ライフサイエンスコーパス: pocket

1 loop 2 (EL2) at the entrance to the binding pocket.

2 conformation and also reorient while in its pocket.

3 lated to a rapid CO2 accumulation in the air pocket.

4 ent complementary information on the binding pocket.

5 acid residues in the receptor ligand-binding pocket.

6 by a characteristic peptide binding groove B pocket.

7 LIMK activity by binding to the ATP-binding pocket.

8 that 3'-adenosine may occupy the ATP-binding pocket.

9 formational changes in the substrate-binding pocket.

10 erved aromatic residue in the ligand-binding pocket.

11 like NLS1 that associates with the minor NLS-pocket.

12 inhabits the gingival sulcus or periodontal pocket.

13 the size and shape of the substrate binding pocket.

14 ss to key catalytic residues lining the RuvC pocket.

15 ons between the modulators and their binding pocket.

16 e alpha-helix close to the substrate-binding pocket.

17 rizability of the environment in its binding pocket.

18 ghlighted the versatility of the MR1 binding pocket.

19 acids surrounding the ligand in the binding pocket.

20 rangement and protection of the heme binding pocket.

21 ices, which have a large hydrophobic central pocket.

22 ve of which acetyl mark is inserted into the pocket.

23 tricting the pathway toward the deep binding pocket.

24 as it sits deep within the receptor-binding pocket.

25 posed region of the enzyme catalytic binding pocket.

26 ositioning them distant from the active site pocket.

27 bset of nucleotides in the cobalamin-binding pocket.

28 the nearby Tyr(62) within this same binding pocket.

29 kely dictates its orientation in the binding pocket.

30 ophobic channel adjacent to the heme-binding pocket.

31 b(2+) cofactor is bound at the pre-organized pocket.

32 ene-1,2-diyl bridging unit in the bimetallic pocket.

33 only if the CBI monomer possesses molecular pockets.

34 pnictides containing both electron and hole pockets.

35 lectrostatic interactions with ACE catalytic pockets.

36 and non-target DNA strand cleavage catalytic pockets.

37 se-like activity to create substrate binding pockets.

38 ge at the boundary between electron and hole pockets.

39 ends tucked inside the major A and F binding pockets.

40 g the structural relationships of functional pockets.

41 cking into one of hAgo1's tryptophan-binding pockets.

42 se microenvironments, known as Hematopoietic Pockets.

43 pY site while pS1493 binds an unanticipated pocket 70 A distant.

44 ttachment by the flagellum and the flagellar pocket, a Leishmania-like flagellum attachment zone, and

45 These pockets accommodate a wide range of residues, while main

46 vins bind to Asn263 and Asp206, which form a pocket adjacent to the active site, and galloyl-containi

47 First, we identified a shallow pocket adjacent to the groove in the N-terminal region o

48 ed in expelling the product from the binding pocket after the reaction is complete.

49 bound anticooperatively within well-defined pockets; an X-ray crystal structure of three fullerenes

50 sZ CTD residue Phe-377 inserts into the ZapD pocket, anchoring the CTD in place and permitting hydrop

51 und that HLA-DQ2.5 has an unusually large P4 pocket and a positively charged peptide-binding groove t

52 s have the Ntn-hydrolase fold, a putative S1 pocket and conserved candidate catalytic residues Thr1,

53 at POmega, which enabled them to open the F pocket and expose their C-terminal extension into the so

54 avel past the loop to reach the deep binding pocket and from there are transported outside the cell v

55 tudies revealed binding to the basic surface pocket and interactions between the allylic hydroxyl gro

56 the shape and size of the substrate binding pocket and its mutation has major long-range effects.

57 no FFA is observed and the ceramide binding pocket and putative zinc catalytic site are exposed to t

58 that both variants alter the GTP/GDP binding pocket and show that they both have localization pattern

59 pendent on an intact receptor ligand-binding pocket and that FES binds to ERalpha with high specifici

60 formation that shapes the ATP ribose binding pocket and that is preferred in CDK2 but has not been ob

61 the hydrophobicity of the substrate binding pocket and the plasticity of the amino acids surrounding

62 rizability of the environment in its binding pocket and, more importantly, to the conformation of its

63 an oral microbiome that inhabits periodontal pockets and contributes to chronic periodontitis.

