ライフサイエンスコーパス: poly-N-acetyllactosamine

1 ctures with increased branching and extended poly-N-acetyllactosamine.

2 beta1-3GalNAc termini, and some increases in poly-N-acetyllactosamines.

3 in adding a galactose to linear and branched poly-N-acetyllactosamines.

4 fficiently add N-acetyllactosamine to linear poly-N-acetyllactosamines.

5 onstrated that itraconazole globally reduced poly-N-acetyllactosamine and tetra-antennary complex N-g

6 Poly-N-acetyllactosamines are attached to N-glycans, O-g

7 nsferases, which play important roles in how poly-N-acetyllactosamines are synthesized in different a

8 d on blood group H on a 6-linked branch of a poly-N-acetyllactosamine backbone.

9 found that 4-F-GlcNAc (putative inhibitor of poly-N-acetyllactosamine biosynthesis) was more potent t

10 I-branched poly-N-acetyllactosamine can carry bivalent functional o

11 bodies with IGHV4-34*01 heavy chains bind to poly-N-acetyllactosamine carbohydrates (I/i antigen) on

12 mannosyl core may carry predominantly linear poly-N-acetyllactosamine chains, whereas the Manalpha1-3

13 lpha1-3 arm may carry predominantly branched poly-N-acetyllactosamine chains.

14 Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assemb

15 Characterization of the large poly-N-acetyllactosamine containing N-glycans of the TbG

16 that TbGT8 influences the processing of the poly N-acetyllactosamine-containing asparagine-linked gl

17 glycans, including some exceptionally large poly-N-acetyllactosamine-containing structures.

18 on T cells, indicating direct inhibition on poly-N-acetyllactosamine elongation and selectin-binding

19 enhancement of both beta(1,6) branching and poly-N-acetyllactosamine expression on N-cadherin.

20 poly-N-acetyllactosamine synthesis, allowing poly-N-acetyllactosamine extension mostly along the line

21 Poly-N-acetyllactosamine extension of core 4 branches is

22 the branched acceptor than the summation of poly-N-acetyllactosamines formed individually on each un

23 inyltransferase, was capable of synthesizing poly-N-acetyllactosamine in core 2 branched oligosacchar

24 irely consistent with previous findings that poly-N-acetyllactosamines in human erythrocytes, PA-1 em

25 Poly-N-acetyllactosamines in mucin-type O-glycans can be

26 In the present study, we first found that poly-N-acetyllactosamines in N-glycans are most efficien

27 in the presence of core 1 O-glycans, but not poly-N-acetyllactosamine, in apically targeted MUC1 and

28 I-branched poly-N-acetyllactosamine is a unique carbohydrate compos

29 Poly-N-acetyllactosamine is a unique carbohydrate compos

30 Poly-N-acetyllactosamine is a unique carbohydrate that c

31 It has been shown that the amount of poly-N-acetyllactosamine is increased in N-glycans, when

32 Poly-N-acetyllactosamine oligomer is a type-2 glycan cor

33 tosamine (LN; Galbeta1-4GlcNAc) sequences on poly-N-acetyllactosamine (PL; (-3Galbeta1-4GlcNAcbeta1-)

34 sed in olfactory sensory neurons (OSNs) with poly-N-acetyllactosamine (PLN) oligosaccharides determin

35 in exhibited higher binding for glycans with poly-N-acetyllactosamine (poly(LacNAc)) sequences (Galbe

36 Enzymatic reduction in surface poly-N-acetyllactosamine (polyLacNAc) glycans in HL60 ce

37 essing moderate amounts of sialyl Lewis X in poly-N-acetyllactosamines produced large numbers of lung

38 a paucity of the Lewis(x) sequence based on poly-N-acetyllactosamine recognized by anti-SSEA-1; (ii)

39 n of N-acetylglucosamine residues within the poly(N-acetyllactosamine) repeat sequence and signals re

40 que LOS glycoforms containing di-, tri-, and poly-N-acetyllactosamine repeats added to the terminal r

41 n of branched oligosaccharides with multiple poly-N-acetyllactosamine repeats is nearly abolished by

42 actosamine extension mostly along the linear poly-N-acetyllactosamine side chain.

43 Galectin-3 binds poly-N-acetyllactosamine structures on glycoproteins, bu

44 ever, they produced extended GlcNAc-sulfated poly-N-acetyllactosamine structures with more than four

45 to longer carbohydrate substrates that have poly-N-acetyllactosamine structures, suggesting the invo

46 ndicate that beta4Gal-TIV is responsible for poly-N-acetyllactosamine synthesis in core 2 branched O-

47 These results, taken together, indicate that poly-N-acetyllactosamine synthesis in N-glycans and core

48 ta4Gal-TI was found to be most efficient for poly-N-acetyllactosamine synthesis in N-glycans.

49 branch is a rate-limiting step in I-branched poly-N-acetyllactosamine synthesis, allowing poly-N-acet

50 B3GNT1, an enzyme proposed to be involved in poly-N-acetyllactosamine synthesis, were causal for cong

51 To determine how this increased synthesis of poly-N-acetyllactosamines takes place, the branched acce

52 on at multiple internal GlcNAc of unbranched poly-N-acetyllactosamine, termed "myeloglycan," the phys

53 branched O-glycans contain fewer and shorter poly-N-acetyllactosamines than N-glycans in many cells.

54 tylglucosaminyltransferase, the formation of poly-N-acetyllactosamine was found to be extremely ineff

55 When a beta1,6-GlcNAc branched poly-N-acetyllactosamine was incubated with a mixture of

56 Surprisingly, poly-N-acetyllactosamine was more efficiently formed on

57 rgeting when galectin-3, with preference for poly-N-acetyllactosamine, was depleted from polarized MD

58 cetyllactosamine branches attached to linear poly-N-acetyllactosamine, which is synthesized by I-bran

59 poorly to beta1,6-GlcNAc attached to linear poly-N-acetyllactosamines, while beta1, 3-N-acetylglucos