ライフサイエンスコーパス: poly(ADP ribosyl)ation

1 CTCF participate in DNA damage response via poly(ADP-ribosylation).

2 trations required to maximally activate auto-poly(ADP-ribosylation).

3 r sumoylation), or nucleotides (for example, poly(ADP-ribosyl)ation).

4 ver, histone phosphorylation is modulated by poly(ADP-)ribosylation.

5 econdensation are similar to the kinetics of poly(ADP-ribosyl)ation.

6 ARG activity regulates the extent of in vivo poly(ADP-ribosyl)ation.

7 and is consumed in lysine deacetylation and poly(ADP-ribosyl)ation.

8 n of Mre11 foci coincide with these areas of poly(ADP-ribosyl)ation.

9 these agents had opposite effects on protein poly(ADP-ribosyl)ation.

10 32P]beta NAD+ resulted in its time-dependent poly(ADP-ribosyl)ation.

11 mere function in human cells is regulated by poly(ADP-ribosyl)ation.

12 e next examined p53 as a covalent target for poly(ADP-ribosyl)ation.

13 associating with them or by catalyzing their poly(ADP-ribosyl)ation.

14 plicing, but its function can be modified by poly(ADP-ribosyl)ation.

15 osylate aspartate residues in the process of poly(ADP-ribosyl)ation.

16 chitecture of the genome may be modulated by poly(ADP-ribosyl)ation.

17 ribose-ribose glycosidic bond formed during poly(ADP-ribosyl)ation.

18 mportant cellular processes are regulated by poly(ADP-ribosyl)ation.

19 localize to the sites of DNA-damage-induced poly(ADP-ribosyl)ation.

20 otif is also required for post-translational poly(ADP-ribosyl)ation.

21 odification mixture stimulates total protein-poly(ADP-ribosyl)ation 3- to 4-fold.

22 In response to DNA damage, poly(ADP-ribosyl)ation, a unique post-translational modi

23 The dsDNAs activated trans-poly(ADP-ribosylation) about 5 times more effectively th

24 Inhibition of TNKS1/2 poly(ADP-ribosyl)ation activity by JW55 led to stabiliza

25 binding domain of WRN strongly inhibits the poly(ADP-ribosyl)ation activity in H2O2-treated control

26 OGG1 stimulated the poly(ADP-ribosyl)ation activity of PARP-1, whereas decre

27 tecture that couples DNA damage detection to poly(ADP-ribosyl)ation activity through a poorly underst

28 Purified vaults also contain the poly(ADP-ribosyl)ation activity, indicating that the ass

29 ss-of-function, which caused increased Hrp38 poly(ADP-ribosyl)ation, also resulted in the rough-eye p

30 P-ribose may not be unique to PARPs and that poly(ADP-ribosylation), an established nuclear activity,

31 RP +/+ fibroblasts showed the early burst of poly(ADP-ribosyl)ation and a rapid apoptotic response wh

32 s a dual function being involved both in the poly(ADP-ribosyl)ation and being a constituent of the NA

33 ), that modifies various nuclear proteins by poly(ADP-ribosyl)ation and functions as a key enzyme in

34 ow PARG activity controls reversible protein poly(ADP-ribosyl)ation and potentially of how the defect

35 odels, under hypoxic conditions, we detected poly(ADP-ribosyl)ation and reduced activity of GAPDH; in

36 ular nucleases of this type are inhibited by poly(ADP-ribosyl)ation and suggested that subsequent cle

37 Protein poly(ADP-ribosyl)ation and ubiquitination are two key po

38 Mg2+ inhibited trans-poly(ADP-ribosylation) and so did dcDNA at concentration

39 ies through aberrant crosstalk between CTCF, poly(ADP-ribosyl)ation, and DNA methylation may be a gen

40 These data implicate intra-mitochondrial poly(ADP-ribosylation) as an important therapeutic targe

41 ic activity is required for PARP-1-dependent poly(ADP-ribosyl)ation at the promoters of commonly regu

42 Poly(ADP-ribosyl)ation, attaching the ADP-ribose polymer

43 Suppression of DNA damage-induced poly(ADP-ribosyl)ation by PARP inhibitors impairs early

44 rom human cells and serves as an acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in vitro.

