ライフサイエンスコーパス: point

1 5 percentage points (CI, 14 to 35 percentage points).

2 d overall survival (OS) as the secondary end point.

3 to establish a pivotal allosteric branching point.

4 core-matched populations was the primary end point.

5 ectrodes on the 384-MMEA to a single contact point.

6 ed radiographic stability at the 5-year time point.

7 nctional, QL or immune parameter at any time point.

8 ntial at full saturation and the turgor loss point.

9 ated acute kidney injury was a secondary end point.

10 appropriate materials to a quantum critical point.

11 exhibit critical scaling near the transition point.

12 f the Fermi energy with respect to the Dirac point.

13 nce intensity value of C1q-dnDSA at all time-points.

14 ecline compared with control eyes at all end points.

15 confirmation using traditional efficacy end points.

16 ts or -2 dB/year or more (P < 0.01) for edge points.

17 (LDL-CN or LDL-CF) category by clinical cut points.

18 ogression-free survival were the primary end points.

19 fied noninferiority margin of 3.2 percentage points.

20 d for bacterial colonization at various time points.

21 e differences in CRs not exceed 7 percentage points.

22 dritic spine density in the PFC at both time points.

23 across regenerative and nonregenerative time points.

24 or the expression values of the non selected points.

25 at capture financial and quality-of-life end points.

26 These critics made six major points.

27 ival and overall survival were secondary end points.

28 This commentary makes three points: (1) the existing evidence does not consistently

29 ficantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; h

30 baseline to after treatment deferral (-0.03 points [4.04]; -0.94 to 0.88; between-group difference C

31 b; IQR 40.8-59.3 for chemotherapy), at which point 415 patients had died (214 in the chemotherapy gro

32 ntly expanding over 500 km from its starting point [7-11].

33 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 9

34 with absolute differences of -7.4 percentage points (95% CI, -19 to 4.3 percentage points) to 25 perc

35 t share of detailed drugs of 1.67 percentage points (95% CI, -2.18 to -1.18 percentage points; P < .0

36 hare of nondetailed drugs of 0.84 percentage points (95% CI, 0.54 to 1.14 percentage points; P < .001

37 surance coverage increased by 4.9 percentage points (95% CI, 4.4 to 5.4), not having to forgo a physi

38 in group (difference in risk, 2.9 percentage points; 95% CI, 0.1 to 5.6).

39 p (difference in event rates, 0.7 percentage points; 95% confidence interval [CI], -1.5 to 2.8; P=0.0

40 ontrols, for a difference of 15.8 percentage points; 97.5% confidence interval [CI] 0.5-31.2; P = .02

41 KEY POINTS: A tonically active, muscarinic cholinergic inhib

42 dentity-based representation at several time points after 200 ms.

43 here was no observable benefit at early time points after transplantation, both anatomic and function

44 KEY POINTS: Ageing is associated with an increased risk of c

45 osseous artifacts, particularly split-based points, alongside the remains of Neanderthals is a resul

46 mpared between the 2 arms as the primary end point and overall survival (OS) as the secondary end poi

47 strategy was used for the second primary end point and the secondary end points in the final analysis

48 coupled as nucleosome sliding reaches an end point and this is controlled by the Ino80CTD.

49 However, the Weyl points and Fermi arcs live entirely above the Fermi leve

50 length (TICL) were compared among these time points and the nasal, temporal, and inferior quadrants.

51 KEY POINTS: Applications of transcranial direct current stim

52 .93 percent points) than urban (0.52 percent points) areas.

53 ; minimum clinically important difference, 1 point), assessed at 90 days by postal questionnaire (par

54 The point at which this occurs is modifiable, in this case c

55 ints at 30 days and 31.9 (95% CI, 31.3-32.6) points at 1 year.

56 he KCCQ-OS score of 27.6 (95% CI, 27.3-27.9) points at 30 days and 31.9 (95% CI, 31.3-32.6) points at

57 The package is developed based on a change-point based method with optimal computational complexity

58 th of the aluminas was determined with the 4-point bending test.