64 inoculated both cervically and in salpingeal pockets and in one of three persistently infected animal

65 LM to FMUD leads to better reduction of deep pockets and Pg at 6 months compared with FMUD alone.

66 ceptor that can be exploited as drug binding pockets and the ability of individual drugs to enrich su

67 ed DNA of natural ferns, their enriched leaf pockets and water filtrate from the surrounding ditch es

68 ove relaxation, modifications of key binding pockets, and domain adjustments.

69 erplay among the helical assembly, molecular pockets, and solvent molecules is further unraveled by e

70 The ligand binding pockets are allosterically tuned by monoprotonation of t

71 optimization, open, solvent-exposed protein pockets are often disregarded as prospective binding sit

72 A wide proline pocket as well as molecular complementarity and capping

73 Even pockets as tightly defined and as deeply studied as that

74 lex with cholesterol, which sits in a closed pocket at the centre of the lipocalin barrel.

75 e same general region, but in a distinct sub-pocket at the interface between helices V and VI, which

76 ggest a Fermi liquid behavior with two Fermi pockets at low temperatures.

77 onstruct a similarity network of RNA-binding pockets based on a non-sequential-order structure alignm

78 mer, filling a deep hydrophobic channel-like pocket between two PD-L1 molecules.

79 area, volume, and thickness of maximum fluid pockets between the 2 surgical techniques, but both tech

80 Proportion of teeth with pocket, bleeding, or calculus; number of DMFT; toothbrus

81 orient substituents toward S1, S1', and S2' pockets both in the solution and in the bound states.

82 ly contributed to lowering O2 levels in leaf pockets but did not release detectable amounts of the st

83 anche, is possible in the presence of an air pocket, but limited in time as hypoxia and hypercapnia r

84 c) superconductors, which have no hole Fermi pockets, but have a notably high T c, have challenged th

85 ts that isoflurane and propofol bind to this pocket by forming H-bond and halogen-bond interactions w

86 n the organization of water within a binding pocket can alter the thermodynamics of protein-ligand as

87 est that controlling access to the adenosine pocket can contribute to substrate specificity but is no

88 The organization of water within a binding pocket can thus determine whether the hydrophobic intera

89 specialty, pharmacy benefit manager, out-of-pocket cost (copay), clinical diagnoses, lipid-lowering

90 in Medicare, the corresponding total out-of-pocket cost will increase from $9,200 to $57,000 (520% i

91 g kidney donors have donation-related out-of-pocket costs (direct costs) and/or ongoing daily expense

92 ing a nursing home and the associated out-of-pocket costs are important for the saving decisions by i

93 on up to 18 y of nursing home use and out-of-pocket costs drawn from the Health and Retirement Study,

94 n 1-year adherence to AET and whether out-of-pocket costs explain the racial/ethnic disparities in ad

95 Out-of-pocket costs for AET medication were associated with low

96 Out-of-pocket costs for AET medications were standardized for a

97 Limiting out-of-pocket costs for expensive anticancer drugs like the IMi

98 me subsidy (LIS) substantially lowers out-of-pocket costs for qualifying Medicare Part D beneficiarie

99 To characterize Medicare and patient out-of-pocket costs for topical steroids, and to model potentia

100 For individual patients, the high out-of-pocket costs of PCSK9 inhibitors may impede access and r

101 ) gained, healthcare costs saved, and out-of-pocket costs were estimated for each SEIFA quintile.

102 caregiver burden, time tradeoffs, and out-of-pocket costs.

103 atch and/or the tyrosine-based motif binding pocket could rescue the micro1 knockout phenotype comple

104 We show that a pocket created near the active site base of the enzyme k

105 age of sites (0%, <30%, >/=30%) with probing pocket depth (PD) >/=4 mm, and NAFLD status was determin

106 irwise comparison of 90,000 putative binding pockets detected in 3,700 proteins, and find that 23,000

107 s can submit either a PDB ID or PDB file for pocket detection to our NVIDIA GPU-equipped servers thro

108 nt to a computationally designed hydrophobic pocket during directed evolution.

