ライフサイエンスコーパス: poised

1 and absolute; the earth is only temporarily poised a quantifiable distance from the thermodynamic eq

2 of G4 sequence motifs upstream of TSS of non-poised active genes suggests a potential role of quadrup

3 ts, we additionally generated global maps of poised and active enhancer elements marked by histone H3

4 the context-specific reestablishment of the poised and active states of normal colon cells, which we

5 dependent nucleosomal phasing across active, poised, and inactive genomic elements.

6 Secondary DNA structures are uniquely poised as therapeutic targets due to their molecular swi

7 eference electrode, biocathode potential was poised at -0.8 V (versus SHE) using a potentiostat, with

8 Poised at a critical turning point in the history of gen

9 en reduction region and the ring voltage was poised at a value at which superoxide oxidation ensued y

10 ence suggests that the neuronal dynamics are poised at criticality.

11 ists and differentially affected lymphocytes poised at distinct activation thresholds.

12 n factor leading to a developmental decision poised at the edge of ambiguity.

13 The periplasmic domains of YidC and SecD are poised at the protein-channel exit-site of SecY, presuma

14 We presently are poised at the threshold of regulatory innovation for ant

15 l of the redox couple and eventually becomes poised at this value.

16 arginine, suggesting starved T cells remain poised awaiting nutrients.

17 Poised (bivalent) chromatin is defined by the simultaneo

18 t of H3K27me3-associated inactive states and poised (bivalent) enhancer states.

19 4 motifs in the context of poised versus non-poised but active genes.

20 ZRS at early embryonic stages maintaining a poised, but inactive state broadly across the distal lim

21 stem cells, shows that REST target genes are poised by a mechanism independent of Polycomb, even at p

22 that, in vivo, mammalian germ cells maintain poised chromatin at promoters of many genes that regulat

23 tes esBAF and PRC functions to establish the poised chromatin configuration in ES cells, which is ess

24 Poised chromatin in ES cells contains both H3 Lys-4 trim

25 We propose three roles for poised chromatin in the mammalian germ line: prevention

26 e of the cardiac genes by switching open and poised chromatin marks associated with active and repres

27 r, our results identify the acquisition of a poised chromatin state at enhancers as a mechanism by wh

28 cells revealed the en masse acquisition of a poised chromatin state at enhancers specific to endoderm

29 We hypothesize that the poised chromatin state is essential for germ cell identi

30 One key feature is the poised chromatin state of master developmental genes tha

31 arise because cellular plasma membranes are poised close to a miscibility transition under growth co

32 ruits RNA polymerase II (Pol II), often in a poised configuration in which Pol II accumulates near tr

33 ve these signature loci in an epigenetically poised configuration.

34 ta support the hypothesis of an endogenously poised cytokine profile in neonates and suggest a link b

35 ors for the maintenance of transcriptionally poised developmental genes.

36 (inoculum), acetate as electron donor and a poised electrode (+397mV vs. SHE).

37 bilization appears to disrupt the delicately poised energy balance governing thin filament regulation

38 this approach to investigate mechanisms for poised enhancer establishment in primary human erythroid

39 n in the Drosophila embryo, we find that the poised enhancer signature is specifically generated duri

40 The poised enhancer signature, involving H3K4me1 and low lev

41 We discuss the possibility that the poised enhancer state is more generally the result of re

42 ermediate step before future activation, the poised enhancer state may be a mark for spatial regulati

43 Experimentally, the acquisition of this poised enhancer state predicts the ability of endodermal

44 enome-wide maps of active, intermediate, and poised enhancers determined by chromatin immunoprecipita

45 onents Med1 and Smc1a at newly activated and poised enhancers in ESC-derived epiblast-like cells.

46 Some sites of hypomethylation occur at weak/poised enhancers marked with H3K4 monomethylation in hem

47 Stem cells use poised enhancers of developmental regulators to maintain

48 5hmC was enriched within poised enhancers, and depleted within active enhancers,

49 hich is normally observed in developmentally poised enhancers.

50 factor genes, the majority of which contact poised enhancers.

51 or binding sites, and enriched at active and poised enhancers.