59 well as the spine mechanical properties (two-points bending tests) in a cidaroid (Eucidaris tribuloid

60 osynaptic plasticity shifted their operating point between regimes dominated by associative plasticit

61 ation is expected to improve success rate of point-by-point radiofrequency ablation.

62 physician visit increased by 2.4 percentage points (CI, 1.9 to 2.9), and having a checkup increased

63 9 to 4.3 percentage points) to 25 percentage points (CI, 14 to 35 percentage points).

64 having a checkup increased by 2.7 percentage points (CI, 2.2 to 3.4).

65 w scores (RD for score >/=2, 0.20 percentage point [CI, -1.20 to 1.60 percentage points]; RD for scor

66 ge points]; RD for score <2, 2.58 percentage points [CI, 0.71 to 4.46 percentage points]; P = 0.046).

67 Using quantum point contact measurements on single nucleotides within

68 only a few binding sites near the collision point contribute significantly to the binding energy.

69 Two donors exceeded 10-point declines in SF-36 summary scores and increased the

70 L) was used to estimate the concentration of point defects in GaN.

71 clustering of 4 cell lines within each time point demonstrated that changes in genome-wide chromatin

72 A change-point detection is proposed by using a Bayesian-type sta

73 mplete remission and the composite renal end point did not differ significantly between groups.

74 Power analysis predicts that a 1-point difference on this 5-step scale would be detectabl

75 EHF activates expression of the SAM pointed domain-containing ETS transcription factor, whic

76 for macrosclerid cells at six different time points during seed development.

77 A, B, C) measured PVRs at two different time points during the first and the last follow-up visits.

78 scores and increased their HADS scores by 6 points during the observation period.

79 ventricle, correlated to the degree of J-ST point elevation (Pearson R, 0.81; P<0.001).

80 n controls, there was minimal change in J-ST point elevation, conduction delay, or activation recover

81 At this point elimination and rearomatization occurs with neopen

82 The point estimate of 1.5X faster rate of mutational decay

83 DRIL predicted 8-month improvement in BCVA (point estimate, 0.03; 95% CI, 0.01-0.05, P = .04), with

84 ially mediated by rate of cortical thinning (point estimate=0.078 (95% CIs: 0.003, 0.168), p=0.03).

85 Clinical outcomes were compared using point estimates for weighted values of median overall su

86 A primary end-point event occurred in 68 of 1012 patients (6.7%) in th

87 deviation close to 0.14% for the 15,298 data points examined during this work.

88 maize flours was developed following a cloud point extraction (CPE) procedure.

89 A simple ultrasound assisted-cloud point extraction (UA-CPE) method was developed and combi

90 The findings are an important starting point for clinicians considering the introduction of one

91 ther imaging modalities and forms a starting point for further steps of data analytics and modeling o

92 thin the spinal cord constitute the starting point for handedness, implying a fundamental shift in ou

93 l of long-patch BER and a new key regulation point for pathway choice in BER.

94 s a promising MMP-14 inhibitor as a starting point for the development of protein-based anticancer th

95 for tezacaftor-ivacaftor and 4.7 percentage points for ivacaftor alone (P<0.001 for both comparisons

96 d by 7-25 and 2-8 absolute median percentage points for PSC and WRA, respectively, compared with unad

97 centage of predicted FEV1 was 6.8 percentage points for tezacaftor-ivacaftor and 4.7 percentage point

98 umor after having diverged at different time points from the primary tumor lineage.

99 etabolizes the gamma-carboxyl linked, branch point glutamate.

100 or nonlinearity.Maternal weight at each time point had a consistent nonlinear relation with SGA risk.

101 ncreasingly recognized as a critical control point in dynamically altering gene expression during str

102 odel supports use of PB-MRD as a primary end point in randomized clinical trials of chemoimmunotherap

103 time of seed germination is a major decision point in the life of plants determining future growth an

104 s and epithelial cell monolayers at discrete points in a sample.

