ライフサイエンスコーパス: poly ADP-ribosylation

1 CTCF participate in DNA damage response via poly(ADP-ribosylation).

2 trations required to maximally activate auto-poly(ADP-ribosylation).

3 tes the crosstalk between ubiquitination and poly-ADP-ribosylation.

4 This modification can occur as mono- or poly-ADP-ribosylation.

5 ver, histone phosphorylation is modulated by poly(ADP-)ribosylation.

6 The dsDNAs activated trans-poly(ADP-ribosylation) about 5 times more effectively th

7 P-ribose may not be unique to PARPs and that poly(ADP-ribosylation), an established nuclear activity,

8 erent domains that interpret either mono- or poly-ADP-ribosylation and the implications for cellular

9 Mg2+ inhibited trans-poly(ADP-ribosylation) and so did dcDNA at concentration

10 increase in GAPDH activity, decreased GAPDH poly-ADP-ribosylation, and nuclear translocation of GAPD

11 These data implicate intra-mitochondrial poly(ADP-ribosylation) as an important therapeutic targe

12 ar concentrations of ATP inhibit PARP-1 auto(poly-ADP-ribosylation) but less so the transfer of oligo

13 Activation of auto-poly(ADP-ribosylation) by dcDNA was 10 times greater tha

14 An allosteric activation of auto(poly-ADP-ribosylation) by physiologic cellular component

15 Axin turnover is controlled by its poly-ADP-ribosylation catalyzed by tankyrase (TNKS), whi

16 Poly-ADP-ribosylation, catalyzed by PARP1, is a post-tra

17 Collectively these data suggest that poly(ADP-ribosylation) compartmentalized to the mitochon

18 regulated kinase (ERK) signaling, Parp1 auto-poly ADP-ribosylation enhances Sox2-Parp1 interactions,

19 nction of the DLK regeneration pathway, that poly-(ADP ribosylation) inhibits axon regeneration acros

20 Poly-ADP-ribosylation is a post-translational modificati

21 Poly-ADP-ribosylation is a unique post-translational mod

22 n) was at least 100-fold lower than in trans-poly(ADP-ribosylation) (K(a) = 1400 versus 3-15, respect

23 We found reduced poly(ADP)ribosylation levels in nic2-1 seed, which were

24 PDH activity/intracellular localization, and poly-ADP-ribosylation of GAPDH.

25 function, stimulating NAD(+)-dependent auto-poly-ADP-ribosylation of poly(ADP-ribose) polymerase 1 (

26 merase (PARP) activity and posttranslational poly-ADP-ribosylation of several regulatory proteins inv

27 In contrast, poly-ADP-ribosylation of Spt16 by PARP1 significantly in

28 is reduced shortly after viral infection via poly-ADP-ribosylation of the RNA-induced silencing compl

29 We also found that tankyrase1-mediated poly-ADP-ribosylation of TRF1 is important for both the

30 Mg2+ activated auto-poly(ADP-ribosylation) of PARP I.

31 ed SSB level, gamma-H2AX foci formation, and poly(ADP-ribosylation) of PARP-1, which were associated

32 (mono-ADP-ribosylation) or polymeric chains (poly-ADP-ribosylation) of ADP-ribose are conjugated to p

33 ansfer to histone H(1) is 1% of that of auto(poly-ADP-ribosylation) of PARP-1, and this trans(ADP-rib

34 ose from NAD to histone H1 (defined as trans-poly(ADP-ribosylation)) or to PARP I (defined as auto-po

35 ns of oxidative stress and energy depletion, poly(ADP-ribosylation) paradoxically contributes to mito

36 Enzymes involved in poly(ADP-ribosylation) participate in several critical p

37 polymerases (PARPs) catalyze massive protein poly ADP-ribosylation (PARylation) within seconds after

38 RTD1/PARP1) and erasers (e.g. PARG, ARH3) of poly-ADP-ribosylation (PARylation) are relatively well d

39 Here, we found unlike PARP1-mediated Poly-ADP-Ribosylation (PARylation) at genomic damage sit

40 PARP1-dependent poly-ADP-ribosylation (PARylation) participates in the r

41 id not alter in vitro PARP1 enzyme activity, poly-ADP-ribosylation (PARylation), nor did inhibition o

42 y(ADP-ribose) polymerase 1 (Parp1) catalyzes poly(ADP-ribosylation) (PARylation) and induces replicat

43 abase chromatin domains surrounding DSBs via poly-ADP-ribosylation, phosphorylation, acetylation, and

44 Furthermore, inhibition of poly(ADP-ribosylation) prevented intranuclear localizati

45 Poly(ADP-ribosylation), primarily via poly(ADP-ribose) p

46 ribosylation)] or to PARP-1 [defined as auto(poly-ADP-ribosylation)] requires binding of coenzymic DN

47 Our data reveal the mechanism of poly-ADP-ribosylation reversal, with ADP-ribose as the d

48 for PARP I and catalyze preferentially trans-poly(ADP- ribosylation), thereby opening the possibility

49 However, the direct involvement of poly ADP-ribosylation was also apparent as 3-AB was able

50 Treatment with inhibitors of poly-ADP-ribosylation was also strongly protective, with

51 of PARP I toward dcDNA or dsDNA in the auto-poly(ADP-ribosylation) was at least 100-fold lower than

52 ribosylation)) or to PARP I (defined as auto-poly(ADP-ribosylation)) was studied with respect to the

53 To this end, the presence of PARP-1 and poly(ADP-ribosylation) were verified within mitochondria

54 cts of H2O2 can be overcome by inhibitors of poly(ADP)-ribosylation, which also preserve cellular ATP

55 Rates of auto(poly-ADP-ribosylation) with dsDNAs as coenzymes were nea

56 Inhibition of poly(ADP-ribosylation) within the mitochondrial compartm

57 Although it has been presumed that poly(ADP-ribosylation) within the nucleus mediates this