ライフサイエンスコーパス: pluripotent cell

1 stem cells, embryonal carcinomas and induced pluripotent cells).

2 growth factor GDF9 can reprogram hADFs into pluripotent cells.

3 and effectiveness of cell differentiation of pluripotent cells.

4 ning the culture requirements of naive human pluripotent cells.

5 ay to drive mesendodermal differentiation of pluripotent cells.

6 ry meristems can be traced back to groups of pluripotent cells.

7 es that have bivalent chromatin structure in pluripotent cells.

8 ng loci were bound by Mediator or cohesin in pluripotent cells.

9 lation, suggesting it is a pivotal marker of pluripotent cells.

10 engraftment of blood progenitors from human pluripotent cells.

11 ry program at the G(1)/S-phase transition in pluripotent cells.

12 cations at the Oct4 locus in fibroblasts and pluripotent cells.

13 tive way to induce CPCs from mouse and human pluripotent cells.

14 is the key feature of murine totipotent and pluripotent cells.

15 lture can also induce abnormalities in these pluripotent cells.

16 ith endoderm promotes induction of CPCs from pluripotent cells.

17 aining the differentiation responsiveness of pluripotent cells.

18 erences between in vitro and ex vivo primate pluripotent cells.

19 ion between embryonic stem cells and induced pluripotent cells.

20 tified proteins and phosphorylation sites in pluripotent cells.

21 n the formation of teratomas by transplanted pluripotent cells.

22 C/C substrates are also present during G1 of pluripotent cells.

23 ariants affecting the transcriptome of human pluripotent cells.

24 on in a broad range of cell types, including pluripotent cells.

25 lls and in epigenetic remodeling of germ and pluripotent cells.

26 cle structure and transcriptional network of pluripotent cells.

27 feeders for both autologous and heterologous pluripotent cells.

28 tional regulator of differentiation in these pluripotent cells.

29 y novel peptides that bind to the surface of pluripotent cells.

30 dynamics during lineage commitment of human pluripotent cells.

31 via diploid aggregation, unique to bona fide pluripotent cells.

32 tained the matrix signal for differentiating pluripotent cells.

33 ns methylated differently in fibroblasts and pluripotent cells.

34 ing networks that control differentiation of pluripotent cells.

35 n epigenetic mechanism of gene repression in pluripotent cells.

36 tween Oct4/Sox2 and cell cycle regulation in pluripotent cells.

37 microRNAs expressed specifically in ESCs and pluripotent cells.

38 or genetic studies of human pre-implantation pluripotent cells.

39 ether are sufficient to generate retina from pluripotent cells.

40 y in controlling early neural development of pluripotent cells.

41 he role of the transcription factor Foxd3 in pluripotent cells.

42 alance between transcriptional programmes in pluripotent cells.

43 ction in gene expression regulation in mouse pluripotent cells.

44 the genetic regulation of gene expression in pluripotent cells.

45 ure cell types of all three germ layers from pluripotent cells.

46 in the transcriptional regulatory network of pluripotent cells.

47 we show that this instability only occurs in pluripotent cells.

48 ed in undifferentiated hPSCs compared to non-pluripotent cells.

49 ns of the endogenous Oct4 distal enhancer in pluripotent cells.

50 fic genome structures and gene expression in pluripotent cells.

51 ted, contractile fibers from mouse and human pluripotent cells.

52 omatic cells, resulting in the generation of pluripotent cells.

53 required to produce cellular diversity from pluripotent cells.

54 ating that they were fully reprogrammed into pluripotent cells.

55 Lack of MEG3 expression in human induced pluripotent cells altered the chromatin distribution of

56 The terms pluripotent cell and stem cell are often used interchang

57 tand the role of this molecular pathway in a pluripotent cell and the impact of CSB mutation during h

58 of up to 100 cardiomyocytes for every input pluripotent cell and was effective in 11 hiPSC lines tes

59 w that Jarid2/Jumonji, a protein enriched in pluripotent cells and a founding member of the Jumonji C

60 he grafted cells by separating contaminating pluripotent cells and committed neural cells using fluor

61 rgent homeodomain protein found in mammalian pluripotent cells and developing germ cells.

