ライフサイエンスコーパス: poison

1 "The dose makes the poison".

2 nse, following the dogma "the dose makes the poison".

3 introduces sodium ions--a potential catalyst poison.

4 HQNO, a quorum-sensing-regulated respiratory poison.

5 gamete-killing poison and an antidote to the poison.

6 cal disease and cellular sensitivity to Top2 poisons.

7 conferring cellular resistance against Top2 poisons.

8 idual sensitivities to chemotherapeutic Top2 poisons.

9 ls from arresting in response to microtubule poisons.

10 rylation during hypoxia and by mitochondrial poisons.

11 s and extreme sensitivity to topoisomerase 2 poisons.

12 1.5 inhibition by hypoxia and mitochondrial poisons.

13 f stored hydrogen and/or introduce fuel cell poisons.

14 rrest and sensitized cancer cells to mitotic poisons.

15 val responses of cells against mitochondrial poisons.

16 s and thereby potentiate the effects of Top1 poisons.

17 e efficacy of regimens incorporating topo II poisons.

18 hydrometalation which are otherwise catalyst poisons.

19 mammalian cells to acquire resistance to Eg5 poisons.

20 generated new type II topoisomerase (topoII) poisons.

21 ycle was inhibited, or when Muller glia were poisoned.

22 d musculoskeletal diseases, and injuries and poisoning.

23 , driven by mental illness and injury and/or poisoning.

24 ate to treat or prevent organophosphate (OP) poisoning.

25 se as a first specific treatment for sulfide poisoning.

26 emission, raising the possibility of (210)Po poisoning.

27 oach for adults with calcium channel blocker poisoning.

28 pylobacter jejuni is the major cause of food poisoning.

29 a reduction in blood oxygen level and acute poisoning.

30 pal neurogenesis after acute carbon monoxide poisoning.

31 , and no specific therapy exists for sulfide poisoning.

32 marine food webs and leads to ciguatera fish poisoning.

33 uring the first 7 days after carbon monoxide poisoning.

34 initiated urgently in the context of severe poisoning.

35 formation on both nanocatalysis and catalyst poisoning.

36 eam inflammatory and oxidative effects of CO poisoning.

37 e in the treatment of patients with methanol poisoning.

38 icant advance for treating and preventing CO poisoning.

39 drug therapy against acute organophosphorus poisoning.

40 real removal in the case of severe metformin poisoning.

41 alone kills at 20 mM, CN must potentiate HP poisoning.

42 gnostic marker of death after acute paraquat poisoning.

43 ns for extracorporeal treatment in metformin poisoning.

44 e for bacterial infectious diseases and food poisoning.

45 ons for extracorporeal treatment in methanol poisoning.

46 sk of suicide following discharge after self-poisoning.

47 enteritis necroticans, gas gangrene and food poisoning.

48 old pesticide storage reduces pesticide self-poisoning.

49 containers for prevention of pesticide self-poisoning.

50 ropriate flushing procedures to prevent lead poisoning.

51 ributing to the lack of heterocycle catalyst poisoning.

52 or storage and prevention of accidental self-poisoning.

53 resenting an established plasma biomarker of poisoning.

54 treatment is recommended in severe metformin poisoning (1D).

55 e-treated control, (2) acute carbon monoxide poisoning, (3) acute carbon monoxide poisoning followed

56 on died during the period studied, with lead poisoning a primary factor in six deaths.

57 ent neurological and affective effects of CO poisoning, a portion of survivors still have substantial

58 Pesticide self-poisoning accounts for 14-20% of suicides worldwide.

59 ited enhanced resistance to sintering and CO poisoning, achieving an order of magnitude increase in s

60 position for topoisomerase IB (Top1) enzyme poisoning activity and cytotoxicity to human cancer cell

61 the 3-nitro group with minimal loss of Top1 poisoning activity.

62 Carbon monoxide (CO) poisoning affects 50,000 people a year in the United Sta

63 a formal total synthesis of the famous arrow poison alkaloid tubocurarine.

