ライフサイエンスコーパス: ploidy

1 d are rarely scalable to genomes with higher ploidy.

2 of cell lines with experimentally determined ploidy.

3 rst scalable polyplotyping method for higher ploidy.

4 kably, loss of FLVCR increased megakaryocyte ploidy.

5 nhanced K accumulation of plants with higher ploidy.

6 ble to account for unknown tumour purity and ploidy.

7 talytic subunit results in rapid increase in ploidy.

8 gene expression profiles, and increased DNA ploidy.

9 tients according to 14q32 translocations and ploidy.

10 th enhanced cell proliferation and increased ploidy.

11 osity and not further enhanced by increasing ploidy.

12 t they become essential in cells with higher ploidy.

13 the ability of MKs to achieve high levels of ploidy.

14 DNA copy number relative to overall genomic ploidy.

15 ases whose overexpression leads to increased ploidy.

16 t proteins in a cell increases linearly with ploidy.

17 1.92% +/- 0.12%) with significantly reduced ploidy.

18 individuals to the general case of arbitrary ploidy.

19 ied 16 kinases whose loss leads to increased ploidy.

20 dle arrangement, chromosome segregation, and ploidy.

21 megakaryocytes with a concurrent increase in ploidy.

22 pes upon biomarker expression and chromosome ploidy.

23 y of cell progeny characterized by different ploidy.

24 ppropriate cell cycle phase to ensure proper ploidy.

25 tic effect in all individuals, regardless of ploidy.

26 as also been shown to regulate megakaryocyte ploidy.

27 by which RB-deficient cells acquire elevated ploidy.

28 ely to harbor hepatocytes exhibiting altered ploidy.

29 yll cells and, in some cases, increased leaf ploidy.

30 vels as well as an increase in cell size and ploidy.

31 er, there are many exceptions to grouping by ploidy.

32 sis, resulting in an increase in nuclear DNA ploidy.

33 oduction by 50% and had significantly higher ploidy.

34 tely spawning proliferative cells of reduced ploidy.

35 amage in diploid daughter cells and elevated ploidy.

36 association with hybridisation and shifts in ploidy.

37 ed with distinct genetic aberrations and DNA ploidies.

38 st cells of different sizes due to different ploidies.

39 fferent copy numbers, resulting in different ploidies.

40 y reduced numbers of MKs in culture of lower ploidy (2N and 4N) than wild-type controls, implicating

41 ls are produced by increasing DNA content or ploidy, a developmental strategy employed throughout the

42 romotes ICL repair in a manner that controls ploidy, a role that we show is not shared by the Fanconi

43 sed, high-throughput method called selective ploidy ablation (SPA).

44 A damage checkpoint appear to fuel increased ploidy abnormalities upon p53/p73 loss, while primary mi

45 taxa, we know very little about how elevated ploidy above the diploid level might affect plasticity.

46 of polyploid cells, higher mean and maximum ploidy, accelerated DNA synthesis, and delayed apoptosis

47 new generation, and meiosis thus stabilizes ploidy across generations.

48 psy, estimating cancerous cell purity, tumor ploidy, allele-specific copy number, and clonality and r

49 y and can be dramatically changed because of ploidy alteration.

50 of individual blastomeres are diagnostic of ploidy, amenable to automated tracking algorithms, and l

51 multiparameter analysis of apoptosis and DNA ploidy analysis in human hematopoietic cancer cells.

52 simple and robust algorithm to infer purity, ploidy and absolute copy numbers in whole numbers for tu

53 In particular, we describe ConPADE (Contig Ploidy and Allele Dosage Estimation), a probabilistic me

54 We used the bioinformatics tools 'expanding ploidy and allele frequency on nested subpopulations' (E

55 situ hybridization, revealed an increase in ploidy and aneuploidy.

56 iomarkers (low-grade dysplasia, abnormal DNA ploidy and Aspergillus oryzae lectin) can identify patie

57 F expression in RB-proficient cells elevated ploidy and bypassed the response to nocodazole-induced c

58 e expression is linearly correlated with the ploidy and can be dramatically changed because of ploidy

59 opy number calls corrected for tumor purity, ploidy and clonal heterogeneity, with comprehensive outp

60 has been implicated in proliferation of MKs, ploidy and deposition of fibers.