62 Genome-wide profiling of pluripotent cells and differentiated cells suggests glob

63 is sufficient to drive iXEN cells from mouse pluripotent cells and differentiated neural cells.

64 Tet1 and Tet2 are highly expressed in mouse pluripotent cells and downregulated to different extents

65 chanism of histone methylation regulation in pluripotent cells and during early cell-fate transitions

66 f the mutated cell; earlier mutations target pluripotent cells and generate more widespread disease a

67 , including mouse embryonic stem and induced pluripotent cells and human oocytes.

68 mportance of post-transcriptional control in pluripotent cells and identify miRNAs and RNA-binding pr

69 HH signaling keeps XCI in check in pluripotent cells and is transduced by GLI transcription

70 aling potently induces SMC-specific genes in pluripotent cells and prevents dedifferentiation of arte

71 ty to detect chromosomal gains and losses in pluripotent cells and their derivatives, as well as meio

72 n of haemangioblasts and cardiomyocytes from pluripotent cells, and for the origins of stem cells in

73 limiting requirement for differentiation of pluripotent cells, and that experimental suppression of

74 oportion of the protein kinase complement of pluripotent cells, and there is accumulating evidence th

75 The generation of patient-derived pluripotent cells applicable to disease modelling, drug

76 Finally, while macroH2A dKO-induced pluripotent cells are able to differentiate properly in

77 ow intracellular signaling pathways in human pluripotent cells are coordinated and how they maintain

78 ylation during reprogramming, while ESC-like pluripotent cells are distinguished by extension of deme

79 Over 12-14 d, pluripotent cells are efficiently specified along the ne

80 When pluripotent cells are exposed to a uniform culture envir

81 t silence retrotransposons in germ cells and pluripotent cells are important for limiting the accumul

82 fferentiation, which could shed light on why pluripotent cells are only receptive to differentiation

83 XD3 modulates the developmental potential of pluripotent cells as they differentiate.

84 MSC (C3H10T1/2 pluripotent cells as well as mouse marrow-derived MSC) w

85 of the distal TSS is highly active in naive pluripotent cells, autonomously reports Tet1 expression

86 complex cell and environmental regulation of pluripotent cell behaviour, and suggest simple determini

87 The recent advent of pluripotent cell biology has opened new avenues for neur

88 loci indicates that a subset is expressed in pluripotent cells but not in diverse fetal and adult tis

89 Such marks have been identified in pluripotent cells, but it is unknown how such marks occu

90 iated hPS cells, had little or no binding on pluripotent cells, but preferential binding to certain e

91 nes the subtype of cancer arising from these pluripotent cells by altering their fate.

92 henomenon of somatic cell reprogramming into pluripotent cells by exposure to sublethal stimuli, whic

93 he strictest of all developmental assays for pluripotent cells by generating completely iPSC-derived

94 Secondary growth is initiated from groups of pluripotent cells, called meristems, which are establish

95 The acquisition of pluripotent cells can be achieved by combined overexpres

96 Transitory pluripotent cells can be captured at different time poin

97 Pluripotent cells can be captured via the archetypal der

98 Pluripotent cells can be derived from fibroblasts by ect

99 Pluripotent cells can be derived from various types of s

100 Here we demonstrate that reprogrammed pluripotent cells can be isolated from genetically unmod

101 These pluripotent cells can be propagated indefinitely in vitr

102 nscriptionally distinct teratomas from which pluripotent cells can be recovered.

103 reporter-based studies of gene expression in pluripotent cells can be significantly influenced by the

104 However, much work remains to be done before pluripotent cells can be used for preclinical and clinic

105 The advantages that these pluripotent cells can offer in comparison to other sourc

106 tracellular matrix populated with autologous pluripotent cells can result in de-novo organogenesis, b

107 These induced pluripotent cells can subsequently be differentiated int

108 fined culture environments the properties of pluripotent cells change in an orderly sequence.