64 : self-injury alone pound753 (SD 2061), self-poisoning alone pound806 (SD 1568), self-poisoning and s

65 1150 (70%) presentations were for self-poisoning alone, 367 (22%) for self-injury alone, and 13

66 transcripts to encode both a gamete-killing poison and an antidote to the poison.

67 litate the oxidative removal of carbonaceous poison and combination with CH3CO radicals on adjacent P

68 hen he first raised the possibility of being poisoned and revealed his background and former identity

69 Mercury poisoning and "hot filtration" experiments ruled out lea

70 um perfringens enterotoxin (CPE) causes food poisoning and antibiotic-associated diarrhea.

71 rfringens enterotoxin (CPE) cause human food poisoning and antibiotic-associated diarrhea.

72 (GI) symptoms of C. perfringens type A food poisoning and CPE-associated non-food-borne human GI dis

73 V) in people who have recovered from arsenic poisoning and in patients with acute promyelocytic leuke

74 Bacillus cereus a pathogen that causes food poisoning and life-threatening wound infections, secrete

75 Addition of detergent in milk can cause food poisoning and other complications.

76 ylactic therapeutics against organophosphate poisoning and other important targets.

77 nal bicyclopentadione) mediate topoisomerase poisoning and possibly many other activities of curcumin

78 favour the adsorption of O2, alleviating CO poisoning and promoting the catalysis.

79 (upper gastrointestinal haemorrhage, alcohol poisoning and related head injury, and a completed suici

80 Self-poisoning and self-injury are associated with a high ris

81 elf-poisoning alone pound806 (SD 1568), self-poisoning and self-injury pound987 (SD 1823; p<0.0001).

82 10)Po) gained widespread notoriety after the poisoning and subsequent death of Mr Alexander Litvinenk

83 A damages induced by topoisomerase II (Top2) poisons and causes resistance to these drugs.

84 atients to the broadly used topoisomerase II poisons and defines alternative pathways that could be t

85 n response to electron transport chain (ETC) poisons and mitochondrial DNA-linked disease mutations,

86 of heterogeneous DNA damage that causes Top2 poisoning, and indicate that evaluation of Tdp2 status m

87 oints were highest for deaths due to injury, poisoning, and other external causes, in both men (7.89;

88 , recent history of intentional use for mass poisoning, and the absence of a known antidote raise pub

89 dministration as an antidote for (134/137)Cs poisoning, and use for (131/137)Cs radiotherapy (brachyt

90 nd nanoparticles of Ni3S2 are highly active, poison- and corrosion-resistant catalysts for oxygen red

91 translated as a rapid recovery of previously poisoned animals.

92 Early symptoms of (210)Po poisoning are indistinguishable from those of a wide ran

93 The paralytic shellfish poisons are a collection of guanidine-containing natural

94 TOP2 poisons are valuable and widely used anticancer drugs, b

95 ratio=15.86, 95% CI=10.7-23.4; computed with poisoning as reference), and to a lesser extent after ev

96 e theoretical basis behind carbon and sulfur poisoning, before examining the strategies toward carbon

97 s therefore not only the dose that makes the poison but also the exposure sequence.

98 In the absence of severe poisoning but if the methanol concentration is elevated

99 resistant to treatment with topoisomerase II poisons but not other DNA damaging agents.

100 cyanide antidote in animal models of cyanide poisoning, but it is unstable in solution and poorly abs

101 ive decarbonylation pathways are selectively poisoned by CO.

102 1 forming a heterooligomer with PEX6 that is poisoned by pex1-3 subunits.

103 riggered by Top2 engagement of DNA damage or poisoning by anticancer drugs.

104 s O2 , and Ag/Pt surface proximity disfavors poisoning by CO or oxidized species.

105 eaction will be inhibited because of surface poisoning by CO.

106 HQNO induces specific self-poisoning by disrupting the flow of electrons through th

107 , moderate and severe acute organophosphorus poisoning by exposing zebrafish larvae to different conc

108 euRS), while the TM84-producer prevents self-poisoning by expressing a resistant LeuRS AgnB2.

