ライフサイエンスコーパス: pneumonic plague

1 bacterium Yersinia pestis results in primary pneumonic plague.

2 sease that can manifest as either bubonic or pneumonic plague.

3 and F1 antigens protected mice in a model of pneumonic plague.

4 ce for the pathogenesis of plague, including pneumonic plague.

5 dent manner in the lungs during experimental pneumonic plague.

6 e cells to vaccine-primed protection against pneumonic plague.

7 . pestis infection, an experimental model of pneumonic plague.

8 terized an intranasal mouse model of primary pneumonic plague.

9 llular immunity will most effectively combat pneumonic plague.

10 ion, protected mice in models of bubonic and pneumonic plague.

11 able impact on the progression or outcome of pneumonic plague.

12 stis KIM, the etiologic agent of bubonic and pneumonic plague.

13 of Yersinia pestis, the agent of bubonic and pneumonic plague.

14 pestis causes the fatal respiratory disease pneumonic plague.

15 nuation at 11 or 12 LD50 in a mouse model of pneumonic plague.

16 3SS as a potential vaccine candidate against pneumonic plague.

17 icantly protected from developing subsequent pneumonic plague.

18 pha and IFN-gamma in protecting mice against pneumonic plague.

19 d for production of bubonic, septicemic, and pneumonic plague.

20 a pestis, the causative agent of bubonic and pneumonic plague.

21 mportant for development of both bubonic and pneumonic plague.

22 ing specific roles for these pathways during pneumonic plague.

23 d lethality in murine models of systemic and pneumonic plague.

24 ironment during the preinflammatory phase of pneumonic plague.

25 , Yersinia-specific sRNA in a mouse model of pneumonic plague.

26 m that is the causative agent of bubonic and pneumonic plague.

27 positive strains of Y. pestis in bubonic and pneumonic plague.

28 th Yersinia pestis, the agent of bubonic and pneumonic plague.

29 a live attenuated cell-based vaccine against pneumonic plague.

30 bt, that plays a role in the pathogenesis of pneumonic plague.

31 anism and the causative agent of bubonic and pneumonic plague.

32 for virulence in mouse models of bubonic and pneumonic plague.

33 the use of an iron dextran-treated model of pneumonic plague.

34 CO92 in mouse and rat models of bubonic and pneumonic plague.

35 pigmented Yersinia pestis does not result in pneumonic plague.

36 e was no disease pathology characteristic of pneumonic plague.

37 tis primes T cells that protect mice against pneumonic plague.

38 n in virulence in mouse models of bubonic or pneumonic plague.

39 derivative, V10, to protect these rats from pneumonic plague.

40 to become the causative agent of bubonic and pneumonic plague.

41 . pestis CO92 in mouse models of bubonic and pneumonic plague.

42 pestis is the etiologic agent of bubonic and pneumonic plagues.

43 ulmonary infection by Yersinia pestis causes pneumonic plague, a necrotic bronchopneumonia that is ra

44 Vaccines against primary pneumonic plague, a potential bioweapon, must be tested

45 of the bacterium Yersinia pestis causes the pneumonic plague, a rapidly fatal disease.

46 ulmonary infection by Yersinia pestis causes pneumonic plague, a rapidly progressing and often fatal

47 Acute pneumonic plague accompanies the up-regulation of pro-in

48 pestis is the causative agent of bubonic and pneumonic plague, an acute and often fatal disease in hu

49 am-negative bacterium Yersinia pestis causes pneumonic plague, an acutely lethal septic pneumonia.

50 he potential virulence properties of Psa for pneumonic plague, an Escherichia coli strain expressing

51 Pneumonic plague, an often-fatal disease for which no va

52 on with the bacterium Yersinia pestis causes pneumonic plague, an often-fatal disease for which no va

53 rat as an alternative small animal model for pneumonic plague and characterized both the efficacy and

54 studying T-cell-mediated protection against pneumonic plague and demonstrates the capacity for live,

55 ficantly affected by the Pla protease during pneumonic plague, and although A2AP participates in immu

56 ynergistically in protecting animals against pneumonic plague, and we have demonstrated an immunologi

57 onsequences of neutrophil recruitment during pneumonic plague, and we studied the susceptibility of C

58 rsinia pestis-laden aerosols that results in pneumonic plague, arming both the mucosal and systemic i

59 n CO92 and screened them in a mouse model of pneumonic plague at a dose equivalent to 5 50% lethal do

60 dicate that Y. pestis was capable of causing pneumonic plague before it evolved to optimally cause in

61 lly virulent in animal models of bubonic and pneumonic plague but also break through immune responses

62 is essential for Y. pestis to cause primary pneumonic plague but is less important for dissemination

63 d Yersinia pestis confers protection against pneumonic plague but is not considered safe for general

64 uvant to enhance protective immunity against pneumonic plague, but in a dose-dependent fashion.