61 ocytes from these mice were blocked at 2N/4N ploidy and did not survive ex vivo.

62 such factors as age at presentation, stage, ploidy and genomic abnormalities.

63 can be divided into two groups according to ploidy and hyperdiploidy versus nonhyperdiploidy.

64 synthesis, and accumulate cells with higher ploidy and micronuclei.

65 nuclear localization and rescues defects in ploidy and mitosis.

66 The decrease in megakaryocyte ploidy and platelet counts of DKO mice is more severe th

67 nd ploidy, suggesting that CCL5 increases MK ploidy and proplatelet formation in a CCR5-dependent man

68 potential to improve the estimation of tumor ploidy and purity.

69 and because crop plants have highly variable ploidy and repeat content, the performance of GBS analys

70 lineages of Mercurialis that differ in their ploidy and sexual system to ascertain the extent to whic

71 -induced MC are more plastic with regards to ploidy and that this plasticity allows them to reorganiz

72 s of the mean (modes) to identify underlying ploidy and the contamination level, and finally we perfo

73 Megakaryocyte ploidy and the generation of pre/proplatelets are both i

74 to the accumulation of MKs with low nuclear ploidy and to decreased platelet production.

75 igen, phosphorylated histone 3, mitosis, and ploidy), and regeneration-associated molecules.

76 nting different tissues of origin, different ploidies, and two different species, demonstrating homol

77 iology of eusocial species, independently of ploidy, and add support to the idea that haplodiploidy h

78 multilocus sequence type (ST), mating type, ploidy, and allelic profile.

79 Low-grade dysplasia, abnormal DNA ploidy, and AOL can be used to identify patients with BE

80 comprising low-grade dysplasia, abnormal DNA ploidy, and AOL most accurately identified progressors a

81 ed maturation, decreased survival, decreased ploidy, and developmental abnormalities, including abnor

82 MYCN, 11q, mitosis-karyorrhexis index (MKI), ploidy, and lactate dehydrogenase were independently sta

83 FU-MK), mature megakaryocytes, megakaryocyte ploidy, and moderate increases in resting platelet numbe

84 National Cancer Institute (NCI) risk status, ploidy, and race, the G allele of a common polymorphism

85 reatment decisions, accurate, tumor purity-, ploidy- and clonal heterogeneity-adjusted integer copy n

86 artners distinguishable by their morphology, ploidy, antigens, biochemical traits, gene expression, a

87 proliferation, germline endoreplication and ploidy are also affected by the loss of FMRP during ovar

88 B1 expression whereas megakaryocytes of high ploidy are inhibited by lamin suppression.

89 Estimates of tumor purity and ploidy are necessary to correctly infer copy number, and

90 Hence GS and ploidy are significant traits affecting biomass growth u

91 Ploidy assessed by DI was also a favorable factor: the h

92 the best indicator for excellent outcome was ploidy assessed by karyotype because patients with 58-66

93 ogeographic impacts of reproductive mode and ploidy because it is composed of diploid sexual and both

94 p allows each individual to have a different ploidy, but ploidy cannot vary over the genomic region a

95 lication programme, increasing their nuclear ploidy, but subsequently reinitiate mitotic division cou

96 upport routine use in clinical practice: DNA/ploidy by flow cytometry, p53, cathepsin D, cyclin E, pr

97 es of polyploids, especially those with high ploidies, can reveal fundamental processes in speciation

98 h individual to have a different ploidy, but ploidy cannot vary over the genomic region analysed.

99 Thus, alteration of ploidy caused subtle expression changes of a substantial

100 ESCs to tolerate/survive varying degrees of ploidy change could complicate genome-reprogramming stud

101 uence for cotton (Gossypium spp.) revealed a ploidy change of a complexity unprecedented to date, ind

102 Age-related accumulation of ploidy changes is associated with decreased expression o

103 c principles of sex are conserved, including ploidy changes, the formation of gametes via meiosis, ma

104 ed the presence of alterations in hepatocyte ploidy compared with tissue from control individuals.