109 antagonists is most commonly associated with poisoning by or surreptitious ingestion of warfarin, war

110 emory impairment after acute carbon monoxide poisoning by preserving adult neurogenesis via an increa

111 ever no efficient and approved treatment for poisoning by ricin inhalation, although there have been

112 These materials are resistant to poisoning by small reactive gases (CO and H2S) that may

113 Pt is notorious for its sensitivity to poisoning by strong CO adsorption.

114 or PDK1 siRNA antagonized the topoisomerase poisons by diminishing DNA synthesis, a process that con

115 Methanol poisoning can induce death and disability.

116 Organophosphate poisoning can occur from exposure to agricultural pestic

117 Colorado and documented the response of the Poison Canyon aquifer system several years after upward

118 cs of groundwater-methane attenuation in the Poison Canyon aquifer: (i) consumption of methane and su

119 the distal regions of gene bodies, and TOP2 poisons cause a proximal shift in their distribution.

120 phimurium (ST), a major source of human food poisoning, caused inflammation of murine intestinal tiss

121 In the absence of Sarm1, the mitochondrial poison CCCP still induces depolarization of mitochondria

122 hich receives exposure reports from regional poison centers serving the United States, Puerto Rico, a

123 ther data from drug-diversion investigators, poison centers, substance-abuse treatment centers, and c

124 ively related to incidence of ciguatera fish poisoning (CFP).

125 ike state in the presence of the microtubule poison colcemid, suggesting that the two viral proteins

126 ete peptides and proteins to communicate, to poison competitors, and to manipulate host cells.

127 formation on 1,102 CFP-related calls to U.S. poison control centers during 2001-2011 from the Nationa

128 especially for young people and against self-poisoning, could potentially lower future costs at a tim

129 Poison-dart Phyllobates terribilis frogs sequester letha

130 According to National Poison Data System, the most common reported ocular effe

131 METHOD: The National Poison Data System, which receives exposure reports from

132 l centers during 2001-2011 from the National Poison Data System.

133 uicides and mischaracterization of most drug poisoning deaths as "accidents" on death certificates.

134 e SuperMICAR text entries to study the 7,817 poisoning deaths that occurred among Washington State re

135 e control group; incidence of pesticide self-poisoning did not differ between groups (293.3 per 100 0

136 ISPR/Cas9-mediated chromosome cutting, or by poisoning DNA decatenation resulted in mistiming of MapZ

137 otoxic treatments, using other topoisomerase poisons, DNA synthesis inhibitors, interstrand cross-lin

138 The topoisomerase II poisons doxorubicin and etoposide constitute longstandin

139 eriod (AD 500-1450) show patterns of chronic poisoning due to exposure to geogenic arsenic.

140 .g. steam) and the presence of various metal poisons (e.g. V, Fe and Ni) in the crude oil feedstocks

141 ed directing group capable of overriding the poisoning effect of a wide range of heterocycle substrat

142 ymer layer as a transducer did not show this poisoning effect.

143 tter tolerance for methanol crossover and CO poisoning effects, long-term durability than commercial

144 lity and free from any methanol-crossover/CO-poisoning effects.

145 Most suicides occur long after the index poisoning, emphasizing the importance of longitudinal, s

146 mental remediation to address childhood lead poisoning epidemic due to artisanal gold mining in Zamfa

147 identified all individuals with a first self-poisoning episode in Ontario, Canada, from April 1, 2002

148 A first self-poisoning episode is a strong predictor of subsequent su

149 Patients with a self-poisoning episode were also more likely to die because o

150 For each individual with a deliberate self-poisoning episode, we randomly selected 1 control from t

151 ears) who were discharged after a first self-poisoning episode.

152 der age, male sex, multiple intervening self-poisoning episodes, higher socioeconomic status, depress

153 ion in the liver, posing a risk of secondary poisoning especially in liver-failure patients.

154 The TOP2 poison etoposide has been implicated in the generation o

155 an enhanced response to the topoisomerase-II poison etoposide.

