ライフサイエンスコーパス: polo-like kinase 1

1 al that is controlled by phosphorylation via Polo-like kinase 1.

2 nase 2 (Mst2) and Nek2A but does not involve polo-like kinase 1.

3 pericentriolar material proteins, including Polo-like kinase 1.

4 and a subsequent delay in the activation of polo-like kinase 1.

5 the CDH1 targets such as Aurora kinase A and Polo-like kinase 1.

6 For Polo-like kinase 1, 2, and 3, and their homologs, the en

7 Phosphorylated BLM interacts with polo-like kinase 1, a mitotic kinase that binds to phosp

8 we found that Chk2 coimmunoprecipitates with Polo-like kinase 1, a regulator of chromosome segregatio

9 bitors, small-molecule inhibitors (e.g., for Polo-like kinase 1 and aminopeptidase), inhibitors of mu

10 ociated with decreased protein levels of the Polo-like kinase 1 and Aurora B kinase, which phosphoryl

11 chromosome arms occurs under the control of Polo-like kinase 1 and Aurora B, while Shugoshin is thou

12 Nek6, as well as its upstream activators polo-like kinase 1 and Aurora-A, targeted Hsp72 to the p

13 lex dynamics are linked to the cell cycle by Polo-like kinase 1 and govern the movement of PAR protei

14 eport on a combination approach co-targeting polo-like kinase 1 and MEK in NRAS-mutant melanomas.

15 Our results show that dual inhibition of polo-like kinase 1 and RhoA/Rho kinase (ROCK) leads to t

16 egulators that control PCM assembly in vivo, Polo-like kinase-1 and SPD-2/Cep192.

17 ammed to upregulate the mitotic kinase Plk1 (Polo-like kinase 1) and other M-phase cell-cycle protein

18 Here we identified PLK1 (Polo-like kinase 1) as a novel interaction partner of JL

19 E), leading to impaired cytokinesis, loss of Polo-like kinase-1 at the midbody, and the accumulation

20 directed the disassembly of Shugoshins in a polo-like kinase 1-augmented manner, aiding centromere r

21 nd found frequent overexpression of securin, polo-like kinase 1, aurora A, and Skp2 in malignant tumo

22 els of the mitotic regulatory genes encoding polo-like kinase 1, aurora B kinase, and survivin, all o

23 ascular endothelial growth factor receptors, Polo-like kinase 1, Aurora B kinase, laminin alpha4 (Lam

24 r regions of several oncogenes such as PLK1 (Polo-like kinase 1), C-MYC, serine-threonine kinase BUB1

25 In this study, we have found that Plk1 (polo-like kinase 1) can phosphorylate MyoGEF, thereby re

26 nt CSF release, and is rapidly degraded in a Polo-like kinase 1-dependent manner in response to calci

27 Greatwall, and is mediated by Cdk-, but not Polo-like kinase 1-dependent phosphorylation.

28 a melanogaster Polo and its human orthologue Polo-like kinase 1 fulfill essential roles during cell d

29 Plk1 (Polo-like kinase 1) has been documented as a critical re

30 We identified Polo-like kinase 1-interacting checkpoint helicase (PICH

31 Plk1 (Polo-like kinase 1) is a critical regulator of cell cycl

32 PLK1 (polo-like kinase 1) is a key mitotic kinase and a therap

33 y of Kindlin-1 to bind integrins but also on Polo-like kinase 1-mediated Kindlin-1 phosphorylation.

34 ond-line setting; new targets include CD105, polo-like kinase-1, phosphatidylinositide 3-kinases (PI3

35 ed with several small-molecule inhibitors of Polo-like Kinase 1 (PLK 1) (e.g., HMN-214 and BI 2536),

36 human cells and Caenorhabditis elegans, the Polo-like kinase 1 (PLK-1) is recruited to the nuclear p

37 ted by multiple defense mechanisms including polo-like kinase 1 (Plk-1), protein kinase B (Akt-1), an

38 hich coincides with higher cyclin B/CDK1 and Polo-like kinase 1 (PLK1) activities in an S-phase-enric

39 In this study, we show that Polo-like kinase 1 (Plk1) also phosphorylates key factor

40 lysis, we show that two of these regulators, polo-like kinase 1 (Plk1) and Aurora A, are degraded at

41 Herein, we have identified polo-like kinase 1 (Plk1) and casein kinase 2 (CK2) as t

42 luding pituitary tumour transforming gene 1, Polo-like kinase 1 (PLK1) and Caveolin-2.

