ライフサイエンスコーパス: poise

1 higher CEF, perhaps for maintenance of redox poise.

2 and absolute; the earth is only temporarily poised a quantifiable distance from the thermodynamic eq

3 of G4 sequence motifs upstream of TSS of non-poised active genes suggests a potential role of quadrup

4 e of both mycobacterial physiology and redox poise, an axis that is dispensable for survival under no

5 the context-specific reestablishment of the poised and active states of normal colon cells, which we

6 ory state is encoded epigenetically, through poising and transcriptional memory.

7 dependent nucleosomal phasing across active, poised, and inactive genomic elements.

8 straints follow from heuristic thermodynamic poise approximations that take anticipated cellular meta

9 respiration helps control the stromal redox poise as a crucial part of high-light acclimation in C.

10 Secondary DNA structures are uniquely poised as therapeutic targets due to their molecular swi

11 eference electrode, biocathode potential was poised at -0.8 V (versus SHE) using a potentiostat, with

12 en reduction region and the ring voltage was poised at a value at which superoxide oxidation ensued y

13 ence suggests that the neuronal dynamics are poised at criticality.

14 ists and differentially affected lymphocytes poised at distinct activation thresholds.

15 n factor leading to a developmental decision poised at the edge of ambiguity.

16 The periplasmic domains of YidC and SecD are poised at the protein-channel exit-site of SecY, presuma

17 We presently are poised at the threshold of regulatory innovation for ant

18 l of the redox couple and eventually becomes poised at this value.

19 arginine, suggesting starved T cells remain poised awaiting nutrients.

20 t of H3K27me3-associated inactive states and poised (bivalent) enhancer states.

21 4 motifs in the context of poised versus non-poised but active genes.

22 ZRS at early embryonic stages maintaining a poised, but inactive state broadly across the distal lim

23 rposed to promote epigenetic transcriptional poising by a highly conserved mechanism.

24 suggest that homo- and heterodimer formation poise C/EBPbeta to execute diverse and stage-specific tr

25 entation and validation of the thermodynamic poise calculation itself.

26 f HPFSa in preserving ribosome integrity and poising cells for translational restart, a process that

27 tes esBAF and PRC functions to establish the poised chromatin configuration in ES cells, which is ess

28 Poised chromatin in ES cells contains both H3 Lys-4 trim

29 r, our results identify the acquisition of a poised chromatin state at enhancers as a mechanism by wh

30 cells revealed the en masse acquisition of a poised chromatin state at enhancers specific to endoderm

31 One key feature is the poised chromatin state of master developmental genes tha

32 arise because cellular plasma membranes are poised close to a miscibility transition under growth co

33 ruits RNA polymerase II (Pol II), often in a poised configuration in which Pol II accumulates near tr

34 ve these signature loci in an epigenetically poised configuration.

35 ors for the maintenance of transcriptionally poised developmental genes.

36 Thus Pol II poising does not only mark genes for rapid expression in

37 , manifested in amniotes by H3K4me3/H3K27me3 poising, early in metazoan evolution.

38 (inoculum), acetate as electron donor and a poised electrode (+397mV vs. SHE).

39 This unusual poise enables gradual post-translational regulation of t

40 bilization appears to disrupt the delicately poised energy balance governing thin filament regulation

41 n in the Drosophila embryo, we find that the poised enhancer signature is specifically generated duri

42 The poised enhancer signature, involving H3K4me1 and low lev

43 We discuss the possibility that the poised enhancer state is more generally the result of re

44 ermediate step before future activation, the poised enhancer state may be a mark for spatial regulati

45 Experimentally, the acquisition of this poised enhancer state predicts the ability of endodermal

46 onents Med1 and Smc1a at newly activated and poised enhancers in ESC-derived epiblast-like cells.

47 Some sites of hypomethylation occur at weak/poised enhancers marked with H3K4 monomethylation in hem

48 Stem cells use poised enhancers of developmental regulators to maintain

49 5hmC was enriched within poised enhancers, and depleted within active enhancers,

50 hich is normally observed in developmentally poised enhancers.

51 factor genes, the majority of which contact poised enhancers.

