ライフサイエンスコーパス: pol gene

1 al frameshift event to enter the overlapping pol gene.

2 ance arising from point mutations in the CMV Pol gene.

3 tivator, and a potential promoter within the pol gene.

4 clinically relevant escape mutations in the Pol gene.

5 ively structure-free template from the HIV-1 pol gene.

6 er junctions were distributed throughout the pol gene.

7 eletions were also introduced into the viral pol gene.

8 , presumably corresponding to the end of the pol gene.

9 in the human immunodeficiency type 1 (HIV-1) pol gene.

10 age RNA molecules that encode HERV-K-related pol genes.

11 promoter in antisense orientation to the gag-pol genes.

12 B env gene rather than the subtype C gag and pol genes.

13 nous retrovirus K10 in 3.5 kb of the gag and pol genes.

14 n influenza virus A, and HIV-1 env, vif, and pol genes.

15 of diversity and divergence in both env and pol genes.

16 d in the hepatitis B virus (HBV) polymerase (Pol) gene.

17 transcriptase encoded by the HBV polymerase (pol) gene.

18 5%) followed by alkyl phosphonate-associated pol-gene (7.4%), immune-associated S gene (specifically

19 highly conserved regions of the polymerase (pol) gene, allowed the identification of two novel porci

20 istic evolutionary model for analyses of the pol gene, although it is inapplicable to analyses involv

21 eotide ligation assay specific codons in the pol gene amplified by PCR.

22 ce analysis of the RT-encoding region of the pol gene amplified from resistant viruses consistently i

23 ce analysis of the RT-encoding region of the pol gene amplified from the plaque-purified mutants reve

24 The primers used for nested PCR of the HIV-1 pol gene amplified templates from a reference panel of m

25 blindly for HIV-1 subtypes by sequencing the pol gene and by gag-HMA.

26 PR-Cas9, we disrupted all copies of the PERV pol gene and demonstrated a >1000-fold reduction in PERV

27 s biotinylated proteins encoded by the HIV-1 pol gene and neighbor Gag proteins, but, surprisingly, o

28 ntral polypurine tract (cPPT) from the HIV-1 pol gene and removing the cytoplasmic tail of EnvA, the

29 e primary site of hypermutation is the viral pol gene and the dominant selective force acting on this

30 an internal deletion that removes all of the pol gene and various amounts of gag and env gene sequenc

31 ift similar to frameshifts in retroviral gag-pol genes and bacterial insertion elements was found to

32 The pol genes and deduced amino acid sequences from 23 provi

33 sted of two plasmids, one expressing the gag/pol genes and the other expressing the env gene of FeLV-

34 lated depended on the individual env and gag-pol genes and their suppressive effects on virus replica

35 dogenous mammalian DNA polymerase beta (beta-pol) gene and of the cloned promoter in transient expres

36 iral diversity and divergence in the env and pol genes, and determined coreceptor tropism and the fre

37 lass was observed in l-nucleoside-associated pol gene/antiviral-associated S gene mutations (cumulati

38 Incidence of l-nucleoside-associated pol-gene/antiviral-associated S gene mutations was signi

39 murine leukemia virus (MuLV), whose gag and pol genes are in the same reading frame but separated by

40 rtain mutations in the viral DNA polymerase (pol) gene are known to confer drug resistance when trans

41 ion between two viruses containing subtype B pol genes (B/B) and between viruses with pol genes from

42 -acting element located at the 3' end of the pol gene between position 6486 and 6975 to be critical f

43 ng the Moloney murine leukemia virus gag and pol genes but lacking virus envelope genes produce virus

44 ched the subtypes determined for the gag and pol genes but not the env gene, suggesting that a recomb

45 (A62V, V75I, F77L, F116Y, and Q151M) in the pol gene conferring resistance to multiple dideoxynucleo

46 f the Moloney murine leukemia virus (M-MuLV) pol gene encoding the connection-RNase H domains of reve

47 In this study, an individual patient's HIV-1 pol gene encoding the full length of protease and part o

48 Sequence comparison of portions of the PoEV pol gene expressed in pig cell lines productively infect

49 t is a required transcription factor in beta-pol gene expression.

50 res a programmed -1 ribosomal frameshift for Pol gene expression.

51 ification at one ambiguous site in the viral pol gene for biological activity.

52 le that SFV-1 contains a promoter within the pol gene for initiating a reverse transcriptase transcri

53 ducting a BLASTN search, the initial partial pol gene fragment was found to have 95% to 97% nucleotid

54 HTLV-1 pol gene fragments encoding reverse transcriptase were a

55 vity, we sequenced and phenotypically tested pol genes from a variety of HTLV-1 isolates derived from

56 VA-TZC (MVA-T) vaccines contain gag, env and pol genes from HIV-1 subtypes CRF01_AE, A and C, respect

57 e B pol genes (B/B) and between viruses with pol genes from subtype B or F (B/F).

58 our rate estimates for the RNA polymerase 3D(pol) gene from five viruses to four published 3D(pol) ra

59 e of infection without selection pressure on pol gene function were analyzed by single-genome sequenc

60 l repeat and the 5' half of env; the gag and pol genes have been partially deleted.