156 s and transforms the topoisomerase II (TOP2) poisons etoposide and mitoxantrone to chemical forms tha

157 illed medication prescriptions, and nonfatal poisoning events during the 30 days and 12 months before

158 ecular weight neurotoxin, is responsible for poisoning events that traditionally occur from consumpti

159 te that disrupts normal skipping of the FLNA poison exon in NPCs and causes a brain-specific malforma

160 vel isoforms in the Camk2 family and a novel poison exon in Ptbp1, a key splice factor in neurogenesi

161 cal progenitors partly through suppressing a poison exon of Flna in NPCs, Rbfox proteins promote neur

162 ns, especially in the setting of intentional poisoning, fire-related toxic gas exposures, and inhalat

163 onoxide poisoning, (3) acute carbon monoxide poisoning followed by 7-day hyperbaric oxygen treatment,

164 B-Fc) chimera, and (5) acute carbon monoxide poisoning followed by intracerebroventricular infusion o

165 ted by the use of arsenic (As) alloying as a poison for the cathodic reaction, leading to significant

166 duct aniline, left unprotonated, serves as a poison for the QD catalyst by adsorbing to its surface.

167 nsor was 100% accurate in diagnosing cyanide poisoning for acutely exposed rabbits.

168 amino acid replacements that differed among poison frog lineages.

169 y serves to prevent misdirected care in this poison frog.

170 Here we show experimentally that male poison frogs adjust their parental responses - care or i

171 Poison frogs have a diverse arsenal of defensive alkaloi

172 id replacement, which evolved three times in poison frogs, decreased epibatidine sensitivity but at a

173 ive OD were identified using ICD-9 codes for poisoning from opioids or adverse effects from opioids.

174 novo synthesis of three paralytic shellfish poisons, gonyautoxin 2, gonyautoxin 3, and 11,11-dihydro

175 years or older, 611 cases of pesticide self-poisoning had occurred by 3 years in the intervention gr

176 herichia coli strains, and outbreaks of food poisoning have caused significant mortality rates as, fo

177 noisoquinoline human topoisomerase IB (Top1) poisons have potent antiproliferative effects on cancer

178 ders, including food allergy, scombroid food poisoning, histamine intolerance, irritable bowel syndro

179 r in nZVI lies essentially in its ability to poison hydrogen recombination, which drives surface reac

180 termediate in electro-oxidation of CO2 and a poison in partial oxidation reactions.

181 hromatography and was found to be a catalyst poison in thiourea-catalyzed glycosylations of galactals

182 We developed a model of CO poisoning in anesthetized and mechanically ventilated mi

183 hot pellets constitutes the main cause of Pb poisoning in avifauna.

184 dren (R(2) = 0.68) and the incidence of lead poisoning in children under age 1.3 years (R(2) = 0.64).

185 letal muscle cytochrome c oxidase to sulfide poisoning in ethylmalonic encephalopathy, resulting from

186 ance against both carbon build-up and sulfur poisoning in hydrocarbon fuels.

187 mary outcome was incidence of pesticide self-poisoning in people aged 14 years or older during 3 year

188 be-PVC-based membrane, suffered from sulfide poisoning in the deeper, sulfidic regions of the lake.

189 major cause of mortality resulting from food poisoning in the United States.

190 ses addressed an unprecedented epidemic lead poisoning in Zamfara State, northern Nigeria.

191 or extracorporeal treatment: Severe methanol poisoning including any of the following being attribute

192 spiratory complications after OP insecticide poisoning, including onset of delayed neuromuscular junc

193 Extracorporeal Treatments in Poisoning inhibitors and folic/folinic acid should be co

194 Acetaminophen (APAP, paracetamol) poisoning is a leading cause of acute liver failure (ALF

195 Organophosphorus (OP) compound poisoning is a major global public health problem.

196 Agricultural pesticide self-poisoning is a major public health problem in rural Asia

197 Selenium poisoning is a significant health problem in parts of Pu

198 Staphylococcal food poisoning is caused by enterotoxins excreted into foods

199 Paracetamol poisoning is common worldwide.

200 t universally fatal, survival following self-poisoning is common, providing an opportunity for second

201 Food poisoning is one of the leading causes of morbidity and

202 Deliberate self-poisoning is the leading method of attempted suicide.

203 of suicide following a first episode of self-poisoning is unknown.

