ライフサイエンスコーパス: podophyllotoxin

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1 otubule depolymerizing drugs (colchicine and podophyllotoxin).

2 he important antiviral and anticancer agent, podophyllotoxin.

3 ymerization is retarded but not prevented by podophyllotoxin.

4 synthetic epimerization and demethylation of podophyllotoxin.

5 immediate precursor of etoposide and, unlike podophyllotoxin, a potent topoisomerase inhibitor.

6 Podophyllum species are sources of (-)-podophyllotoxin, an aryltetralin lignan used for semi-sy

7 In addition, podophyllotoxin and CA-4 inhibited the binding of compou

8 e of the potent antimitotic natural products podophyllotoxin and combretastatin A-4 and to that of NS

9 ve evolved in vascular plants; some, such as podophyllotoxin and enterodiol, have important roles in

10 first catalytic, asymmetric synthesis of (-)-podophyllotoxin and its C(2)-epimer, (-)-picropodophylli

11 Podophyllotoxin and nocodazole, other colchicine site li

12 38067 and the noncovalent agents colchicine, podophyllotoxin, and 2-methoxyestradiol.

13 ent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4.

14 g effects comparable to those of colchicine, podophyllotoxin, and combretastatin A-4.

15 ent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4.

16 ent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4.

17 Polygamain has structural similarities to podophyllotoxin, and molecular modeling simulations were

18 Derivatives of alpha-conidendrin, podophyllotoxin, and sikkimotoxin were prepared to evalu

19 Several pinacol derivatives of podophyllotoxins bearing different side chains and funct

20 cation of enzymes putatively involved in (-)-podophyllotoxin biosynthesis and underscores the deducti

21 genes previously established as involved in podophyllotoxin biosynthesis as well as other candidate

22 ace similar to the trimethoxyphenyl group of podophyllotoxin but with distinct interactions within th

23 A novel podophyllotoxin derivative, XWL-1-48, was synthesized as

24 bited the binding of crocin to tubulin while podophyllotoxin did not inhibit the crocin binding indic

25 nacol (7beta-OH) series behaved similarly to podophyllotoxin in all the assays and proved to be the m

26 8-8'-lignans, including the antiviral agent podophyllotoxin in Podophyllum species and its semi-synt

27 (lactonization, SEM deprotection) or to (-)-podophyllotoxin, in three steps, through the introductio

28 GTP and taxol or DMSO, is very sensitive to podophyllotoxin inhibition, and can overcome urea-mediat

29 Podophyllotoxin is the natural product precursor of the

30 xol, colchicine, or other MBAs (vincristine, podophyllotoxin, nocodazole) stimulated the activity of

31 bited by the antimicrotubule drugs Colcemid, podophyllotoxin, nocodazole, and vinblastine.

32 bioactive small molecules including AZD6244, podophyllotoxin, paclitaxel, and docetaxel.

33 apple) to identify biosynthetic genes in the podophyllotoxin pathway.

34 ran derivatives of alpha-conidendrin (ACON), podophyllotoxin (PT), and sikkimotoxin (SK) were prepare

35 A short total synthesis of podophyllotoxin, the prototypical aryltetralin lignan na

36 y bullatacin and various antimitotic agents (podophyllotoxin, vinblastine, and colchicine), but only

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