45 In vitro, TIN2 protected TRF1 from poly(ADP-ribosyl)ation by tankyrase 1 without affecting

46 Activation of auto-poly(ADP-ribosylation) by dcDNA was 10 times greater tha

47 clearly shows that XPC-RAD23B is a target of poly(ADP-ribosyl)ation catalyzed by PARP1, which can be

48 Collectively these data suggest that poly(ADP-ribosylation) compartmentalized to the mitochon

49 Therefore, our results suggest that Hrp38 poly(ADP-ribosyl)ation controls eye pattern formation vi

50 PARP-1 poly(ADP-ribosyl)ation correlated directly with inductio

51 Interestingly, p65 NF-kappaB poly(ADP-ribosyl)ation decreased its interaction with Cr

52 de that NF-kappaB-p50 DNA binding is protein-poly(ADP-ribosyl)ation dependent.

53 uce Wnt/beta-catenin signaling by preventing poly(ADP-ribosyl)ation-dependent AXIN degradation, there

54 We mapped the poly(ADP-ribosyl)ation domains and engineered MeCP2 muta

55 er nuclear proteins, p53 undergoes extensive poly(ADP-ribosyl)ation early during the apoptotic progra

56 Importantly, poly(ADP-ribosyl)ation facilitates intrachromosomal inte

57 The generality of this early burst of poly(ADP-ribosyl)ation has now been investigated with hu

58 Here, we report that HMGN1 affects the self-poly(ADP-ribosyl)ation (i.e., PARylation) of poly(ADP-ri

59 activity and provided evidence for a role of poly(ADP ribosyl)ation in Stat-mediated transcriptional

60 nerve immunohistochemistry revealed enhanced poly(ADP-ribosyl)ation in all experimental groups manife

61 n this review, we discuss recent findings on poly(ADP-ribosyl)ation in DNA damage response as well as

62 Previously, we hypothesized a role for poly(ADP-ribosyl)ation in plant defense responses when w

63 The role of poly(ADP-ribosyl)ation in plant defenses was more extens

64 nuclease (CME) DNAS1L3 and its inhibition by poly(ADP-ribosyl)ation in the DNA degradation that accom

65 The DNAS1L3 protein also underwent poly(ADP-ribosyl)ation in transfected mouse skin fibrobl

66 pendent endonuclease DNAS1L3 is inhibited by poly(ADP-ribosyl)ation in vitro, and its activation duri

67 Moreover, the rates of CD auto-poly(ADP-ribosyl)ation increased with second-order kinet

68 ATP or release certain nuclear proteins from poly(ADP-ribosyl)ation-induced inhibition, both of which

69 caspase-3 might release these nucleases from poly(ADP-ribosyl)ation-induced inhibition.

70 Our data show that poly(ADP-ribosyl)ation inhibits Hrp38 binding to the Nan

71 Poly(ADP-ribosyl)ation is a common post-translational mo

72 Poly(ADP-ribosyl)ation is a critical post-translational

73 We conclude that poly(ADP-ribosyl)ation is a functional component in plan

74 Poly(ADP-ribosyl)ation is a posttranslational protein mo

75 Poly(ADP-ribosyl)ation is a posttranslational protein mo

76 Poly(ADP-ribosyl)ation is a reversible post-translationa

77 Poly(ADP-ribosyl)ation is a reversible post-translationa

78 Our results suggest that PARP-1 poly(ADP-ribosyl)ation is a terminal event in the apopto

79 In animals, poly(ADP-ribosyl)ation is associated with DNA damage res

80 The reversion of poly(ADP-ribosyl)ation is catalysed by poly(ADP-ribose)

81 Poly(ADP-ribosyl)ation is catalyzed by a family of enzym

82 Poly(ADP-ribosyl)ation is involved in diabetes-induced r

83 Arsenite inhibition of poly(ADP-ribosyl)ation is one likely mechanism for the r

84 Recent studies suggest that poly(ADP-ribosyl)ation is one of the first steps of cell

85 Poly(ADP-ribosyl)ation is rapidly stimulated in cells af

86 this mobilization is largely independent of poly(ADP-ribosyl)ation, it cannot solely explain the chr

87 n) was at least 100-fold lower than in trans-poly(ADP-ribosylation) (K(a) = 1400 versus 3-15, respect

88 We found reduced poly(ADP)ribosylation levels in nic2-1 seed, which were

89 These results suggest that p65 NF-kappaB poly(ADP-ribosyl)ation may be a critical determinant for

90 in ligases, our results suggest that protein poly(ADP-ribosyl)ation may be a general mechanism to tar

91 These results suggest that poly(ADP-ribosyl)ation may play a role in the regulation

92 These results suggest that PARP and poly(ADP-ribosyl)ation may trigger key steps in the apop

93 We find that poly(ADP-ribosyl)ation mediated primarily by poly(ADP-ri

94 ut is also necessary to release DNAS1L3 from poly(ADP-ribosyl)ation-mediated inhibition.