204 untermeasures against acute organophosphorus poisoning is urgently needed.

205 fishery products, responsible for scombroid poisoning, is essential to guarantee the safety of food.

206 h at the site of contact with allergens like poison ivy or nickel.

207 Human subjects with poison-ivy dermatitis had a similar cytokine signature f

208 Acute OP insecticide self-poisoning kills over 200,000 people every year, the majo

209 Phototherapy administered during severe CO poisoning limited the blood COHb increase and improved t

210 ases, we suggest that the very nature of CS2 poisoning may be related to interrupting or overwhelming

211 Here we show that metal poisoning may have caused these aberrant morphologies du

212 This "self-poisoning" mechanism explains the need to mix CO into th

213 could protect hematopoietic cells from TOP2 poison-mediated genotoxic damage and, therefore, reduce

214 to as nitrocobinamide) that rescues cyanide-poisoned mice and rabbits when given by intramuscular in

215 In CO-poisoned mice, phototherapy of exposed lungs at 532, 570

216 al activity of EDP on food spoilage and food poisoning microorganisms was evaluated through the measu

217 and budding yeast, and studying meiosis with poisoned microtubules indicates that the increased gamet

218 ts can be obtained from others, stabbing and poisoning neighbouring cells, or colonising spaces while

219 inically described as neurological shellfish poisoning (NSP).

220 from a home marine aquarium involved in the poisoning of a whole family.

221 rent length scales for the analysis of metal poisoning of an individual catalyst particle.

222 ersibly store hydrogen prevents the hydrogen poisoning of Ru surfaces.

223 The poisoning of rural populations in South and Southeast As

224 ct experimental support to the well-accepted poisoning of the TPRE and IIT mechanisms, but also provi

225 re-entrant edge (TPRE) mechanism as well as poisoning of the TPRE mechanism are valid under certain

226 However, IIT, TPRE or poisoning of the TPRE mechanism cannot be used to interp

227 re-entrant edge, inducing TPRE mechanism or poisoning of the TPRE mechanism, and (iii) the segregati

228 mits formation of EPFRs due to inhibition or poisoning of the transition metal active sites necessary

229 reversal protects forks from breakage after poisoning of Topoisomerase 1.

230 On the other hand, phosphorus poisoning of zeolite-based catalysts, which are used for

231 ic deactivation due to hydrocarbon coking or poisoning of zeolites at an unprecedented spatial resolu

232 the multiple respiratory complications of OP poisoning offers additional therapeutic opportunities.

233 We demonstrate that the poison oligomers can act as habit modifiers both during

234 The introduction of "poison" oligonucleotides that specifically disrupt criti

235 subsequent oxidative removal of carbonaceous poison on neighbouring platinum sites.

236 cides) to describe such metabolites that can poison or inhibit the parent via induced biosynthesis or

237 elf-harm (intentional acts of non-fatal self-poisoning or self-injury) is common, particularly in you

238 onspecific ocular chemical burn and chemical poisoning or toxic effects were eligible for inclusion.

239 lead compound, 3, were identified as either poisons or inhibitors of Top1.

240 C/C inhibitor, apcin, but not to the spindle poison paclitaxel.

241 ermining substances involved when treating a poisoned patient.

242 roximately one-third of moderate to severely poisoned patients exhibit cardiac dysfunction, including

243 eaction tolerates heterocycles that commonly poison Pd catalysts.

244 uggesting that cleaved C0-C1f could act as a poison polypeptide and disrupt the interaction of native

245 Paralytic shellfish poisoning (PSP) is a serious human illness caused by the

246 PtO-like surface oxide phase on bare non-CO poisoned Pt regions with PtO2 as majority spectator spec

247 in genes involved in translocations in TOP2 poison-related leukemia.

248 monoxide (CO) exposure is a leading cause of poison-related mortality.

249 Treatment of CO poisoning requires rapid removal of CO and restoration o

250 ive introgression event involving the rodent poison resistance gene Vkorc1, in addition to other newl

251 Furthermore, acute carbon monoxide poisoning resulted in a delayed impairment of cognitive

252 rly triggering prematurely induced by energy poisons resulted in many fewer visible holes, consistent

253 Suicides by carbon monoxide poisoning resulting from burning barbecue charcoal reach

254 migrated to the nucleus, bound nucleoli, and poisoned RNA biogenesis, which caused cell death.