43 are associated with induction of the mitotic polo-like kinase 1 (Plk1) and down-regulation of the chr

44 altered network identified a central role of Polo-like kinase 1 (PLK1) and known PLK1 targets.

45 Here, we identify polo-like kinase 1 (Plk1) as a centromere-localized regu

46 have identified the serine/threonine kinase Polo-like kinase 1 (PLK1) as a host kinase that phosphor

47 Our previous studies identified polo-like kinase 1 (PLK1) as a major regulator of FoxM1b

48 We identified Polo-like kinase 1 (Plk1) as a parallel activator of cen

49 polo-box domain (PBD) of the mitotic kinase polo-like kinase 1 (Plk1) as a specific phosphoserine (p

50 g a library targeting 720 kinases identified Polo-like kinase 1 (PLK1) as one of the top genes whose

51 lyses revealed a consistent up-regulation of polo-like kinase 1 (PLK1) as well as other genes control

52 27 Thr186, to generate an anchoring site for polo-like kinase 1 (Plk1) at kinetochores.

53 sociates with Aurora kinase A (Aurora-A) and Polo-like kinase 1 (Plk1) at the centrosomes and spindle

54 Here, we report that in G2 phase polo-like kinase 1 (Plk1) can trigger centrosome separat

55 We demonstrate that Polo-like kinase 1 (Plk1) creates the 3F3/2 phosphoepito

56 We previously reported that polo-like kinase 1 (Plk1) depletion by lentivirus-based

57 e, Parkin is phosphorylated and activated by polo-like kinase 1 (Plk1) during mitosis.

58 s cohesin and how cohesin phosphorylation by polo-like kinase 1 (Plk1) enhances cleavage.

59 tudy, data revealed that mutant NRAS induced Polo-like kinase 1 (Plk1) expression, and pharmacologic

60 ragment of IKKbeta as substrate and purified Polo-like kinase 1 (Plk1) from HeLa cell extracts by sta

61 Polo-like kinase 1 (Plk1) functions as a key regulator o

62 Polo-like kinase 1 (Plk1) has been shown to be a crucial

63 Polo-like kinase 1 (PLK1) has important functions in mai

64 roles of Dishevelled 2 (Dvl2) and interphase polo-like kinase 1 (Plk1) in primary cilia disassembly.

65 Herein, we show pX activates Polo-like kinase 1 (Plk1) in the G(2) phase, thereby att

66 ever, we identified a site phosphorylated by Polo-like kinase 1 (PLK1) in the GRASP65 N-terminal doma

67 f Nek2 inhibitors derived from the published polo-like kinase 1 (Plk1) inhibitor (R)-1.