105 ne marrow mononuclear cells displayed higher ploidy compared with wild-type controls.

106 arch of molecular factors that regulate this ploidy consistency, we isolated an Arabidopsis thaliana

107 role in consolidating the male gametophytic ploidy consistency.

108 and increased abnormal mitoses and cellular ploidy, consistent with on-target activity.

109 d aneuploidy, a phenomenon that we term the 'ploidy conveyor'.

110 me aneuploid in a dynamic process called the ploidy conveyor.

111 Unexpectedly, higher ploidy correlated with reduced tumor-forming capacity.

112 We also discover that ploidy correlates with Stentor's cell size.

113 The data suggest that tumor cell ploidy could potentially be used to identify candidates

114 ivity inhibition by blebbistatin rescued the ploidy defect of FPD/AML MKs.

115 mediated GEF-H1 knockdown alone rescues this ploidy defect.

116 and abnormal spindle polarity, resulting in ploidy defects.

117 ion of nodule-specific genes correlated with ploidy-dependent opening of the chromatin as well as, in

118 The reasons for this ploidy-dependent reproductive isolation remain unknown.

119 ication stress, early events associated with ploidy dictate the repair pathway choice.

120 nome rearrangements, copy number variations, ploidy differences, and DNA sequence polymorphisms--is c

121 that infers tumor purity and malignant cell ploidy directly from analysis of somatic DNA alterations

122 per muscle cell and with increasing nuclear ploidy during development.

123 thesis that blastomere behaviour may reflect ploidy during the first two cleavage divisions.

124 This ploidy effect is independent of mating type heterozygosi

125 lation accompanying changes in lifestyle and ploidy, especially in carbon metabolism.

126 four benchmark datasets for both purity and ploidy estimates, and may offer a simple solution to cop

127 henotypic study showed that plants of higher ploidy exhibit increased cell size but slower growth rat

128 ogous chromosomes during meiosis I to reduce ploidy for gamete production.

129 Production of gametes of halved ploidy for sexual reproduction requires a specialized ce

130 Importantly, DNA repair, ploidy formation, and cell fusion were not implicated in

131 It is concluded that ploidy gave less variation than temperature.

132 For triploid and higher ploidy genomes, we demonstrate that HapTree substantiall

133 ion of sexual reproduction, mutational load, ploidy, genomic complexity, speciation, and the origin o

134 Three tumours with the highest ploidy had little genome-wide LOH, yet one of these had

135 ed genetic backgrounds, we found that higher ploidy has a minor negative effect on virulence in a mur

136 ivergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors.

137 ced by tumor sample characteristics, such as ploidy, heterogeneity, and purity.

138 Challenges in sequencing any genome include ploidy, heterozygosity and paralogy, all which are ampli

139 t megakaryocytes had partial blocks at 2N/4N ploidy; however, only the latter exhibited reduced propl

140 We examined ploidy in a naturally multinucleate fungus, Ashbya gossy

141 elet counts in peripheral blood, and reduced ploidy in bone marrow megakaryocytes.

142 during development could affect mitosis and ploidy in post-mitotic differentiated tissue.

143 CitK, Ephrin/Eph signaling controls neuronal ploidy in the developing neocortex.

144 om mitotic progression led to altered genome ploidy in the liver.

145 fusion of two gametes restores the original ploidy in the new generation, and meiosis thus stabilize

146 survivin, alone, does not interfere with MK ploidy in vivo.

147 population rapidly converges toward a stable ploidy in which centrosome amplification is significantl

148 by simultaneously altering nuclear size and ploidy in X. laevis embryos.

149 maturation of neonatal MKs without affecting ploidy, in contrast to the synchronous inhibition of pol

150 Here we show that an abrupt five- to sixfold ploidy increase approximately 60 million years (Myr) ago

151 uard cell nuclear size did not justify for a ploidy increase.

152 an additional mechanism of cyclin E-mediated ploidy increase.

