ライフサイエンスコーパス: polyadenylation

1 itive and negative regulators of alternative polyadenylation.

2 BM1 expression by promoting IBM1 mRNA distal polyadenylation.

3 ugh alternative transcription, splicing, and polyadenylation.

4 (UTRs) generated by alternative cleavage and polyadenylation.

5 eb1 cotranscriptionally controls alternative polyadenylation.

6 s, DOG1 transcript is subject to alternative polyadenylation.

7 expected role for hnRNP A2/B1 in alternative polyadenylation.

8 through alternative splicing and alternative polyadenylation.

9 th as a consequence of increased alternative polyadenylation.

10 ed widespread alternative trans-splicing and polyadenylation.

11 , independently of its effect on alternative polyadenylation.

12 ron excision events that follow cleavage and polyadenylation.

13 nscriptional, some introns are excised after polyadenylation.

14 in mediating PAS-dependent RNA cleavage and polyadenylation.

15 MeCP2 dysregulation via altered alternative polyadenylation.

16 ative splicing, and alternative cleavage and polyadenylation.

17 demarcate sites of alternative splicing and polyadenylation.

18 sion of these genes by promoting mRNA distal polyadenylation.

19 RNA binding proteins, or during alternative polyadenylation.

20 g RNAs (lncRNAs), undergo trans-splicing and polyadenylation.

21 ed from the unc-44 locus through alternative polyadenylation.

22 onses relative to its interactions with mRNA polyadenylation.

23 oding RNAs, which undergo trans-splicing and polyadenylation.

24 Polyadenylation, a critical step in the production of ma

25 e protein isoform produced through premature polyadenylation aberrantly localizes to the plasma membr

26 identify prominent alternative splicing and polyadenylation abnormalities in infant CDM muscle, and,

27 CR-III has been linked to polymerase and polyadenylation activity, CR-V to mRNA capping and CR-VI

28 d for poly(A) polymerase I (PAP I)-dependent polyadenylation after Rho-independent transcription term

29 Misregulated alternative polyadenylation also occurs in skeletal muscle in a mous

30 iral capsid gene via its role in alternative polyadenylation and alternative splicing of the single M

31 ously unappreciated link between alternative polyadenylation and chromatin signaling.

32 ha regulated PAP (Star-PAP) controls E6 mRNA polyadenylation and expression and modulates wild-type p

33 ects of RNA processing including alternative polyadenylation and intron retention.

34 ts of the underlying mechanisms for non-3UTR polyadenylation and its regulation in plants.

35 ions involving RNase R treatment followed by Polyadenylation and poly(A)+ RNA Depletion (RPAD), which

36 While the roles of PABPN1 in nuclear polyadenylation and regulation of alternative poly(A) si

37 e expression, including splicing, transport, polyadenylation and RNA stability.

38 is shared between ICP27-mediated alternative polyadenylation and splicing.

39 nd sensing to the regulation of translation, polyadenylation and splicing.

40 access via its role in alternative internal polyadenylation and splicing.

41 he de novo synthesis of this subunit whereas polyadenylation and translation of cyb mRNA were unaffec

42 generate these isoforms (such as alternative polyadenylation) and RNA surveillance.

43 between alternative splicing and alternative polyadenylation, and it is their concerted actions that

44 tabilization, mRNA nuclear export, increased polyadenylation, and transcriptional activation.

45 tions as the interface between mRNA editing, polyadenylation, and translation.

46 e control of chromatin dynamics, cytoplasmic polyadenylation, and translation.

47 The recent emergence of alternative polyadenylation (APA) as an engine driving transcriptomi

48 CFIm regulates global alternative polyadenylation (APA) by specifically binding and activa

49 ve alternative splicing (AS) and alternative polyadenylation (APA) defects in the cerebellum of c9ALS

50 Alternative cleavage and polyadenylation (APA) generates mRNA isoforms with diffe

51 Alternative cleavage and polyadenylation (APA) generates mRNAs with different 3'

52 Alternative polyadenylation (APA) has been implicated in a variety o

53 de alternative splicing (AS) and alternative polyadenylation (APA) in the rhizome system.

54 Alternative polyadenylation (APA) is a pervasive mechanism in the re

55 Alternative polyadenylation (APA) is a process that changes the post

56 Alternative polyadenylation (APA) is a widespread gene regulatory me

57 Alternative polyadenylation (APA) is a widespread mechanism that gen

58 Alternative polyadenylation (APA) is increasingly recognized to regu

59 Alternative polyadenylation (APA) is widespread in neuronal developm

60 (PASs), leading to expression of alternative polyadenylation (APA) isoforms with distinct functions.