68 Therefore, we studied the effect of polo-like kinase 1 (Plk1) inhibitors on prostate cancer

69 In a search for Polo-like kinase 1 (Plk1) interaction proteins, we have

70 Polo-like kinase 1 (Plk1) is a conserved serine/threonin

71 Polo-like kinase 1 (Plk1) is a critical regulator in man

72 Polo-like kinase 1 (PLK1) is a key cell cycle regulator

73 Polo-like kinase 1 (Plk1) is a key player in mitosis and

74 Polo-like kinase 1 (Plk1) is a key regulator of cell div

75 Polo-like kinase 1 (Plk1) is a key regulator of progress

76 Polo-like kinase 1 (Plk1) is a mitotic kinase that has b

77 Polo-like kinase 1 (Plk1) is a serine/threonine-protein

78 Polo-like kinase 1 (Plk1) is a well-established mitotic

79 Polo-like kinase 1 (Plk1) is an attractive target for th

80 Polo-like kinase 1 (PLK1) is an evolutionarily conserved

81 Polo-like kinase 1 (PLK1) is an oncogenic kinase that co

82 Mammalian polo-like kinase 1 (Plk1) is critical for proper mitotic

83 The activity of polo-like kinase 1 (Plk1) is elevated in tissues and cel

84 As a key regulator of mitosis, Polo-like kinase 1 (Plk1) is essential for this attachme

85 The polo-box domain (PBD) of mammalian polo-like kinase 1 (Plk1) is essential in targeting its

86 However, we show here that Polo-like kinase 1 (Plk1) is required for endomitosis, a

87 Polo-like kinase 1 (Plk1) is required for multiple stage

88 Polo-like kinase 1 (Plk1) is required for the generation

89 Phosphorylation of cohesin subunit SA2 by polo-like kinase 1 (Plk1) is required for the removal of

90 We published previously that polo-like kinase 1 (Plk1) is upregulated in E6/E7-expres

91 sociated with an ATR-dependent inhibition of polo-like kinase 1 (Plk1) kinase activity and a decrease

92 veal that GOF mutant Shp2 hyperactivates the Polo-like kinase 1 (Plk1) kinase by enhancing c-Src kina

93 on of Cep55 was accompanied by repression of polo-like kinase 1 (Plk1) levels due to p53 induction.

94 ll, Shrestha et al. (2015) show that mitotic Polo-like kinase 1 (Plk1) links internalization of PCP p

95 Here we provide evidence that a mammalian polo-like kinase 1 (Plk1) localizes to mitotic spindles

96 study, we measured the impact of inhibiting polo-like kinase 1 (Plk1) on both dynein populations.

97 c6), a DNA replication initiation factor, by polo-like kinase 1 (Plk1) on the regulation of chromosom

98 Mammalian polo-like kinase 1 (Plk1) plays a pivotal role during M-

99 Polo-like kinase 1 (Plk1) plays a pivotal role in the re

100 Polo-like kinase 1 (Plk1) plays essential roles at multi

101 Polo-like kinase 1 (Plk1) plays pivotal roles in mitosis

102 Polo-like kinase 1 (Plk1) plays several roles in mitosis

103 anine nucleotide exchange factor (MyoGEF) by polo-like kinase 1 (Plk1) promotes the localization of M

104 usefulness of this method by monitoring both Polo-like kinase 1 (Plk1) protein abundance in multiple

105 Mammalian polo-like kinase 1 (Plk1) rapidly accumulates at centros

106 59 in mitosis, that phosphorylation requires polo-like kinase 1 (PLK1) rather than DNA-PKcs, that SAF

107 Here, we report that the polo-like kinase 1 (PLK1) regulates BMI1 expression, and

108 We further show that polo-like kinase 1 (Plk1) regulates Nek2 phosphorylation

109 he existence of a MYC-protein kinase A (PKA)-polo-like kinase 1 (PLK1) signaling loop in cells.

110 h a G2/M cell cycle arrest via inhibition of polo-like kinase 1 (PLK1) signalling pathway and down-mo

111 ously reported the phenotype of depletion of polo-like kinase 1 (Plk1) using RNA interference (RNAi)

112 Polo-like kinase 1 (PLK1) was found to be significantly

113 on of Pten results in elevated expression of Polo-like kinase 1 (Plk1), a critical regulator of the c

114 Polo-like kinase 1 (Plk1), a serine/threonine protein ki

115 ay from APC/CCDH1, triggering proteolysis of polo-like kinase 1 (PLK1), a tumor suppressor and multit

116 Polo-like kinase 1 (PLK1), an essential regulator of cel

117 e protein expression of cathepsin E, maspin, polo-like kinase 1 (Plk1), and survivin in patients with

118 Disengagement requires the activity of Polo-like kinase 1 (Plk1), but how Plk1 drives this proc

119 tive PKD1 inhibition when compared with AKT, polo-like kinase 1 (PLK1), CDK activating kinase (CAK),

120 showed that Chk1 is a negative regulator of polo-like kinase 1 (Plk1), in either the absence or pres

121 Another serine/threonine kinase, polo-like kinase 1 (Plk1), is an important regulator of

122 se and promotes Aur-A-mediated activation of Polo-like kinase 1 (Plk1), leading to the activation of

123 e we show that two mitotic kinases, Cdk1 and polo-like kinase 1 (Plk1), phosphorylate ECT2 in vitro.