105 AD decreased by a median of 11-18 percentage points in PSC compared with unadjusted values.

106 al-impairment scores improved by 4.2 and 4.8 points in the 70-mg and 140-mg erenumab groups, respecti

107 ay-activities scores improved by 5.5 and 5.9 points in the 70-mg and 140-mg erenumab groups, respecti

108 cond primary end point and the secondary end points in the final analysis.

109 b groups, respectively, as compared with 2.4 points in the placebo group (P<0.001 for each dose vs. p

110 b groups, respectively, as compared with 3.3 points in the placebo group (P<0.001 for each dose vs. p

111 mphasized the value of a change of 2 or more points in the Sequential [Sepsis-related] Organ Failure

112 l measure of sensitization for allocation of points in the US Kidney Allocation System and Eurotransp

113 e likely to achieve the primary efficacy end point: in trial A, 188 of 254 (74.0%) vs 21 of 254 (8.3%

114 KEY POINTS: In lean individuals, 6 weeks of extended morning

115 Secondary end points included anatomic patency, adverse event rate, an

116 Secondary end points included change in body weight and cardiometaboli

117 Secondary end points included clinical outcomes (major adverse cardiac

118 Secondary end points included disease-free survival and the cumulative

119 Secondary end points included intraoperative and postoperative complic

120 The primary end point was PFS; secondary end points included overall survival (OS), objective respons

121 Secondary end points included overall survival, distant metastasis-fre

122 The secondary end points included short-term weight loss, serum obesity-re

123 Secondary end points included the proportion of patients with at least

124 ombination therapy coverage (3.56 percentage point increase, 95% CI -0.07-7.19), though this associat

125 KEY POINTS: Intracellular pH regulation is vital to neurons

126 he shortest Hamiltonian path, and the change-point is estimated by using ratio cut.

127 the presence of at least 2 adjacent testing points located within the same hemifield that showed pro

128 sk of primary nonadherence was 16 percentage points lower among patients given an electronic prescrip

129 KEY POINTS: Mammalian cells are frequently exposed to stress

130 Use of this end point may expedite therapeutic development with the inte

131 te randomized control trial, 3 groupsx4 time points mixed factorial design conducted from July 2015 t

132 D that is heterozygous for a disease-causing point mutation (Gfap(R236H)(/+)) (and thus expresses bot

133 w that DIM-2 can also mediate repeat-induced point mutation (RIP) of repetitive DNA in N. crassa.

134 eration DNA sequencing reactions and in situ point mutation detection assays in preserved tumour samp

135 nerated a novel murine allele by inserting a point mutation identified in a patient with NSCL/P.

136 FD is caused by a point mutation in the gene IKBKAP/ELP1 that results in a

137 suzukii, by creating a temperature-sensitive point mutation in the sex-determination gene, transforme

138 Therefore, the point mutation on NFU1 impairs downstream cluster traffi

139 mouse model with NB disruption mediated by 2 point mutations (C62A/C65A) in the Pml RING domain.

140 Loss-of-function point mutations in a component of this ligase complex, F

141 For somatic point mutations in coding and non-coding regions of the

142 Point mutations in genes encoding sarcomeric proteins ar

143 We identified BRPF1 deletions or point mutations in six additional individuals with a sim

144 We identified single-point mutations in the Fc domain (e.g., E345K or E430G)

145 two filament states, we successfully predict point mutations that shift the equilibrium between those

146 Consistently, Kabuki causative point mutations upstream of the JmjC domain do not disru

147 ptase (TERT), which was associated with TERT point mutations, rearrangements, DNA amplifications and

148 0.99) and a lower risk of the composite end point of brain damage, nursing home admission, or death

149 nd portable solution is in highly demand for point of care test.

150 guide correct antibiotic prescription at the point of care.

151 gment-elevation myocardial infarction at the point of care.

152 ollow-up of 3.9+/-2.4 years, the primary end point of death, transplant, or admission for heart failu

153 d function of the device is not fixed at the point of fabrication.