153 es in trichome nuclear size likely reflected ploidy increases while the moderate increases in guard c

154 nds on the intact SAC as well as increase in ploidy (Ipl1)/Aurora kinase and a centromere-associated

155 We conclude that ploidy is a substantially stronger and more common drive

156 Elevated ploidy is associated with enhanced cell size, metabolic

157 bperineurial glia (SPG) to be polyploid, and ploidy is coordinated with brain mass.

158 ng coverage is available, or the true contig ploidy is low.

159 Significant phenotypic variation including ploidy is present across the two primary ecotypes of swi

160 Ploidy is relayed by autosomal signal elements (ASEs), w

161 How cells maintain their ploidy is relevant to cellular development and disease.

162 These data suggest that mixed ploidy is tolerated in these syncytia; however, there ma

163 Local changes in ploidy, known as copy number variations (CNV), arise thr

164 ass of angiosperm species with different GS, ploidy level and Grime's C-S-R (competitive, stress-tole

165 biosynthesis in the argan seed, the anatomy, ploidy level and lipid composition of mature seed tissue

166 Their unusual ploidy level and pattern of inheritance imply that sex c

167 situations where asexual taxa are of higher ploidy level and phosphorus availability limits importan

168 Ploidy level differences have not been investigated in t

169 Overall, we found that an increase in ploidy level from 4x to 6x in M. annua is associated wit

170 vin expression in the MK lineage might alter ploidy level in vivo.

171 ides no support for the idea that increasing ploidy level increases the ability to express different

172 iosynthesis are required for maintaining the ploidy level of the premeiotic germ lineage and that sub

173 change in DNA heterochromatinization, as the ploidy level of wild-type and RNAi-silenced nodule cells

174 MK ploidy level was low and mature MKs displayed a major de

175 s showed no detectable changes in MK number, ploidy level, and platelet and erythrocyte counts, as co

176 fascinating example of the interplay between ploidy level, hybridisation and alien plant invasion.

177 iated with model crops, including changes in ploidy level, loss of shattering, multiple origins, and

178 hickness were positively correlated with the ploidy level.

179 nd 5S rDNA amounts increased with increasing ploidy level.

180 NA units, chromosome number, genome size and ploidy level.

181 Here, we ask whether different ploidy levels > 2x express different plasticity in the r

182 transcriptional waves correlate with growing ploidy levels and have investigated how the epigenome ch

183 with 24 species, ten genome types, different ploidy levels and over threefold genome size variation,

184 hepatocytes were able to dynamically resolve ploidy levels and return to normal by the end of regener

185 screens, scaling down a tetraploid to lower ploidy levels and swapping of nuclear and cytoplasmic ge

186 ow cytometry analyses allowed us to evaluate ploidy levels and to monitor cell cycle progression in l

187 genes DNA methylation was unaffected by the ploidy levels and was independent of the genes' active o

188 Plants of different ploidy levels are separated by a strong postzygotic hybr

189 Nevertheless, taxa within ploidy levels could be largely distinguished according t

190 mosomes, thereby enabling the restoration of ploidy levels during fertilization.

191 In quiescent liver, normally high ploidy levels in adult mice increased with loss of p53.

192 Ploidy levels increased during regeneration of both wild

193 sex ratios, respectively, regardless of the ploidy levels involved (diploid, tetraploid or hexaploid

194 This genetic isolation between ploidy levels is confirmed by a detailed analysis of a s

195 Hybridisation among taxa with different ploidy levels is often associated with hybrid sterility.

196 en related plant populations which differ in ploidy levels is problematic, with common statistical me

197 these regions within and across species and ploidy levels provided several insights into the spatio-

198 Chromosomal markers on three diverse ploidy levels reflecting different stages of rediploidiz

199 wing) regions of 3-day-old hypocotyls showed ploidy levels to be lower in abcb19 mutants compared wit

200 stem hydraulic efficiency and safety across ploidy levels underlies niche differentiation among diff

201 Increased ploidy levels were found in some but not all enlarged or

202 e phenotypes, including thick leaves, higher ploidy levels, and larger palisade mesophyll cells.