52 or binding sites, and enriched at active and poised enhancers.

53 ange the nucleotide sequence of that RNA, is poised for a major expansion in scientific interest and

54 Cebpa and Pparg) expressed at low levels yet poised for activation when differentiation is required.

55 atory genes expressed at very low levels and poised for activation.

56 until, at its most advanced position, it is poised for another Heinrich event.

57 hodological innovation ongoing, the field is poised for breakthroughs elucidating the developmental o

58 The field appears poised for breakthroughs, including the exciting prospec

59 tructure not only visualizes the active site poised for catalysis of APOBEC3A, but pinpoints the resi

60 ceptors are in late-stage preclinical tests, poised for clinical evaluation.

61 tions of androgen-independent cells that are poised for clonal selection after androgen-deprivation t

62 All complexes are well poised for dCTP insertion.

63 The phosphotransfer center is asymmetric, poised for dissociative nucleophilic substitution.

64 Our results suggest grasslands are poised for drastic changes in function and highlight the

65 s (RRP) in sub-pools that are differentially poised for exocytosis shapes short-term plasticity.

66 f rapid development so that this organism is poised for exploitation as an industrial biotechnology p

67 or molecules with demethylated promoters and poised for expression.

68 reported to mark inactive enhancers that are poised for future activation.

69 and origin licensing factors and are likely poised for genome re-replication.

70 functional Ag-specific CD8 T cells that are poised for immediate protection; however, this is at the

71 tational pausing at the tetrameric conformer poised for ligation.

72 rth Atlantic phytoplankton community appears poised for marked shift and shuffle, which may have broa

73 step: an initial peroxo-anion intermediate, poised for nucleophilic attack on the C20 position by a

74 Criticality keeps a network poised for optimal information processing, but this view

75 The heme is poised for peroxidase activity with water bound in place

76 ficient high-temperature superconductors are poised for power transmission and magnetic imaging appli

77 reversible transfer of cells between states poised for proliferation or differentiation may provide

78 enhancer elements in healthy fibroblasts and poised for rapid activation in response to DNA damage.

79 ions keeps genes expressed at low levels but poised for rapid activation.

80 orm a weakly populated excited state that is poised for rapid product release.

81 interface that place key catalytic residues poised for reaction.

82 eristics suggested CD5(hi) cells were better poised for reactivity and differentiation than were CD5(

83 in its N-terminal DHH domain, which appears poised for replisome interactions.

84 ate cancer that are androgen independent and poised for selection as dominant clones after androgen d

85 l-tolerated and effective treatment strategy poised for testing in patients with chemoresistant serou

86 s to a broad range of microorganisms and are poised for Th1 responses before birth.

87 render the underlying genes either silent or poised for transcription.

88 phaHb, coordinate to the heme iron, which is poised for transfer into the heme-binding pocket of IsdB

89 , who reciprocally harbor alphaherpesviruses poised for zoonotic transmission to humans.

90 ct, asynchronous mechanisms: an early locus 'poising' function dependent on TCF-1 and GATA-3, a stoch

91 2) in regulating the epigenetic landscape of poised genes activated at the onset of neuronal differen

92 viously identified for other cell types, non-poised genes are B cell state specific.

93 om individual species act downstream of core poised genes during development in a species-specific fa

94 We also enlighten a new set of poised genes expressed by protective cells that is stron

95 We found that while Pol II poised genes generally overlap functionally among differ

96 s induce lineage-appropriate developmentally poised genes poorly while lineage-inappropriate genes, i

97 ly due to changes of chromatin structures at poised genes, particularly those key developmental genes

98 pore as an organizing scaffold for inducible poised genes.

99 ity is in large part DNA-encoded and that it poises genes for future context-specific activation in r

100 We examined the poised (H3K4me3/H3K27me3 bivalent) epigenetic state in m

101 er loops is tightly coupled to activation of poised (histone H3 lysine 4 mono- and dimethylated) enha

102 SAL1) senses changes in photosynthetic redox poise, hydrogen peroxide, and superoxide concentrations

103 currents were related to the conformational poise imposed on the pump.