109 n a combination of hydrophobic and auxiliary pocket effects that yielded high ( approximately 500-fol

110 Rhizobiales genomes were identified in leaf-pocket-enriched samples from ditch grown A. filiculoides

111 Averaged over all persons, total out-of-pocket expenditures looking forward from age 57 were app

112 t burden was reported by some with no out-of-pocket expenses (presumably due to lost wages and contin

113 A large glycan binding pocket extends into the dimeric interface, and docking o

114 Pockets extruding from either side of the microchannels

115 ceptor by binding to an extended hydrophobic pocket facilitated by the large outward movement of the

116 sted an optimal binding to the NNRTI binding pocket favoring the high anti-viral potency.

117 satisfaction and were willing to pay out of pocket for access to such services.

118 ) and the proportion of people paying out-of-pocket for healthcare from 34.4% to 58.7% (RR = 1.69) be

119 The structures reveal a common binding pocket for negative allosteric modulators, present in bo

120 TMM interaction with ERL1 creates a binding pocket for recognition of EPF1 and EPF2, indicating that

121 -type (WT), leads (A) to the loss of the V27 pocket for the adamantyl cage and to a predominant orien

122 cilitated the prediction of possible binding pockets for small molecules and definition of correspond

123 The methyltransferase contains in-line pockets for substrate binding and the active site.

124 degradation; and (4) intermediate micro-gas pocket formation in the neighboring tissue ex vivo model

125 screened for the presence of small druggable pockets formed from contributions from both proteins.

126 ed a constrained, horseshoe-shaped substrate pocket, formed from an alpha-helix, a 310 helix, and a r

127 HDP structure in the heme/hemoglobin-binding pockets from Maybridge Screening Collection identified a

128 the H526Y mutation reshapes the RIF binding pocket, generating significant steric conflicts that ess

129 p presented lower means of probing depth for pockets >/=7 mm at 6 months (4.0 +/- 1.7 mm) compared wi

130 We conclude that the Ub-binding pocket has a chaperone function involved in bud initiati

131 poverty gap increase attributable to out-of-pocket health expenditures among the 122 countries in ou

132 centage of people in households whose out-of-pocket health expenditures are large relative to their i

133 pital stays, and (4) total annual and out-of-pocket healthcare expenditures.

134 tagenesis of residues within the GDP-binding pocket identified Arg(93) as playing a key role in the n

135 e AR AF-1 are within a potentially druggable pocket, implicating Bag-1L as a potential therapeutic ta

136 insights into a proposed allosteric binding pocket in BGT1, which accommodates the binding site for

137 ver, their favorable interactions with the A-pocket in conjunction with VDR translocation studies sug

138 abidopsis ABA receptors, but the ABA binding pocket in FePYR1 shows discrepant residues resulting in

139 that altered structures surrounding the RBS pocket in MACV GP1 impede access of JUNV-elicited antibo

140 terminus binds to the well-known p53-binding pocket in mdm2 whereas the N-terminal helix serves as an

141 aliphatic tail (KK174), we mapped a binding pocket in mVDAC1 localized to Thr(83) and Glu(73), respe

142 an interaction of JNJ0966 with a structural pocket in proximity to the MMP-9 zymogen cleavage site n

143 RPA phosphorylation and a positively charged pocket in PRP19.

144 nto the interlayer space pointing toward the pocket in the adjacent layer.

145 ling revealed that MB-10 binds to a specific pocket in the C-terminal domain of Tim44 of the protein-

146 he dynamic nature of the polypeptide-binding pocket in the Hsp70 chaperone cycle.

147 the temperature is lowered, a small electron pocket in YbAl3 becomes completely unoccupied while the

148 the polymorphic MHC specificity determining pockets in a way that leads to high-affinity peptide bin

149 lignment strategy, the consensus RNA-binding pockets in each group are identified.

150 B separates the access and deep drug binding pockets in every protomer.

151 resolution and shows that it fills three key pockets in the active site.

152 An Skp2/Cks1 pocket inhibitor preferentially collapsed DKO prostate t

153 class II alleles which share the HLA-DRB1-P4 pocket is also observed.