61 We found sequences homologous to retroviral pol genes in the cell-free cerebrospinal fluids (CSFs) o

62 LV with differences from EU-8 in the gag and pol genes, induces rapid-onset lymphoma at only a low in

63 HIV-1 pol gene intersubtype and RC differences are associated

64 d the finding of a cis-acting element in the pol gene is unique among retroviruses.

65 is virus (MHV) gene 1, the 22-kb polymerase (pol) gene, is first translated into a polyprotein and su

66 nd the identification of clinically relevant pol gene length polymorphisms will impact the generaliza

67 iations with treatment experience, clade, or pol gene mutations were observed.

68 0/s145, 6.4%), and d-cyclopentane-associated pol-gene mutations (2.4%).

69 ion to patient data from one-time samples of pol gene obtained by single-genome sequencing from repre

70 tified a conserved cis-acting element in the pol gene of gammaretroviruses, including murine leukemia

71 describes the detection of mutations in the pol gene of human immunodeficiency virus type 1 associat

72 the 3' end of the gag gene and preceding the pol gene of SFV-1.

73 tional frameshift similar to that of the gag-pol genes of many retroviruses to produce the proteins g

74 frames (ORFs) that correspond to the gag and pol genes of previously described retrotransposons and r

75 the env gene of HIV-1 HXBc2 and the gag and pol genes of simian immunodeficiency virus SIVmac239.

76 A 182-bp fragment of the pol genes of the two remaining mandrill SIV isolates was

77 ct of a gene-targeted disruption in the beta-pol gene on DNA repair capacity and on in vivo sensitivi

78 ther simian immunodeficiency virus (SIV) gag/pol genes or no SIV genes in vivo to test the additional

79 Moloney murine leukemia virus (MLV) gag and pol genes produce large amounts of noninfectious virus-l

80 the primer species can be attributed to the pol gene product, nothing is known regarding mechanisms

81 at resulted in two amino acid changes in the pol gene product; and a single nucleotide change in the

82 and SNV vectors, indicating that the gag and pol gene products from two different viruses can functio

83 ng elements are not ideal substrates for MLV pol gene products since infectious viruses were generate

84 n a multiple cycle assay, so that functional pol gene products were selected.

85 In all other retroviruses, the pol gene products, including reverse transcriptase, are

86 d as genomic RNA and as mRNA for the Gag and Pol gene products.

87 spliced RNAs as mRNAs to produce the gag and pol gene products.

88 al TATA-less human DNA polymerase beta (beta-pol) gene promoter.

89 drug pressure can direct evolution of viral pol gene quasispecies independently of direct drug-resis

90 mployed for an extensive genetic analysis of pol gene quasispecies.

91 ear evidence of A/B recombination within the pol gene segment, whereas in the other patient, GA132, n

92 To determine whether variations in the pol gene sequence correlated with virus infectivity, we

93 hree distinct strains A, B, and C defined by pol gene sequence divergences, is endemic in the large o

94 The pol gene sequence was amplified to ascertain the HIV-1 s

95 mong 159 case patients who had an HIV type 1 pol gene sequence, 157 (98.7%) had sequences that were h

96 molecular epidemiology studies analyse viral pol gene sequences due to their availability, but whole

97 Phylogenetic analysis of HIV-1 pol gene sequences from Britain showed at least six larg

98 We extracted all subtype B HIV-1 pol gene sequences from treatment-naive patients within

99 enetic analysis of 14,061 HIV type 1 (HIV-1) pol gene sequences generated in the United Kingdom from

100 FIV-Pco pol gene sequences isolated from pumas revealed extensiv

101 ylodynamic analysis was performed on partial pol gene sequences obtained for routine clinical care fr

102 from the conserved motifs of the polymerase pol gene sequences to detect members of the Paramyxoviri

103 Using HTLV-I/II pol primers, no HTLV-I pol gene sequences were detected.

104 ntical to viruses in resting CD4+ T cells by pol gene sequencing.

105 the Alu repeat in human genomic DNA and HIV pol gene simultaneously.

106 te the genetic relationship to SIVcpz in the pol gene, SIVrcmNG411 did not replicate in chimpanzee pe

107 opteran (moth) retroelement contains gag and pol genes that encode proteins capable of forming virusl

108 Vectors carrying pol genes that matched the consensus sequence had the hi

109 y conserved region of integrase in the HIV-1 pol gene (the integrase single-copy assay [iSCA]), and i

110 ORFs 1 and 3 correspond to gag and pol genes; the second ORF, pro, corresponding to proteas

111 nsposon Ty1 element is replaced with the HBV pol gene to produce the hybrid Ty1/HBV element.

112 fragments of envelope (env) and polymerase (pol) genes, two genetically distinct lineages of FIVpco

113 Sequencing of the CMV pol gene was performed in 30 isolates.

114 Genotyping of the HIV-1 pol gene was performed using a broadly sensitive in-hous

115 ing human immunodeficiency virus env and gag-pol genes, we detected nonexpressing mutants by immunost

116 INS elements from the HIV-1 p17 gag and pol genes were equally active in complementing Rev-depen

117 Mutations at the POLTERGEIST (POL) gene were previously described as phenotypic suppre

118 ines depends on an enhancer within the viral pol gene which can be localized to a minimal 183-bp regi

119 (A62V, V75I, F77L, F116Y, and Q151M) in the pol gene, which confers resistance to multiple dideoxynu

120 The POL gene, which encodes a functional protein phosphatase