61 Alternative splicing and alternative polyadenylation (APA) of pre-mRNAs greatly contribute to

62 n one PAS, which can produce the alternative polyadenylation (APA) phenomenon and affect the stabilit

63 Alternative cleavage and polyadenylation (APA) plays a crucial role in the regula

64 (PAT) sequencing approach, mRNA alternative polyadenylation (APA) profiles after auxin treatment wer

65 action landscape and changed the alternative polyadenylation (APA) profiles and/or transcript levels

66 inhibited by its 3'UTR, and that alternative polyadenylation (APA) results in the production of ECE-1

67 differences in the use of tandem alternative polyadenylation (APA) sites by methylated and nonmethyla

68 ng largely from the use of known alternative polyadenylation (APA) sites.

69 tening of messenger RNAs through alternative polyadenylation (APA) that occurs during enhanced cellul

70 of human genes use alternative cleavage and polyadenylation (ApA) to generate messenger RNA transcri

71 port exhibited mostly changes in alternative polyadenylation (APA), cell cycle genes showed mostly al

72 Alternative polyadenylation (APA), in which a transcript uses one of

73 udes comprehensive assessment of alternative polyadenylation (APA), which is subject to broad tissue-

74 en used for testing differential alternative polyadenylation (APA).

75 th alternative splicing (AS) and alternative polyadenylation (APA).

76 , suggesting that coupling of Musashi to the polyadenylation apparatus is a conserved mechanism to pr

77 occur in the nucleus-capping, splicing, and polyadenylation-are mechanistically linked to the proces

78 secondary structure at sites of alternative polyadenylation, as well as strong secondary structure a

79 we observed no general shift in alternative polyadenylation associated with PE, the EO-PE and LO-PE

80 the capsid transcript but not suppression of polyadenylation at (pA)p.

81 Specifically, alternative polyadenylation at Intron-2 of OXT6 produces a transcrip

82 ger RNA precursors must undergo cleavage and polyadenylation at their 3'-end for maturation.

83 lice sites and poly(A) signals were mutated, polyadenylation became the preferred mode of OXT6 proces

84 tes intron excision in the context of 3'-end polyadenylation but not when bound to internal A-tracts.

85 ly active PNPase is required for normal mRNA polyadenylation by PAP I.

86 In contrast, homozygous insertion of a polyadenylation cassette 80 bp downstream of the Lockd t

87 that Pcf11, a component of the cleavage and polyadenylation complex (CPAC), is also generally requir

88 but also revealed their association with the polyadenylation complex in the latter.

89 We have identified a minimal polyadenylation complex that includes the conserved nucl

90 quilibrium between free PNPase and the PAP I polyadenylation complex.

91 Several PPRs also populate the polyadenylation complex; among these, KPAF1 and KPAF2 fu

92 e exosome cofactor TRAMP (Trf4/5-Air1/2-Mtr4 polyadenylation) complex, dMtr4 and dZcchc7, as antivira

93 ut rather selection of a distal cleavage and polyadenylation (CP) site.

94 rmined that CDK11 regulates the cleavage and polyadenylation (CPA) of all viral transcripts.

95 t multiple alternative positions by cleavage/polyadenylation (CPA).

96 132) gene undergoes alternative cleavage and polyadenylation during transcription, giving rise to two

97 Aplysia cytoplasmic polyadenylation element binding (CPEB) protein, a transl

98 tified that the mRNA splicing of cytoplasmic polyadenylation element binding 2 (CPEB2), a translation

99 mouse mammary epithelial cells, cytoplasmic polyadenylation element binding protein 1 (CPEB1) mediat

100 Cytoplasmic polyadenylation element binding protein 2 (CPEB2) is an

101 The cytoplasmic polyadenylation element-binding (CPEB) family of RNA-bin

102 The translational regulator cytosolic polyadenylation element-binding protein 2 (CPEB2) has tw

103 Orb2 is a cytoplasmic polyadenylation element-binding protein homolog in Droso

104 e translational regulator CPEB3 (cytoplasmic polyadenylation element-binding protein).

