell proliferation.

285 bolically neutral, well tolerated, and poses pleiotropic effects that could work alone or in combinat

286 regulation of c-di-GMP production results in pleiotropic effects that disable E. coli in the urinary

287 The results demonstrate the pleiotropic effects that IL-27 has on L. major-driven Th

288 In addition to lipid lowering, statins have pleiotropic effects that improve endothelial function, a

289 at protein interacts, were used to elucidate pleiotropic effects that may alter the flux of intermedi

290 HSP overaccumulation was not associated with pleiotropic effects that might decrease yields.

291 with eGFR in the UCLEB sample, but has known pleiotropic effects that prevent us from drawing a causa

292 Infection of these cells results in pleiotropic effects that serve to deregulate the host im

293 As Hox gene disruption often has pleiotropic effects, the root cause of this behavioral d

294 mulating evidence suggests that statins have pleiotropic effects; therefore, these drugs could be a p

295 However, TSLP has pleiotropic effects upon immune cells, and although exte

296 ivergence, suggesting that the nature of the pleiotropic effects was adaptive.

297 In addition, pleiotropic effects were observed with a reduction in vi

298 r Kal in autoantibody-induced arthritis with pleiotropic effects, which suggests that it is a new tar

299 t mutations in some genetic targets minimize pleiotropic effects while simultaneously maximizing adap

300 and invasion in vitro, but it also exhibited pleiotropic effects with altered cell morphology and gro