109 We find that in pluripotent cells, clustered CpG-islands at genes predic

110 MEK1 was required to make Xenopus pluripotent cells competent to respond to all cell fate

111 hether endothelial cells differentiated from pluripotent cells could serve as surrogates to test emer

112 We also apply this system to pluripotent cell culture and demonstrate that it faithfu

113 The greatest potential for induced pluripotent cells derived from affected individuals is l

114 Epiblast stem cells (EpiSCs) are pluripotent cells derived from post-implantation late ep

115 Embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass (ICM)

116 Induced pluripotent cell-derived motoneurons (iPSCMNs) are sough

117 Pluripotent cells develop within the inner cell mass of

118 ighting gene expression changes during human pluripotent cell differentiation.

119 In pluripotent cells, divergent lncRNAs regulate the transc

120 neurons made from PD patient-derived induced pluripotent cells, dramatically reduced LRRK2-dependent

121 E-1 (L1) retrotransposons, which mobilize in pluripotent cells early in development.

122 ein network (PluriNet) that is shared by the pluripotent cells (embryonic stem cells, embryonal carci

123 pecification occurs either by induction from pluripotent cells (epigenesis) or by a cell-autonomous m

124 preimplantation embryonic lethality because pluripotent cells fail to form and all cells differentia

125 se embryonic stem cells (ESCs) and defined a pluripotent cell fate (PCF) gene signature associated wi

126 of stem cell microenvironments that regulate pluripotent cell fate decisions and morphogenesis.

127 richardii, the WUS pro-orthologue marks the pluripotent cell fate of immediate descendants of the ro

128 cells (ESCs) provide an unlimited supply of pluripotent cells for articular cartilage tissue enginee

129 human blood cells and the potential of these pluripotent cells for disease modeling.

130 In addition, the use of pluripotent cells for drug screening could enable routin

131 prior to and independently of Cdh1 to prime pluripotent cells for mesoderm differentiation, thus hel

132 Direct isolation of pluripotent cells from cultured somatic cells is of pote

133 These conditions shield pluripotent cells from differentiation-inducing stimuli.

134 ERK signalling, which promotes exit of naive pluripotent cells from self-renewal, does not prevent JA

135 Pluripotent cells from the early stages of embryonic dev

136 In culture, the ability of pluripotent cells from the embryo to respond to the FGF

137 ell lines and interrogated to understand how pluripotent cells generate distinct fates during early d

138 Pluripotent cells generated from patients with T1D would

139 mine the trajectories connecting somatic and pluripotent cells, genetic and chemical methodologies fo

140 Previous reports have shown that naive pluripotent cells grown in the presence of 2i are charac

141 fects in a dataset profiling differentiating pluripotent cells (GSE32923) and another from human brai

142 that can restore muscle function from human pluripotent cells has not been achieved.

143 Recently, methods to derive ECs from pluripotent cells have extended the scientific range of

144 The recent derivation of human induced pluripotent cells (hiPSCs) provides a potential supply o

145 for precise genome editing in human-induced pluripotent cells (hiPSCs) will enable sophisticated gen

146 (NuRD) is required for lineage commitment of pluripotent cells; however, the mechanism through which

147 ly embryonic-lethal due to the abrogation of pluripotent cells in blastocysts.

148 that geminin is present in G1 phase of mouse pluripotent cells in contrast to somatic cells, where an

149 Nanog orthologs supported self-renewal of pluripotent cells in the absence of leukemia inhibitory

150 Thus, PGCs can give rise to pluripotent cells in the course of the developmental cyc

151 key role in choreographing the responses of pluripotent cells in the early embryo to the signals tha

152 Its inhibition lowers the percentage of pluripotent cells in the early mouse embryo and signific

153 Pluripotent cells in the embryo can generate all cell ty

154 ed-specific, proteins were also expressed by pluripotent cells in the human preimplantation embryo.

155 Pluripotent cells in the inner cell mass (ICM) are the d

156 hereas Oct3/4 is expressed in totipotent and pluripotent cells in the mouse life cycle, Rex1 expressi

157 mplications for the generation of HSPCs from pluripotent cells in vitro.