52 ange the nucleotide sequence of that RNA, is poised for a major expansion in scientific interest and

53 The resulting vinylcyclobutane products are poised for a variety of further diversification reaction

54 Cebpa and Pparg) expressed at low levels yet poised for activation when differentiation is required.

55 atory genes expressed at very low levels and poised for activation.

56 until, at its most advanced position, it is poised for another Heinrich event.

57 helicase core in a manner that appears to be poised for binding to branched replication fork DNA stru

58 hodological innovation ongoing, the field is poised for breakthroughs elucidating the developmental o

59 The field appears poised for breakthroughs, including the exciting prospec

60 he triphosphate moiety of AMPPNP*Mg2+ is not poised for catalysis in the open domain conformation.

61 tructure not only visualizes the active site poised for catalysis of APOBEC3A, but pinpoints the resi

62 The D38N enzyme is poised for catalysis, but cannot execute because it lack

63 ating formation of an active ternary complex poised for chemistry.

64 ceptors are in late-stage preclinical tests, poised for clinical evaluation.

65 tions of androgen-independent cells that are poised for clonal selection after androgen-deprivation t

66 All complexes are well poised for dCTP insertion.

67 The phosphotransfer center is asymmetric, poised for dissociative nucleophilic substitution.

68 Our results suggest grasslands are poised for drastic changes in function and highlight the

69 s (RRP) in sub-pools that are differentially poised for exocytosis shapes short-term plasticity.

70 f rapid development so that this organism is poised for exploitation as an industrial biotechnology p

71 or molecules with demethylated promoters and poised for expression.

72 reported to mark inactive enhancers that are poised for future activation.

73 and origin licensing factors and are likely poised for genome re-replication.

74 Probing the oxy-complexes of CYP19A1 poised for hydroxylase and lyase chemistries using reson

75 functional Ag-specific CD8 T cells that are poised for immediate protection; however, this is at the

76 tational pausing at the tetrameric conformer poised for ligation.

77 rth Atlantic phytoplankton community appears poised for marked shift and shuffle, which may have broa

78 To stay poised for mature blood production, hematopoietic stem c

79 step: an initial peroxo-anion intermediate, poised for nucleophilic attack on the C20 position by a

80 Criticality keeps a network poised for optimal information processing, but this view

81 The heme is poised for peroxidase activity with water bound in place

82 ficient high-temperature superconductors are poised for power transmission and magnetic imaging appli

83 reversible transfer of cells between states poised for proliferation or differentiation may provide

84 enhancer elements in healthy fibroblasts and poised for rapid activation in response to DNA damage.

85 ions keeps genes expressed at low levels but poised for rapid activation.

86 orm a weakly populated excited state that is poised for rapid product release.

87 interface that place key catalytic residues poised for reaction.

88 eristics suggested CD5(hi) cells were better poised for reactivity and differentiation than were CD5(

89 in its N-terminal DHH domain, which appears poised for replisome interactions.

90 ate cancer that are androgen independent and poised for selection as dominant clones after androgen d

91 l-tolerated and effective treatment strategy poised for testing in patients with chemoresistant serou

92 s to a broad range of microorganisms and are poised for Th1 responses before birth.

93 render the underlying genes either silent or poised for transcription.

94 phaHb, coordinate to the heme iron, which is poised for transfer into the heme-binding pocket of IsdB

95 , who reciprocally harbor alphaherpesviruses poised for zoonotic transmission to humans.

96 2) in regulating the epigenetic landscape of poised genes activated at the onset of neuronal differen

97 associated with transcriptionally active or poised genes and required for postnatal neurogenesis wit

98 viously identified for other cell types, non-poised genes are B cell state specific.

99 om individual species act downstream of core poised genes during development in a species-specific fa

100 We also enlighten a new set of poised genes expressed by protective cells that is stron

101 We found that while Pol II poised genes generally overlap functionally among differ

102 s induce lineage-appropriate developmentally poised genes poorly while lineage-inappropriate genes, i

103 ly due to changes of chromatin structures at poised genes, particularly those key developmental genes

104 pore as an organizing scaffold for inducible poised genes.

