ライフサイエンスコーパス: poloxamer 188

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1 membranes and membranes treated with 1.0 mM poloxamer 188.

2 lipid bilayer of the type that are sealed by poloxamer 188.

3 eversed using the membrane sealant copolymer poloxamer 188.

4 receive an intravenous infusion of purified poloxamer 188, 100 mg/kg for 1 hour followed by 30 mg/kg

5 crisis resolution was increased by purified poloxamer 188 (65/126 [52%] vs 45/123 [37%]; P =.02).

6 33 (41) hours in those treated with purified poloxamer 188, a 9-hour reduction (P =.04).

7 These findings suggest that poloxamer 188 adsorbs into the lipid bilayers, thereby d

8 and that application of the membrane sealant poloxamer 188 corrects these defects in vitro.

9 s indicated an even more pronounced purified poloxamer 188 effect in children aged 15 years or younge

10 articles (CGT-NP) prepared using gelatin and Poloxamer 188-grafted heparin copolymer demonstrated sig

11 bFGF-loaded NP (bFGF-NP) were prepared with Poloxamer 188-grafted heparin copolymer using water-in-w

12 g to optimal dosing and long-term effects of poloxamer 188 in humans have been resolved, chemical-bas

13 fety and efficacy of adjunctive therapy with poloxamer 188 in patients receiving thrombolytic therapy

14 xo Wellcome Inc, Research Triangle Park, NC; poloxamer 188) Injection is a nonionic surfactant with h

15 RheothRx (poloxamer 188) is a surfactant with hemorheological and

16 Purified poloxamer 188 may increase tissue oxygenation and thereb

17 nic block co-polymeric surface active agent, poloxamer 188, on electroporation of artificial lipid me

18 c administration, and time to treatment with poloxamer 188 or placebo.

19 omized 114 patients to a 48-hour infusion of poloxamer 188 or vehicle placebo beginning immediately a

20 repair acutely with the non-ionic surfactant poloxamer 188 (P188) restored cell viability to control

21 The mechanism by which poloxamer 188 (P188) seals a damaged cell membrane is ex

22 Adjunctive therapy with poloxamer 188 resulted in substantial benefit in this ra

23 In vivo administration of poloxamer 188 to dystrophic mice instantly improved vent

24 First, addition of a poloxamer 188 to nanoparticle formulations increased upt

25 charge pulse and voltage clamp experiments, poloxamer 188-treated membranes exhibited a statisticall

26 Also, poloxamer 188-treated membranes were found to have a rel

27 Poloxamer 188-treated patients demonstrated a 38% reduct

28 the symptoms were observed when the purified poloxamer 188-treated patients were compared with the pa

29 Poloxamer 188 treatment also resulted in a reduced incid

30 Although the mechanisms are unproven, poloxamer 188 treatment may accelerate thrombolysis, red

31 Furthermore, addition of poloxamer 188 was found to reduce the membrane capacitan

32 Poloxamer 188 was well tolerated without adverse hemodyn

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