154 As primary care is the first point of healthcare contact for most children, we sought

155 teolysis, revealing a useful pharmacological point of intervention for the treatment of Huntington's

156 erapeutics in brain parenchyma away from the point of local administration.

157 Of particular interest are systems near the point of mechanical instability, which recently have bee

158 Because endonuclease cleavage is a likely point of regulation for RNA editing, we elucidated endon

159 s for RVAD implantation and the combined end point of RVAD or death within 14 days of LVAD were asses

160 rstanding and controlling the central branch point of this pharmacologically important group of compo

161 esting both nutritionally and from a sensory point of view, and furthermore with a beneficial effect

162 (mu3-O)2(O2C-)12] carboxylate-based cluster, points of extension matching the 12 vertices of hexagona

163 nding the Gamma = (0, 0) and X = (pi/aFe, 0) points of FeSe and to measure the corresponding supercon

164 Despite points of similarity, there is no mention of Rushton's c

165 We found points of spectral sensitivity responding to experimenta

166 s unfolded, we attempt to describe different points of view fairly but not neutrally, so as to identi

167 ogy that intended to develop next generation point-of-care (POC) detection system.

168 hallenge is the lack of a rapid and accurate point-of-care (PoC) device that can perform these measur

169 Point-of-care (POC) diagnostic testing platforms are a g

170 nable inexpensive molecular detection at the point-of-care and at home with minimal or no instrumenta

171 icenter prospective evaluation of the use of point-of-care BLAST by ASPs.

172 ss, the development and commercialization of point-of-care combination tests capable of detecting mar

173 e implementation of amplification methods in point-of-care diagnostic devices and devices to be used

174 cations in a wide range of fields, including point-of-care diagnostics or cellular in vivo biosensing

175 Technologic advances are leading to point-of-care kits that incorporate nucleic acid-based a

176 Effective viral load monitoring and point-of-care resistance tests could help to mitigate th

177 sensing system towards realizing a reusable, point-of-care sensor that snugly fits around a smartphon

178 D has great potential for the development of point-of-care testing (POCT) devices that can be applied

179 Rapid point-of-care testing (POCT) for respiratory viruses mig

180 e underway to develop inexpensive, reliable, point-of-care tests to diagnose infection.

181 ulture and therefore, is not compatible with point-of-care treatment.

182 ted in this work is simple and effective for point-of-use multiplexing of immunoassays and was applie

183 5% CI, 0.57 to 1.20; P < .001) than MI (0.20 points on the disability scale; 95% CI, 0.06 to 0.35; P

184 me of the event was greater for stroke (0.88 points on the disability scale; 95% CI, 0.57 to 1.20; P

185 mination revealed normal cognition (29 of 30 points on the Mini-Mental State Examination and 27 of 30

186 e Mini-Mental State Examination and 27 of 30 points on the Montreal Cognitive Assessment) and normal

187 icroscopic insights provide a solid standing point, on which perovskite solar cells can be understood

188 None of the secondary end point or day-30 all-cause mortality or heart failure hos

189 Four experiments used pointing or left/right 2-alternative forced choice tasks

190 e of -1 dB/year or more (P < 0.01) for inner points or -2 dB/year or more (P < 0.01) for edge points.

191 tudies have primarily focused on single time points or a few individuals.

192 Conclusions pointed out an urgent need to review legislative limits

193 The results found pointed out that both SW-ASV approaches were suitable an

194 ipal Component Analysis of the whole dataset pointed out that the TF system at reduced thickness coul

195 cial systems and complex ecosystems has been pointed out: in both cases, topological features of netw

196 n between stent fracture and the primary end point (P=0.86) or with restenosis (P=0.53).

197 n a week after transplant than at later time points (P = 0.008).

198 ge points (95% CI, -2.18 to -1.18 percentage points; P < .001) and an increase in the market share of

199 tage points (95% CI, 0.54 to 1.14 percentage points; P < .001).