65 ation protected mice from lethal bubonic and pneumonic plague caused by CO92, a wild-type F1+ strain,

66 Pneumonic plague, caused by inhalation of Yersinia pesti

67 ation resulted in partial protection against pneumonic plague challenge with 250 MLD Y. pestis CO92,

68 ague have highlighted a significant role for pneumonic plague during outbreaks of Y. pestis infection

69 is review we describe the characteristics of pneumonic plague, focusing on its disease progression an

70 Yersinia pestis, which causes bubonic and pneumonic plague, forms pigmented red colonies on Congo

71 lence testing in mouse models of bubonic and pneumonic plague found only a modest increase in surviva

72 a pestis, the causative agent of bubonic and pneumonic plagues, has undergone detailed study at the m

73 course, severity, and difficulty of treating pneumonic plague highlight how differences in the route

74 protease is essential for the development of pneumonic plague; however, the complete repertoire of su

75 For pneumonic plague, immunized mice required immunity to bo

76 severely attenuated Y. pestis CO92 to evoke pneumonic plague in a mouse model while retaining the re

77 ighly attenuated in evoking both bubonic and pneumonic plague in a mouse model.

78 The mean lethal dose (MLD) for pneumonic plague in guinea pigs was estimated to be 1000

79 Yersinia pestis causes primary pneumonic plague in many mammalian species, including hu

80 ented Y. pestis were reported to cause fatal pneumonic plague in mice, suggesting a useful model for

81 in virulence for bubonic plague but not for pneumonic plague in mice.

82 To develop an alternative to pneumonic plague in nonhuman primates, we explored guine

83 ting type III secretion in the prevention of pneumonic plague in rats and reveal critical contributio

84 deeply rooted strains of Y. pestis to cause pneumonic plague, indicating that Y. pestis was primed t

85 Pneumonic plague is a deadly respiratory disease caused

86 Human pneumonic plague is a devastating and transmissible dise

87 Disease progression of primary pneumonic plague is biphasic, consisting of a preinflamm

88 Pneumonic plague is one of the world's most deadly infec

89 Although pneumonic plague is the deadliest manifestation of disea

90 Pneumonic plague is the most severe manifestation of pla

91 Primary pneumonic plague is transmitted easily, progresses rapid

92 m-negative bacterium that causes bubonic and pneumonic plague, is able to rapidly disseminate to othe

93 In a coinfection model of pneumonic plague, it appears that Yersinia pestis quickl

94 Despite the importance of pneumonic plague, little is known of the early pulmonary

95 rovide 90 to 100% survivability to mice in a pneumonic plague model at 20 to 50 LD50.

96 double mutant was still fully virulent in a pneumonic plague model but had an approximately 90-fold

97 he Deltalpp or DeltamsbB single mutant, in a pneumonic plague model were significantly protected agai

98 Surprisingly, via intranasal instillation (pneumonic plague model), we saw a difference in the viru

99 In murine pneumonic plague models, passive transfer of convalescen

100 virulence of Y. pestis in either bubonic or pneumonic plague models.

101 In a parallel study with the pneumonic plague mouse model, after 72 h postinfection,

102 also attenuated (40 to 100%) at 12 LD50 in a pneumonic plague mouse model.

103 tion mutant was decreased about 10-fold in a pneumonic plague mouse model.

104 caf mutant was as virulent as WT CO92 in the pneumonic plague mouse model; however, it was attenuated

105 portant role for RovA in bubonic plague than pneumonic plague or systemic infection.

106 ernative small animal model for the study of pneumonic plague pathogenesis and immunity.

107 Pneumonic plague represents the most severe form of dise

108 We hypothesized that the pathophysiology of pneumonic plague resulting from expression of proteins e

109 Pneumonic plague resulting from Yersinia pestis induces

110 that protect mice against bubonic plague and pneumonic plague, suggesting that rV10 may serve as an i

111 t is less important for dissemination during pneumonic plague than during bubonic plague.

112 ulence factors required for the induction of pneumonic plague that are independent of iron scavenging

113 ared to the WT bacterium in a mouse model of pneumonic plague, the Deltalpp Deltaail double mutant an

114 le this modification is unnecessary to cause pneumonic plague, the substitution is instead needed to

115 utant and comparing its ability in mediating pneumonic plague to that of the wild type in two animal

116 ary Y. pestis challenge, and we suggest that pneumonic plague vaccines should aim to induce mixed typ

117 vations strongly suggest that development of pneumonic plague vaccines should strive to prime both CD

118 To aid the development of safe and effective pneumonic plague vaccines, we are deciphering mechanisms

119 y host response during the course of primary pneumonic plague was investigated in two mouse strains,

120 tis virulence in mouse models of bubonic and pneumonic plague, we characterized an msbB in-frame dele

121 sing the C57BL/6 mouse models of bubonic and pneumonic plague, we determined that all of these genes

122 produces a severe primary pneumonia known as pneumonic plague, which is contagious and highly lethal

123 esidues 271-300, elicited protection against pneumonic plague, which seemed to be based on conformati

124 illation, these rats rapidly developed fatal pneumonic plague within 2 to 4 days of infection.