ライフサイエンスコーパス: polarity gene

1 ogue of the Drosophila planar cell or tissue polarity gene.

2 identified rasp, a novel Drosophila segment polarity gene.

3 e eye, likewise dependent on the planar cell polarity genes.

4 nes into the segmental expression of segment polarity genes.

5 n and growth of lateral organ primordia, and polarity genes.

6 has not been defined for any of the segment-polarity genes.

7 maternal effect, gap, pair-rule, and segment polarity genes.

8 ith pod-1, defines a new class of C. elegans polarity genes.

9 Mutation of different apicobasal polarity genes activates c-Jun N-terminal kinase (JNK) s

10 l: a cell fate programme mediated by segment polarity genes and a boundary/epithelial integrity progr

11 s may not control segmentation, some segment polarity genes and their interactions are conserved.

12 s are homologs of the Drosophila dsh segment polarity gene, and are involved in the Wnt/wingless sign

13 suggest it requires cytoplasmic dynein, cell polarity genes, and microtubule-associated proteins that

14 on is directed by the activity of the planar polarity genes, and, in particular, higher activity of t

15 Key polarity genes aPKC, par6, vang, pk, and fmi are upregul

16 These segment polarity genes are expressed in some, but not all of the

17 trunk of the Drosophila embryo, the segment polarity genes are initially activated by the pair-rule

18 To understand how these segment polarity genes are regulated, we examined the results of

19 These findings show that planar cell polarity genes are required for responses to cell death.

20 ression of the gap, segmentation and segment polarity genes, as well as changes in early morphologica

21 ressor function, consistent with the loss of polarity genes associated with hyperproliferation in Dro

22 e for 1000 generations without the important polarity gene BEM1.

23 Inactivation of these cell polarity genes cannot drive metastatic behavior alone or

24 ter simulations, that the Drosophila segment polarity genes constitute such a module, and that this m

25 Mutation of the polarity gene Crumbs homolog 1 (CRB1) is responsible for

26 The Drosophila segment polarity gene cubitus interruptus (ci) encodes a zinc fi

27 The segment polarity gene cubitus interruptus (ci) maps to the most

28 signaling is thought to involve the segment polarity gene cubitus interruptus (ci).

29 , the human homologue of the Drosophila cell polarity gene dachsous (ds), that segregates with MVP in

30 reoriented mitosis required the planar cell polarity genes dachsous, fat, and atrophin.

31 ene is an ortholog of the Drosophila segment polarity gene Dishevelled, a member of the highly conser

32 ree mouse homologs of the Drosophila segment polarity gene Dishevelled, were created by gene targetin

33 have recently characterized a second segment polarity gene, dTCF or pan, 12 kb upstream of ci, in a h

34 key to the coordinated regulation of segment-polarity genes during embryogenesis.

35 of rin are similar to those of RhoA and the polarity genes, e.g. fz and dsh.

36 la, members of the frizzled family of tissue-polarity genes encode proteins that are likely to functi

37 at naked cuticle (nkd), a Drosophila segment-polarity gene, encodes an inducible antagonist for the W

38 The expression domains of the segment polarity gene engrailed (en) allow one to subdivide the

39 rizing the expression pattern of the segment polarity gene engrailed (en) in a basal annelid, the pol

40 The segment-polarity gene Engrailed and the homeotic genes Ultrabith

41 and En-2, homologs of the Drosophila segment polarity gene engrailed, in regulating the development o

42 One example is the expression of the segment polarity gene engrailed, which at embryonic and early po

43 embles the expression stripes of the segment-polarity gene engrailed, which has a key role in establi

44 e in repressing transcription of the segment-polarity gene engrailed.

45 ntrol the periodic expression of the segment polarity genes engrailed (en) and wingless (wg) via regu

46 ects of otd on the expression of the segment polarity genes engrailed (en) and wingless (wg).