105 We examined the poised (H3K4me3/H3K27me3 bivalent) epigenetic state in m

106 er loops is tightly coupled to activation of poised (histone H3 lysine 4 mono- and dimethylated) enha

107 We find that core genes poised in germ cells from multiple amniote species are a

108 CCL1 and GM-CSF genes are also poised in human memory CD8 T cells.

109 Thus, we are poised in our ability to investigate how immunosuppressi

110 issue-resident macrophages are metabolically poised in situ to protect and exploit their tissue-niche

111 ral agencies, and industry, such that we are poised in the ensuing years to positively address the un

112 ere, we demonstrate that the Mn4O5Ca complex poised in the S0 state contains an exchangeable hydroxo

113 ically "preprogrammed" macrophages result in poised macrophages in peripheral tissue and negatively i

114 eriod, when subsurface soil temperatures are poised near 0 degrees C.

115 sponds to the distribution of activity being poised near an unusual kind of critical point.

116 trols the initial stages of transition from 'poised', non-transcribed rDNA chromatin into its active

117 Our data indicate that the GerA receptor is poised on a knife's edge during spore development.

118 ss premature Ca(2+) release in eggs that are poised on the brink of development.

119 Here, we explore a cobalt(I) system that is poised on the brink of hemilability and of a spin-state

120 Two poised one-electron transfer systems (potassium ferricya

121 een Ca(2+) oscillation states that represent poised or activated modes of proliferation, respectively

122 Bivalent (poised or paused) chromatin comprises activating and rep

123 can be explained by their transcriptionally poised, permissive chromatin state prior to stimulation.

124 yos, revealing that early embryos accumulate poised Pol II and that poising is dynamic.

125 histone hypoacetylation is associated with a poised polymerase, H3K27me3 displaces polymerase from ch

126 d to a two-chamber reactor and operated at a poised potential of -0.5 V vs SHE.

127 re enhanced approximately 6-fold in 160 h of poised-potential incubation, indicating that the acclima

128 lso show marked enrichment for enhancers and poised promoters across multiple cell types.

129 ing, the derepression of a specific class of poised promoters during differentiation, and lineage spe

130 active promoters; and 6.9% to be at weak and poised promoters.

131 SOX2 binds to bivalently marked promoters of poised proneural genes [neurogenin 2 (Ngn2) and neurogen

132 ctor, Zelda, is responsible for establishing poised RNA polymerase at Dorsal target genes before Dors

133 omatin structure and promoter recruitment of poised RNA polymerase II preinitiation complex (RNAPII P

134 We found many more genes with poised RNA polymerase than had been observed previously

135 ue, which is consistent with the presence of poised RNAPII as a function of Erk1/2 activation.

136 ccupancy and decreased occupancy of PRC2 and poised RNAPII at Erk2-PRC2-targeted developmental genes.

137 or, during memory, Cdk8(+) Mediator recruits poised RNAPII PIC lacking the Kin28 CTD kinase.

138 genes and their enhancers in a silenced but poised spatial network.

139 esting B cell and shifted from non-poised to poised state after B cell activation.

140 ro, both proteins are required to maintain a poised state at the Il2 target locus in resting but prev

141 changes indicating that NtcA can reside in a poised state controlled by other factors.

142 ate that the erm enhancer is maintained in a poised state in neural stem cells by the histone deacety

143 erm immature INP enhancer in an inactive but poised state in neuroblasts.

144 n of non-covalent chromatin structure to the poised state is not well understood.

145 We suggest that the indicated poised state of NtcA enables a more differentiated respo

146 Thus, the poised state that allows rapid meiotic reentry in mouse

147 acts as an epigenetic switch that confers a poised state to the Foxp3 promoter in precursor cells to

148 emodeling of nucleosomes is important to the poised state, we characterized the function of BAF250a,

149 Bcl2l11 promoter to maintain this gene in a poised state.

150 rity of such changes were from poised to non-poised state.

151 lso observed a transition from non-poised to poised state.