104 We find that core genes poised in germ cells from multiple amniote species are a

105 CCL1 and GM-CSF genes are also poised in human memory CD8 T cells.

106 Thus, we are poised in our ability to investigate how immunosuppressi

107 issue-resident macrophages are metabolically poised in situ to protect and exploit their tissue-niche

108 ral agencies, and industry, such that we are poised in the ensuing years to positively address the un

109 ere, we demonstrate that the Mn4O5Ca complex poised in the S0 state contains an exchangeable hydroxo

110 To elucidate the role of Pol II poising in B cell activation, we compared Pol II profile

111 tissue development, whereas genes that gain poising in germ cells from individual species act downst

112 velopmental genes supports their epigenetic "poising" in hSSCs for future/embryonic expression, while

113 odynamic constraints, and that thermodynamic poise information is actionable during network reconcili

114 Thus, the ER redox poise is tuned by reciprocal control of glutathione impo

115 ly embryos accumulate poised Pol II and that poising is dynamic.

116 e full genome-wide regulatory role of Pol II poising is yet to be delineated.

117 ce at promoters, referred to here as Poll II poising, is mainly (but not exclusively) attributed to t

118 dimensional conformation of the X chromosome poises it for exploitation by the MSL complex, thereby f

119 ically "preprogrammed" macrophages result in poised macrophages in peripheral tissue and negatively i

120 eriod, when subsurface soil temperatures are poised near 0 degrees C.

121 sponds to the distribution of activity being poised near an unusual kind of critical point.

122 trols the initial stages of transition from 'poised', non-transcribed rDNA chromatin into its active

123 s of biosynthesis with maintaining the redox poise of the electron transport chain.

124 tathionylation depends on the conformational poise of the Na(+)-K(+) pump, and glutathionylation with

125 Our data indicate that the GerA receptor is poised on a knife's edge during spore development.

126 ss premature Ca(2+) release in eggs that are poised on the brink of development.

127 Here, we explore a cobalt(I) system that is poised on the brink of hemilability and of a spin-state

128 Two poised one-electron transfer systems (potassium ferricya

129 een Ca(2+) oscillation states that represent poised or activated modes of proliferation, respectively

130 Bivalent (poised or paused) chromatin comprises activating and rep

131 can be explained by their transcriptionally poised, permissive chromatin state prior to stimulation.

132 ion is not modulated by SERCA conformational poise, PLB binding, or PLB phosphorylation.

133 yos, revealing that early embryos accumulate poised Pol II and that poising is dynamic.

134 histone hypoacetylation is associated with a poised polymerase, H3K27me3 displaces polymerase from ch

135 d to a two-chamber reactor and operated at a poised potential of -0.5 V vs SHE.

136 re enhanced approximately 6-fold in 160 h of poised-potential incubation, indicating that the acclima

137 lso show marked enrichment for enhancers and poised promoters across multiple cell types.

138 ing, the derepression of a specific class of poised promoters during differentiation, and lineage spe

139 active promoters; and 6.9% to be at weak and poised promoters.

140 SOX2 binds to bivalently marked promoters of poised proneural genes [neurogenin 2 (Ngn2) and neurogen

141 ctor, Zelda, is responsible for establishing poised RNA polymerase at Dorsal target genes before Dors

142 omatin structure and promoter recruitment of poised RNA polymerase II preinitiation complex (RNAPII P

143 We found many more genes with poised RNA polymerase than had been observed previously

144 or, during memory, Cdk8(+) Mediator recruits poised RNAPII PIC lacking the Kin28 CTD kinase.

145 genes and their enhancers in a silenced but poised spatial network.

146 esting B cell and shifted from non-poised to poised state after B cell activation.

147 ro, both proteins are required to maintain a poised state at the Il2 target locus in resting but prev

148 changes indicating that NtcA can reside in a poised state controlled by other factors.

149 ate that the erm enhancer is maintained in a poised state in neural stem cells by the histone deacety

150 erm immature INP enhancer in an inactive but poised state in neuroblasts.

151 n of non-covalent chromatin structure to the poised state is not well understood.