158 portance of Mbd3/NuRD for the development of pluripotent cells in vivo and for their ex vivo progress

159 iew recent insights into the nature of human pluripotent cells in vivo, obtained by the deep sequenci

160 These inhibitors generate human pluripotent cells in which transcription factors associa

161 riNet seems to be a common characteristic of pluripotent cells, including mouse embryonic stem and in

162 The process by which pluripotent cells incorporate into host embryos is of in

163 The ability to differentiate pluripotent cells into anterior foregut endoderm (AFE) d

164 ial for driving the differentiation of human pluripotent cells into cell types useful for clinical ap

165 tively amplified upon differentiation of the pluripotent cells into disease-relevant lineages.

166 We differentiated pluripotent cells into either cortical or olfactory plac

167 upport a role for Wnts in differentiation of pluripotent cells into profibrotic fibroblasts and the p

168 ereby allowing for functional engraftment of pluripotent cells into regenerating tissue.

169 ssue or neural cultures derived from induced pluripotent cells (iPS), in conjunction with transcripto

170 Knockdown of SETDB1 in PWS-specific induced pluripotent cells (iPSCs) causes a decrease in the accum

171 Using induced pluripotent cells (iPSCs) from patients with mutation in

172 Generation of patient-specific induced pluripotent cells (iPSCs) holds great promise for regene

173 uman embryonic stem cells (ESCs) and induced pluripotent cells (iPSCs) into neurons are often cumbers

174 Reprogramming somatic cells into induced-pluripotent cells (iPSCs) provides new access to all som

175 iving lung progenitors from patient-specific pluripotent cells is a key step in producing differentia

176 Targeted genetic engineering of human pluripotent cells is a prerequisite for exploiting their

177 generation of differentiated DA neurons from pluripotent cells is a prerequisite for the use of hiPSC

178 The conversion of somatic cells into pluripotent cells is transforming the way diseases are r

179 Additionally, quiescent pluripotent cells lacking Mga are lost during embryonic

180 n vitro and in vivo differentiation of human pluripotent cells, likely through defects in the silenci

181 oduct, the HERVK accessory protein Rec, in a pluripotent cell line is sufficient to increase IFITM1 l

182 scle that is potentially applicable to other pluripotent cell lines and to generating other forms of

183 Here we review the family of pluripotent cell lines derived from early embryos and fr

184 epiblast stem cells (EpiSCs), self-renewing pluripotent cell lines equivalent to the postimplantatio

185 Recently, haploid pluripotent cell lines from medaka fish (Oryzias latipes

186 strate the derivation of robustly expandable pluripotent cell lines from STAP cells.

187 The peptides supported growth of eight pluripotent cell lines on a variety of scaffolds.

188 All pluripotent cell lines showed similar gene expression pa

189 of both enzymes in tandem results in viable, pluripotent cell lines with distinct effects on the DNA

190 aled 23 distinguishing candidate genes among pluripotent cell lines with divergent cardiogenic potent

191 ranscriptional and epigenetic comparisons of pluripotent cell lines, explaining some of the previousl

192 ubstantial variation has been reported among pluripotent cell lines, which could affect their utility

193 cells (EGCs) represent two classic types of pluripotent cell lines, yet their molecular equivalence

194 euroepithelial-like stem cells (lt-NES) from pluripotent cell lines.

195 quick and comprehensive characterization of pluripotent cell lines.

196 NT2 cell population density; levels of Oct4 (pluripotent cell marker) and HCMV genome penetration are

197 e the level of HCMV genomes in nuclei, Oct4 (pluripotent cell marker), or hDaxx (cellular repressor o

198 Resultant iPSC clones expressed pluripotent cell markers and generated teratomas.

199 that vector silencing follows acquisition of pluripotent cell markers.

200 f Arabidopsis in vitro regeneration, where a pluripotent cell mass termed callus is induced.

201 activating EMT, and that the Nanog marker of pluripotent cells may act as the primary transcription f

202 bryos and suggest that a chimera assay using pluripotent cells may not be feasible.

203 Prematurely slowing MCM loading in pluripotent cells not only lengthens G1 but also acceler

204 rom a specified germ cell to a population of pluripotent cells occurs rapidly following fertilization

205 omplex vertebrate nervous system begins when pluripotent cells of the early embryo are directed to ac

206 ssential for formation of the totipotent and pluripotent cells of the early embryo.