47 sion of orthologues of the arthropod segment polarity genes engrailed (en), hedgehog (hh), and wingle

48 s fail to maintain expression of the segment polarity genes engrailed (en), wingless (wg), and hedgeh

49 We report that primary segment polarity genes (engrailed, hedgehog and wingless) are no

50 To determine whether segment polarity gene expression is established differently outs

51 These results show that segment polarity gene expression is necessary for the survival o

52 pe-specific defects in pair-rule and segment polarity gene expression.fish mutant embryos also exhibi

53 oskeleton, but in addition they control cell polarity, gene expression, microtubule dynamics and vesi

54 Fmi2, homologs of the Drosophila planar cell polarity gene, flamingo; hFat2, a homolog of the Drosoph

55 y phenotype by mutations in two other tissue polarity genes, flamingo and prickle.

56 tion, highlighting the importance of "planar polarity" genes for defining the shape of a neuron in al

57 mammalian homologs of the Drosophila tissue polarity gene frizzled.

58 We study four polarity genes, frizzled (fz), prickle (pk), Van gogh/st

59 Previous studies of segment polarity gene function largely focused on neuroblasts th

60 mbryos, a hierarchy of gap/pair-rule/segment polarity gene function may be a shared and ancestral fea

61 The tissue polarity gene fuzzy (fy) has two roles in the developmen

62 We also provide evidence that the segment-polarity gene, gooseberry (gsb), controls expression of

63 he Drosophila wing, a "core" group of planar polarity genes has been identified which acts downstream

64 Segment polarity genes have a dual function in early neurogenesi

65 picardial lineage only and finally, the cell polarity genes heart and soul and nagie oko are required

66 rtebrate homologue of the Drosophila segment-polarity gene hedgehog, has been reported to play an imp

67 n of secreted signals encoded by the segment polarity genes hedgehog (hh) and wingless (wg) and are i

68 We show that the segment polarity genes hedgehog and wingless specify the identit

69 factors); Wnt 7a and Shh (Drosophila segment polarity gene homologs); Msx-1 and Msx-2 (Msx class home

70 The segment polarity gene homologues have a conserved role in the sp

71 Here, we describe a new C. elegans polarity gene identified during screens for conditional

72 Lethal giant larvae (Lgl) is an apical-basal polarity gene identified in Drosophila, where it functio

73 asolateral, recycling, implicating this cell polarity gene in assembly or maintenance of the apical e

74 n vivo invasion model via knocking down cell polarity gene in Drosophila wing discs, and identify Rho

75 ed recently to represent Stardust, a crucial polarity gene in Drosophila.

76 rosophila melanogaster pair rule and segment polarity genes in a range of arthropods.

77 ry pair-rule genes directly regulate segment polarity genes in Drosophila, we analyzed Tc-prd and Tc-

78 ferentiation by transcriptionally repressing polarity genes in neuronal progenitors.

79 -2 genes appear to act downstream of the par polarity genes in the one- and two-cell stages and downs

80 mal pattern in each segment, several segment polarity genes, including gooseberry (gsb), specify cell

81 chy of maternal, gap, pair-rule, and segment polarity gene interactions regulates virtually simultane

82 segment exhibits a unique network of segment polarity gene interactions.

83 Expression of the Drosophila segment polarity genes is initiated by a pre-pattern of pair-rul

84 Here we tested whether cell polarity genes, known to regulate embryonic neuroblast a

85 a mammalian ortholog of the Drosophila cell polarity gene lgl, exhibit MCCs resembling severe perive

86 is repressed in mice mutant for the segment polarity gene Mesp2 and expanded in Splotch mutants.

87 Here we show that the segment polarity gene midline is required for neuroblast formati

88 Hence, the segment polarity genes midline and H15 play an important role in

89 n Drosophila, hedgehog is one of the segment-polarity genes, mutations of which disrupt the pattern a

90 The Drosophila segment polarity gene naked cuticle (nkd) encodes an EF hand pro

91 la melanogaster, was identified as a segment polarity gene necessary for the transduction of wingless

92 We anticipate that co-option of the polarity gene network is a fundamental mechanism shaping

93 e show that co-option of the abaxial-adaxial polarity gene network plays a role in the evolution of s

94 ed to a Drosophila melanogaster segmentation polarity gene network to identify regulatory function pe

95 insights into the functioning of the segment polarity gene network, such as the crucial role of the w

96 that, in sporadic CRCs of both species, cell polarity genes not only contribute in preventing cancer

97 Here we describe a new segment polarity gene of Drosophila melanogaster, oroshigane (or

98 netic evidence showing that lines, a segment polarity gene of Drosophila, is required for the functio

99 stripes of expression of several key segment-polarity genes, one stripe for each parasegment, in the

100 d-type worms in histology, expression of key polarity genes, or neoblast distribution.