152 We suggest that the indicated poised state of NtcA enables a more differentiated respo

153 Thus, the poised state that allows rapid meiotic reentry in mouse

154 acts as an epigenetic switch that confers a poised state to the Foxp3 promoter in precursor cells to

155 emodeling of nucleosomes is important to the poised state, we characterized the function of BAF250a,

156 Bcl2l11 promoter to maintain this gene in a poised state.

157 rity of such changes were from poised to non-poised state.

158 lso observed a transition from non-poised to poised state.

159 3K27me3) signals and are thought to be in a 'poised' state for subsequent activation or silencing dur

160 stream versus downstream of TSS depending on poising status.

161 In mESCs, the proteins bind to active and poised TBP-bound promoters along with promoters of polyc

162 erged is that CAM operates with a diel redox poise that is shifted relative to that in Arabidopsis.

163 c and photoprotective activities required to poise the etioplast for light development.

164 s role at these non-regulated loci may be to poise the region for subsequent regulation.

165 ing it with a medium containing nitrates and poising the electrode at -303mV vs. SHE.

166 We propose that poising the fast-activating enhancers of master regulato

167 during apoptosis, implying that dying cells poise to recover, even while under apoptotic stress.

168 nd inexpensive technologies, biochemists are poised to accelerate the annotation of biochemical pathw

169 Policymakers are poised to act and 1 proposal entails reorganizing the cu

170 N1 position of G33 and N3 position of A1 are poised to act as a general base and acid, respectively,

171 ly the basolateral and CeM amygdalar nuclei, poised to activate CeM for autonomic arousal.

172 This constellation of residues is poised to activate the substrate by Schiff base formatio

173 es in the past few years and ongoing work is poised to add even more.

174 in both medicine and research, are uniquely poised to address pressing challenges at the forefront o

175 ol for data and specimen collection, and are poised to address this critical research need.

176 When unperturbed, somatic stem cells are poised to affect immediate tissue restoration upon traum

177 KEAP1 is thus poised to affect MCM2-7 dynamics or function rather than

178 at neural induction triggers a switch from a poised to an active chromatin state at GLI3.

179 in which 5 binds to S2 with its C6-C11 group poised to attack C1 in GPP to form the moenocinyl sidech

180 iated herpesvirus (KSHV) latent episomes are poised to be activated by the KSHV replication and trans

181 ic cul-de-sacs, many mountain streams appear poised to be redoubts for cold-water biodiversity this c

182 osphorus (BP), also known as phosphorene, is poised to be the most attractive graphene analogue owing

183 rimental demonstration provided here, PLM is poised to become a powerful technique for revealing the

184 The landscape approach is thus poised to become one of the most influential methods for

185 ctions also target the striatum, oxytocin is poised to bias the balance of DA tone through multiple s

186 E4(4H) is poised to bind and reduce N2 through reductive eliminati

187 g surface stabilize the linker in a geometry poised to bind RNA.

188 for the first time, the field seems uniquely poised to bring these new tools to effectively tackle EB

189 etic engineering, and cell manufacturing are poised to broaden T-cell-based therapies and foster new

190 active oligomers and active monomeric BiP is poised to buffer fluctuations in ER unfolded protein loa

191 CCR4 is poised to contribute to central tolerance due to its exp

192 link the Piezo repeats to the pore, and are poised to control gating allosterically.

193 dapt to a new host may help identify viruses poised to cross species barriers before an outbreak occu

194 ng that only a minority of S. pneumoniae are poised to cross the BBB.

195 ion that online electrochemical reduction is poised to decrease the complexity of sample handling and

196 respiratory tract, alveolar macrophages are poised to defend against hantavirus infection, but those

197 eal a specialized LN antigen delivery system poised to deliver gp120 and likely other pathogen derive

198 With this knowledge, we are poised to design the next generation of complex biologic

199 els, located at the tops of stereocilia, are poised to detect tension induced by hair bundle deflecti

200 ity to differentiate into Th1 cells but were poised to differentiate better into induced nTreg cells,

201 tes produced from methanol decomposition are poised to directly undergo hydroformylation upon migrati

202 e the DNA exits the nucleosome, and are thus poised to disrupt DNA-histone interactions.