207 through regulation of the polyamine pool in pluripotent cells of the embryo, whether they are in a p

208 predispose blastomeres to contribute to the pluripotent cells of the ICM.

209 transcription factor Mga is expressed in the pluripotent cells of the inner cell mass (ICM) and epibl

210 Both lin28a and lin28b are expressed in pluripotent cells of the Xenopus embryo and are enriched

211 Human trisomy 21 pluripotent cells of various origins, human embryonic st

212 factors to reprogram somatic cells to become pluripotent cells, offers a significant technical simpli

213 icient for neural induction, Tbx3-expressing pluripotent cells only form retina in the context of the

214 uivalent to a certain developmental stage of pluripotent cells or a heterogeneous population composed

215 Whether regeneration is accomplished by pluripotent cells or by the collective activity of multi

216 the cells retained spectroscopic features of pluripotent cells or developed spectroscopic features su

217 n genomes due to their ability to amplify in pluripotent cells or developing germ cells.

218 The reprogramming of adult cells into pluripotent cells or directly into alternative adult cel

219 analysed and their silencing in germ cells, pluripotent cells or somatic cells remains poorly unders

220 nown whether there are additional classes of pluripotent cells, or what the spectrum of reprogrammed

221 scription factors that maintain an important pluripotent cell population called the shoot apical meri

222 ex vivo fail to expand their Oct4-positive, pluripotent cell population despite producing robust end

223 e first two lineages to differentiate from a pluripotent cell population during mammalian development

224 d that the Msx1-expressing cells represent a pluripotent cell population for the regenerating digit.

225 rived from the blastema, an undifferentiated pluripotent cell population thought to be derived from m

226 stricted to the ICM, and is downregulated in pluripotent cell populations in the later stages, i.e. t

227 minates in the establishment of two distinct pluripotent cell populations: the shoot apical meristem

228 Pluripotent cells possess the ability to differentiate i

229 sient downregulation of Nanog in a subset of pluripotent cells predisposes them toward differentiatio

230 d proliferative characteristics of embryonic pluripotent cells, reduces expression of pluripotency fa

231 tion as both a repressor and an activator in pluripotent cells, regulating expression of developmenta

232 re of embryonic development, but the role of pluripotent cell regulation in somatic tissue regenerati

233 argeted single-copy genomic integration into pluripotent cells, reporter assays and flow cytometry ar

234 Pluripotent cells represent a powerful tool for tissue r

235 er specification of definitive endoderm from pluripotent cells results in a highly enriched AFE popul

236 mming and the pooled selection of polyclonal pluripotent cells results in high-quality, stable iPSCs.

237 d female monkey ICMs indicating that ex vivo pluripotent cells retain XaXa.

238 work and will enhance our ability to control pluripotent cell self-renewal and differentiation.

239 differentiation-promoting conditions, these pluripotent cells showed the same general trends of gene

240 ated derivatives of fatty acids (NO2-FA) are pluripotent cell-signaling mediators that display anti-i

241 in histone acetylation on cardiomyocyte and pluripotent cell-specific gene promoters.

242 scription factors, DNA methylation status at pluripotent cell-specific genes, and the capacity to dif

243 The latter also determines the pluripotent cell state, that is, naive or primed.

244 s the possibility of transitioning through a pluripotent cell state.

245 n can also promote reversion back to a naive pluripotent cell state.

246 Amplification of one or both pluripotent cell subpopulations can occur in diseases; f

247 Pluripotent cells, such as embryonic stem cells, are inv

248 ifferentiated cells can be reprogrammed into pluripotent cells, suggesting that in vitro reprogrammin

249 e, neither class of contacts was observed in pluripotent cells, suggesting that lineage-specific chro

250 s suggest a mechanism whereby Mga influences pluripotent cell survival through regulation of the poly

251 Lin28, can reprogram somatic cells back into pluripotent cells, termed induced pluripotent stem cells

252 ed, exhibiting lower nucleosome occupancy in pluripotent cells than in somatic cells.

253 thylation was slightly more prevalent in the pluripotent cells than in the fibroblasts.