95 Posttranslational poly(ADP-ribosyl)ation of an oscillator component may co

96 We propose that poly(ADP-ribosyl)ation of chromatin-associated Parp1 ser

97 Interestingly, defective poly(ADP-ribosyl)ation of CTCF and dissociation from the

98 ro and in vivo data support a model in which poly(ADP-ribosyl)ation of DDB2 suppresses DDB2 ubiquityl

99 t2(+), and pathogen-dependent changes in the poly(ADP-ribosyl)ation of discrete proteins were also ob

100 DNA fragmentation and resulted in persistent poly(ADP-ribosyl)ation of DNAS1L3; it did not, however,

101 Here we show poly(ADP-ribosyl)ation of endogenous MeCP2 in mouse brai

102 In conclusion, these data indicate that poly(ADP-ribosyl)ation of GAPDH and the subsequent inhib

103 inhibition was found to be a consequence of poly(ADP-ribosyl)ation of GAPDH by poly(ADP-ribose) poly

104 Elevated glucose increased poly(ADP-ribosyl)ation of GAPDH in WT aortae, but not in

105 Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucl

106 The biological functions of poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucl

107 o-activators of PARP-1 auto-modification and poly(ADP-ribosyl)ation of histone H1 in the absence of f

108 However, poly(ADP-ribosyl)ation of K566 in CP190 promotes protein

109 A transient burst of poly(ADP-ribosyl)ation of nuclear proteins occurs early,

110 Poly(ADP-ribosyl)ation of nuclear proteins plays a signi

111 MPTP elicits a novel pattern of poly(ADP-ribosyl)ation of nuclear proteins that complete

112 An early transient burst of poly(ADP-ribosyl)ation of nuclear proteins was recently

113 ss, PARP-1 itself becomes activated, but the poly(ADP-ribosyl)ation of other cellular proteins is sev

114 The hetero-poly(ADP-ribosyl)ation of p53 also showed that high conc

115 Our results show that the covalent poly(ADP-ribosyl)ation of p53 is a time-dependent protei

116 1 confirmed our conclusion that the covalent poly(ADP-ribosyl)ation of p53 results in the transcripti

117 We have characterized the covalent poly(ADP-ribosyl)ation of p53 using an in vitro reconsti

118 m was poly(ADP-ribosyl)ated, suggesting that poly(ADP-ribosyl)ation of PCNA may regulate its function

119 NF-kappaB sites and showed that TNF induced poly(ADP-ribosyl)ation of RelA when bound to the Phex pr

120 by and binds to DNA breaks and catalyzes the poly(ADP-ribosyl)ation of several substrates involved in

121 ts showed that Parg null mutation does cause poly(ADP-ribosyl)ation of Squid and hrp38 protein, as we

122 Following that, we demonstrated that poly(ADP-ribosyl)ation of Squid and hrp38 proteins inhib

123 d by binding to nicked DNA, PARP-1 catalyzes poly(ADP-ribosyl)ation of the acceptor proteins and itse

124 d by binding to nicked DNA, PARP-1 catalyzes poly(ADP-ribosyl)ation of the acceptor proteins using NA

125 ation in proximal tubules after IRI leads to poly(ADP-ribosyl)ation of the key glycolytic enzyme glyc

126 Phosphorylation, acetylation, or poly(ADP-ribosyl)ation of the linker residues may theref

127 The poly(ADP-ribosyl)ation of three of these yeast proteins,

128 ction (PARP-1 action) or by the formation of poly(ADP-ribosyl)ation of topoisomerase I (PARP-1/NAD ac

129 Poly(ADP-ribosyl)ation of topoisomerase I by PARP-1 in t

130 Poly(ADP-ribosyl)ation of transcription factors and core

131 at binding factor 2 (TRF2) and is capable of poly(ADP-ribosyl)ation of TRF2, which affects binding of

132 We demonstrate that DDB2 facilitated poly(ADP-ribosyl)ation of UV-damaged chromatin through t

133 Poly(ADP-ribosyl)ation of various nuclear proteins catal

134 Mg2+ activated auto-poly(ADP-ribosylation) of PARP I.

135 ed SSB level, gamma-H2AX foci formation, and poly(ADP-ribosylation) of PARP-1, which were associated

136 Poly(ADP-ribosyl)ation often involves the addition of lo

137 ose from NAD to histone H1 (defined as trans-poly(ADP-ribosylation)) or to PARP I (defined as auto-po

138 p50 was not an efficient covalent target for poly(ADP-ribosyl)ation, our results are consistent with

139 ns of oxidative stress and energy depletion, poly(ADP-ribosylation) paradoxically contributes to mito

140 eins to tankyrase 1 usually results in their poly(ADP-ribosyl)ation (PARsylation) and can lead to ubi