200 rcentage points [CI, 0.71 to 4.46 percentage points]; P = 0.046).

201 Digital polymerase chain reaction (dPCR) end point platforms directly estimate the number of DNA targ

202 expected to improve success rate of point-by-point radiofrequency ablation.

203 rcentage point [CI, -1.20 to 1.60 percentage points]; RD for score <2, 2.58 percentage points [CI, 0.

204 equence motifs found in the potential branch-point region differed between retained and constitutive

205 tion with mean deviation of the 4 central VF points (rho = -0.420; P < .001).

206 anges in vaginal atrophy using a validated 4-point scale, and comparison of E2 levels.

207 A clinical point score was generated, and its diagnostic performanc

208 and language treatment (mean difference 2.61 points [SD 4.94]; 95% CI 1.49 to 3.72), but not from bas

209 ing TPS to study mouse lung development, the points selected by TPS can be used to reconstruct an acc

210 Here we present the Time Point Selection (TPS) method that solves this combinator

211 KEY POINTS: Severe aortic valve diseases are common cardiac

212 cision immediately and yet feel that at some point she had made up her mind.

213 ers, by linking photolysis to an isoelectric point shift, which itself is linked to a solubility shif

214 Two case-control studies established a point-source outbreak associated with 2 specific duodeno

215 ly encoded Zn(2+) sensors at a range of time points spanning several seconds and subsequently sort a

216 ion effect at this new scale, and the system point-spread function (PSF) serves as the key for encryp

217 rature-driven effects can be classified into point stresses, where a temperature event during a sensi

218 articular new drug using an intermediate end point, such as MRD, would require confirmation using tra

219 s also show a loss of ITCs at postnatal time points, suggesting that Foxp2 may function downstream of

220 KEY POINTS: Synaptic transmission at the endbulb of Held was

221 such as the Hazard Analysis Critical Control Point system by seafood companies, the number of seafood

222 adjustment and the incidence of torsades de pointes (TdP) were identified.

223 trolling for continuous air temperature, dew-point temperature, day of week, holidays, and time trend

224 al response criteria for the two primary end points than did those who received placebo.

225 more rapidly annually in rural (0.93 percent points) than urban (0.52 percent points) areas.

226 the points they raised, here we offer a few points that are complementary.

227 At both time points the genome-wide mapping reveals that there is sig

228 nd Dirac semimetals feature zero-dimensional points, the band crossing of nodal-line semimetals forms

229 KEY POINTS: The AMPA-type ionotropic glutamate receptors (AM

230 KEY POINTS: There are serotonergic projections to both the m

231 Because we agree with most of the points they raised, here we offer a few points that are

232 This might point to a ceiling effect for enteral protein intake wit

233 mic change in mammalian sperm methylomes and point to a divergence in trans-epigenetic mechanisms tha

234 r) and dissolved organic matter in the ocean point to a marine source for the measured OVOCs.

235 These data point to a new type of protumorigenic CAF in the tumor m

236 Our data also point to a potential biomarker of target engagement for

237 Our results point to an EsRalpha-dependent, reciprocal interaction b

238 xercise-induced pain have been developed and point to central mechanisms underlying this phenomena, s

239 CXR/MRI, whereas U.S. guidelines preferably point to CHCT/MRI in patients with head and neck squamou

240 W. smithii provides a unique starting point to determine if there are universal nonbiting gene

241 These studies will serve as a starting point to explore the nonlinear dynamics of atrial cells

242 CN as a potent regulator of angiogenesis and point to its potential as a new therapeutic target for a

243 lenging to identify, but once found they can point to larger networks of interactions, such as with p

244 r ambient temperatures, these properties all point to NESMD as a promising solution for household- or

245 Findings point to neural signatures of risk for maintaining PTSD

246 KATP channel activity and insulin secretion point to participation of the cGMP/PKG and cAMP/PKA/Epac

247 ASs were associated with ledipasvir failure, pointing to a limited efficacy of ledipasvir in patients

248 the presence of the chemoattractant serine, pointing to a physiological relevance of the observed th

249 genous long terminal repeat (LTR) sequences, pointing to a select role of BRD4S-BRG1 complexes in gen

250 entified, including 9 low-frequency variants pointing to functional candidates.