254 s differentiation and enable self-renewal of pluripotent cells that are ex vivo counterparts of naive

255 nique relationship between the germ line and pluripotent cells that are present during the earliest s

256 mbryonic stem (hES) cells are self-renewing, pluripotent cells that are valuable research tools and h

257 he recent discovery of novel means to derive pluripotent cells that avoid embryo destruction, includi

258 ells (hiPSCs) provides a potential supply of pluripotent cells that avoid immune rejection and could

259 The ability to reprogram somatic cells into pluripotent cells that can be differentiated in vitro pr

260 Mesenchymal stem cells (MSCs) are pluripotent cells that can promote expansion of immune r

261 low us to manipulate the germ line to create pluripotent cells that could serve as a critical tool in

262 During early mammalian development, as the pluripotent cells that give rise to all of the tissues o

263 Setting aside pluripotent cells that give rise to the future body is a

264 Human embryonic stem cells (hESCs) are pluripotent cells that have indefinite replicative poten

265 f mammalian embryos, which has favored using pluripotent cells that recapitulate cardiac myogenesis.

266 These 3D regulatory maps of human pluripotent cells therefore provide a foundation for fut

267 by triggering genetic variation in germ and pluripotent cells through mutation followed by natural s

268 studies have aimed to convert cultured human pluripotent cells to a naive state, but it remains uncle

269 t, lineage-specific differentiation of human pluripotent cells to a NCSC fate.

270 of Tbx3 and Pax6 is sufficient to determine pluripotent cells to a retinal lineage.

271 uently, Foxd3 needs to be silenced in primed pluripotent cells to allow re-activation of relevant gen

272 ic biology underlying the differentiation of pluripotent cells to cardiac lineages and describe curre

273 ellite cells and directed differentiation of pluripotent cells to mature skeletal muscle have proved

274 nds to achieve efficient conversion of human pluripotent cells to NCSCs in ~15 d.

275 factors that would be sufficient to instruct pluripotent cells to organize the embryo.

276 f7l1 as a unique factor that is necessary in pluripotent cells to prepare them for lineage specificat

277 ly development is governed by the ability of pluripotent cells to retain the full range of developmen

278 essary for a rapid switch in the response of pluripotent cells to Wnt/beta-catenin stimulation, from

279 imary human cells, including multipotent and pluripotent cells, to uncover both the underlying mechan

280 method for directed differentiation of human pluripotent cells toward neural crest stem cells has yet

281 lar mechanisms found in germ cells and other pluripotent cell types and identify genetic regulators o

282 Human embryonic stem cells (hESCs) are pluripotent cell types derived from the inner cell mass

283 nocytic stem cells in the hair follicle, and pluripotent cell types from the hair follicle and papill

284 Differences between pluripotent cell types were not observed in carbohydrate

285 lled stem cells, even though they range from pluripotent cells-typified by embryonic stem cells, whic

286 During embryonic development, uncommitted pluripotent cells undergo progressive epigenetic changes

287 e 3D chromatin landscape of naive and primed pluripotent cells, unveiling common features as well as

288 efficient targeting of three genes in human pluripotent cells using zinc-finger nuclease (ZFN)-media

289 x: How is cell-cycle progression possible in pluripotent cells when oscillations of key regulatory pr

290 Pluripotent cells, when fused with somatic cells, have t

291 ligase III, SSrp1, Xrcc-6/Ku70, and Parp2 in pluripotent cells, which decreased during the differenti

292 s transition coincides with the formation of pluripotent cells, which in mammals can be used to gener

293 In clinical practice, most pluripotent cells will be differentiated into useful the

294 Studies have shown that pluripotent cells with abnormal karyotypes may grow fast

295 is possible to apply genome editing to human pluripotent cells with minimal impact on genomic mutatio

296 e site-specific genome modification in human pluripotent cells with similar efficiency and precision

297 Pluripotent cells within embryonal carcinoma (EC) can di

298 approach is accomplished directly from human pluripotent cells without the need for coculture on feed

299 generate hematopoietic stem cells from human pluripotent cells would enable many biomedical applicati

300 In vitro differentiation of pluripotent cells yields mostly alpha- and polyhormonal