124 Polo-like kinase 1 (Plk1), the best characterized member

125 Polo-like kinase 1 (Plk1), the best characterized Ser/Th

126 t functions of a pleiotropic mitotic kinase, Polo-like kinase 1 (Plk1), via distinct thresholds of ki

127 hat cell-cycle-related genes, in particular, Polo-like kinase 1 (PLK1), were associated with disease

128 Here, we report that Polo-like kinase 1 (Plk1), which is vital for cell proli

129 In a search for Polo-like kinase 1 (Plk1)-interacting proteins using a y

130 hat during mitosis, mammalian MYPT1 binds to polo-like kinase 1 (PLK1).

131 lating mitotic regulatory pathways including polo-like kinase 1 (Plk1).

132 sitive to inhibitors of G2/M kinases such as polo-like kinase 1 (PLK1).

133 y reported that wortmannin potently inhibits Polo-like kinase 1 (Plk1).

134 ntain "phosphorylation consensus motifs" for Polo-like kinase 1 (Plk1).

135 The direct target of the Chfr pathway is Polo-like kinase 1 (Plk1).

136 er fertilization requires phosphorylation by Polo-like kinase 1 (Plk1).

137 which are acutely sensitive to inhibition of Polo-like kinase 1 (Plk1).

138 phorylates NPM1 at Ser-4, a site shared with polo-like kinase 1 (PLK1).

139 iscovery of a series of potent inhibitors of Polo-like kinase 1 (PLK1).

140 controls mitosis, apparently by antagonizing polo-like kinase 1 (PLK1).

141 , we identified Numb as a novel substrate of Polo-like kinase 1 (Plk1).

142 otein regulator of cytokinesis 1 (PRC1), and polo-like kinase 1 (PLK1).

143 this reduplication requires the activity of Polo-like kinase 1 (Plk1).

144 sion factor recruitment is controlled by the Polo-like kinase 1 (Plk1).

145 ns responsive to activation by overexpressed Polo-like kinase 1 (PLK1).

146 One of these genes is the mitotic kinase Polo-like kinase 1 (Plk1).

147 A gating mechanism dependent on polo-like kinase-1 (PLK1) activity underlies this hetero

148 Reduction of polo-like kinase-1 (Plk1) at kinetochores as cells progr

149 Polo-like kinase-1 (Plk1) is a highly conserved kinase w

150 Polo-like kinase-1 (Plk1) phosphorylates a number of mit

151 Polo-like kinase-1 (PLK1) plays a major role in driving

152 Small-molecule inhibitors for one target, Polo-like kinase-1 (PLK1), are already in clinical trial

153 including cullin 1, beta-TrCP, Aurora A, and Polo-like kinase-1 (PLK1).

154 ein, we identified cellular serine/threonine Polo-like-kinase 1 (PLK1) as a positive effector of HBV

155 The Xenopus polo-like kinase 1 (Plx1) is essential during mitosis fo

156 Xenopus polo-like kinase 1 (Plx1) is required for activation of

157 protein by polo-like kinase 1/Xenopus laevis polo-like kinase 1 (Plx1) on kinetochores lacking tensio

158 During mitosis the Xenopus polo-like kinase 1 (Plx1) plays key roles in the activat

159 nt kinase 1 activity, cyclin B1 protein, and Polo-like kinase 1 protein turnover remained intact when

160 e and especially cyclin B--Cdc2, but not the polo-like kinase 1, remove cyclin E--Cdk2 from chromatin

161 antly occurs upstream of Aurora A kinase and Polo-like kinase 1, resulting in a failure to remove the

162 Moreover, the delivery of siRNA targeting polo-like kinase 1 (siPLK1) efficiently silenced PLK1 ex

163 eins securin, cyclin B, aurora A kinase, and polo-like kinase 1, the anaphase promoting complex/cyclo

164 n-dependent kinase 1 (Cdk1) or Plx1 (Xenopus polo-like kinase 1), whereas depletion of Gwl from extra

165 the phosphorylation of an unknown protein by polo-like kinase 1/Xenopus laevis polo-like kinase 1 (Pl