101 ules, as well as decreased expression of the polarity gene Par3 (pard3).

102 the human homolog of the drosophila segment polarity gene patched (ptc).

103 n homologue (PTCH) of the Drosophila segment polarity gene patched have been identified in NBCCS pati

104 ammalian homologue of the Drosophila segment polarity gene patched, is a receptor for hedgehog (HH) a

105 tein kinase A and the product of the segment polarity gene patched.

106 by its genetic interactions with the segment polarity genes patched (ptc) and fused (fu).

107 mmalian homologues of the Drosophila segment polarity gene, patched (ptc) and its ligand, sonic hedge

108 he human homologue of the Drosophila segment polarity gene, patched (PTCH), the adenomatous polyposis

109 the hereditary basal cell carcinoma/segment polarity gene, patched.

110 th strong homology to the Drosophila segment polarity gene, patched.

111 Here we show that the tissue polarity gene prickle (pk) encodes a protein with a trip

112 dy shows that, in ascidians, the planar cell polarity gene prickle regulates sequential establishment

113 ns closely related to the Drosophila segment polarity gene product armadillo.

114 lanar polarity and for the novel planar cell polarity gene, Ptk7, as essential regulators of mediolat

115 ir-rule transcription factor Runt in segment-polarity gene regulation.

116 Drosophila patched is a segment polarity gene required for the correct patterning of lar

117 b(ponli) (ponli) and crumbs2b (crb2b) apical polarity genes' restrictive transcription in the red, gr

118 ns in the Arabidopsis KANADI (KAN) and YABBY polarity genes result in amorphous or arrested integumen

119 We show that MDCK cells silenced for the polarity gene scribble (scrib(KD)) are hypersensitive to

120 Loss of the epithelial polarity gene scribble in clones of Drosophila imaginal

121 two of these: a mutation in the planar cell polarity gene scribbled homolog (Drosophila) (Scrib) and

122 Here we show that the segment-polarity gene smoothened is required for the response of

123 We found that the polarity genes SPA2, PEA2, BUD6, and BNI1 participate in

124 sophila Crumbs also interacts with two other polarity genes, Stardust and Discs Lost.

125 enopus homolog of the Drosophila planar cell polarity gene strabismus (stbm) participates in the regu

126 While the expression patterns of segment polarity genes such as engrailed have been shown to be s

127 and segments, via the regulation of segment polarity genes such as gooseberry, which in turn regulat

128 itional information to pair-rule and segment-polarity genes, the latter forming a segmental pre-patte

129 ods to the regulatory network of the segment polarity genes, thus gaining novel insights into the dev

130 d interacts genetically with all of the core polarity genes to influence the specification of the R3

131 Mutations in the core planar cell polarity gene Van Gogh-like 2 (Vangl2) result in hair ce

132 ined with a mutant allele of the planar cell polarity gene Vangl2 (Vangl2(Lp)), Fz1 and/or Fz2 mutati

133 matrix, epithelial cilia or the planar cell polarity genes Vangl2 and Ptk7 In wild-type mice, collag

134 o in vivo screen on a subcohort of candidate polarity genes, which revealed 6 novel positive regulato

135 We have expressed the segment polarity gene wingless (wg) ectopically in imaginal disc

136 The Drosophila segment polarity gene wingless (wg) is essential for cell fate d

137 the Runt-dependent regulation of the segment-polarity genes wingless (wg) and engrailed (en).

138 The expression patterns of the segment polarity genes wingless and engrailed are conserved duri

139 ed for the correct expression of the segment polarity genes wingless, engrailed and gooseberry.

140 the anterior-posterior axis, several segment polarity genes (wingless, engrailed, hedgehog, and patch

141 gene products subsequently 'imprint' segment polarity genes with reiterated patterns, thus defining t