152 3K27me3) signals and are thought to be in a 'poised' state for subsequent activation or silencing dur

153 In mESCs, the proteins bind to active and poised TBP-bound promoters along with promoters of polyc

154 red three classes of primary TF targets: (i) poised (TF-bound but not TF-regulated), (ii) stable (TF-

155 nd inexpensive technologies, biochemists are poised to accelerate the annotation of biochemical pathw

156 Policymakers are poised to act and 1 proposal entails reorganizing the cu

157 Aided by divalent cations, P4 is poised to act as a "screw cap" on preQ1 recognition to b

158 N1 position of G33 and N3 position of A1 are poised to act as a general base and acid, respectively,

159 ly the basolateral and CeM amygdalar nuclei, poised to activate CeM for autonomic arousal.

160 This constellation of residues is poised to activate the substrate by Schiff base formatio

161 es in the past few years and ongoing work is poised to add even more.

162 in both medicine and research, are uniquely poised to address pressing challenges at the forefront o

163 ol for data and specimen collection, and are poised to address this critical research need.

164 When unperturbed, somatic stem cells are poised to affect immediate tissue restoration upon traum

165 KEAP1 is thus poised to affect MCM2-7 dynamics or function rather than

166 at neural induction triggers a switch from a poised to an active chromatin state at GLI3.

167 in which 5 binds to S2 with its C6-C11 group poised to attack C1 in GPP to form the moenocinyl sidech

168 iated herpesvirus (KSHV) latent episomes are poised to be activated by the KSHV replication and trans

169 ic cul-de-sacs, many mountain streams appear poised to be redoubts for cold-water biodiversity this c

170 osphorus (BP), also known as phosphorene, is poised to be the most attractive graphene analogue owing

171 rimental demonstration provided here, PLM is poised to become a powerful technique for revealing the

172 The landscape approach is thus poised to become one of the most influential methods for

173 The field is now poised to begin addressing these issues by defining and

174 ctions also target the striatum, oxytocin is poised to bias the balance of DA tone through multiple s

175 E4(4H) is poised to bind and reduce N2 through reductive eliminati

176 g surface stabilize the linker in a geometry poised to bind RNA.

177 for the first time, the field seems uniquely poised to bring these new tools to effectively tackle EB

178 etic engineering, and cell manufacturing are poised to broaden T-cell-based therapies and foster new

179 active oligomers and active monomeric BiP is poised to buffer fluctuations in ER unfolded protein loa

180 a provide an unprecedented view of an intein poised to carry out the rate-limiting step in protein sp

181 CCR4 is poised to contribute to central tolerance due to its exp

182 link the Piezo repeats to the pore, and are poised to control gating allosterically.

183 dapt to a new host may help identify viruses poised to cross species barriers before an outbreak occu

184 ng that only a minority of S. pneumoniae are poised to cross the BBB.

185 ion that online electrochemical reduction is poised to decrease the complexity of sample handling and

186 respiratory tract, alveolar macrophages are poised to defend against hantavirus infection, but those

187 eal a specialized LN antigen delivery system poised to deliver gp120 and likely other pathogen derive

188 With this knowledge, we are poised to design the next generation of complex biologic

189 els, located at the tops of stereocilia, are poised to detect tension induced by hair bundle deflecti

190 ity to differentiate into Th1 cells but were poised to differentiate better into induced nTreg cells,

191 tes produced from methanol decomposition are poised to directly undergo hydroformylation upon migrati

192 e the DNA exits the nucleosome, and are thus poised to disrupt DNA-histone interactions.

193 BMP-mediated pSmad1/5/8 signalling, which is poised to downregulate Shh.

194 The immune system recognizes and is poised to eliminate cancer but is held in check by inhib

195 oaches with emerging molecular tools will be poised to elucidate the functional importance of endophy

196 come available for many more species, we are poised to emerge from the bottleneck and once again expl

197 New techniques are now poised to enable the measurement of cell-generated mecha

198 DNA recognition-competent structure that is poised to engage double-stranded DNA target sequences.

199 their location, these aromatase neurons are poised to engage nociceptive circuits, whether it is thr

200 to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and tre

201 caused widespread changes in gene expression poised to enhance vascular inflammation, thrombosis, lea