203 BMP-mediated pSmad1/5/8 signalling, which is poised to downregulate Shh.

204 The immune system recognizes and is poised to eliminate cancer but is held in check by inhib

205 oaches with emerging molecular tools will be poised to elucidate the functional importance of endophy

206 come available for many more species, we are poised to emerge from the bottleneck and once again expl

207 New techniques are now poised to enable the measurement of cell-generated mecha

208 DNA recognition-competent structure that is poised to engage double-stranded DNA target sequences.

209 their location, these aromatase neurons are poised to engage nociceptive circuits, whether it is thr

210 to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and tre

211 caused widespread changes in gene expression poised to enhance vascular inflammation, thrombosis, lea

212 n from environmental challenges but are also poised to execute a program of compositional and conform

213 ition, this degree of extensive CDF would be poised to exert large order-of-magnitude effects on shor

214 Developmental systems biology is poised to exploit large-scale data from two approaches:

215 ytes are circulating mononuclear phagocytes, poised to extravasate to sites of inflammation and diffe

216 llectively referred to as soft photonics-are poised to form the platform for tunable optical devices

217 nk represents a new branch on a tree that is poised to grow rapidly and offer new kinds of insights o

218 mportant generalization of the HMM, which is poised to have a deep impact across the field of biophys

219 ddressing these challenges, iGxE research is poised to help identify the neural mechanisms underlying

220 Programmable protein phosphorylation is poised to help reveal the structural and functional info

221 ake the choices they do, then we may be more poised to help them manage their medications, influence

222 or developing accountable care organizations poised to improve cancer outcomes and eliminate disparit

223 The field of congenital heart surgery is poised to incorporate new innovations such as bioenginee

224 atures go up, the use of air conditioning is poised to increase dramatically.

225 ness remains challenging, clinal genomics is poised to increase our understanding of local adaptation

226 ind that multiple UbiB-specific features are poised to inhibit protein kinase activity, including an

227 olitogenic memory CD4+ T cell subset that is poised to initiate inflammation when there is loss of to

228 Prior to S phase, multiple origins are poised to initiate replication by recruitment of the pre

229 The insights presented herein are poised to inspire the design of other catalyst-controlle

230 ions of the brain's "scene network" are well poised to integrate retinal input and memory [1]: they a

231 it suggests that the ATP lid of CheA may be poised to interact with receptors and coupling proteins.

232 terial interaction with fibronectin, RevA is poised to interact with the extracellular matrix of the

233 mmensal yeast living on skin and mucosa, but poised to invade injured tissue to cause local infection

234 ese features, the cyclopropenone ligation is poised to join the ranks of chemistries with utility in

235 The National Institutes of Health (NIH) is poised to lift its funding moratorium on research involv

236 ls reside in tissues where they appear to be poised to locally regulate tissue function.

237 om the pharmaceutical industry, the field is poised to make a breakthrough.

238 as a valuable tool in drug discovery, and is poised to make a major impact on the design of enzyme in

239 rials developed and studied in this area are poised to make a substantial impact in real-world applic

240 nusual profiles of transcribed genes and are poised to make rapid changes in those profiles upon indu

241 rative of the unique contribution SiMPull is poised to make to in planta protein interaction studies.

242 cellular, and organismal biology are clearly poised to massively expand.

243 analysis reveals that B. phytofirmans PRF is poised to metabolize thiosulfate to sulfite in a sulfur

244 explain how a strong pOFC pathway, which is poised to moderate activity of CeM, through IM, can be u

245 site of intense immune cell activity that is poised to mount an effective response against a pathogen

246 macrophages of the islets of Langerhans are poised to mount an immune response even at steady state,

247 that the majority of such changes were from poised to non-poised state.

248 Gastroenterologists are uniquely poised to participate in the multidisciplinary managemen

249 tion of metabolic outputs, sirtuins are well poised to play pivotal roles in tumor progression and su

250 essed in resting B cell and shifted from non-poised to poised state after B cell activation.

251 ngly, we also observed a transition from non-poised to poised state.