255 ety of stresses, including the mitochondrial poison rotenone, amyloid beta-peptide, hydrogen peroxide

256 which are commonly ingested in acts of self-poisoning, seem to be effective in reducing pesticide-sp

257 This first set of hybrid topoII poisons shows promising antiproliferative activity on hu

258 Acute carbon monoxide poisoning significantly suppressed adult hippocampal neu

259 n is critical for C. perfringens type A food poisoning since spores contribute to transmission and re

260 rial targeting by activating a mitochondrial poison specifically within that organelle.

261 , a derivative of C. perfringens type A food-poisoning strain NCTC8798.

262 ly, several metabolites were predicted to be poisons, strongly suggesting the need for further experi

263 Four examined acute exposure: Three neonic poisoning studies reported two fatalities (n = 1,280 cas

264 Four examined acute Three neonic poisoning studies reported two fatalities (n = 1,280 cas

265 ignificant number of patients who survive CO poisoning suffer from long-term neurological and affecti

266 underestimated owing to misclassification of poisoning suicides and mischaracterization of most drug

267 tes a tightly regulated QS self-defense anti-poisoning system.

268 red the response of cells to the microtubule poison Taxol.

269 ibitor dexrazoxane (ICRF187) and mechanistic poison teniposide (VM26), can interfere with DNA gate dy

270 ry mechanistic studies, assisted by catalyst poison tests and stoichiometric tests performed using an

271 surface catalysts, this *OH binding does not poison the multi-metal-atom site but acts as a modifying

272 vity may prevent iron hydride formation from poisoning the P3(B)Fe system.

273 oxygen formed after the dissociation of CO2 poisons the surface by blocking further adsorption of CO

274 n into highly toxic oligomers that potently "poisoned" the ability of major actin assembly proteins,

275 In the absence of severe poisoning, the decision to use extracorporeal treatment

276 ransiently reducing paralysis following BoNT poisoning, the precise mechanisms by which aminopyridine

277 e determinant for C. perfringens type-A food poisoning, the second most common bacterial food-borne i

278 mechanism of action from a topoisomerase II poison to a DNA cross-linker.

279 no evidence of switching from pesticide self-poisoning to other forms of self-harm, with no significa

280 enge the rational design of isoform-specific poisons to further delineate these processes.

281 increase their chances of spreading by using poisons to kill other alleles, and antidotes to save the

282 arkable given the propensity for sulfides to poison transition-metal catalysts.

283 Lead (Pb) poisoning via ingestion of shot pellets is a frequent ca

284 emediation to abate exposures to 17,000 lead poisoned villagers, to facilitate chelation treatment of

285 Acute carbon monoxide poisoning was achieved by exposing the rats to carbon mo

286 of lung phototherapy administered during CO poisoning was also studied.

287 of adult neurogenesis by the carbon monoxide poisoning was appreciably alleviated by early treatment

288 The risk of suicide following self-poisoning was markedly increased relative to controls (h

289 Thallium poisoning was suspected and investigated but ultimately

290 n method of suicide (125 [73%] of 171), self-poisoning was the main reason for presenting to hospital

291 Azaspiracid (AZA) poisoning was unknown until 1995 when shellfish harveste

292 Patients with acute paraquat poisoning were recruited.

293 To enact drive, all gametes are poisoned, whereas only those that inherit wtf4 are rescu

294 Methanol is a poison which is frequently discovered in alcoholic bever

295 SEA is the main cause of food poisoning, while SEB is a common toxin manufactured as a

296 Metformin poisoning with lactic acidosis appears to be amenable to

297 ical course prompted active consideration of poisoning with radioactive material, with the diagnosis

298 The Extracorporeal Treatments in Poisoning workgroup aimed to develop evidence-based cons

299 Here, the Extracorporeal Treatments In Poisoning workgroup, comprising international experts re

300 ellosis is one of the leading causes of food poisoning worldwide.