105 tional regulation of VEGF by the cytoplasmic polyadenylation element-binding proteins CPEB1 and CPEB4

106 Both Orb and Orb2 bind linear cytoplasmic polyadenylation element-like sequences in the 3' UTRs of

107 Alternative cleavage and polyadenylation enables differential post-transcriptiona

108 dies have reported previously less-addressed polyadenylation events located in other parts of genes i

109 to misregulation of thousands of alternative polyadenylation events.

110 methodologies designed to assess genome-wide polyadenylation events.

111 the 1-megadalton multiprotein cleavage and polyadenylation factor (CPF).

112 -containing RNA binding protein, kinetoplast polyadenylation factor 3 (KPAF3), and demonstrate its ro

113 th morpholino technology or silencing of the polyadenylation factor CPSF1 caused a splice switch that

114 ng a truncated form of the mRNA cleavage and polyadenylation factor CPSF6, the completion of HIV-1 ve

115 including an association of PAF1-C with the polyadenylation factor CstF.

116 -PCR profiling identified elevated levels of polyadenylation factor CSTF3 in tumors with APA.

117 of this intronic PAS depends on the nuclear polyadenylation factor SYDN-1, which inhibits the RNA po

118 , our results implicate CstF64, an essential polyadenylation factor, as a master regulator of 3'-UTR

119 on the roles played by general cleavage and polyadenylation factors (CPA factors).

120 tone cleavage complex (HCC), and a subset of polyadenylation factors including the endonuclease CPSF7

121 Surprisingly, polyadenylation factors promote RNP coassembly in vivo,

122 yer regulatory mechanisms controlling fungal polyadenylation factors, which have profound implication

123 cleavage complex (HCC) consisting of several polyadenylation factors.

124 the function of SSUP-72 and several nuclear polyadenylation factors.

125 Alternative cleavage and polyadenylation generate two VDAC3 mRNA isoforms differi

126 Alternative cleavage and polyadenylation generates multiple transcript variants p

127 Alternative polyadenylation has been recognized as a key contributor

128 re-mRNA alternative splicing and alternative polyadenylation have been implicated to play important r

129 pmentally regulated alternative splicing and polyadenylation in congenital myotonic dystrophy (CDM).

130 Our studies uncover a new function for polyadenylation in controlling the expression of a subse

131 Here, we describe that alternative intronic polyadenylation in intron 10 of the gp130 transcript res

132 CLIP, which can be used to study alternative polyadenylation in the CNS.

133 n compete both with alternative splicing and polyadenylation in the upstream gene.

134 ex and factors involved in mRNA splicing and polyadenylation, including an association of PAF1-C with

135 ly(A) polymerases that regulates cytoplasmic polyadenylation-induced translation, but its target mRNA

136 A-binding protein that regulates cytoplasmic polyadenylation-induced translation.

137 Moreover, polyadenylation is a crucial step in the maturation of a

138 3' polyadenylation is a key step in eukaryotic mRNA biogene

139 Polyadenylation is an essential process during eukaryoti

140 Processing of mRNA precursors (pre-mRNAs) by polyadenylation is an essential step in gene expression.

141 Finally, inefficient polyadenylation is associated with impaired recruitment

142 To assess the full panoply of mRNAs whose polyadenylation is controlled by GLD4, we performed an u

143 gene expression at the level of cytoplasmic polyadenylation is important for many biological phenome

144 Although polyadenylation is well known for marking the end of a 3

145 and we found that the majority of them lacks polyadenylation, is resistant to RNase R digestion and l

146 equence similarity in the motifs utilized by polyadenylation machinery and the PUM complex.

147 I (CFI) proteins are core components of the polyadenylation machinery that can regulate several step

148 r to obtaining a structural blueprint of the polyadenylation machinery that explains both how this co

149 II termination via depletion of the cleavage/polyadenylation machinery, circular RNA levels were simi

150 es, termination is initiated by the cleavage/polyadenylation machinery.

151 We provide genome-wide, high-resolution polyadenylation maps of the human heart and show that th

152 Therefore, inhibition of polyadenylation may lead to gene silencing.

153 hat are created on the mRNA level by a novel polyadenylation mechanism found only in Blastocystis.

154 t had not been clear how the potent internal polyadenylation motif is suppressed to allow processing,

155 s transcription elongation, termination, and polyadenylation, must also be considered as potential me

156 homozygous mutation resulted in the loss of polyadenylation of all mitochondrial transcripts assesse

157 in silencing mechanism involving alternative polyadenylation of antisense transcripts.