202 However, ultracold physics is now poised to enter a new regime, where much more complex sp

203 n from environmental challenges but are also poised to execute a program of compositional and conform

204 ition, this degree of extensive CDF would be poised to exert large order-of-magnitude effects on shor

205 Developmental systems biology is poised to exploit large-scale data from two approaches:

206 ytes are circulating mononuclear phagocytes, poised to extravasate to sites of inflammation and diffe

207 llectively referred to as soft photonics-are poised to form the platform for tunable optical devices

208 nk represents a new branch on a tree that is poised to grow rapidly and offer new kinds of insights o

209 mportant generalization of the HMM, which is poised to have a deep impact across the field of biophys

210 cell engineering and mechanotransduction are poised to have substantial implications for stem cell bi

211 ddressing these challenges, iGxE research is poised to help identify the neural mechanisms underlying

212 Programmable protein phosphorylation is poised to help reveal the structural and functional info

213 ake the choices they do, then we may be more poised to help them manage their medications, influence

214 or developing accountable care organizations poised to improve cancer outcomes and eliminate disparit

215 The field of congenital heart surgery is poised to incorporate new innovations such as bioenginee

216 atures go up, the use of air conditioning is poised to increase dramatically.

217 ness remains challenging, clinal genomics is poised to increase our understanding of local adaptation

218 Future rates depend on many factors and are poised to increase.

219 ind that multiple UbiB-specific features are poised to inhibit protein kinase activity, including an

220 olitogenic memory CD4+ T cell subset that is poised to initiate inflammation when there is loss of to

221 Prior to S phase, multiple origins are poised to initiate replication by recruitment of the pre

222 The insights presented herein are poised to inspire the design of other catalyst-controlle

223 ions of the brain's "scene network" are well poised to integrate retinal input and memory [1]: they a

224 phosphoinositide head group at its nexus and poised to interact with other proteins.

225 it suggests that the ATP lid of CheA may be poised to interact with receptors and coupling proteins.

226 terial interaction with fibronectin, RevA is poised to interact with the extracellular matrix of the

227 mmensal yeast living on skin and mucosa, but poised to invade injured tissue to cause local infection

228 ese features, the cyclopropenone ligation is poised to join the ranks of chemistries with utility in

229 The National Institutes of Health (NIH) is poised to lift its funding moratorium on research involv

230 ls reside in tissues where they appear to be poised to locally regulate tissue function.

231 om the pharmaceutical industry, the field is poised to make a breakthrough.

232 as a valuable tool in drug discovery, and is poised to make a major impact on the design of enzyme in

233 rials developed and studied in this area are poised to make a substantial impact in real-world applic

234 nusual profiles of transcribed genes and are poised to make rapid changes in those profiles upon indu

235 rative of the unique contribution SiMPull is poised to make to in planta protein interaction studies.

236 cellular, and organismal biology are clearly poised to massively expand.

237 Even though the brain is poised to mediate the effects of GLP1 analogs, it remain

238 analysis reveals that B. phytofirmans PRF is poised to metabolize thiosulfate to sulfite in a sulfur

239 explain how a strong pOFC pathway, which is poised to moderate activity of CeM, through IM, can be u

240 site of intense immune cell activity that is poised to mount an effective response against a pathogen

241 macrophages of the islets of Langerhans are poised to mount an immune response even at steady state,

242 that the majority of such changes were from poised to non-poised state.

243 of chemical bonds in polyatomic molecules is poised to open new pathways for the laser-driven synthes

244 Gastroenterologists are uniquely poised to participate in the multidisciplinary managemen

245 tion of metabolic outputs, sirtuins are well poised to play pivotal roles in tumor progression and su

246 essed in resting B cell and shifted from non-poised to poised state after B cell activation.

247 ngly, we also observed a transition from non-poised to poised state.