203 S) morphological aspect and exhibited higher ploidy levels, as compared with MKs in liquid culture.

204 ng of CYCD5;1 were effective in changing DNA ploidy levels, confirming CYCD5;1 to be a previously und

205 found increased mesophyll cell size and leaf ploidy levels, suggesting that endoreduplication underpi

206 gh polymorphism is extensively shared across ploidy levels, there is strong ploidy-specific different

207 ated with adaptation to hosts with different ploidy levels.

208 at differentiation among plants of different ploidy levels.

209 their overexpression triggers increased DNA ploidy levels.

210 e analyzed using flow cytometry to determine ploidy levels.

211 for maintenance of chromosome stability and ploidy levels.

212 etect patterns that are indicative of higher ploidy levels.

213 l for comparing related species of different ploidy levels.

214 ploid Restharrows in Britain, but not within ploidy levels.

215 e found that the same Caph2 mutation impairs ploidy maintenance to a different extent in different he

216 s study provides insights into the impact of ploidy, mating type, and serotype on virulence and the i

217 Tumor cell ploidy may be a clinically useful factor for prognostica

218 ecessary to correctly infer copy number, and ploidy may itself be a prognostic factor in cancer progr

219 rs producing increased, abnormally small low-ploidy megakaryocytes.

220 lastoma factors, including age, MYCN status, ploidy, mitosis-karyorrhexis index, and histologic grade

221 low) mice, where there is an increase in low ploidy MKs, augmented levels of PDGF-BB, and an extensiv

222 d that, in a system with an abundance of low ploidy MKs, LOX could be highly expressed and with funct

223 ional belief, are more mature than adult low-ploidy MKs.

224 t levels and significant reduction of higher ploidy MKs.

225 in different hematopoietic cell types, with ploidy most severely perturbed at the CD4(+)CD8(+) T-cel

226 n the present study, we demonstrate that low-ploidy neonatal MKs, contrary to traditional belief, are

227 n endoreplicating normally and reach a final ploidy of >1000C in the absence of zygotic synthesis of

228 H-PoP might be applied to help determine the ploidy of an organism.

229 ), a probabilistic method that estimates the ploidy of any given contig/scaffold based on its allele

230 rform this estimation and supports a maximum ploidy of eight.

231 dasatinib-treated mice was increased and the ploidy of MKs derived from bone marrow progenitor cells

232 d SMR1 play different roles in affecting the ploidy of trichome and leaf cells, respectively.

233 e different combinations of tumor purity and ploidy often explain the sequencing data equally well.

234 or sequences adjacent to the polyQ, altering ploidy or chaperone dosage, or deleting anti-aging facto

235 t, reduced p53 expression did not affect the ploidy or DNA synthesis of CHRF cells in the absence of

236 me sequencing precluded inferences about its ploidy or sexual cycle.

237 tion and maintenance of meiotically unstable ploidy or structural variants and provides an alternativ

238 To achieve this reduction in ploidy, organisms must devise strategies to couple siste

239 We find that ploidy per se has little effect.

240 Among these ploidy phenotypes, a progeny of small mononucleated cell

241 Despite the widespread failure to increase ploidy prior to entering meiosis, the fecundity of parth

242 geted to megakaryocytes display an increased ploidy profile.

243 Allelic composition and ploidy profiling analysis revealed extensive intratumor

244 uencing, chromosome aberration analysis, and ploidy profiling on multiple spatially separated samples

245 We have developed a method we call Sector-Ploidy-Profiling (SPP) to study the clonal composition o

246 infers genome-wide parameters such as cancer ploidy, purity and heterogeneity.

247 he creation of tumour samples with different ploidy, purity and polyclonality features.

248 ure and as xenografts, hybrids underwent DNA ploidy reduction and morphological reversal to breast ca

249 dom homologous chromosome segregation during ploidy reduction can expose deleterious mutations throug

250 a midgut are replaced by spindle-independent ploidy reduction of cells in the enterocyte lineage thro

251 in a pathway responsible for a component of ploidy-related hypocotyl growth.