158 bly, arsenic exposure dramatically increased polyadenylation of canonical histone H3.1 mRNA possibly

159 Thus, polyadenylation of canonical histone mRNA following arse

160 Alternative polyadenylation of COOLAIR transcripts correlates with d

161 h CstF-64 and tauCstF-64 function to inhibit polyadenylation of histone mRNAs.

162 etition between the splicing and alternative polyadenylation of KCNH2 intron 9.

163 ctivity: a post-fertilisation wave involving polyadenylation of maternal transcripts; a broad wave of

164 tr3(Gt-ex13) gene trap insertion disturb the polyadenylation of MATR3 transcripts and alter Matrin 3

165 to such challenges involves the alternative polyadenylation of mRNA.

166 1 and requires the factors essential for the polyadenylation of mRNAs.

167 cilitating splicing and suppressing internal polyadenylation of MVC pre-mRNAs.

168 Polyadenylation of nascent RNA by poly(A) polymerase (PA

169 he newly discovered alternative cleavage and polyadenylation of NaV1.8 mRNA.

170 We show that Nudt21 directs differential polyadenylation of over 1,500 transcripts in cells acqui

171 mutations in genes involved in stability and polyadenylation of RNA.

172 contiguous location in the genome and shared polyadenylation of several of the ORF57-dependent genes,

173 The dual polyadenylation of snoRNA intermediates is carried out b

174 The lack of PDE12 results in a spurious polyadenylation of the 3' ends of the mitochondrial (mt-

175 The dual polyadenylation of the precursor snoRNAs by PAPs may fun

176 Binding of U1A inhibits polyadenylation of the SMN pre-mRNA by specifically inhi

177 scriptome-wide analysis revealed alternative polyadenylation of thousands of genes, most of which res

178 overexpression of CPEB4 promoted cytoplasmic polyadenylation of VEGF messenger RNA, increasing its tr

179 ce of capping and methylation reactions, and polyadenylation of viral messages.

180 Alternative polyadenylation often regulates mRNA isoform usage.

181 pts would either have to undergo cytoplasmic polyadenylation or retain a reasonably long poly(A) tail

182 ance and therapeutic potential of modulating polyadenylation patterns in stem-cell populations.

183 s were constructed to alter the splicing and polyadenylation patterns of OXT6.

184 DM, resulting in the persistence of neonatal polyadenylation patterns.

185 Differential mRNA polyadenylation plays an important role in shaping the n

186 studies have revealed widespread alternative polyadenylation (polyA) in eukaryotes, leading to variou

187 ncluding the transcription activation (TAR), polyadenylation (PolyA), and primer binding (PBS) elemen

188 ew mechanism by which premature cleavage and polyadenylation (pPA) of RNA can produce an oncogenic pr

189 By monitoring polyadenylation profiles in these hearts, we identified

190 pression is regulated by the testis-specific polyadenylation protein CFIm25, which is downregulated i

191 or transposable elements within the intronic polyadenylation region.

192 Our data suggest that polyadenylation requires a functional degradosome to mai

193 Further analysis of intronic polyadenylation revealed that LTR/Gypsy and LTR/Copia we

194 t regulate alternative splicing, alternative polyadenylation, RNA stability and RNA localization.

195 s of dsDNA, ssRNA and dsRNA viral markers of polyadenylation-selected RNA sequences from microbial co

196 vidence that evolutionary divergence in core polyadenylation signal (PAS) and downstream sequence ele

197 his process is the recognition of the AAUAAA polyadenylation signal (PAS), and the molecular mechanis

198 e demonstrate that targeting either the mRNA polyadenylation signal and/or cleavage site is an effici

199 hexanucleotide AAUAAA motif in the pre-mRNA polyadenylation signal by the cleavage and polyadenylati

200 Next, mice with a floxed polyadenylation signal causing premature transcriptional

201 Insertion of a multipartite polyadenylation signal immediately downstream of iss1(+)

202 e development of new therapies targeting the polyadenylation signal in AR intron 3 as a strategy to p

203 AR-V9 is regulated coordinately by a single polyadenylation signal in AR intron 3.

204 ent genes, ORF57 regulation was promoter and polyadenylation signal independent, suggesting that the

205 pulohumeral muscular dystrophy-specific DUX4 polyadenylation signal is surprisingly inefficient, and

206 Here, we replace the L1 polyadenylation signal with sequences derived from a non

207 loaded onto polyribosomes and lack a strong polyadenylation signal, resulting in poor translation ef

208 , which likely represents a new cleavage and polyadenylation signal.