154 or PtdCho into and through the lipid-binding pocket is chaperoned by sets of PITPalpha residues conse

155 Strikingly, the polypeptide-binding pocket is completely closed, seemingly excluding any sub

156 ting access mechanism, where the ion-binding pocket is exposed in succession either to the extracellu

157 that, although proton sensing in the acidic pocket is not required for channel function, it does con

158 ch the motion of the H3O(+) ion in the crown pocket is strongly coupled with its OH stretches.

159 s form a covalent adduct near the Ub-binding pocket leading to the disruption of Ub, but not PTAP bin

160 the antagonist A-967079 a potential binding pocket lined by residues in the S5, S6, and the first po

161 lipolytic enzymes with the specific binding pocket located at the cap domain instead of the interfac

162 ing of the farnesyl group to the hydrophobic pockets located at both CaM lobes further enhanced CaM-H

163 dhood cancer were more likely to have out-of-pocket medical costs >/= 10% of annual income (10.0% v 2

164 higher percentage of income spent on out-of-pocket medical costs (>/= 10% of annual income) and issu

165 higher percentage of income spent on out-of-pocket medical costs was significantly associated with p

166 ants reported their household income, out-of-pocket medical costs, and issues related to financial bu

167 higher percentage of their income on out-of-pocket medical costs, which may influence their health-s

168 Out-of-pocket medical spending and financial burden (OOP expend

169 ng minorities, and is associated with out-of-pocket medication costs.

170 Subsequent to binding pocket modifications designed to provide dual d-Ala-d-Al

171 reported and was found to provide a binding pocket-modified vancomycin analog with a second mechanis

172 d drug design to target small molecules to a pocket near the p38alpha glutamate-aspartate (ED) substr

173 chieved by blocking the enzymes' specificity pockets, nearby exosites, and downstream domains.

174 itors, which significantly overlaps with the pocket occupied by some H3 HA-specific inhibitors, indic

175 ructural studies have identified the binding pocket of 1-EBIO and NS309 that is located at the interf

176 adipose tissue; and in a third, an anomalous pocket of adipose tissue in the central vitreous.

177 and relies on the hydrophobic ligand-binding pocket of AHR, with identical structural signatures for

178 NMR studies confirmed the pocket of binding of 12 as predicted by the Glide dockin

179 tifying novel substituents for the apolar S2 pocket of cathepsin L and was conducted entirely in a pr

180 The plasticity of the binding pocket of CB1 seems to be a common feature among certain

181 nd allow for an optimum fit into the binding pocket of CeuE, the inter-planar angle in the structure

182 ntaminants of American hives into the active pocket of CYP9Q1, a broadly substrate-specific P450 with

183 method (multiple site test from the deepest pocket of each quadrant [MT4]; control).

184 gingival plaque was sampled from the deepest pocket of each quadrant by using paper points and by gai

185 terations were made to enlarge the adenosine pocket of EhACK and reduce that of MtACK.

186 ing that, within the confines of the binding pocket of HCAII, binding events associated with enthalpi

187 the interaction of PK11195 with the binding pocket of hCAR to favor activation.

188 glutamate residue embedded in a hydrophobic pocket of HdeA, is important in controlling HdeA stabili

189 is poised for transfer into the heme-binding pocket of IsdB.

190 Here we mapped the H4-tail binding pocket of ISWI.

191 he K36M residue interacts with the catalytic pocket of SETD2.

192 is studies demonstrated residues in the back pocket of the active site are important for GSK690693 se

193 s the P-CR connector loop into a hydrophobic pocket of the catalytic core, with the coiled-coil align

194 Their interactions with the allosteric pocket of the enzyme were characterized by crystallograp

195 to the various surface charges of the active pocket of the enzyme, which may make their combination m

196 ign to target the conserved receptor-binding pocket of the hemagglutinin protein and to match the tri

197 well-accessible hydrophobic S1' specificity pocket of the metalloprotease thermolysin with purposefu

198 -methylscopolamine (NMS) bind to the binding pocket of the muscarinic acetylcholine receptor formed b

199 dentify one residue in the substrate binding pocket of the phosphatase domain that confers specificit

200 g liquid in a metastable state, with trapped pockets of air between the substrate and the liquid.

201 nsformation, in the form of small ( 5-10 nm) pockets of alpha-SiC forming in the beta matrix.