251 on rates indicating metabolic depression and pointing to particular sensitivity of E. verrucosus to p

252 thod correlated with the BLI findings, which points to (19)F MRI as a reliable method with which to t

253 Growing evidence points to a disruption of cortico-thalamo-cortical circu

254 missense mutations in five ARS genes, which points to a shared mechanism of disease.

255 ot rely on kinetic parameters, and therefore points to a theoretical framework for describing a broad

256 Mounting evidence points to an intricate relationship between DSBs and tra

257 ptors and ion channels, however new evidence points to critical effects on intra-neuronal microtubule

258 Much genetic and physiologic evidence points to impaired arousal responses to hypercarbia and

259 uble rnhAB mutants to translation inhibition points to R-loops as precursors for R-lesions.

260 Mounting evidence points to specialized neuronal subtypes within the serot

261 at pleiotropy is a widespread phenomenon and points to specific instances of both agonistic and antag

262 is well characterized, accumulating evidence points to the existence of multiple, less well-defined l

263 entage points (95% CI, -19 to 4.3 percentage points) to 25 percentage points (CI, 14 to 35 percentage

264 ort timescales and provide a candidate entry point toward a better understanding of cognitive archite

265 mode of Hsp70 inactivation by AMPylation and point toward a role for protein AMPylation in the regula

266 Moreover, our findings point toward monitoring pathobiont-induced changes in mi

267 for asthma, eczema, and allergy in childhood pointing toward in utero immune programming of the child

268 The accumulated evidence from literature points toward a future UWM that offers significant poten

269 This pattern of results points toward DNAm as a potentially important biological

270 CI by dampening inflammatory cytokines, thus pointing towards a new direction of immunomodulation for

271 arm optimization (PSO) for the maximum power point tracking (MPPT) control of a PV system consisting

272 ver, detection of H. pylori infection at any point up to age 6.5 years was associated with a signific

273 iety of biological systems affect apical end points used in regulatory risk assessments, and without

274 nt agreement with the data for all selection points using the same value of the conversion processivi

275 ients listed with HCC who received exception points versus patients listed with LABMELD.

276 on, we must quantify the heritability of set-point viral load, which is the fraction of variation in

277 KEY POINTS: Visceral thermoreceptors that modify thermoregul

278 In the YAG laser group, the 10-point visual disturbance score improved by 3.2 vs 0.1 in

279 The primary efficacy end point was a composite of adjudicated cardiovascular deat

280 The primary efficacy end point was change in serum phosphate concentration from b

281 The primary end point was daily combined symptom-medication scores durin

282 The primary end point was death, myocardial infarction, or unstable angi

283 The primary end point was freedom from repeat coronary revascularization

284 The primary end point was overall response rate (ORR).

285 The primary end point was PFS; secondary end points included overall sur

286 The primary end point was the detection of bone lesions at diagnosis by

287 The primary end point was the development of asthma until age 12 years.

288 The primary end point was the identification of the maximum tolerated do

289 The primary end point was the incidence of somatic mutations of the RAS,

290 The end point was the risk difference in the onset of new allerg

291 At all time points, we found a hypomethylated region mapping to Iqga

292 subdomain score changes at each serial time point were compared with the baseline score by using pai

293 Secondary end points were a 50% or greater reduction in mean migraine

294 The two primary end points were a four-component composite of death through

295 Clinical end points were AD dementia and any type of dementia after 1

296 Secondary ischemic end points were also evaluated.

297 Secondary study end points were fractional flow reserve during vessel patenc

298 Secondary end points were the number of telephone calls and emails to

299 , certain landscapes could be near a tipping point where relatively small changes to their fire regim

300 symptom scores of nose and eye were 0 and 1 point without any rescue drugs, accounted for 9 and 24%