209 ion of in-frame stop codon, or the lack of a polyadenylation signal.

210 of the stop codon, +20 bp downstream of the polyadenylation signal.

211 rely cleaved and polyadenylated from cryptic polyadenylation signals (PAS) located in intron 1 or 2 o

212 HLA-A alleles indicated the presence of two polyadenylation signals (PAS).

213 ing theciselements that function as internal polyadenylation signals in the capsid protein-expressing

214 riptome-wide gene expression and alternative polyadenylation signatures associated with early-onset P

215 Here, we identify a key role for an intronic polyadenylation site (PAS) in temporal- and tissue-speci

216 anscription termination at a strong intronic polyadenylation site (PAS) in unc-44/ankyrin yet promote

217 tail addition at the 3' end of mRNAs at the polyadenylation site (PAS).

218 n breakpoints (BPs) up to 896 kb 3' of SATB2 polyadenylation site cause a phenotype which is indistin

219 of APA mRNA isoforms, but also by affecting polyadenylation site choice.

220 ption support PROMPT formation, but owing to polyadenylation site constraints, these transcripts tend

221 levated NUDT21 increases usage of the distal polyadenylation site in the MECP2 3' UTR, resulting in a

222 icular features at the 5' end and around the polyadenylation site indicate that this polymerase under

223 plicing and the read-through of the proximal polyadenylation site of the HBoV1 precursor mRNA, essent

224 Binding of Sam68 to an intronic polyadenylation site prevents its recognition and premat

225 unction in NNS-like termination but promotes polyadenylation site selection of coding and noncoding g

226 cy in parallel with defects in DOG1 proximal polyadenylation site selection, suggesting that the shor

227 Here we used polyadenylation site sequencing (PAS-Seq) of RNA from no

228 molecule long-read sequencing technology and polyadenylation site sequencing (PAS-seq) to re-annotate

229 EF-RNA interactions upon RNA cleavage at the polyadenylation site triggers disassembly of the elongat

230 o proteins in regulating promoter, exon, and polyadenylation site usage in cells.

231 nscript 3' end shortening through changes in polyadenylation site usage occurs following T cell activ

232 H2 mRNA are regulated by PABPN1 via proximal polyadenylation site usage.

233 intron immediately upstream of the internal polyadenylation site, (pA)p, and that generation of thes

234 cumulate RNA polymerases in proximity of the polyadenylation site, a trend that coincided with longer

235 h mouse and human MOR-1A and their conserved polyadenylation site, and defined the role the 3'-UTR in

236 pecificity to the SMN 3'-UTR adjacent to the polyadenylation site, independent of the U1 snRNP (U1 sm

237 serted into intron 35 exposes an alternative polyadenylation site, resulting in a truncated Pkhd1 tra

238 erves as a cryptic transcription termination/polyadenylation site, which rarely also functions to edi

239 an intron and the suppression of an internal polyadenylation site.

240 ene terminus to a highly conserved alternate polyadenylation site.

241 y defining the primary transcript beyond the polyadenylation site.

242 Focusing on the non-3UTR polyadenylation sites (n3PASs), we detected and characte

243 on about transcription start sites (TSS) and polyadenylation sites (PAS).

244 nscription start sites (TSS) or cleavage and polyadenylation sites (PAS).

245 tematically mapped and compared cleavage and polyadenylation sites (PASs) in two yeast species, S. ce

246 Most mammalian genes harbor multiple polyadenylation sites (PASs), leading to expression of a

247 tage-specific preferential trans-splicing or polyadenylation sites and differentially expressed genes

248 st highly conserved motif in eukaryotic mRNA polyadenylation sites and, in mammals, is specifically r

249 ne enables the profiling of both 5' ends and polyadenylation sites at near-base resolution.

250 u elements introduced new terminal exons and polyadenylation sites during human genome evolution.

251 In addition, we characterized 25 069 polyadenylation sites from 11 450 genes, 6311 of which h

252 nome-wide maps of alternative exon usage and polyadenylation sites in the kidney.

253 3'-UTR of NRT1.1 showed that the pattern of polyadenylation sites was altered in the cpsf30 mutant.