202 late or form clathrates within the molecular pockets of CBI-35CH at low temperature (263 K), thereby

203 s of interaction with two tryptophan-binding pockets of CNOT9, previously found to interact with anot

204 ic environment resembling the constraints in pockets of enzymes stabilizing active sites.

205 particular positions in the peptide-binding pockets of HLA-DRB1 molecule account for a significant i

206 Small pockets of low magnetic field strength, small radius of

207 e presence of DNA is revealed, and druggable pockets of p53 are identified via solvent mapping to aid

208 be able to survive future climate change in pockets of suitable microclimate, termed 'microrefugia'.

209 y whilst simultaneously tackling significant pockets of sustained or increasing transmission.

210 used in many of the region's countries, and pockets of unimmunized or underimmunized children exist

211 three small rotationally equivalent electron pockets, offering a valley degree of freedom to charge c

212 ruside, which targets a distinct, non-taxoid pocket on beta-tubulin.

213 ifferent chains, that inserts into a central pocket on JUNV GP1 and effectively mimics the contacts m

214 s 125-128 of AKAP79) that occupies a binding pocket on PP2B utilized by the immunosuppressive drug cy

215 sphorylated Thr-348 to an allosteric binding pocket on the kinase domain.

216 eport the identification of a new allosteric pocket on Ube2T through a fragment screening using bioph

217 rt of the UIS, occupies a negatively charged pocket on UFM1's surface.

218 rotruding from RidL inserts into a conserved pocket on VPS29 that is also used by cellular ligands, s

219 ork community decomposition, the RNA-binding pockets on protein surfaces are clustered into groups wi

220 Large-scale RNA-binding pockets on protein surfaces are grouped by measuring the

221 RNA-binding events often take place at pockets on protein surfaces.

222 both histones 3 and 4 via bipartite binding pockets on the DPF2 surface.

223 ening methodologies and well-defined binding pockets on the Ras proteins.

224 of a lack of adequate small-molecule-binding pockets on the Ras surface.

225 ace analysis of K1-K10-2B identified several pockets, one adjacent to the disulfide linkage and conse

226 To measure out-of-pocket (OOP) costs incurred by Medicare beneficiaries wi

227 etail the trends in use and total and out-of-pocket (OOP) expenditures associated with statins in a r

228 ned trends in TOAM prices and patient out-of-pocket (OOP) payments in Medicare Part D and estimated t

229 Here, we show that the mechanism of F pocket opening is dictated by the charge of the first ch

230 tatic interactions, without specific binding pockets or penetration into the lipid bilayer.

231 Calculus, pocket, or bleeding presence at age 24 years separately

232 surface of this compound consists of several pockets originating from fairly compensated multi-band e

233 -IDL also binds with the shallow hydrophobic pocket outside the groove of the NHR trimer, resulting i

234 luid volume (P = .002), largest fluid volume pocket (P = .002), max fluid area (P = .006), mean fluid

235 The potential health care savings and out-of-pocket patient savings from substitution of the cheapest

236 Total and potential Medicare and out-of-pocket patient spending.

237 smoking, physical activity, obesity, out-of-pocket payments and unmet needs for healthcare using nat

238 Composition of the methyllysine-binding pocket plays an essential role in determining the select

239 n extended pocket that connects two isolated pockets previously found to engage small-molecule ligand

240 A higher out-of-pocket price for mental health care may lead not only to

241 tch national government increased the out-of-pocket price of mental health services for adults by up

242 partner DP1 reveals the molecular basis for pocket protein-E2F binding specificity and how cyclin-de

243 in-dependent kinases differentially regulate pocket proteins through CTD phosphorylation.

244 The characterisation of the allosteric pocket provides a new and novel target for rational P2X7

245 et it remains unclear where the drug binding pocket resides.

246 L12W/T48W substitutions within the binding pocket resulted in a 9-fold decrease in drug response, s

247 1 that corresponds to the allosteric binding pocket revealed by the hSERT crystal structure.

248 a range of other enzymes having constrained pocket-shaped active sites.

249 ever, has been hindered by their constrained pocket-shaped active sites.

250 but lacking general-base capability in this pocket shuts off rescue.