141 Enzymes involved in poly(ADP-ribosylation) participate in several critical p

142 RP-1 inhibitor) also prevented mitochondrial poly(ADP-ribosyl)ation (PARylation) and ROS formation.

143 Protein poly(ADP-ribosyl)ation (PARylation) has a role in divers

144 PARP1 binds to and modifies PAP by poly(ADP-ribosyl)ation (PARylation) in vitro, which inhi

145 Poly(ADP-ribosyl)ation (PARylation) is a post-translatio

146 Poly(ADP-ribosyl)ation (PARylation) is a post-translatio

147 Poly(ADP-ribosyl)ation (PARylation) is a posttranslation

148 Poly(ADP-ribosyl)ation (PARylation) is mainly catalysed

149 se) (PAR) polymerase 1 (PARP1) catalyzes the poly(ADP-ribosyl)ation (PARylation) of proteins, a postt

150 Poly(ADP-ribosyl)ation (PARylation) plays diverse roles

151 , was associated with an increase in protein poly(ADP-ribosyl)ation (PARylation), and was blocked by

152 Posttranslational modifications, such as poly(ADP-ribosyl)ation (PARylation), regulate chromatin-

153 t EBNA1 is subject to negative regulation by poly(ADP-ribosyl)ation (PARylation).

154 is interaction occurs with or without PARP-1 poly(ADP-ribosyl)ation (PARylation).

155 f different repair pathways to block histone polyADP-ribosylation (PARylation), a known effect of che

156 y(ADP-ribose) polymerase 1 (Parp1) catalyzes poly(ADP-ribosylation) (PARylation) and induces replicat

157 we found that WS cells are deficient in the poly(ADP-ribosyl)ation pathway after they are treated wi

158 Poly(ADP-ribosyl)ation plays a major role in DNA repair,

159 Furthermore, inhibition of poly(ADP-ribosylation) prevented intranuclear localizati

160 Poly(ADP-ribosylation), primarily via poly(ADP-ribose) p

161 ave focused on the signaling role of PARP in poly(ADP-ribosyl)ation rather than any role that can be

162 syl)ation of p53 is a time-dependent protein-poly(ADP-ribosyl)ation reaction and that the addition of

163 consistent with the conclusion that the auto-poly(ADP-ribosyl)ation reaction catalyzed by PARP-1 faci

164 PARP, this domain is capable of catalyzing a poly(ADP-ribosyl)ation reaction; thus, the 193-kD protei

165 In contrast to p53, a positive acceptor in poly(ADP-ribosyl)ation reactions, E2F-1 was not poly(ADP

166 st-translational modification of proteins by poly(ADP-ribosyl)ation regulates many cellular pathways

167 Taken together, these findings suggest that poly(ADP-ribosyl)ation regulates the interaction between

168 etected defense-associated expression of the poly(ADP-ribosyl)ation-related genes PARG2 and NUDT7 and

169 p38 represses Nanos translation, whereas its poly(ADP-ribosyl)ation relieves the repression effect, a

170 An inhibitor of poly(ADP-ribosyl)ation rescued the period phenotype of t

171 Additionally, DDB2 itself was targeted by poly(ADP-ribosyl)ation, resulting in increased protein s

172 ition of WRN by PARP-1 was influenced by the poly(ADP-ribosyl)ation state of PARP-1.

173 for PARP I and catalyze preferentially trans-poly(ADP- ribosylation), thereby opening the possibility

174 be due to the suppression of topoisomerase I poly(ADP-ribosyl)ation through the competition with NAD

175 of PARP I toward dcDNA or dsDNA in the auto-poly(ADP-ribosylation) was at least 100-fold lower than

176 ribosylation)) or to PARP I (defined as auto-poly(ADP-ribosylation)) was studied with respect to the

177 nduced decrease in activity of GAPDH and its poly(ADP-ribosyl)ation were prevented by overexpression

178 To this end, the presence of PARP-1 and poly(ADP-ribosylation) were verified within mitochondria

179 rt oligomers predominate early during hetero-poly(ADP-ribosyl)ation, whereas longer ADP-ribose chains

180 cts of H2O2 can be overcome by inhibitors of poly(ADP)-ribosylation, which also preserve cellular ATP

181 ted with a decrease in the extent of DNAS1L3 poly(ADP-ribosyl)ation, which likely releases DNAS1L3 fr

182 in is rapidly modified by tankyrase-mediated poly(ADP-ribosyl)ation, which promotes the proteolysis o

183 Inhibition of poly(ADP-ribosylation) within the mitochondrial compartm

184 Although it has been presumed that poly(ADP-ribosylation) within the nucleus mediates this