254 criptional variants of Pdgfra with different polyadenylation sites, including an intronic variant tha

255 MVC contains two polyadenylation sites, one at the right-hand end of the

256 MVC contains two polyadenylation sites, one at the right-hand end of the

257 are commonly terminated early, influenced by polyadenylation sites, promoters often cluster so that t

258 ein ELAV inhibits RNA processing at proximal polyadenylation sites, thereby fostering the formation o

259 llele, which disrupts the most distal of two polyadenylation sites.

260 tion sites, spliced variants and alternative polyadenylation sites.

261 namely, transcription start sites (TSSs) and polyadenylation sites.

262 X2 and the truncated version of cleavage and polyadenylation specific factor 6 (CPSF6), as well as th

263 lation with serum THOC5 forms a complex with polyadenylation-specific factor 100 (CPSF100).

264 mRNA 3' end formation factors, cleavage and polyadenylation specificity factor (CPSF) and SYMPK, are

265 F100 is a core component of the cleavage and polyadenylation specificity factor (CPSF) complex for 3'

266 rfering with recruitment of the cleavage and polyadenylation specificity factor (CPSF) complex.

267 A polyadenylation signal by the cleavage and polyadenylation specificity factor (CPSF) complex.

268 eract with Fip1, a component of cleavage and polyadenylation specificity factor (CPSF).

269 ng to the 30-kDa subunit of the cleavage and polyadenylation specificity factor (CPSF30), a cellular

270 (Cstf64) and 73-kDa subunit of cleavage and polyadenylation specificity factor (CPSF73), was reduced

271 Cleavage and polyadenylation specificity factor 30 (CPSF30) is a key

272 decreasing its interaction with cleavage and polyadenylation specificity factor 30 (CPSF30), leading

273 eased the binding of NS1 to the cleavage and polyadenylation specificity factor 30 (CPSF30).

274 nt whose mutation mapped to the Cleavage and Polyadenylation Specificity Factor 30 gene (CPSF30-L).

275 impair its interaction with the cleavage and polyadenylation specificity factor 6 (CPSF6) and its abi

276 This requires cleavage and polyadenylation specificity factor 6 (CPSF6), a cellular

277 another capsid binding protein, cleavage and polyadenylation specificity factor 6 (CPSF6), has not be

278 t of this complex is likely the cleavage and polyadenylation specificity factor 73 kDa-I (CSPF73-I),

279 ncodes a homologue of mammalian cleavage and polyadenylation specificity factor subunit 3 (CPSF-73 or

280 Cleavage and polyadenylation specificity factor subunit 6 (CPSF6), a

281 nized by the multisubunit CPSF (cleavage and polyadenylation specificity factor) complex.

282 utilising cyclophilin A (CypA), cleavage and polyadenylation specificity factor-6 (CPSF6), Nup358 and

283 y inhibiting 3' cleavage by the cleavage and polyadenylation specificity factor.

284 tholog of 30 kDa subunit of the Cleavage and Polyadenylation Specificity Factor.

285 ps of mRNA life cycle, including alternative polyadenylation, splicing, export and decay.

286 cts of RNA structure on messenger RNA (mRNA) polyadenylation, splicing, translation, and turnover.

287 ny biological processes, including splicing, polyadenylation, stability, transportation, localization

288 Codon composition affects both polyadenylation status and translation efficiency.

289 sults in even greater levels of histone mRNA polyadenylation, suggesting that both CstF-64 and tauCst

290 sed via alternative splicing and alternative polyadenylation to generate at least 8 mRNA transcripts.

291 F3 and SRSF7 couple alternative splicing and polyadenylation to NXF1-mediated mRNA export, thereby co

292 sed via alternative splicing and alternative polyadenylation to produce at least 8 mRNA transcripts.

293 factors required for specific and efficient polyadenylation, to help coordinate mRNA 3'-end processi

294 clear exosome cofactor Trf4/5p-Air1/2p-Mtr4p polyadenylation (TRAMP) complex before subsequent nuclea

295 mponent of the U1 snRNP, is known to inhibit polyadenylation upon direct binding to mRNA.

296 r of translation control through alternative polyadenylation usage required to fine-tune the timing o

297 Alternative polyadenylation was largely independent from the relativ

298 rgely retained in the absence of cytoplasmic polyadenylation, which indicated that selective poly(A)-

299 mination of mRNAs is coupled to cleavage and polyadenylation while noncoding transcripts are terminat

300 Cryptic polyadenylation within coding sequences (CDS) triggers r