251 s breathing into snow with an artificial air pocket, snow density had a direct influence on ventilati

252 drop can spread and recoil over trapped air pockets so quickly that it can completely bounce off the

253 In all countries, out-of-pocket spending can be both catastrophic and impoverishi

254 We find impoverishment due to out-of-pocket spending even in countries where the entire popul

255 ount and poverty gap with and without out-of-pocket spending included in household total consumption.

256 Patients' annual out-of-pocket spending increased from $41.4 million to $101.8 m

257 been a sharp increase in Medicare and out-of-pocket spending on topical steroids that is driven by hi

258 in peptide binding specificities and binding pocket structure.

259 Nostoc azollae residing in specialized leaf pockets supports prolific growth of the floating fern Az

260 s that the resistance mutations cluster in a pocket surrounding the branch point adenosine, suggestin

261 s on TM3 and TM7 form a broad ligand-binding pocket that can accommodate the diverse structural featu

262 biquitin (Ub) E2 variant (UEV) domain with a pocket that can bind PT/SAP motifs and another pocket th

263 cket that can bind PT/SAP motifs and another pocket that can bind Ub.

264 ell as conserved elements in the PAR-binding pocket that can serve as hotspots for the development of

265 or domain is remodeled to expose an extended pocket that connects two isolated pockets previously fou

266 emethoxystreptonigrin binds in a hydrophobic pocket that mainly consists of cap domain residues and i

267 res, highlighting flexibility in the binding pocket that may facilitate the development of A2AR-selec

268 nding on its surface, along with a catalytic pocket that predominantly assumes a closed conformation.

269 hat calcium is concentrated in intracellular pockets that are subsequently exported from the cell whe

270 oove comprising two electronegative B- and E-pockets that coincide with the preference for P2 and P7

271 The surface state connects hole and electron pockets that would otherwise be separated by an indirect

272 site by making interactions with the binding pocket, thus acting predominantly as a competitive antag

273 e of the protease without addressing the S1' pocket, thus transforming it into an enclosed cavity.

274 s a highly unfavorable side chain for the p9 pocket to an optimal one that is dependent on the beta57

275 tituents placing polar decoy groups into the pocket to capture putatively present water molecules cou

276 the key residues in the 5-nucleotide binding pocket to compensate for the change introduced by the mo

277 actions between residues in the NADH-binding pocket to facilitate substrate turnover in the DD-CoA bi

278 of PI3Kalpha to progressively transform the pocket to mimic that of ATR.

279 binds DNA; and (2) Est1 employs two separate pockets to bind distinct motifs of Cdc13.

280 sive benchmark comparing LDM-refined binding pockets to GPCR X-ray crystal structures across seven di

281 ding to other receptors with similar binding pockets to select iterative series of minilibraries.

282 emtosecond-assisted 9.5-mm diameter lamellar pocket under topical anesthesia.

283 -carboxamide, ML402-define a cryptic binding pocket unlike other ion channel small-molecule binding s

284 bservation of crystallization within surface pockets using optical microscopy and also interferometry

285 In both animals inoculated in salpingeal pockets, viable M. genitalium was recovered for 2 weeks.

286 Specific contrast from dental pockets was achieved with food-grade cuttlefish ink as a

287 ants, targeted to the NADH co-factor binding pocket were created.

288 de test positivity and three or more >/=4 mm pockets were associated with vitamin D receptor (VDR) (r

289 We demonstrated that these pockets were functionally important for 5-LOX activity.

290 Two propofol binding pockets were identified near the active site of 5-LOX.

291 which a set of 13,858 small molecule binding pockets were identified.

292 ine teeth (12 teeth with artificially deeper pockets) were treated with the contrast agent, and the p

293 n of a deep, solvent-accessible, active-site pocket, which may allow recognition of specific, structu

294 In the center of the barrel is a deep pocket, which, based on mutagenesis data and amino acid

295 ubdomain, in contrast, had a well-delineated pocket with a small molecule that we identified as lacta

296 -C alleles sharing a common binding groove F pocket with HLA-C*04:01.

297 portion of teeth with calculus, bleeding, or pocket with income; number of lost teeth; sex; education

298 hat bind to diverse Cyp isoforms in distinct pockets with low millimolar dissociation constants.

299 nary structures for the formation of binding pockets with uniform size and function.

300 h other eradication efforts, these high-risk pockets witnessed an increase in full routine immunizati