252 synaptic modulation and show that Munc13 is poised to profoundly impact information transfer at nerv

253 TPH cells appear to be uniquely poised to promote B-cell responses and antibody producti

254 shape changes, but if they go awry, they are poised to promote disease states such as cancer cell met

255 raphy-tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules underlyi

256 mediators of central tolerance, DCs are thus poised to provide homeostatic regulation of thymic expor

257 The developed constructs provide a platform poised to provide new insights into the subcellular dist

258 t exposes its ligand-binding site, but it is poised to rapidly assemble into intracellular signal-gen

259 These memory CD8 T cells remain poised to rapidly elaborate effector functions upon re-e

260 Immune memory cells are poised to rapidly expand and elaborate effector function

261 Macrophages stand poised to rapidly produce large amounts of inflammatory

262 evelopment, physiological cardiac models are poised to realise the promise of translational research

263 ficial nor purely biological approaches seem poised to realize the potential of solar-to-chemical syn

264 unteract numerous cellular defenses that are poised to recognize viruses as nonself and to activate a

265 area required a community of arbovirologists poised to refocus their research efforts and rapidly cha

266 roplet microfluidic screening processors are poised to replace robotic automation by miniaturizing bi

267 sickness), orally dosed fexinidazole stands poised to replace the current treatment regimen for Tryp

268 The United Network for Organ Sharing is poised to resolve geographic disparity in liver transpla

269 initiate differentiation are suppressed, but poised to respond rapidly to developmental signals.

270 erprint of their effector history and remain poised to respond rapidly upon re-exposure to the pathog

271 motors operating at intermediate speeds are poised to respond sharply to changes in mechanical conte

272 We find that animal cells are poised to respond to both increases and decreases in C18

273 We demonstrate that the MHB region is poised to respond to calcium transients that occur in th

274 LC), a diverse class of lymphocytes that are poised to respond to environmental insults including vir

275 th unperturbed forks, implying that they are poised to respond to stalling and collapse.

276 In summary, hepatic ILC2s are poised to respond to the release of IL-33 upon liver tis

277 structures below the diffraction limit--are poised to reveal in quantitative detail the stoichiometr

278 tremendous advances in cardiac modelling are poised to revolutionize medical treatment and prevention

279 They are poised to revolutionize optics by enabling complex low-c

280 , induced pluripotent stem cells (iPSCs) are poised to revolutionize stem cell biology and regenerati

281 on, revealing that tissue-resident cells are poised to sense and respond to alterations in microbial

282 The VA is poised to share and extend best practices to other healt

283 Use of the technology is poised to substantially advance integrated control of se

284 Single-cell microfluidic devices are poised to substantially impact the hematology field by p

285 d maternal-child health researchers who were poised to tackle this new public health challenge; and (

286 ies in the animal kingdom, plant studies are poised to take a lead role in this area because of their

287 indicating that the genetic loci are already poised to transcribe these novel RNAs.

288 Microbial whole-genome sequencing (WGS) is poised to transform many of the currently used approache

289 icate that not only is resting alphaIIbbeta3 poised to undergo a conformational change that exposes i

290 en bond donor catalyzed cascade reaction are poised to undergo a McMurry coupling to form previously

291 l reasons, biological mixtures are naturally poised to undergo a small number of demixing phase trans

292 unsaturated morpholine derivatives that are poised to undergo further functionalization for the prep

293 on to hydrolysis, the hydrazone products are poised to undergo numerous different known synthetic tra

294 olymeric capsules, the developed strategy is poised to usher the development of the next generation o

295 however, because macrophages and DCs remain poised to vigorously respond to pathogens that breach th

296 H3K9ac and H3K9me3 reveal a progression from poised, to active, to repressive marks, correlating with

297 , acetaldehyde, and ethanol but seemed to be poised toward the production of ethanol from acetaldehyd

298 7me3 at developmental promoters represents a poised transcriptional state.

299 the presence of G4 motifs in the context of poised versus non-poised but active genes.

300 stone deacetylase HDAC2 and ensures that the poised ZRS remains transcriptionally inactive.