248 synaptic modulation and show that Munc13 is poised to profoundly impact information transfer at nerv

249 TPH cells appear to be uniquely poised to promote B-cell responses and antibody producti

250 shape changes, but if they go awry, they are poised to promote disease states such as cancer cell met

251 raphy-tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules underlyi

252 mediators of central tolerance, DCs are thus poised to provide homeostatic regulation of thymic expor

253 The developed constructs provide a platform poised to provide new insights into the subcellular dist

254 t exposes its ligand-binding site, but it is poised to rapidly assemble into intracellular signal-gen

255 These memory CD8 T cells remain poised to rapidly elaborate effector functions upon re-e

256 Immune memory cells are poised to rapidly expand and elaborate effector function

257 Macrophages stand poised to rapidly produce large amounts of inflammatory

258 evelopment, physiological cardiac models are poised to realise the promise of translational research

259 ficial nor purely biological approaches seem poised to realize the potential of solar-to-chemical syn

260 unteract numerous cellular defenses that are poised to recognize viruses as nonself and to activate a

261 area required a community of arbovirologists poised to refocus their research efforts and rapidly cha

262 roplet microfluidic screening processors are poised to replace robotic automation by miniaturizing bi

263 sickness), orally dosed fexinidazole stands poised to replace the current treatment regimen for Tryp

264 The United Network for Organ Sharing is poised to resolve geographic disparity in liver transpla

265 initiate differentiation are suppressed, but poised to respond rapidly to developmental signals.

266 erprint of their effector history and remain poised to respond rapidly upon re-exposure to the pathog

267 motors operating at intermediate speeds are poised to respond sharply to changes in mechanical conte

268 We find that animal cells are poised to respond to both increases and decreases in C18

269 We demonstrate that the MHB region is poised to respond to calcium transients that occur in th

270 LC), a diverse class of lymphocytes that are poised to respond to environmental insults including vir

271 th unperturbed forks, implying that they are poised to respond to stalling and collapse.

272 In summary, hepatic ILC2s are poised to respond to the release of IL-33 upon liver tis

273 structures below the diffraction limit--are poised to reveal in quantitative detail the stoichiometr

274 R/Cas9 is a game-changing technology that is poised to revolutionise basic research and plant breedin

275 ogies for rapid microbial identification are poised to revolutionize clinical microbiology and enable

276 tremendous advances in cardiac modelling are poised to revolutionize medical treatment and prevention

277 They are poised to revolutionize optics by enabling complex low-c

278 , induced pluripotent stem cells (iPSCs) are poised to revolutionize stem cell biology and regenerati

279 on, revealing that tissue-resident cells are poised to sense and respond to alterations in microbial

280 The VA is poised to share and extend best practices to other healt

281 Use of the technology is poised to substantially advance integrated control of se

282 Single-cell microfluidic devices are poised to substantially impact the hematology field by p

283 al and a molecular machine in particular are poised to support protein-based heredity in the bacteria

284 d maternal-child health researchers who were poised to tackle this new public health challenge; and (

285 ies in the animal kingdom, plant studies are poised to take a lead role in this area because of their

286 indicating that the genetic loci are already poised to transcribe these novel RNAs.

287 Microbial whole-genome sequencing (WGS) is poised to transform many of the currently used approache

288 icate that not only is resting alphaIIbbeta3 poised to undergo a conformational change that exposes i

289 en bond donor catalyzed cascade reaction are poised to undergo a McMurry coupling to form previously

290 l reasons, biological mixtures are naturally poised to undergo a small number of demixing phase trans

291 unsaturated morpholine derivatives that are poised to undergo further functionalization for the prep

292 on to hydrolysis, the hydrazone products are poised to undergo numerous different known synthetic tra

293 olymeric capsules, the developed strategy is poised to usher the development of the next generation o

294 however, because macrophages and DCs remain poised to vigorously respond to pathogens that breach th

295 H3K9ac and H3K9me3 reveal a progression from poised, to active, to repressive marks, correlating with

296 , acetaldehyde, and ethanol but seemed to be poised toward the production of ethanol from acetaldehyd

297 7me3 at developmental promoters represents a poised transcriptional state.

298 the presence of G4 motifs in the context of poised versus non-poised but active genes.

299 ling, evidence that this system is naturally poised without tuning on the verge of ferromagnetic orde

300 stone deacetylase HDAC2 and ensures that the poised ZRS remains transcriptionally inactive.