252 hat p53 plays a role in mitotic fidelity and ploidy resolution in hepatocytes of normal and regenerat

253 Analysis of mutants that alter cell size or ploidy revealed that SAC strength is determined primaril

254 ynamic model of hepatocyte polyploidization, ploidy reversal and aneuploidy, a phenomenon that we ter

255 epatocytes become polyploid and then undergo ploidy reversal and become aneuploid in a dynamic proces

256 ploid hepatocytes and can result in one-step ploidy reversal to generate offspring with halved chromo

257 ly, we demonstrated that the opposite event, ploidy reversal, also occurs in polyploid hepatocytes ge

258 negative continuous correlation through the ploidy series between their protein expression per genom

259 ffects in maize, we developed an inbred Oh43 ploidy series consisting of the diploid (2X), tetraploid

260 square root of the ploidy through a 1N/2N/4N ploidy series, consistent with simple stochastic models

261 Hence, in the Oh43 ploidy series, expression for most proteins in a cell in

262 This ploidy shift coincided with anisogamous mating, during w

263 At the stem level, cytotypes of higher ploidy showed consistently lower leaf-specific hydraulic

264 ndependently of beneficial mutations through ploidy-specific changes in cell physiology.

265 Two major ploidy-specific cutoffs in LST distributions were suffic

266 shared across ploidy levels, there is strong ploidy-specific differentiation in 39 regions spanning 4

267 control in tissue-, grain development-, and ploidy-specific manners.

268 eproductive modes of the same species, (iii) ploidy-specific niche differentiation within and among s

269 This study reports an unusual ploidy-specific response to replication stress presented

270 ts in meiotic cell division and reproductive ploidy stability occur in Arabidopsis plants depleted of

271 elet counts with megakaryocytes that reached ploidy states comparable with those of control littermat

272 with different parental genomes or different ploidy states in a single individual, respectively.

273 We tested the ploidy status of available chromosomal markers after the

274 onfirming the association of CIN rather than ploidy status with multidrug resistance, tetraploid isog

275 rsed the augmented proplatelet formation and ploidy, suggesting that CCL5 increases MK ploidy and pro

276 ture, survivin expression, cytokinesis, cell ploidy, symmetrical cell division, and tissue architectu

277 ve and give rise to MKs smaller and of lower ploidy than adult MKs.

278 and are more sensitive to changes in genome ploidy than the consistent contacts.

279 e significantly smaller in size and lower in ploidy than those of control mice; however, because of t

280 izing gene diversity in samples of arbitrary ploidy that contain related or inbred individuals.

281 because it is distinct from the increase in ploidy that is inherited through the germline and presen

282 ivation, there was an increase in hepatocyte ploidy that was accompanied by hyperphysiological assemb

283 The precise contributions of increased ploidy, the effect of hybridization between serotypes A

284 the number of X chromosomes relative to the ploidy, the number of sets of autosomes.

285 in G1 decreases with the square root of the ploidy through a 1N/2N/4N ploidy series, consistent with

286 oid Arabidopsis into a diploid, reducing its ploidy to simplify breeding.

287 MYCN status, tumor cell ploidy, treatment, and outcome of patients with stage A,

288 reported in vitro data showing decreased MK ploidy upon retroviral-mediated overexpression of surviv

289 ify true copy numbers, and calculate average-ploidy value.

290 d, and thus there is incomplete buffering of ploidy variation despite a common cytosol.

291 The consequences of ploidy variation in syncytia are difficult to predict be

292 The degree of ploidy variation increases as cells age.

293 Ploidy variation is found in contexts as diverse as soli

294 y several specific genomic features as broad ploidy variation, high chromosome numbers, presence of n

295 The term 'ploidy' was subsequently derived to describe the total c

296 To examine the effect of ploidy, we autotetraploidized the Arabidopsis (Arabidops

297 YCN oncogene, chromosome 11q status, and DNA ploidy were the most highly statistically significant an

298 ts can lead to asexual lineages of increased ploidy when favorable combinations of parental genomes a

299 rations in hepatocyte nuclear morphology and ploidy with RB loss.

300 ied cell cycle that allows cells to increase ploidy without subsequent cell division, is a key compon